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The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
SPARC is not prognostic in Pancreatic Adenocarcinoma (TCGA)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
1330.8
Number of samples
176
Samples
Sample
Description
TPM
TCGA-IB-7893-01A
0 years, male, white, stage:Stage IIA, dead, 117 days
7929.2
TCGA-HZ-7925-01A
0 years, male, white, stage:Stage IIB, dead, 614 days
6716.1
TCGA-IB-AAUV-01A
0 years, male, white, stage:Stage IIB, alive, 404 days
5888.8
TCGA-IB-7890-01A
0 years, male, stage:Stage IB, dead, 598 days
5439.3
TCGA-HZ-7922-01A
0 years, female, white, stage:Stage IIB, alive, 4 days
4698.9
TCGA-FB-AAPS-01A
0 years, female, white, stage:Stage IIB, alive, 228 days
4247.9
TCGA-IB-7646-01A
0 years, male, white, stage:Stage IIB, dead, 145 days
4084.6
TCGA-XD-AAUG-01A
0 years, female, white, stage:Stage IV, alive, 420 days
3960.3
TCGA-YH-A8SY-01A
0 years, female, white, stage:'--, alive, 388 days
3640.5
TCGA-HZ-8005-01A
0 years, male, white, stage:Stage IIB, dead, 120 days
3484.0
TCGA-HZ-8002-01A
0 years, male, white, stage:Stage IIB, dead, 366 days
3324.6
TCGA-IB-7645-01A
0 years, female, stage:Stage IIB, dead, 1502 days
3314.9
TCGA-HZ-A77Q-01A
0 years, female, white, stage:Stage IIB, alive, 33 days
3225.0
TCGA-IB-7654-01A
0 years, male, white, stage:Stage IIB, dead, 476 days
3197.8
TCGA-IB-A5SS-01A
0 years, female, white, stage:Stage IIB, dead, 460 days
3011.4
TCGA-YB-A89D-01A
0 years, male, white, stage:Stage IIB, alive, 350 days
2703.2
TCGA-3A-A9IC-01A
0 years, female, white, stage:Stage IIB, dead, 738 days
2633.0
TCGA-IB-A5SQ-01A
0 years, female, white, stage:Stage IB, dead, 219 days
2522.6
TCGA-HZ-8001-01A
0 years, male, white, stage:Stage III, alive, 706 days
2519.2
TCGA-IB-7897-01A
0 years, female, white, stage:Stage IIB, dead, 486 days
2480.8
TCGA-F2-7273-01A
0 years, male, black or african american, stage:Stage IIB, dead, 592 days
2479.6
TCGA-HV-AA8V-01A
0 years, male, asian, stage:Stage IIB, alive, 920 days
2469.4
TCGA-IB-7888-01A
0 years, female, black or african american, stage:Stage IIA, dead, 1332 days
2456.7
TCGA-IB-AAUS-01A
0 years, female, white, stage:Stage IIB, alive, 225 days
2407.8
TCGA-HZ-8636-01A
0 years, female, white, stage:Stage IV, dead, 545 days
2363.9
TCGA-IB-7886-01A
0 years, male, white, stage:Stage IIB, dead, 123 days
2268.9
TCGA-IB-AAUP-01A
0 years, male, white, stage:Stage IIB, alive, 431 days
2266.9
TCGA-IB-7885-01A
0 years, female, white, stage:Stage IIB, alive, 1257 days
2258.4
TCGA-IB-7652-01A
0 years, female, asian, stage:Stage IIB, alive, 1116 days
2115.3
TCGA-3A-A9I7-01A
0 years, male, black or african american, stage:Stage IIB, alive, 1323 days
2076.4
TCGA-HZ-7918-01A
0 years, male, white, stage:Stage IIB, alive, 969 days
2067.9
TCGA-F2-7276-01A
0 years, male, white, stage:Stage IIB, dead, 216 days
2050.9
TCGA-IB-7891-01A
0 years, female, white, stage:Stage IIB, dead, 913 days
2039.3
TCGA-XD-AAUL-01A
0 years, male, white, stage:Stage IIA, alive, 498 days
2036.6
TCGA-XN-A8T5-01A
0 years, female, white, stage:Stage IB, alive, 720 days
2019.6
TCGA-FB-A7DR-01A
0 years, male, asian, stage:Stage IIA, dead, 353 days
