Single cell type - SLC31A2 - The Human Protein Atlas

SLC31A2

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC31A2
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 31 member 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Serous glandular cells - Salivary secretion (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Monocytes, Serous glandular cells, Kupffer cells, Oligodendrocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.59
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enriched (Oligodendrocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (non-classical monocyte, neutrophil, intermediate monocyte, classical monocyte, myeloid DC)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Monocytes, Serous glandular cells, Kupffer cells, Oligodendrocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enriched (Oligodendrocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Group enriched (non-classical monocyte, neutrophil, intermediate monocyte, classical monocyte, myeloid DC)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

SLC31A2 is part of cluster 75 Serous glandular cells - Salivary secretion with confidenceⁱ 1
145 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DNASE2B	Deoxyribonuclease 2 beta	0.8054	75
CAMP	Cathelicidin antimicrobial peptide	0.7408	75
RRAGD	Ras related GTP binding D	0.7405	75
STATH	Statherin	0.7313	75
AMY1A	Amylase alpha 1A	0.7306	75
SMR3B	Submaxillary gland androgen regulated protein 3B	0.7306	75
PRR27	Proline rich 27	0.7305	75
HTN3	Histatin 3	0.7287	75
HTN1	Histatin 1	0.7283	75
PRH1	Proline rich protein HaeIII subfamily 1	0.7274	75
PRR4	Proline rich 4	0.7274	75
PRB2	Proline rich protein BstNI subfamily 2	0.7271	75
ZG16B	Zymogen granule protein 16B	0.7270	75
PRH2	Proline rich protein HaeIII subfamily 2	0.7267	75
LPO	Lactoperoxidase	0.7261	75

IMMUNE CELLS

SLC31A2 is part of cluster 37 Monocytes & Neutrophils - Innate immune response with confidenceⁱ 1
275 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
STX11	Syntaxin 11	1.0000	37
SERPINA2	Serpin family A member 2 (gene/pseudogene)	1.0000	37
PLEKHO2	Pleckstrin homology domain containing O2	1.0000	37
RXRA	Retinoid X receptor alpha	1.0000	37
LRRC25	Leucine rich repeat containing 25	1.0000	37
CCDC96	Coiled-coil domain containing 96	1.0000	37
AP3S2	Adaptor related protein complex 3 subunit sigma 2	1.0000	37
LCN2	Lipocalin 2	1.0000	37
ITGAX	Integrin subunit alpha X	1.0000	37
CASP1	Caspase 1	1.0000	37
PSME3	Proteasome activator subunit 3	1.0000	37
AMPD2	Adenosine monophosphate deaminase 2	1.0000	37
TRPC4AP	Transient receptor potential cation channel subfamily C member 4 associated protein	1.0000	37
PPM1F	Protein phosphatase, Mg2+/Mn2+ dependent 1F	1.0000	37
CRISP3	Cysteine rich secretory protein 3	1.0000	37

Adipocytes	12.4 nTPM
Adipose tissue	18.4 nTPM
Breast	6.4 nTPM

Alveolar cells type 1	5.9 nTPM
Lung	5.9 nTPM

Alveolar cells type 2	4.8 nTPM
Lung	4.8 nTPM

Astrocytes	2.2 nTPM
Brain	2.2 nTPM

B-cells	6.8 nTPM
Skin	27.1 nTPM
Salivary gland	16.0 nTPM
Esophagus	11.8 nTPM
Lung	9.4 nTPM
Kidney	5.2 nTPM
Liver	4.8 nTPM
PBMC	4.6 nTPM
Adipose tissue	4.1 nTPM
Thymus	3.4 nTPM
Stomach	1.3 nTPM
Spleen	0.5 nTPM
Lymph node	0.4 nTPM
Bone marrow	0.0 nTPM

Ciliated cells	15.4 nTPM
Endometrium	24.1 nTPM
Lung	13.6 nTPM
Bronchus	13.5 nTPM
Fallopian tube	10.4 nTPM

Club cells	13.9 nTPM
Lung	16.4 nTPM
Bronchus	13.6 nTPM
Prostate	11.8 nTPM

Endothelial cells	9.3 nTPM
Liver	36.5 nTPM
Salivary gland	20.0 nTPM
Prostate	13.3 nTPM
Skin	11.9 nTPM
Lung	9.9 nTPM
Ovary	8.6 nTPM
Tongue	7.9 nTPM
Pancreas	7.8 nTPM
Thymus	7.8 nTPM
Skeletal muscle	7.2 nTPM
Breast	7.0 nTPM
Vascular	5.2 nTPM
Fallopian tube	4.9 nTPM
Endometrium	4.4 nTPM
Heart muscle	4.1 nTPM
Esophagus	3.9 nTPM
Testis	3.4 nTPM
Placenta	2.8 nTPM

