Single cell type - TTLL5 - The Human Protein Atlas

TTLL5

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TTLL5
Gene descriptionⁱ Full gene name according to HGNC.	Tubulin tyrosine ligase like 5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Oligodendrocytes - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oligodendrocytes, Excitatory neurons, Inhibitory neurons, Early spermatids, Late spermatids, Rod photoreceptor cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.56
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Excitatory neurons, Inhibitory neurons, Early spermatids, Late spermatids, Rod photoreceptor cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TTLL5 is part of cluster 51 Oligodendrocytes - Unknown function with confidenceⁱ 1
302 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SAMD12	Sterile alpha motif domain containing 12	0.6282	51
RTL4	Retrotransposon Gag like 4	0.5824	51
WDPCP	WD repeat containing planar cell polarity effector	0.5820	51
UNC5C	Unc-5 netrin receptor C	0.5808	65
MAP7	Microtubule associated protein 7	0.5796	51
AGAP5	ArfGAP with GTPase domain, ankyrin repeat and PH domain 5	0.5681	13
TTLL11	Tubulin tyrosine ligase like 11	0.5582	51
DIS3L2	DIS3 like 3'-5' exoribonuclease 2	0.5365	8
ENOX1	Ecto-NOX disulfide-thiol exchanger 1	0.5357	8
FMNL2	Formin like 2	0.5339	51
IL1RAPL1	Interleukin 1 receptor accessory protein like 1	0.5265	65
TECPR2	Tectonin beta-propeller repeat containing 2	0.5260	51
KIF6	Kinesin family member 6	0.5245	51
IGSF11	Immunoglobulin superfamily member 11	0.5223	65
NSMCE2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase	0.5195	51

IMMUNE CELLS

TTLL5 is part of cluster 5 Non-specific - Cell proliferation with confidenceⁱ 1
689 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KLF9	KLF transcription factor 9	0.9762	5
RAD52	RAD52 homolog, DNA repair protein	0.9762	5
WASL	WASP like actin nucleation promoting factor	0.9524	5
PDE6B	Phosphodiesterase 6B	0.9524	5
IBA57	Iron-sulfur cluster assembly factor IBA57	0.9286	5
HNRNPH1	Heterogeneous nuclear ribonucleoprotein H1	0.9286	5
PIGO	Phosphatidylinositol glycan anchor biosynthesis class O	0.9286	5
MARCHF9	Membrane associated ring-CH-type finger 9	0.9286	5
MTRF1	Mitochondrial translation release factor 1	0.9286	5
RCL1	RNA terminal phosphate cyclase like 1	0.9048	5
ERCC3	ERCC excision repair 3, TFIIH core complex helicase subunit	0.9048	5
TBC1D32	TBC1 domain family member 32	0.9048	5
AKAP1	A-kinase anchoring protein 1	0.9048	5
HOXB3	Homeobox B3	0.9048	5
TRDMT1	TRNA aspartic acid methyltransferase 1	0.9048	5

Adipocytes	6.8 nTPM
Adipose tissue	7.9 nTPM
Breast	5.6 nTPM

Alveolar cells type 1	6.8 nTPM
Lung	6.8 nTPM

Alveolar cells type 2	10.2 nTPM
Lung	10.2 nTPM

Astrocytes	68.1 nTPM
Brain	68.1 nTPM

B-cells	4.8 nTPM
Skin	8.5 nTPM
Stomach	8.4 nTPM
Salivary gland	8.1 nTPM
Thymus	7.6 nTPM
Spleen	5.9 nTPM
Lymph node	5.7 nTPM
Adipose tissue	5.3 nTPM
Bone marrow	5.3 nTPM
Lung	4.0 nTPM
PBMC	3.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM

Ciliated cells	35.2 nTPM
Bronchus	42.7 nTPM
Lung	39.6 nTPM
Endometrium	34.9 nTPM
Fallopian tube	23.6 nTPM

Club cells	7.0 nTPM
Prostate	8.7 nTPM
Bronchus	6.2 nTPM
Lung	6.0 nTPM

Endothelial cells	10.3 nTPM
Esophagus	15.6 nTPM
Endometrium	13.2 nTPM
Salivary gland	12.7 nTPM
Ovary	12.6 nTPM
Heart muscle	12.2 nTPM
Vascular	11.1 nTPM
Placenta	10.8 nTPM
Skin	10.7 nTPM
Testis	10.4 nTPM
Thymus	10.4 nTPM
Liver	10.1 nTPM
Tongue	10.1 nTPM
Lung	8.3 nTPM
Pancreas	7.8 nTPM
Skeletal muscle	7.8 nTPM
Prostate	7.0 nTPM
Breast	7.0 nTPM
Fallopian tube	6.9 nTPM

