Single cell type - TTLL11 - The Human Protein Atlas

TTLL11

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TTLL11
Gene descriptionⁱ Full gene name according to HGNC.	Tubulin tyrosine ligase like 11
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Oligodendrocytes - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Oligodendrocytes, Excitatory neurons, Inhibitory neurons)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.79
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Oligodendrocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Group enriched (Oligodendrocytes, Excitatory neurons, Inhibitory neurons)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Oligodendrocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TTLL11 is part of cluster 51 Oligodendrocytes - Unknown function with confidenceⁱ 1
302 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OTUD7A	OTU deubiquitinase 7A	0.8910	51
MAGI2	Membrane associated guanylate kinase, WW and PDZ domain containing 2	0.8801	51
RAPGEF5	Rap guanine nucleotide exchange factor 5	0.8655	51
RTL4	Retrotransposon Gag like 4	0.8488	51
KLHL32	Kelch like family member 32	0.8476	51
WDPCP	WD repeat containing planar cell polarity effector	0.8331	51
FRMD5	FERM domain containing 5	0.7895	51
DNAJC6	DnaJ heat shock protein family (Hsp40) member C6	0.7828	51
OR2L13	Olfactory receptor family 2 subfamily L member 13	0.7756	34
SLC24A2	Solute carrier family 24 member 2	0.7646	51
WDR7	WD repeat domain 7	0.7587	8
PVALEF	Parvalbumin like EF-hand containing	0.7535	51
RAPGEF6	Rap guanine nucleotide exchange factor 6	0.7327	51
EXOC6B	Exocyst complex component 6B	0.7308	51
PLET1	Placenta expressed transcript 1	0.7300	51

Adipocytes	1.8 nTPM
Breast	2.2 nTPM
Adipose tissue	1.4 nTPM

Alveolar cells type 1	3.5 nTPM
Lung	3.5 nTPM

Alveolar cells type 2	1.4 nTPM
Lung	1.4 nTPM

Astrocytes	17.3 nTPM
Brain	17.3 nTPM

B-cells	1.4 nTPM
Skin	3.4 nTPM
Stomach	3.0 nTPM
Lung	2.7 nTPM
Thymus	2.4 nTPM
Lymph node	2.3 nTPM
Bone marrow	1.6 nTPM
Spleen	1.3 nTPM
Salivary gland	1.1 nTPM
Adipose tissue	0.4 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM

Ciliated cells	1.8 nTPM
Endometrium	2.4 nTPM
Fallopian tube	2.2 nTPM
Lung	2.0 nTPM
Bronchus	0.7 nTPM

Club cells	1.1 nTPM
Prostate	1.7 nTPM
Lung	1.1 nTPM
Bronchus	0.7 nTPM

Endothelial cells	2.2 nTPM
Pancreas	5.2 nTPM
Breast	4.4 nTPM
Thymus	3.7 nTPM
Endometrium	2.7 nTPM
Esophagus	2.6 nTPM
Liver	2.5 nTPM
Skeletal muscle	2.3 nTPM
Testis	2.1 nTPM
Ovary	2.1 nTPM
Vascular	2.0 nTPM
Fallopian tube	2.0 nTPM
Lung	1.9 nTPM
Placenta	1.7 nTPM
Salivary gland	1.4 nTPM
Tongue	1.3 nTPM
Skin	0.9 nTPM
Prostate	0.7 nTPM
Heart muscle	0.0 nTPM

Enteroendocrine cells	2.0 nTPM
Small intestine	3.4 nTPM
Rectum	1.7 nTPM
Colon	0.9 nTPM

Fibroblasts	2.5 nTPM
Thymus	4.7 nTPM
Skin	4.2 nTPM
Esophagus	3.6 nTPM
Adipose tissue	3.1 nTPM
Stomach	2.9 nTPM
Lung	2.9 nTPM
Skeletal muscle	2.8 nTPM
Salivary gland	2.8 nTPM
Vascular	2.8 nTPM
Breast	2.8 nTPM
Pancreas	2.6 nTPM
Fallopian tube	2.2 nTPM
Prostate	2.0 nTPM
Placenta	0.6 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM

