Single cell type - ZNF451 - The Human Protein Atlas

ZNF451

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZNF451
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger protein 451
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Late spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Late spermatids, Oligodendrocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.41
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Late spermatids, Oligodendrocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ZNF451 is part of cluster 11 Late spermatids - Unknown function with confidenceⁱ 1
430 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MEX3C	Mex-3 RNA binding family member C	0.5333	11
APLF	Aprataxin and PNKP like factor	0.5307	11
WDR20	WD repeat domain 20	0.5276	11
ZMYM2	Zinc finger MYM-type containing 2	0.5004	36
MEX3B	Mex-3 RNA binding family member B	0.4917	11
KANSL1	KAT8 regulatory NSL complex subunit 1	0.4833	55
FBXO34	F-box protein 34	0.4810	78
CSNKA2IP	Casein kinase 2 subunit alpha' interacting protein	0.4773	11
EAF1	ELL associated factor 1	0.4728	11
KNSTRN	Kinetochore localized astrin (SPAG5) binding protein	0.4679	11
CASP2	Caspase 2	0.4652	28
CTDSPL2	CTD small phosphatase like 2	0.4583	11
TBC1D23	TBC1 domain family member 23	0.4559	55
MTFR1	Mitochondrial fission regulator 1	0.4553	11
THAP9	THAP domain containing 9	0.4548	11

IMMUNE CELLS

ZNF451 is part of cluster 18 Non-specific - Translation with confidenceⁱ 1
120 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
UQCRH	Ubiquinol-cytochrome c reductase hinge protein	0.9048	18
FAU	FAU ubiquitin like and ribosomal protein S30 fusion	0.9048	18
DYNLT2B	Dynein light chain Tctex-type 2B	0.8810	18
C12orf42	Chromosome 12 open reading frame 42	0.8810	18
PEBP1	Phosphatidylethanolamine binding protein 1	0.8571	18
RNMT	RNA guanine-7 methyltransferase	0.8571	24
SLC16A4	Solute carrier family 16 member 4	0.8571	18
NSUN5	NOP2/Sun RNA methyltransferase 5	0.8571	32
ANKRD10	Ankyrin repeat domain 10	0.8333	24
H2AC14	H2A clustered histone 14	0.8333	18
USP16	Ubiquitin specific peptidase 16	0.8333	24
PTPRK	Protein tyrosine phosphatase receptor type K	0.8333	18
UXT	Ubiquitously expressed prefoldin like chaperone	0.8333	18
SOBP	Sine oculis binding protein homolog	0.8333	18
MRPS18A	Mitochondrial ribosomal protein S18A	0.8333	22

Adipocytes	45.6 nTPM
Adipose tissue	60.7 nTPM
Breast	30.4 nTPM

Alveolar cells type 1	35.5 nTPM
Lung	35.5 nTPM

Alveolar cells type 2	30.9 nTPM
Lung	30.9 nTPM

Astrocytes	64.1 nTPM
Brain	64.1 nTPM

B-cells	43.6 nTPM
Adipose tissue	78.2 nTPM
Salivary gland	57.3 nTPM
Liver	48.3 nTPM
Lymph node	48.2 nTPM
Stomach	46.8 nTPM
Lung	45.6 nTPM
Spleen	44.6 nTPM
Skin	42.3 nTPM
Esophagus	41.3 nTPM
Thymus	39.0 nTPM
PBMC	38.5 nTPM
Bone marrow	36.6 nTPM
Kidney	0.0 nTPM

Ciliated cells	27.7 nTPM
Endometrium	30.8 nTPM
Bronchus	29.8 nTPM
Lung	25.5 nTPM
Fallopian tube	24.8 nTPM

Club cells	24.1 nTPM
Prostate	28.4 nTPM
Bronchus	22.1 nTPM
Lung	21.7 nTPM

Dendritic cells	87.1 nTPM
Adipose tissue	109.5 nTPM
PBMC	64.8 nTPM

Endothelial cells	38.5 nTPM
Liver	63.0 nTPM
Salivary gland	55.1 nTPM
Endometrium	54.2 nTPM
Skeletal muscle	48.6 nTPM
Esophagus	46.1 nTPM
Fallopian tube	41.3 nTPM
Vascular	41.1 nTPM
Prostate	39.5 nTPM
Thymus	38.0 nTPM
Skin	37.6 nTPM
Lung	34.7 nTPM
Placenta	32.9 nTPM
Ovary	31.5 nTPM
Heart muscle	31.0 nTPM
Breast	30.8 nTPM
Tongue	29.1 nTPM
Testis	28.4 nTPM
Pancreas	10.3 nTPM

