Single cell type - THAP9 - The Human Protein Atlas

THAP9

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	THAP9
Gene descriptionⁱ Full gene name according to HGNC.	THAP domain containing 9
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Late spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Late spermatids, Early spermatids, Oligodendrocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.71
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Group enriched (Late spermatids, Early spermatids, Oligodendrocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

THAP9 is part of cluster 11 Late spermatids - Unknown function with confidenceⁱ 1
430 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CEP112	Centrosomal protein 112	0.7545	11
TFAM	Transcription factor A, mitochondrial	0.7364	11
FAM166A	Family with sequence similarity 166 member A	0.7258	11
ATAD1	ATPase family AAA domain containing 1	0.7143	11
BAG5	BAG cochaperone 5	0.7085	11
APLF	Aprataxin and PNKP like factor	0.7039	11
FBXO24	F-box protein 24	0.7034	11
ACP1	Acid phosphatase 1	0.7023	11
MKRN2	Makorin ring finger protein 2	0.6946	11
MS4A5	Membrane spanning 4-domains A5	0.6861	11
TAS2R1	Taste 2 receptor member 1	0.6803	11
GRXCR2	Glutaredoxin and cysteine rich domain containing 2	0.6723	11
CSNKA2IP	Casein kinase 2 subunit alpha' interacting protein	0.6694	11
DEFB136	Defensin beta 136	0.6636	11
CTDSPL2	CTD small phosphatase like 2	0.6612	11

IMMUNE CELLS

THAP9 is part of cluster 14 Non-specific - Unknown function with confidenceⁱ 0.97
292 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GSAP	Gamma-secretase activating protein	0.9762	2
GABPB2	GA binding protein transcription factor subunit beta 2	0.9762	14
SLC17A9	Solute carrier family 17 member 9	0.9286	14
RPRD1A	Regulation of nuclear pre-mRNA domain containing 1A	0.9286	14
PHF7	PHD finger protein 7	0.9048	14
ZNF35	Zinc finger protein 35	0.9048	14
GNA11	G protein subunit alpha 11	0.8810	2
MACROD2	Mono-ADP ribosylhydrolase 2	0.8810	14
DHX57	DExH-box helicase 57	0.8810	14
CCT6B	Chaperonin containing TCP1 subunit 6B	0.8810	14
C1orf198	Chromosome 1 open reading frame 198	0.8810	14
RMDN2	Regulator of microtubule dynamics 2	0.8810	2
DZANK1	Double zinc ribbon and ankyrin repeat domains 1	0.8810	14
SSBP4	Single stranded DNA binding protein 4	0.8571	23
ZSCAN9	Zinc finger and SCAN domain containing 9	0.8571	14

Adipocytes	2.9 nTPM
Adipose tissue	3.0 nTPM
Breast	2.9 nTPM

Alveolar cells type 1	0.9 nTPM
Lung	0.9 nTPM

Alveolar cells type 2	1.9 nTPM
Lung	1.9 nTPM

Astrocytes	8.1 nTPM
Brain	8.1 nTPM

B-cells	2.5 nTPM
Stomach	6.7 nTPM
Salivary gland	4.4 nTPM
Lymph node	4.3 nTPM
Thymus	3.8 nTPM
Adipose tissue	3.3 nTPM
Spleen	3.1 nTPM
Lung	2.7 nTPM
Bone marrow	2.1 nTPM
Skin	1.7 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM

Ciliated cells	2.2 nTPM
Endometrium	3.7 nTPM
Bronchus	2.8 nTPM
Fallopian tube	1.9 nTPM
Lung	0.5 nTPM