Granulocytes	0.8 nTPM
Fallopian tube	1.3 nTPM
Lung	1.0 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	1.2 nTPM
Colon	2.2 nTPM
Rectum	1.3 nTPM
Small intestine	0.1 nTPM

Lymphatic endothelial cells	3.8 nTPM
Ovary	5.5 nTPM
Fallopian tube	2.2 nTPM

Macrophages	1.2 nTPM
Thymus	3.1 nTPM
Stomach	2.6 nTPM
Skin	2.2 nTPM
Prostate	1.9 nTPM
Breast	1.8 nTPM
Lung	1.5 nTPM
Esophagus	1.3 nTPM
Salivary gland	1.3 nTPM
Endometrium	1.2 nTPM
Skeletal muscle	1.1 nTPM
Fallopian tube	1.1 nTPM
Spleen	1.0 nTPM
Adipose tissue	0.8 nTPM
Vascular	0.7 nTPM
Testis	0.6 nTPM
Tongue	0.3 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM

Paneth cells	0.2 nTPM
Rectum	0.5 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Bipolar cells	3.3 nTPM
Eye	3.3 nTPM

Cone photoreceptor cells	10.2 nTPM
Eye	10.2 nTPM

Early spermatids	18.3 nTPM
Testis	18.3 nTPM

Plasma cells	2.6 nTPM
Stomach	4.6 nTPM
Liver	4.5 nTPM
Thymus	3.7 nTPM
Bone marrow	3.0 nTPM
Spleen	2.6 nTPM
Salivary gland	1.3 nTPM
Fallopian tube	0.6 nTPM
Esophagus	0.0 nTPM

Schwann cells	1.3 nTPM
Vascular	3.7 nTPM
Adipose tissue	0.4 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	1.0 nTPM
Salivary gland	2.0 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	2.5 nTPM
Thymus	5.7 nTPM
Skin	3.8 nTPM
Vascular	3.8 nTPM
Adipose tissue	3.6 nTPM
Esophagus	3.6 nTPM
Skeletal muscle	2.8 nTPM
Breast	2.6 nTPM
Fallopian tube	2.5 nTPM
Ovary	2.3 nTPM
Endometrium	2.0 nTPM
Placenta	1.9 nTPM
Prostate	1.8 nTPM
Tongue	1.5 nTPM
Lung	1.2 nTPM
Salivary gland	0.9 nTPM
Liver	0.4 nTPM

T-cells	1.7 nTPM
Esophagus	4.9 nTPM
Thymus	3.2 nTPM
Bone marrow	2.6 nTPM
Lymph node	2.5 nTPM
Spleen	2.2 nTPM
Endometrium	2.0 nTPM
Salivary gland	1.9 nTPM
Breast	1.9 nTPM
PBMC	1.7 nTPM
Stomach	1.7 nTPM
Prostate	1.7 nTPM
Skeletal muscle	1.5 nTPM
Skin	1.4 nTPM
Lung	1.3 nTPM
Liver	1.1 nTPM
Colon	1.0 nTPM
Vascular	0.8 nTPM
Fallopian tube	0.7 nTPM
Adipose tissue	0.5 nTPM
Tongue	0.2 nTPM
Kidney	0.0 nTPM

Undifferentiated cells	1.1 nTPM
Colon	1.2 nTPM
Rectum	1.1 nTPM
Small intestine	1.0 nTPM

Amygdala excitatory	115.7 nTPM
Hypothalamus	152.5 nTPM
Cerebral cortex	125.4 nTPM
Amygdala	120.1 nTPM
Hippocampus	116.3 nTPM
Basal ganglia	102.8 nTPM
Thalamus	77.1 nTPM

Astrocyte	33.3 nTPM
Amygdala	42.4 nTPM
Cerebellum	37.7 nTPM
Midbrain	35.6 nTPM
Hippocampus	33.5 nTPM
Thalamus	33.3 nTPM
Basal ganglia	33.0 nTPM
Hypothalamus	32.2 nTPM
Pons	31.7 nTPM
Medulla oblongata	31.5 nTPM
Cerebral cortex	30.5 nTPM
Spinal cord	24.4 nTPM