Enteroendocrine cells	6.6 nTPM
Colon	9.5 nTPM
Small intestine	6.9 nTPM
Rectum	3.4 nTPM

Fibroblasts	8.3 nTPM
Liver	36.8 nTPM
Skin	9.1 nTPM
Vascular	8.7 nTPM
Heart muscle	8.5 nTPM
Skeletal muscle	8.2 nTPM
Salivary gland	7.8 nTPM
Stomach	7.2 nTPM
Adipose tissue	6.4 nTPM
Thymus	6.3 nTPM
Placenta	6.1 nTPM
Esophagus	5.8 nTPM
Pancreas	5.6 nTPM
Fallopian tube	5.4 nTPM
Breast	4.5 nTPM
Prostate	3.3 nTPM
Lung	3.2 nTPM

Granulocytes	3.8 nTPM
Fallopian tube	8.8 nTPM
Lung	2.5 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	8.2 nTPM
Small intestine	9.2 nTPM
Colon	8.1 nTPM
Rectum	7.1 nTPM

Lymphatic endothelial cells	6.3 nTPM
Fallopian tube	12.6 nTPM
Ovary	0.0 nTPM

Macrophages	6.7 nTPM
Spleen	13.0 nTPM
Pancreas	10.3 nTPM
Testis	9.9 nTPM
Skeletal muscle	8.8 nTPM
Thymus	8.0 nTPM
Skin	7.8 nTPM
Tongue	7.7 nTPM
Vascular	7.2 nTPM
Bone marrow	7.1 nTPM
Salivary gland	6.9 nTPM
Lung	6.4 nTPM
Prostate	6.2 nTPM
Adipose tissue	5.7 nTPM
Breast	4.4 nTPM
Endometrium	4.3 nTPM
Esophagus	3.9 nTPM
Fallopian tube	3.9 nTPM
Kidney	3.5 nTPM
Stomach	2.6 nTPM

Paneth cells	14.0 nTPM
Colon	18.1 nTPM
Small intestine	13.8 nTPM
Rectum	10.0 nTPM

Basal keratinocytes	7.3 nTPM
Tongue	9.6 nTPM
Skin	5.0 nTPM

Cholangiocytes	17.2 nTPM
Liver	17.2 nTPM

Cone photoreceptor cells	42.5 nTPM
Eye	42.5 nTPM

Plasma cells	6.1 nTPM
Spleen	9.9 nTPM
Bone marrow	9.1 nTPM
Thymus	9.0 nTPM
Liver	7.0 nTPM
Salivary gland	4.9 nTPM
Fallopian tube	4.8 nTPM
Stomach	3.8 nTPM
Esophagus	0.0 nTPM

Schwann cells	10.1 nTPM
Esophagus	12.0 nTPM
Vascular	10.4 nTPM
Adipose tissue	7.8 nTPM

Serous glandular cells	7.6 nTPM
Salivary gland	10.8 nTPM
Tongue	4.4 nTPM

Smooth muscle cells	5.6 nTPM
Salivary gland	8.3 nTPM
Endometrium	8.1 nTPM
Vascular	7.3 nTPM
Liver	7.2 nTPM
Placenta	6.4 nTPM
Thymus	5.9 nTPM
Tongue	5.7 nTPM
Skin	5.6 nTPM
Ovary	5.5 nTPM
Skeletal muscle	5.4 nTPM
Adipose tissue	4.9 nTPM
Esophagus	4.8 nTPM
Lung	4.7 nTPM
Fallopian tube	3.3 nTPM
Breast	3.2 nTPM
Prostate	3.0 nTPM

T-cells	7.7 nTPM
Esophagus	12.2 nTPM
Adipose tissue	11.9 nTPM
Tongue	11.2 nTPM
Colon	10.7 nTPM
Skeletal muscle	10.6 nTPM
Stomach	10.4 nTPM
Endometrium	9.9 nTPM
Breast	8.6 nTPM
Thymus	8.2 nTPM
Skin	8.1 nTPM
Vascular	7.6 nTPM
Salivary gland	7.5 nTPM
PBMC	6.6 nTPM
Lung	6.5 nTPM
Fallopian tube	6.1 nTPM
Lymph node	5.7 nTPM
Spleen	5.2 nTPM
Liver	4.4 nTPM
Bone marrow	3.9 nTPM
Prostate	3.6 nTPM
Kidney	2.7 nTPM

Undifferentiated cells	8.9 nTPM
Small intestine	10.1 nTPM
Colon	8.5 nTPM
Rectum	7.9 nTPM