1983.3
TCGA-US-A774-01A
0 years, female, white, stage:Stage IIB, dead, 695 days
1904.1
TCGA-HZ-8519-01A
0 years, male, white, stage:Stage IA, alive, 454 days
1873.8
TCGA-IB-8127-01A
0 years, male, white, stage:Stage IIB, alive, 522 days
1848.6
TCGA-IB-7651-01A
0 years, female, white, stage:Stage IIB, dead, 603 days
1791.9
TCGA-IB-A5ST-01A
0 years, female, white, stage:Stage IIB, alive, 635 days
1784.7
TCGA-RB-A7B8-01A
0 years, female, white, stage:Stage IIB, dead, 466 days
1778.6
TCGA-IB-7644-01A
0 years, female, white, stage:Stage IV, dead, 394 days
1778.4
TCGA-IB-7887-01A
0 years, female, white, stage:Stage IIB, dead, 110 days
1740.3
TCGA-2J-AAB8-01A
0 years, male, white, stage:Stage IIB, alive, 80 days
1735.7
TCGA-HZ-A4BH-01A
0 years, male, white, stage:Stage IIB, alive, 194 days
1726.5
TCGA-F2-A44H-01A
0 years, male, white, stage:Stage IIA, alive, 586 days
1708.3
TCGA-H6-A45N-01A
0 years, female, white, stage:Stage IIB, dead, 397 days
1694.9
TCGA-FB-A4P6-01A
0 years, male, white, stage:Stage IIB, alive, 767 days
1689.8
TCGA-2J-AABE-01A
0 years, male, white, stage:Stage IIA, alive, 676 days
1676.2
TCGA-HV-A5A4-01A
0 years, female, asian, stage:Stage IIA, alive, 232 days
1674.9
TCGA-IB-A5SO-01A
0 years, male, white, stage:Stage IIB, dead, 365 days
1667.2
TCGA-IB-7649-01A
0 years, female, stage:Stage IIB, dead, 467 days
1662.4
TCGA-3A-A9IZ-01A
0 years, male, white, stage:Stage IIB, dead, 308 days
1645.1
TCGA-HZ-7926-01A
0 years, male, black or african american, stage:Stage IIB, dead, 518 days
1632.6
TCGA-XN-A8T3-01A
0 years, male, white, stage:Stage IB, alive, 951 days
1615.2
TCGA-M8-A5N4-01A
0 years, female, stage:Stage IIA, alive, 584 days
1574.4
TCGA-H6-8124-01A
0 years, female, white, stage:Stage IIB, alive, 392 days
1547.1
TCGA-3A-A9IB-01A
0 years, female, white, stage:Stage IIB, dead, 224 days
1545.3
TCGA-2J-AABO-01A
0 years, male, white, stage:Stage IIB, alive, 440 days
1524.9
TCGA-HZ-8315-01A
0 years, female, white, stage:Stage IIA, dead, 299 days
1511.1
TCGA-3A-A9IX-01A
0 years, male, white, stage:Stage IA, alive, 1037 days
1506.1
TCGA-US-A77E-01A
0 years, male, white, stage:Stage IIB, dead, 430 days
1489.0
TCGA-F2-6879-01A
0 years, male, white, stage:Stage IIB, dead, 334 days
1475.7
TCGA-HZ-7919-01A
0 years, female, white, stage:Stage IIB, dead, 593 days
1459.5
TCGA-L1-A7W4-01A
0 years, female, white, stage:Stage IIB, dead, 278 days
1450.3
TCGA-IB-AAUR-01A
0 years, male, white, stage:Stage IIB, alive, 338 days
1450.1
TCGA-HZ-7923-01A
0 years, male, white, stage:Stage IIA, alive, 314 days
1442.2
TCGA-FB-A545-01A
0 years, female, white, stage:Stage IIB, dead, 732 days
1399.4
TCGA-2J-AABF-01A
0 years, male, white, stage:Stage IIB, dead, 691 days
1345.5
TCGA-3A-A9J0-01A
0 years, male, white, stage:Stage IIB, alive, 743 days
1336.2
TCGA-2J-AABP-01A
0 years, female, white, stage:Stage IIB, alive, 463 days
1262.1
TCGA-2J-AAB6-01A
0 years, male, white, stage:Stage IIA, dead, 293 days
1260.1
TCGA-F2-A8YN-01A
0 years, male, white, stage:Stage IIA, alive, 517 days
1250.6
TCGA-2J-AABU-01A
0 years, male, white, stage:Stage IIB, dead, 277 days
1221.3
TCGA-S4-A8RP-01A