Club cells	1.8 nTPM
Bronchus	2.2 nTPM
Prostate	2.0 nTPM
Lung	1.1 nTPM

Endothelial cells	2.1 nTPM
Heart muscle	4.0 nTPM
Testis	3.4 nTPM
Esophagus	3.4 nTPM
Prostate	3.2 nTPM
Skin	2.8 nTPM
Pancreas	2.6 nTPM
Liver	2.5 nTPM
Skeletal muscle	2.3 nTPM
Tongue	2.0 nTPM
Vascular	2.0 nTPM
Ovary	2.0 nTPM
Endometrium	1.5 nTPM
Fallopian tube	1.2 nTPM
Placenta	1.1 nTPM
Lung	1.1 nTPM
Thymus	1.1 nTPM
Salivary gland	1.0 nTPM
Breast	0.9 nTPM

Enteroendocrine cells	1.3 nTPM
Colon	2.2 nTPM
Rectum	1.7 nTPM
Small intestine	0.0 nTPM

Fibroblasts	2.9 nTPM
Heart muscle	8.7 nTPM
Prostate	7.9 nTPM
Esophagus	5.3 nTPM
Placenta	3.4 nTPM
Salivary gland	3.2 nTPM
Breast	3.2 nTPM
Vascular	2.5 nTPM
Fallopian tube	2.1 nTPM
Thymus	1.9 nTPM
Skeletal muscle	1.8 nTPM
Adipose tissue	1.8 nTPM
Skin	1.4 nTPM
Stomach	1.4 nTPM
Lung	0.6 nTPM
Pancreas	0.5 nTPM
Liver	0.0 nTPM

Granulocytes	0.7 nTPM
Fallopian tube	1.5 nTPM
Lung	0.5 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	2.0 nTPM
Colon	3.0 nTPM
Rectum	2.0 nTPM
Small intestine	1.0 nTPM

Lymphatic endothelial cells	4.2 nTPM
Ovary	5.5 nTPM
Fallopian tube	2.9 nTPM

Macrophages	2.5 nTPM
Esophagus	7.7 nTPM
Skeletal muscle	5.8 nTPM
Prostate	4.1 nTPM
Breast	3.6 nTPM
Adipose tissue	3.2 nTPM
Spleen	3.0 nTPM
Vascular	3.0 nTPM
Testis	2.5 nTPM
Thymus	2.5 nTPM
Fallopian tube	2.4 nTPM
Salivary gland	1.9 nTPM
Kidney	1.8 nTPM
Endometrium	1.8 nTPM
Lung	1.4 nTPM
Tongue	1.4 nTPM
Skin	1.1 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	3.1 nTPM
Colon	7.2 nTPM
Rectum	2.2 nTPM
Small intestine	0.0 nTPM

Basal prostatic cells	7.3 nTPM
Prostate	7.3 nTPM

Plasma cells	2.6 nTPM
Spleen	5.1 nTPM
Thymus	3.2 nTPM
Fallopian tube	3.2 nTPM
Stomach	2.9 nTPM
Salivary gland	2.7 nTPM
Liver	2.0 nTPM
Bone marrow	1.5 nTPM
Esophagus	0.0 nTPM

Schwann cells	5.6 nTPM
Esophagus	12.0 nTPM
Vascular	2.6 nTPM
Adipose tissue	2.3 nTPM

Serous glandular cells	3.4 nTPM
Tongue	4.4 nTPM
Salivary gland	2.4 nTPM

Smooth muscle cells	2.2 nTPM
Esophagus	4.8 nTPM
Breast	3.8 nTPM
Prostate	3.6 nTPM
Salivary gland	3.2 nTPM
Vascular	2.8 nTPM
Ovary	2.7 nTPM
Skeletal muscle	2.4 nTPM
Endometrium	2.2 nTPM
Fallopian tube	2.1 nTPM
Adipose tissue	1.8 nTPM
Tongue	1.8 nTPM
Placenta	1.2 nTPM
Thymus	1.1 nTPM
Liver	0.8 nTPM
Skin	0.8 nTPM
Lung	0.0 nTPM