Enteroendocrine cells	30.4 nTPM
Rectum	48.6 nTPM
Small intestine	24.0 nTPM
Colon	18.5 nTPM

Fibroblasts	37.8 nTPM
Heart muscle	66.8 nTPM
Liver	54.6 nTPM
Skin	53.9 nTPM
Fallopian tube	47.3 nTPM
Skeletal muscle	44.7 nTPM
Adipose tissue	41.4 nTPM
Salivary gland	38.9 nTPM
Vascular	37.9 nTPM
Prostate	37.0 nTPM
Esophagus	30.6 nTPM
Stomach	30.3 nTPM
Breast	29.5 nTPM
Placenta	27.9 nTPM
Thymus	26.8 nTPM
Lung	23.1 nTPM
Pancreas	14.1 nTPM

Granulocytes	47.8 nTPM
Fallopian tube	60.7 nTPM
Tongue	48.5 nTPM
Lung	34.3 nTPM

Intestinal goblet cells	23.3 nTPM
Small intestine	27.0 nTPM
Rectum	27.0 nTPM
Colon	15.7 nTPM

Lymphatic endothelial cells	48.4 nTPM
Ovary	49.1 nTPM
Fallopian tube	47.6 nTPM

Macrophages	36.1 nTPM
Adipose tissue	62.6 nTPM
Skin	51.3 nTPM
Stomach	46.3 nTPM
Fallopian tube	46.2 nTPM
Salivary gland	43.4 nTPM
Skeletal muscle	41.9 nTPM
Endometrium	40.6 nTPM
Prostate	38.8 nTPM
Tongue	37.7 nTPM
Vascular	36.7 nTPM
Bone marrow	36.5 nTPM
Lung	32.5 nTPM
Breast	30.4 nTPM
Spleen	28.1 nTPM
Kidney	27.4 nTPM
Thymus	27.4 nTPM
Testis	27.3 nTPM
Esophagus	27.0 nTPM
Pancreas	4.1 nTPM

Basal prostatic cells	30.5 nTPM
Prostate	30.5 nTPM

Basal respiratory cells	19.0 nTPM
Bronchus	19.0 nTPM

Basal squamous epithelial cells	33.5 nTPM
Esophagus	33.5 nTPM

Bipolar cells	46.6 nTPM
Eye	46.6 nTPM

Paneth cells	17.3 nTPM
Rectum	20.2 nTPM
Small intestine	17.3 nTPM
Colon	14.5 nTPM

Plasma cells	29.9 nTPM
Fallopian tube	53.1 nTPM
Salivary gland	44.8 nTPM
Stomach	32.2 nTPM
Thymus	29.4 nTPM
Bone marrow	22.7 nTPM
Spleen	22.1 nTPM
Liver	19.5 nTPM
Esophagus	15.6 nTPM

Schwann cells	41.3 nTPM
Adipose tissue	75.7 nTPM
Vascular	36.0 nTPM
Esophagus	12.0 nTPM

Serous glandular cells	30.0 nTPM
Salivary gland	33.5 nTPM
Tongue	26.5 nTPM

Smooth muscle cells	34.1 nTPM
Skeletal muscle	48.3 nTPM
Adipose tissue	45.9 nTPM
Skin	41.2 nTPM
Endometrium	39.3 nTPM
Liver	38.2 nTPM
Tongue	36.2 nTPM
Esophagus	34.8 nTPM
Fallopian tube	34.3 nTPM
Vascular	33.5 nTPM
Salivary gland	31.7 nTPM
Ovary	31.0 nTPM
Placenta	28.3 nTPM
Breast	27.9 nTPM
Thymus	25.2 nTPM
Prostate	24.9 nTPM
Lung	24.7 nTPM

Suprabasal keratinocytes	34.7 nTPM
Skin	48.3 nTPM
Tongue	21.1 nTPM

T-cells	44.4 nTPM
Adipose tissue	85.7 nTPM
Fallopian tube	58.7 nTPM
Prostate	58.4 nTPM
Tongue	57.0 nTPM
Salivary gland	53.9 nTPM
Vascular	53.1 nTPM
Endometrium	49.8 nTPM
Skin	49.8 nTPM
Skeletal muscle	49.5 nTPM
Esophagus	43.8 nTPM
Breast	43.0 nTPM
Thymus	40.6 nTPM
Lymph node	40.0 nTPM
Lung	37.8 nTPM
Stomach	34.8 nTPM
Colon	34.1 nTPM
Spleen	32.9 nTPM
Bone marrow	32.2 nTPM
PBMC	30.7 nTPM
Kidney	24.8 nTPM
Liver	22.1 nTPM