0 years, female, white, stage:Stage IIB, dead, 702 days
1213.5
TCGA-HZ-A77P-01A
0 years, male, white, stage:Stage IIB, alive, 330 days
1210.8
TCGA-IB-AAUT-01A
0 years, male, white, stage:Stage IIB, alive, 287 days
1204.3
TCGA-HV-A5A5-01A
0 years, female, asian, stage:Stage IIB, alive, 289 days
1123.3
TCGA-RL-AAAS-01A
0 years, female, white, stage:Stage IB, alive, 9 days
1122.4
TCGA-FB-A4P5-01A
0 years, female, white, stage:Stage IIB, dead, 179 days
1118.4
TCGA-RB-AA9M-01A
0 years, male, white, stage:Stage IIB, alive, 286 days
1106.8
TCGA-3E-AAAZ-01A
0 years, male, white, stage:Stage IIA, dead, 2182 days
1088.7
TCGA-HZ-A4BK-01A
0 years, male, white, stage:Stage IIB, alive, 657 days
1057.6
TCGA-HZ-8637-01A
0 years, female, white, stage:Stage IIB, dead, 517 days
1055.3
TCGA-2J-AABA-01A
0 years, male, white, stage:Stage IIB, dead, 607 days
1048.8
TCGA-3A-A9IU-01A
0 years, male, white, stage:Stage IIB, dead, 458 days
1048.6
TCGA-IB-AAUN-01A
0 years, female, white, stage:Stage IB, dead, 144 days
1013.9
TCGA-HZ-8003-01A
0 years, female, white, stage:Stage IIB, dead, 596 days
988.3
TCGA-HZ-A49G-01A
0 years, female, white, stage:Stage IIB, alive, 660 days
978.5
TCGA-2J-AABR-01A
0 years, female, white, stage:Stage IIA, alive, 438 days
974.5
TCGA-PZ-A5RE-01A
0 years, female, white, stage:Stage IIB, dead, 470 days
963.2
TCGA-IB-AAUQ-01A
0 years, male, white, stage:Stage IIB, dead, 183 days
936.4
TCGA-3E-AAAY-01A
0 years, male, white, stage:Stage IIB, alive, 2285 days
932.8
TCGA-2L-AAQA-01A
0 years, male, white, stage:Stage IIB, dead, 143 days
910.8
TCGA-HZ-7920-01A
0 years, male, white, stage:Stage IB, dead, 236 days
903.9
TCGA-F2-A44G-01A
0 years, female, white, stage:Stage IIB, dead, 233 days
895.5
TCGA-HV-A5A6-01A
0 years, female, asian, stage:Stage IIB, dead, 2036 days
891.0
TCGA-2J-AABT-01A
0 years, female, white, stage:Stage IIB, alive, 319 days
880.6
TCGA-2J-AAB9-01A
0 years, female, white, stage:Stage IIB, dead, 627 days
877.7
TCGA-HZ-8317-01A
0 years, female, white, stage:Stage IIB, dead, 378 days
865.0
TCGA-FB-AAPZ-01A
0 years, male, white, stage:Stage IIB, alive, 716 days
852.1
TCGA-2J-AABI-01A
0 years, female, white, stage:Stage IIA, alive, 969 days
848.0
TCGA-HZ-A49H-01A
0 years, female, white, stage:Stage IIB, alive, 491 days
818.8
TCGA-2J-AABH-01A
0 years, male, white, stage:Stage IIA, alive, 1287 days
817.2
TCGA-XD-AAUH-01A
0 years, female, white, stage:Stage IIB, alive, 395 days
815.5
TCGA-2L-AAQE-01A
0 years, male, white, stage:Stage IIB, dead, 684 days
799.9
TCGA-H8-A6C1-01A
0 years, male, white, stage:Stage IIA, alive, 671 days
796.2
TCGA-F2-A7TX-01A
0 years, male, white, stage:Stage IIB, dead, 95 days
737.9
TCGA-HZ-A49I-01A
0 years, male, white, stage:Stage IIB, dead, 308 days
735.7
TCGA-2L-AAQI-01A
0 years, male, white, stage:Stage IIB, dead, 103 days
731.2
TCGA-2L-AAQJ-01A
0 years, female, white, stage:Stage III, dead, 394 days
727.6
TCGA-FB-AAPQ-01A
0 years, male, white, stage:Stage IIB, dead, 1130 days
710.0
TCGA-HV-A5A3-01A
0 years, male, asian, stage:Stage IIA, dead, 128 days
706.3
TCGA-3A-A9IV-01A
0 years, female, white, stage:Stage IB, alive, 1103 days
704.7
TCGA-2J-AAB1-01A