Amygdala excitatory	144.6 nTPM
Hippocampus	162.1 nTPM
Amygdala	157.8 nTPM
Cerebral cortex	154.5 nTPM
Hypothalamus	133.8 nTPM
Thalamus	130.2 nTPM
Basal ganglia	129.4 nTPM

Astrocyte	141.7 nTPM
Spinal cord	196.7 nTPM
Hypothalamus	180.3 nTPM
Medulla oblongata	173.1 nTPM
Amygdala	154.6 nTPM
Hippocampus	137.5 nTPM
Cerebellum	128.5 nTPM
Pons	124.8 nTPM
Cerebral cortex	120.4 nTPM
Basal ganglia	114.9 nTPM
Midbrain	114.2 nTPM
Thalamus	113.6 nTPM

Bergmann glia	161.7 nTPM
Cerebellum	184.3 nTPM
Medulla oblongata	168.4 nTPM
Pons	132.3 nTPM

Central nervous system macrophage	93.1 nTPM
Amygdala	126.1 nTPM
Hypothalamus	105.2 nTPM
Midbrain	96.7 nTPM
Hippocampus	92.0 nTPM
Basal ganglia	91.5 nTPM
Cerebellum	91.3 nTPM
Spinal cord	91.0 nTPM
Thalamus	88.1 nTPM
Pons	86.2 nTPM
Cerebral cortex	82.1 nTPM
Medulla oblongata	73.6 nTPM

Cerebellar inhibitory	132.8 nTPM
Spinal cord	148.5 nTPM
Medulla oblongata	141.8 nTPM
Cerebellum	127.3 nTPM
Pons	124.2 nTPM
Midbrain	122.2 nTPM

Cge interneuron	105.6 nTPM
Hypothalamus	133.9 nTPM
Amygdala	118.6 nTPM
Thalamus	101.4 nTPM
Hippocampus	98.0 nTPM
Basal ganglia	96.9 nTPM
Midbrain	96.4 nTPM
Cerebral cortex	94.5 nTPM

Choroid plexus epithelial cell	329.4 nTPM
Basal ganglia	493.2 nTPM
Thalamus	320.6 nTPM
Medulla oblongata	273.8 nTPM
Hippocampus	230.2 nTPM

Committed oligodendrocyte precursor	115.6 nTPM
Thalamus	156.7 nTPM
Hypothalamus	145.4 nTPM
Cerebellum	134.8 nTPM
Medulla oblongata	127.8 nTPM
Basal ganglia	117.7 nTPM
Pons	109.8 nTPM
Amygdala	106.0 nTPM
Midbrain	101.6 nTPM
Spinal cord	95.7 nTPM
Hippocampus	88.2 nTPM
Cerebral cortex	87.4 nTPM

Deep-layer corticothalamic and 6b	101.3 nTPM
Hypothalamus	131.1 nTPM
Amygdala	102.7 nTPM
Cerebral cortex	102.0 nTPM
Basal ganglia	98.0 nTPM
Hippocampus	97.6 nTPM
Midbrain	76.5 nTPM

Deep-layer intratelencephalic	113.4 nTPM
Hypothalamus	138.6 nTPM
Amygdala	116.2 nTPM
Hippocampus	110.9 nTPM
Cerebral cortex	106.9 nTPM
Basal ganglia	94.4 nTPM

Deep-layer near-projecting	81.2 nTPM
Hypothalamus	101.2 nTPM
Amygdala	88.0 nTPM
Cerebral cortex	84.1 nTPM
Basal ganglia	72.4 nTPM
Hippocampus	60.2 nTPM

Eccentric medium spiny neuron	116.7 nTPM
Hypothalamus	123.4 nTPM
Thalamus	120.7 nTPM
Basal ganglia	116.8 nTPM
Amygdala	116.1 nTPM
Cerebral cortex	114.4 nTPM
Hippocampus	108.6 nTPM

Endothelial cell	178.0 nTPM
Spinal cord	226.1 nTPM
Basal ganglia	206.9 nTPM
Amygdala	203.4 nTPM
Cerebral cortex	196.3 nTPM
Hippocampus	181.1 nTPM
Hypothalamus	179.9 nTPM
Cerebellum	161.8 nTPM
Midbrain	155.9 nTPM
Pons	155.4 nTPM
Thalamus	146.3 nTPM
Medulla oblongata	144.6 nTPM

Ependymal cell	547.9 nTPM
Hypothalamus	767.4 nTPM
Basal ganglia	694.2 nTPM
Amygdala	563.7 nTPM
Thalamus	546.3 nTPM
Midbrain	535.9 nTPM
Hippocampus	502.1 nTPM
Pons	457.7 nTPM
Medulla oblongata	438.6 nTPM
Spinal cord	425.5 nTPM