Undifferentiated cells	20.5 nTPM
Rectum	25.2 nTPM
Small intestine	19.2 nTPM
Colon	17.1 nTPM

Amygdala excitatory	131.1 nTPM
Amygdala	140.5 nTPM
Hippocampus	138.9 nTPM
Hypothalamus	133.0 nTPM
Cerebral cortex	127.5 nTPM
Thalamus	126.1 nTPM
Basal ganglia	120.7 nTPM

Astrocyte	132.0 nTPM
Amygdala	159.2 nTPM
Hypothalamus	147.6 nTPM
Hippocampus	141.7 nTPM
Cerebral cortex	136.5 nTPM
Basal ganglia	134.8 nTPM
Pons	129.7 nTPM
Thalamus	128.6 nTPM
Midbrain	123.2 nTPM
Spinal cord	121.1 nTPM
Medulla oblongata	119.7 nTPM
Cerebellum	110.3 nTPM

Bergmann glia	126.5 nTPM
Cerebellum	145.2 nTPM
Medulla oblongata	136.4 nTPM
Pons	97.8 nTPM

Central nervous system macrophage	153.6 nTPM
Amygdala	205.1 nTPM
Hypothalamus	185.8 nTPM
Basal ganglia	165.0 nTPM
Midbrain	157.5 nTPM
Thalamus	153.5 nTPM
Hippocampus	149.0 nTPM
Pons	143.6 nTPM
Cerebellum	141.4 nTPM
Spinal cord	137.2 nTPM
Cerebral cortex	131.7 nTPM
Medulla oblongata	119.6 nTPM

Cerebellar inhibitory	116.6 nTPM
Pons	120.5 nTPM
Spinal cord	118.2 nTPM
Medulla oblongata	117.7 nTPM
Midbrain	116.0 nTPM
Cerebellum	110.5 nTPM

Cge interneuron	113.6 nTPM
Amygdala	124.1 nTPM
Thalamus	123.6 nTPM
Hypothalamus	117.0 nTPM
Midbrain	114.9 nTPM
Hippocampus	107.1 nTPM
Basal ganglia	106.3 nTPM
Cerebral cortex	102.1 nTPM

Choroid plexus epithelial cell	147.3 nTPM
Basal ganglia	189.8 nTPM
Thalamus	148.0 nTPM
Medulla oblongata	140.6 nTPM
Hippocampus	110.9 nTPM

Committed oligodendrocyte precursor	163.0 nTPM
Hypothalamus	252.0 nTPM
Thalamus	205.1 nTPM
Amygdala	204.1 nTPM
Basal ganglia	161.0 nTPM
Cerebral cortex	151.4 nTPM
Midbrain	151.2 nTPM
Hippocampus	148.5 nTPM
Cerebellum	144.3 nTPM
Spinal cord	136.1 nTPM
Medulla oblongata	123.9 nTPM
Pons	116.0 nTPM

Deep-layer corticothalamic and 6b	124.9 nTPM
Amygdala	135.4 nTPM
Hypothalamus	133.0 nTPM
Midbrain	126.5 nTPM
Hippocampus	124.2 nTPM
Cerebral cortex	116.1 nTPM
Basal ganglia	114.2 nTPM

Deep-layer intratelencephalic	120.7 nTPM
Amygdala	132.8 nTPM
Hippocampus	126.4 nTPM
Hypothalamus	125.1 nTPM
Cerebral cortex	111.2 nTPM
Basal ganglia	108.1 nTPM

Deep-layer near-projecting	116.7 nTPM
Amygdala	130.8 nTPM
Hippocampus	118.1 nTPM
Hypothalamus	115.6 nTPM
Cerebral cortex	111.3 nTPM
Basal ganglia	107.8 nTPM

Eccentric medium spiny neuron	127.4 nTPM
Amygdala	142.9 nTPM
Thalamus	130.5 nTPM
Cerebral cortex	128.3 nTPM
Hypothalamus	126.8 nTPM
Basal ganglia	123.9 nTPM
Hippocampus	111.9 nTPM