0 years, male, white, stage:Stage IIB, dead, 66 days
655.8
TCGA-US-A77J-01A
0 years, female, white, stage:Stage IIB, dead, 568 days
651.8
TCGA-S4-A8RO-01A
0 years, female, white, stage:Stage IIB, alive, 525 days
638.6
TCGA-3A-A9IH-01A
0 years, female, white, stage:Stage IA, alive, 1021 days
635.8
TCGA-XD-AAUI-01A
0 years, female, white, stage:Stage IIB, dead, 366 days
593.6
TCGA-IB-A7LX-01A
0 years, male, white, stage:Stage IIB, dead, 250 days
586.7
TCGA-2L-AAQM-01A
0 years, male, white, stage:Stage IIB, alive, 1383 days
581.4
TCGA-HZ-A77O-01A
0 years, female, white, stage:Stage IIB, dead, 160 days
574.6
TCGA-IB-AAUU-01A
0 years, male, white, stage:Stage IIB, alive, 245 days
558.1
TCGA-IB-AAUW-01A
0 years, female, white, stage:Stage IIB, dead, 230 days
544.7
TCGA-2J-AAB4-01A
0 years, male, white, stage:Stage IIB, alive, 729 days
524.7
TCGA-Q3-A5QY-01A
0 years, male, white, stage:Stage IIB, alive, 416 days
520.3
TCGA-FB-AAQ6-01A
0 years, male, white, stage:Stage IA, dead, 244 days
505.0
TCGA-HV-AA8X-01A
0 years, female, asian, stage:Stage IIB, dead, 532 days
504.0
TCGA-IB-7889-01A
0 years, female, white, stage:Stage IIB, dead, 481 days
491.7
TCGA-HZ-8638-01A
0 years, female, white, stage:Stage IA, dead, 151 days
490.5
TCGA-IB-8126-01A
0 years, female, white, stage:Stage III, alive, 462 days
482.7
TCGA-FB-A5VM-01A
0 years, male, white, stage:Stage IB, dead, 498 days
461.7
TCGA-LB-A9Q5-01A
0 years, female, white, stage:Stage IIB, dead, 313 days
443.7
TCGA-FB-AAPY-01A
0 years, male, white, stage:Stage IIB, dead, 1059 days
442.2
TCGA-HZ-7289-01A
0 years, male, white, stage:Stage IIB, dead, 661 days
424.6
TCGA-HZ-7924-01A
0 years, female, white, stage:Stage IIA, alive, 840 days
422.0
TCGA-OE-A75W-01A
0 years, male, white, stage:Stage IIA, dead, 267 days
414.8
TCGA-FB-AAQ3-01A
0 years, female, white, stage:Stage IIB, dead, 31 days
405.0
TCGA-S4-A8RM-01A
0 years, male, white, stage:Stage IIB, alive, 737 days
398.5
TCGA-IB-A6UF-01A
0 years, male, white, stage:Stage IIB, alive, 666 days
379.5
TCGA-IB-A7M4-01A
0 years, male, white, stage:Stage IIB, alive, 483 days
365.8
TCGA-FB-AAQ1-01A
0 years, male, white, stage:Stage IIB, dead, 123 days
363.2
TCGA-2L-AAQL-01A
0 years, male, white, stage:Stage IIB, dead, 292 days
361.1
TCGA-3A-A9IN-01A
0 years, female, white, stage:Stage IB, alive, 2084 days
346.5
TCGA-Z5-AAPL-01A
0 years, female, white, stage:Stage IIA, alive, 467 days
335.0
TCGA-HZ-A9TJ-01A
0 years, male, white, stage:Stage IV, alive, 603 days
334.4
TCGA-3A-A9I9-01A
0 years, male, white, stage:Stage IIA, dead, 634 days
322.9
TCGA-FB-AAQ2-01A
0 years, female, white, stage:Stage IIB, dead, 153 days
318.9
TCGA-HZ-A8P1-01A
0 years, male, white, stage:Stage IB, alive, 7 days
311.0
TCGA-FB-AAQ0-01A
0 years, male, white, stage:Stage IIA, dead, 473 days
289.9
TCGA-IB-AAUO-01A
0 years, female, white, stage:Stage IIB, dead, 239 days
288.3
TCGA-FB-A78T-01A
0 years, female, white, stage:Stage IIB, dead, 375 days
283.8
TCGA-IB-A6UG-01A
0 years, male, white, stage:Stage IIB, dead, 41 days
282.3
TCGA-FB-AAPU-01A
0 years, female, asian, stage:Stage IIA, dead, 381 days
269.6
TCGA-Q3-AA2A-01A
0 years, female, white, stage:Stage IB, alive, 95 days