Enteroendocrine cells	8.5 nTPM
Small intestine	20.6 nTPM
Colon	5.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	15.3 nTPM
Adipose tissue	59.3 nTPM
Salivary gland	27.0 nTPM
Skeletal muscle	22.3 nTPM
Thymus	20.6 nTPM
Pancreas	19.3 nTPM
Liver	19.0 nTPM
Skin	18.7 nTPM
Vascular	10.9 nTPM
Esophagus	9.7 nTPM
Prostate	7.9 nTPM
Lung	7.6 nTPM
Breast	6.9 nTPM
Placenta	5.6 nTPM
Fallopian tube	4.8 nTPM
Stomach	4.3 nTPM
Heart muscle	1.3 nTPM

Granulocytes	5.5 nTPM
Fallopian tube	6.5 nTPM
Lung	5.0 nTPM
Tongue	4.9 nTPM

Intestinal goblet cells	6.9 nTPM
Small intestine	14.0 nTPM
Colon	5.4 nTPM
Rectum	1.3 nTPM

Lymphatic endothelial cells	5.5 nTPM
Fallopian tube	5.5 nTPM
Ovary	5.5 nTPM

Macrophages	96.9 nTPM
Adipose tissue	264.9 nTPM
Pancreas	209.7 nTPM
Lung	179.1 nTPM
Skeletal muscle	111.2 nTPM
Testis	101.7 nTPM
Salivary gland	101.3 nTPM
Thymus	100.3 nTPM
Vascular	91.5 nTPM
Kidney	88.5 nTPM
Fallopian tube	86.8 nTPM
Stomach	84.9 nTPM
Prostate	69.5 nTPM
Spleen	69.2 nTPM
Bone marrow	62.8 nTPM
Breast	51.7 nTPM
Tongue	50.8 nTPM
Endometrium	47.4 nTPM
Skin	44.6 nTPM
Esophagus	25.7 nTPM

Paneth cells	5.4 nTPM
Small intestine	6.9 nTPM
Rectum	5.6 nTPM
Colon	3.6 nTPM

Basal prostatic cells	34.3 nTPM
Prostate	34.3 nTPM

Basal respiratory cells	35.2 nTPM
Bronchus	35.2 nTPM

Basal squamous epithelial cells	6.2 nTPM
Esophagus	6.2 nTPM

Bipolar cells	7.7 nTPM
Eye	7.7 nTPM

Plasma cells	13.7 nTPM
Salivary gland	31.3 nTPM
Fallopian tube	19.9 nTPM
Liver	15.5 nTPM
Stomach	13.8 nTPM
Esophagus	10.4 nTPM
Thymus	9.5 nTPM
Spleen	6.0 nTPM
Bone marrow	3.0 nTPM

Schwann cells	28.2 nTPM
Adipose tissue	66.4 nTPM
Esophagus	12.0 nTPM
Vascular	6.3 nTPM

Serous glandular cells	227.4 nTPM
Salivary gland	344.4 nTPM
Tongue	110.5 nTPM

Smooth muscle cells	13.7 nTPM
Salivary gland	82.3 nTPM
Adipose tissue	20.9 nTPM
Prostate	12.8 nTPM
Ovary	12.2 nTPM
Lung	11.8 nTPM
Placenta	11.3 nTPM
Skeletal muscle	11.0 nTPM
Tongue	10.8 nTPM
Skin	10.3 nTPM
Thymus	9.2 nTPM
Liver	7.6 nTPM
Vascular	6.7 nTPM
Fallopian tube	4.9 nTPM
Endometrium	3.6 nTPM
Breast	2.9 nTPM
Esophagus	1.2 nTPM

Suprabasal keratinocytes	31.4 nTPM
Skin	39.5 nTPM
Tongue	23.2 nTPM

T-cells	8.3 nTPM
Fallopian tube	19.6 nTPM
Salivary gland	18.4 nTPM
Prostate	15.8 nTPM
Liver	12.1 nTPM
Colon	11.7 nTPM
Tongue	11.4 nTPM
Adipose tissue	9.8 nTPM
Lung	9.0 nTPM
Skin	8.8 nTPM
Stomach	8.8 nTPM
Vascular	8.4 nTPM
Thymus	7.9 nTPM
Breast	7.2 nTPM
Endometrium	5.1 nTPM
Spleen	4.9 nTPM
Skeletal muscle	4.2 nTPM
PBMC	3.9 nTPM
Kidney	2.7 nTPM
Lymph node	2.6 nTPM
Bone marrow	1.6 nTPM
Esophagus	0.0 nTPM