Bergmann glia	39.1 nTPM
Medulla oblongata	46.9 nTPM
Cerebellum	37.2 nTPM
Pons	33.1 nTPM

Central nervous system macrophage	44.1 nTPM
Amygdala	60.5 nTPM
Midbrain	46.3 nTPM
Hypothalamus	45.4 nTPM
Thalamus	45.4 nTPM
Cerebral cortex	43.9 nTPM
Hippocampus	43.9 nTPM
Pons	43.7 nTPM
Cerebellum	42.2 nTPM
Basal ganglia	39.1 nTPM
Medulla oblongata	38.2 nTPM
Spinal cord	36.8 nTPM

Cerebellar inhibitory	70.2 nTPM
Spinal cord	85.2 nTPM
Medulla oblongata	73.8 nTPM
Cerebellum	66.5 nTPM
Pons	65.0 nTPM
Midbrain	60.3 nTPM

Cge interneuron	71.4 nTPM
Hypothalamus	100.1 nTPM
Amygdala	79.5 nTPM
Hippocampus	76.4 nTPM
Cerebral cortex	69.4 nTPM
Basal ganglia	62.3 nTPM
Midbrain	61.9 nTPM
Thalamus	50.2 nTPM

Choroid plexus epithelial cell	135.6 nTPM
Basal ganglia	189.8 nTPM
Thalamus	126.1 nTPM
Medulla oblongata	118.6 nTPM
Hippocampus	108.2 nTPM

Committed oligodendrocyte precursor	174.6 nTPM
Hypothalamus	357.1 nTPM
Amygdala	314.1 nTPM
Thalamus	252.8 nTPM
Cerebral cortex	175.4 nTPM
Hippocampus	171.8 nTPM
Basal ganglia	158.8 nTPM
Midbrain	140.3 nTPM
Pons	114.2 nTPM
Medulla oblongata	87.8 nTPM
Cerebellum	85.6 nTPM
Spinal cord	62.5 nTPM

Deep-layer corticothalamic and 6b	97.4 nTPM
Hypothalamus	121.2 nTPM
Cerebral cortex	118.4 nTPM
Hippocampus	98.6 nTPM
Amygdala	86.2 nTPM
Basal ganglia	81.0 nTPM
Midbrain	78.8 nTPM

Deep-layer intratelencephalic	136.0 nTPM
Hypothalamus	162.7 nTPM
Amygdala	141.8 nTPM
Cerebral cortex	136.5 nTPM
Basal ganglia	129.2 nTPM
Hippocampus	109.5 nTPM

Deep-layer near-projecting	124.7 nTPM
Hypothalamus	157.5 nTPM
Cerebral cortex	146.6 nTPM
Amygdala	139.5 nTPM
Basal ganglia	100.0 nTPM
Hippocampus	79.7 nTPM

Eccentric medium spiny neuron	101.4 nTPM
Thalamus	138.0 nTPM
Basal ganglia	125.5 nTPM
Hippocampus	102.0 nTPM
Amygdala	81.9 nTPM
Cerebral cortex	81.2 nTPM
Hypothalamus	79.8 nTPM

Endothelial cell	37.3 nTPM
Spinal cord	57.0 nTPM
Amygdala	53.7 nTPM
Midbrain	47.3 nTPM
Hippocampus	39.1 nTPM
Pons	38.7 nTPM
Cerebral cortex	35.8 nTPM
Cerebellum	34.1 nTPM
Thalamus	31.6 nTPM
Basal ganglia	28.0 nTPM
Medulla oblongata	27.7 nTPM
Hypothalamus	17.4 nTPM

Ependymal cell	60.2 nTPM
Basal ganglia	67.8 nTPM
Midbrain	67.3 nTPM
Hypothalamus	66.0 nTPM
Amygdala	65.4 nTPM
Pons	56.2 nTPM
Spinal cord	55.6 nTPM
Thalamus	55.5 nTPM
Medulla oblongata	54.9 nTPM
Hippocampus	52.8 nTPM