255.6
TCGA-3A-A9IL-01A
0 years, female, white, stage:Stage I, alive, 2741 days
244.3
TCGA-IB-AAUM-01A
0 years, male, white, stage:Stage IIB, alive, 8 days
240.2
TCGA-IB-A5SP-01A
0 years, male, white, stage:Stage IIA, alive, 482 days
219.0
TCGA-LB-A8F3-01A
0 years, female, black or african american, stage:Stage IIA, alive, 379 days
216.8
TCGA-3A-A9IJ-01A
0 years, male, white, stage:Stage IB, alive, 1854 days
209.8
TCGA-LB-A7SX-01A
0 years, female, black or african american, stage:Stage IIB, dead, 393 days
203.2
TCGA-HV-A7OL-01A
0 years, male, asian, stage:Stage IIA, alive, 252 days
201.2
TCGA-3A-A9I5-01A
0 years, male, white, stage:'--, alive, 1794 days
193.1
TCGA-US-A77G-01A
0 years, male, white, stage:Stage IIB, dead, 12 days
166.1
TCGA-3A-A9IR-01A
0 years, female, white, stage:Stage IB, alive, 1542 days
155.1
TCGA-2J-AABK-01A
0 years, male, white, stage:Stage IIB, alive, 484 days
132.4
TCGA-YY-A8LH-01A
0 years, female, white, stage:Stage IIB, alive, 2016 days
128.3
TCGA-3A-A9IS-01A
0 years, male, white, stage:Stage IB, alive, 998 days
123.3
TCGA-3A-A9IO-01A
0 years, male, white, stage:'--, alive, 1942 days
114.7
TCGA-US-A779-01A
0 years, female, white, stage:Stage IIB, dead, 511 days
113.7
TCGA-FB-AAPP-01A
0 years, male, white, stage:Stage IIB, dead, 485 days
88.9
TCGA-US-A776-01A
0 years, male, white, stage:Stage IIA, alive, 1216 days
81.8
TCGA-F2-6880-01A
0 years, male, white, stage:Stage IIB, alive, 295 days
31.4
TCGA-2J-AABV-01A
0 years, male, white, stage:Stage IIB, dead, 652 days
22.4
TCGA-HV-A7OP-01A
0 years, male, asian, stage:Stage IIB, alive, 978 days
The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
SPARC is not prognostic in Pancreatic Adenocarcinoma (validation)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
767.4
Number of samples
80
Samples
Sample
Description
TPM
DO33168
0 years, female, NA, stage:, dead, 8 days
2385.1
DO49204
0 years, male, NA, stage:, dead, 156 days
2303.8
DO34728
0 years, female, NA, stage:, alive, 508 days
2083.0
DO49170
0 years, male, NA, stage:, alive, 197 days
1977.9
DO49199
0 years, male, NA, stage:, dead, 1095 days
1845.3
DO34905
0 years, male, NA, stage:, alive, 1142 days
1616.6
DO32863
0 years, male, NA, stage:, dead, 715 days
1592.2
DO49185
0 years, male, NA, stage:, alive, 179 days
1568.7
DO33376
0 years, female, NA, stage:, alive, 909 days
1475.1
DO34448
0 years, female, NA, stage:, dead, 719 days
1465.8
DO34600
0 years, male, NA, stage:, dead, 537 days
1416.0
DO33480
0 years, male, NA, stage:, alive, 1054 days
1408.2
DO33408
0 years, female, NA, stage:, alive, 909 days
1273.4
DO33472
0 years, female, NA, stage:, dead, 388 days
1187.1
DO49166
0 years, female, NA, stage:, alive, 222 days
1172.8
DO49129
0 years, male, NA, stage:, alive, 337 days
1133.2
DO34432
0 years, female, NA, stage:, dead, 400 days
1128.6
DO33336
0 years, female, NA, stage:, dead, 451 days
1072.8
DO49135
0 years, male, NA, stage:, alive, 270 days
1016.9
DO49168
0 years, male, NA, stage:, alive, 149 days
1016.9
DO49080
0 years, male, NA, stage:, alive, 83 days
999.4
DO34720
0 years, male, NA, stage:, alive, 555 days
968.2
DO33128
0 years, male, NA, stage:, dead, 423 days