Undifferentiated cells	4.7 nTPM
Small intestine	6.1 nTPM
Colon	4.9 nTPM
Rectum	3.0 nTPM

Amygdala excitatory	2.7 nTPM
Hippocampus	3.8 nTPM
Basal ganglia	3.2 nTPM
Cerebral cortex	2.9 nTPM
Amygdala	2.7 nTPM
Hypothalamus	2.4 nTPM
Thalamus	1.4 nTPM

Astrocyte	5.6 nTPM
Cerebellum	9.5 nTPM
Midbrain	9.0 nTPM
Spinal cord	7.1 nTPM
Thalamus	6.4 nTPM
Pons	5.9 nTPM
Hippocampus	5.2 nTPM
Cerebral cortex	4.5 nTPM
Medulla oblongata	4.1 nTPM
Basal ganglia	3.5 nTPM
Hypothalamus	3.3 nTPM
Amygdala	3.2 nTPM

Bergmann glia	5.4 nTPM
Medulla oblongata	6.4 nTPM
Pons	5.8 nTPM
Cerebellum	4.2 nTPM

Central nervous system macrophage	10.9 nTPM
Spinal cord	15.9 nTPM
Midbrain	13.9 nTPM
Cerebellum	12.9 nTPM
Pons	12.8 nTPM
Thalamus	10.4 nTPM
Amygdala	9.4 nTPM
Medulla oblongata	9.4 nTPM
Hippocampus	9.2 nTPM
Hypothalamus	9.1 nTPM
Cerebral cortex	8.7 nTPM
Basal ganglia	8.5 nTPM

Cerebellar inhibitory	2.7 nTPM
Medulla oblongata	4.6 nTPM
Pons	3.5 nTPM
Cerebellum	2.9 nTPM
Midbrain	2.5 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	3.0 nTPM
Basal ganglia	3.5 nTPM
Cerebral cortex	3.4 nTPM
Hippocampus	3.1 nTPM
Midbrain	3.1 nTPM
Amygdala	2.8 nTPM
Thalamus	2.6 nTPM
Hypothalamus	2.3 nTPM

Choroid plexus epithelial cell	2.9 nTPM
Medulla oblongata	3.8 nTPM
Hippocampus	2.8 nTPM
Thalamus	2.7 nTPM
Basal ganglia	2.3 nTPM

Committed oligodendrocyte precursor	46.7 nTPM
Thalamus	106.9 nTPM
Hypothalamus	77.8 nTPM
Amygdala	73.9 nTPM
Basal ganglia	52.6 nTPM
Midbrain	37.8 nTPM
Hippocampus	35.4 nTPM
Spinal cord	33.1 nTPM
Cerebral cortex	32.9 nTPM
Pons	31.0 nTPM
Cerebellum	20.6 nTPM
Medulla oblongata	11.6 nTPM

Deep-layer corticothalamic and 6b	2.5 nTPM
Hypothalamus	3.3 nTPM
Cerebral cortex	2.6 nTPM
Basal ganglia	2.5 nTPM
Hippocampus	2.4 nTPM
Midbrain	2.2 nTPM
Amygdala	1.9 nTPM

Deep-layer intratelencephalic	3.3 nTPM
Hippocampus	4.6 nTPM
Basal ganglia	3.2 nTPM
Cerebral cortex	3.2 nTPM
Hypothalamus	2.9 nTPM
Amygdala	2.7 nTPM

Deep-layer near-projecting	3.2 nTPM
Basal ganglia	3.6 nTPM
Hypothalamus	3.4 nTPM
Hippocampus	3.3 nTPM
Amygdala	3.0 nTPM
Cerebral cortex	2.9 nTPM

Eccentric medium spiny neuron	2.6 nTPM
Basal ganglia	3.1 nTPM
Hippocampus	2.9 nTPM
Thalamus	2.9 nTPM
Cerebral cortex	2.4 nTPM
Hypothalamus	2.4 nTPM
Amygdala	2.0 nTPM

Endothelial cell	6.6 nTPM
Cerebral cortex	9.6 nTPM
Cerebellum	9.3 nTPM
Hippocampus	8.7 nTPM
Medulla oblongata	8.2 nTPM
Pons	6.9 nTPM
Spinal cord	6.9 nTPM
Hypothalamus	6.2 nTPM
Midbrain	5.7 nTPM
Thalamus	4.5 nTPM
Amygdala	3.4 nTPM
Basal ganglia	2.8 nTPM