944.3
DO34793
0 years, male, NA, stage:, dead, 427 days
935.3
DO49183
0 years, female, NA, stage:, dead, 429 days
928.3
DO32900
0 years, male, NA, stage:, dead, 768 days
843.2
DO49164
0 years, male, NA, stage:, alive, 272 days
817.5
DO34312
0 years, female, NA, stage:, dead, 226 days
803.4
DO34240
0 years, male, NA, stage:, dead, 236 days
776.9
DO49178
0 years, male, NA, stage:, dead, 27 days
772.8
DO49127
0 years, female, NA, stage:, alive, 392 days
767.9
DO32860
0 years, male, NA, stage:, dead, 1259 days
767.0
DO49184
0 years, male, NA, stage:, dead, 455 days
762.9
DO33512
female, NA, stage:, dead, 499 days
759.6
DO33984
0 years, male, NA, stage:, alive, 847 days
739.5
DO32829
0 years, female, NA, stage:T2N0MX, dead, 1874 days
730.4
DO34696
0 years, male, NA, stage:, alive, 689 days
729.6
DO33368
0 years, male, NA, stage:, dead, 98 days
729.1
DO33488
0 years, male, NA, stage:, alive, 844 days
713.2
DO49138
0 years, male, NA, stage:, dead, 230 days
701.9
DO34656
0 years, female, NA, stage:, alive, 834 days
700.0
DO49078
0 years, male, NA, stage:, dead, 465 days
671.2
DO49137
0 years, female, NA, stage:, alive, 232 days
616.3
DO49130
0 years, female, NA, stage:, alive, 351 days
603.3
DO33552
0 years, female, NA, stage:, alive, 873 days
595.8
DO33344
0 years, male, NA, stage:, dead, 361 days
585.4
DO49079
0 years, male, NA, stage:, dead, 332 days
544.5
DO49133
0 years, female, NA, stage:, alive, 188 days
539.1
DO34608
0 years, female, NA, stage:, dead, 709 days
535.2
DO33544
0 years, female, NA, stage:, dead, 412 days
525.3
DO32875
0 years, male, NA, stage:, dead, 348 days
515.1
DO34801
0 years, male, NA, stage:, alive, 626 days
511.3
DO34504
0 years, male, NA, stage:, dead, 257 days
502.3
DO33600
0 years, female, NA, stage:, alive, 854 days
500.9
DO34785
0 years, female, NA, stage:, alive, 721 days
500.4
DO49113
0 years, female, NA, stage:, alive, 413 days
496.2
DO49181
0 years, male, NA, stage:, dead, 1534 days
491.9
DO32878
0 years, female, NA, stage:, dead, 260 days
471.7
DO34640
0 years, female, NA, stage:, dead, 287 days
463.6
DO49193
0 years, male, NA, stage:, dead, 1 days
406.9
DO49087
0 years, female, NA, stage:, dead, 260 days
405.5
DO34849
0 years, female, NA, stage:, dead, 272 days
382.3
DO34680
0 years, male, NA, stage:, dead, 99 days
375.2
DO34264
0 years, female, NA, stage:, dead, 1144 days
358.3
DO34288
0 years, female, NA, stage:, dead, 220 days
328.5
DO34368
0 years, female, NA, stage:, dead, 537 days
295.8
DO33400
0 years, female, NA, stage:, alive, 1043 days
274.4
DO49090
0 years, female, NA, stage:, dead, 152 days
263.9
DO33392
0 years, male, NA, stage:, alive, 1014 days
250.8
DO34736
0 years, female, NA, stage:, dead, 203 days
249.6
DO34817
0 years, female, NA, stage:, alive, 540 days
235.3
DO49172
0 years, female, NA, stage:, dead, 1021 days
230.6
DO49076
0 years, male, NA, stage:, dead, 480 days
180.3
DO49198
0 years, female, NA, stage:, dead, 251 days
109.6
DO34809
0 years, female, NA, stage:, dead, 297 days
95.6
DO34961
0 years, male, NA, stage:, dead, 632 days
67.3
DO49175
0 years, male, NA, stage:, dead, 414 days
59.7
DO34616
0 years, female, NA, stage:, alive, 666 days
50.5
DO49074
0 years, male, NA, stage:, dead, 168 days
48.3
DO34336
0 years, female, NA, stage:, alive, 743 days
26.3
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PANCREATIC DUCTAL ADENOCARCINOMA - Protein relative expression (CPTAC)
Number of samples
235
Samples
Sample ID
Sample type
nRPX
CPT0236340004
Tumor
1.2
CPT0226650004
Tumor
1.0
CPT0226490004
Tumor
0.9
CPT0089720003
Tumor
0.8
CPT0081060004
Tumor
0.8
CPT0217700004
Tumor
0.7
CPT0227930004
Tumor
0.7
CPT0247000003
Normal
0.7
WU-PDA1
Tumor
0.7
CPT0019410004
Tumor
0.7
CPT0237910004
Tumor
0.6
CPT0162760003
Tumor
0.6
CPT0161990005
Tumor
0.6
CPT0108400003
Tumor
0.6
CPT0064090003
Tumor
0.6
CPT0019300004
Tumor
0.6
CPT0197440004
Normal
0.6
CPT0088320003
Tumor
0.5
CPT0207780004
Tumor
0.5
CPT0011520003
Tumor
0.5
CPT0094230004
Tumor
0.5
CPT0123650003
Tumor
0.5
CPT0248410004
Tumor
0.5
CPT0094740004
Tumor
0.5
CPT0077930004
Tumor
0.5
CPT0083270003
Tumor
0.5
CPT0081360004
Tumor
0.5
CPT0237840004
Tumor
0.5
CPT0138990003
Normal
0.5
CPT0247040003
Tumor
0.4
CPT0183750005
Tumor
0.4
CPT0065570003
Tumor
0.4
CPT0238820005
Tumor
0.4
CPT0203850004
Tumor
0.4
CPT0124530003
Normal
0.4
CPT0124360003
Tumor
0.4
CPT0226570004
Tumor
0.4
CPT0208840004
Tumor
0.4
CPT0063570003
Tumor
0.4
CPT0088180004
Tumor
0.4
CPT0094180003
Tumor
0.4
CPT0276010003
Tumor
0.4
CPT0008750003
Tumor
0.4
CPT0008800003
Tumor
0.4
CPT0264150003
Tumor
0.4
CPT0078090004
Tumor
0.4
CPT0238530005
Tumor
0.4
CPT0208690004
Tumor
0.3
CPT0139000004
Tumor
0.3
CPT0109010004
Tumor
0.3
CPT0064110003
Normal
0.3
CPT0123440003
Tumor
0.3
CPT0185920004
Tumor
0.3
CPT0246840003
Tumor
0.3
CPT0001730017
Tumor
0.3
CPT0081470004
Tumor
0.3
CPT0187550004
Tumor
0.3
CPT0246990003
Tumor
0.3
CPT0123990003
Tumor
0.3
CPT0124980004
Tumor
0.3
CPT0123750003
Tumor
0.3
CPT0246720003
Tumor
0.3
CPT0355180003
Normal
0.2
CPT0174700004
Tumor
0.2
CPT0093930004
Tumor
0.2
CPT0198420004
Tumor
0.2
CPT0170240004
Tumor
0.2
CPT0207980005
Tumor
0.2
CPT0078000003
Tumor
0.2
CPT0207990004
Normal
0.2
CPT0226760004
Tumor
0.2
CPT0248590004
Tumor
0.2
CPT0235230004
Tumor
0.2
CPT0237270005
Tumor
0.2
CPT0081260004
Tumor
0.2
CPT0078030003
Normal
0.2
CPT0124500004
Tumor
0.2
CPT0064520004
Tumor
0.2
CPT0246810003
Tumor
0.2
CPT0209310004
Tumor
0.2
CPT0246940003
Tumor
0.2
CPT0109200004
Tumor
0.1
CPT0109300004
Tumor
0.1
CPT0238610009
Tumor
0.1
CPT0064570003
Normal
0.1
CPT0017040004
Tumor
0.1
CPT0236780005
Tumor
0.1
CPT0241510004
Normal
0.1
CPT0014040003
Tumor
0.1
CPT0094130004
Tumor
0.1
CPT0065640003
Tumor
0.1
CPT0088260004
Tumor
0.1
CPT0001750003
Normal
0.1
CPT0183450005
Tumor
0.1
CPT0254680003
Tumor
0.1
CPT0238440005
Tumor
0.1
CPT0218200004
Tumor
0.1
CPT0226600004
Tumor
0.1
CPT0126160004
Tumor
0.1
CPT0077880003
Normal
0.1
CPT0221470005
Tumor
0.1
CPT0246260004
Tumor
0.1
CPT0198910005
Tumor
0.1
CPT0000250017
Tumor
0.1
CPT0187930005
Tumor
0.1
CPT0123860003
Tumor
0.0
CPT0162660004
Tumor
0.0
CPT0238040005
Tumor
0.0
CPT0094940004
Tumor
0.0
CPT0063970004
Tumor
0.0
CPT0161770004
Tumor
0.0
CPT0209640005
Tumor
0.0
CPT0093860003
Tumor
0.0
CPT0239910004
Tumor
0.0
CPT0125130003
Tumor
0.0
CPT0239100009
Tumor
0.0
CPT0226530004
Tumor
0.0
CPT0238710004
Tumor
0.0
CPT0066020003
Normal
0.0
C3L-00401-04
Normal
0.0
CPT0108930003
Tumor
0.0
CPT0248620003
Normal
0.0
CPT0078160004
Tumor
0.0
CPT0198700005
Tumor
-0.1
CPT0236560004
Tumor
-0.1
CPT0125090003
Tumor
-0.1
CPT0077790004
Tumor
-0.1
CPT0124410004
Tumor
-0.1
CPT0077860003
Tumor
-0.1
CPT0174800003
Normal
-0.1
CPT0236700005
Tumor
-0.1
CPT0208550005
Tumor
-0.1
CPT0086190004
Tumor
-0.1
CPT0197420004
Tumor
-0.1
CPT0091660003
Tumor
-0.1
CPT0238920004
Tumor
-0.1
CPT0025750003
Tumor
-0.1
CPT0087890004
Tumor
-0.2
CPT0093880003
Normal
-0.2
CPT0094630004
Tumor
-0.2
KoreanReference1
Tumor
-0.2
CPT0092630003
Tumor
-0.2
CPT0094030003
Tumor
-0.2
CPT0226610004
Normal
-0.2
CPT0124610004
Tumor
-0.2
CPT0221240004
Tumor
-0.3
CPT0241320005
Tumor
-0.3
CPT0236360004
Normal
-0.3
CPT0224460004
Tumor
-0.3
CPT0124000003
Normal
-0.3
CPT0246950003
Normal
-0.3
CPT0246210004
Tumor
-0.3
CPT0086210003
Normal
-0.3
CPT0226680005
Tumor
-0.4
CPT0162670004
Normal
-0.4
CPT0093980004
Tumor
-0.4
CPT0078250003
Tumor
-0.4
CPT0125010003
Normal
-0.4
KoreanReference3
Tumor
-0.4
CPT0123890003
Normal
-0.4
CPT0221250004
Normal
-0.4
CPT0077950003
Normal
-0.4
CPT0011540003
Normal
-0.4
CPT0123460003
Normal
-0.5
CPT0127270003
Tumor
-0.5
CPT0186040004
Tumor
-0.5
CPT0166760004
Tumor
-0.5
CPT0017130003
Normal
-0.6
CPT0247090003
Tumor
-0.6
KoreanReference2
Tumor
-0.6
CPT0123770003
Normal
-0.6
CPT0238640004
Normal
-0.6
CPT0108960003
Normal
-0.6
CPT0123670003
Normal
-0.7
CPT0078180003
Normal
-0.7
CPT0246220004
Normal
-0.7
C3L-03632-04
Normal
-0.7
CPT0241500004
Tumor
-0.7
CPT0162780004
Normal
-0.7
CPT0187540004
Normal
-0.8
CPT0248440003
Normal
-0.8
CPT0025760003
Normal
-0.8
CPT0127290003
Normal
-0.8
C3N-02573-03
Normal
-0.8
CPT0276030003
Normal
-0.8
CPT0239920004
Normal
-0.8
C3N-00709-06
Normal
-0.9
CPT0170260004
Normal
-0.9
CPT0238740004
Normal
-0.9
CPT0355200003
Normal
-0.9
CPT0091680003
Normal
-1.0
CPT0237850004
Normal
-1.0
CPT0063580003
Normal
-1.0
CPT0077810003
Normal
-1.0
CPT0218220004
Normal
-1.1
CPT0183770004
Normal
-1.1
CPT0089750004
Normal
-1.1
CPT0237920004
Normal
-1.1
CPT0236710004
Normal
-1.1
CPT0236800004
Normal
-1.2
CPT0198930003
Normal
-1.2
CPT0239140004
Normal
-1.2
CPT0198440004
Normal
-1.2
CPT0208710004
Normal
-1.3
CPT0166780004
Normal
-1.3
CPT0347790002
Normal
-1.3
CPT0347760002
Normal
-1.4
CPT0208850004
Normal
-1.4
CPT0238940004
Normal
-1.4
CPT0347850002
Normal
-1.4
C3L-00189-04
Normal
-1.5
CPT0209650004
Normal
-1.5
CPT0347820002
Normal
-1.6
CPT0347880002
Normal
-1.7
CPT0355190003
Normal
-1.8
CPT0247050003
Normal
N/A
CPT0108410003
Normal
N/A
CPT0248320003
Normal
N/A
CPT0166650006
Tumor
N/A
CPT0224470004
Normal
N/A
C3L-01687-04
Normal
N/A
CPT0138890003
Normal
N/A
CPT0109110004
Tumor
N/A
WU-pooled sample
Tumor
N/A
CPT0014060003
Normal
N/A
CPT0109130003
Normal
N/A
CPT0138900004
Tumor
N/A
CPT0166680004
Normal
N/A
CPT0094760003
Normal
N/A
CPT0186050004
Normal
N/A
CPT0237290004
Normal
N/A
CPT0264180003
Normal
N/A
CPT0063990003
Normal
N/A
CPT0126200003
Normal
N/A
CPT0198730004
Normal
N/A
Show allShow less
PANCREATIC CANCER - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.
Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
The Human Protein Atlas project is funded