T-cells	2.2 nTPM
Salivary gland	4.6 nTPM
Prostate	4.2 nTPM
Fallopian tube	3.7 nTPM
Adipose tissue	3.5 nTPM
Skeletal muscle	3.0 nTPM
Thymus	2.7 nTPM
Tongue	2.7 nTPM
Breast	2.5 nTPM
Esophagus	2.4 nTPM
Stomach	2.4 nTPM
Endometrium	2.2 nTPM
Colon	1.9 nTPM
Spleen	1.9 nTPM
Lymph node	1.6 nTPM
Lung	1.6 nTPM
Skin	1.4 nTPM
Liver	1.3 nTPM
Vascular	1.2 nTPM
Bone marrow	1.0 nTPM
PBMC	0.8 nTPM
Kidney	0.0 nTPM

Undifferentiated cells	2.4 nTPM
Colon	3.2 nTPM
Small intestine	2.1 nTPM
Rectum	1.8 nTPM

Amygdala excitatory	5.8 nTPM
Basal ganglia	7.8 nTPM
Amygdala	6.4 nTPM
Hippocampus	6.4 nTPM
Cerebral cortex	6.2 nTPM
Thalamus	4.5 nTPM
Hypothalamus	3.6 nTPM

Astrocyte	16.0 nTPM
Hypothalamus	20.1 nTPM
Amygdala	19.5 nTPM
Basal ganglia	17.4 nTPM
Spinal cord	17.0 nTPM
Cerebral cortex	16.8 nTPM
Hippocampus	15.3 nTPM
Medulla oblongata	15.1 nTPM
Midbrain	14.9 nTPM
Thalamus	14.8 nTPM
Pons	14.6 nTPM
Cerebellum	10.0 nTPM

Bergmann glia	17.2 nTPM
Medulla oblongata	21.3 nTPM
Cerebellum	17.3 nTPM
Pons	12.9 nTPM

Central nervous system macrophage	10.7 nTPM
Amygdala	13.1 nTPM
Pons	13.0 nTPM
Basal ganglia	12.1 nTPM
Hypothalamus	11.7 nTPM
Medulla oblongata	10.7 nTPM
Thalamus	10.4 nTPM
Midbrain	10.3 nTPM
Cerebellum	9.9 nTPM
Cerebral cortex	9.6 nTPM
Hippocampus	9.2 nTPM
Spinal cord	7.9 nTPM

Cerebellar inhibitory	9.3 nTPM
Medulla oblongata	12.2 nTPM
Cerebellum	9.2 nTPM
Pons	9.2 nTPM
Spinal cord	8.2 nTPM
Midbrain	7.8 nTPM

Cge interneuron	5.6 nTPM
Thalamus	7.3 nTPM
Hippocampus	6.1 nTPM
Amygdala	5.8 nTPM
Cerebral cortex	5.4 nTPM
Basal ganglia	5.1 nTPM
Midbrain	5.0 nTPM
Hypothalamus	4.6 nTPM

Choroid plexus epithelial cell	10.4 nTPM
Hippocampus	13.9 nTPM
Medulla oblongata	11.5 nTPM
Basal ganglia	10.8 nTPM
Thalamus	5.5 nTPM

Committed oligodendrocyte precursor	12.4 nTPM
Pons	23.9 nTPM
Midbrain	13.4 nTPM
Thalamus	13.3 nTPM
Hypothalamus	13.0 nTPM
Medulla oblongata	12.9 nTPM
Cerebellum	12.7 nTPM
Amygdala	11.8 nTPM
Basal ganglia	11.5 nTPM
Cerebral cortex	10.8 nTPM
Hippocampus	9.3 nTPM
Spinal cord	3.7 nTPM

Deep-layer corticothalamic and 6b	6.4 nTPM
Basal ganglia	8.4 nTPM
Amygdala	8.3 nTPM
Hippocampus	7.6 nTPM
Cerebral cortex	6.7 nTPM
Midbrain	4.4 nTPM
Hypothalamus	3.0 nTPM

Deep-layer intratelencephalic	5.9 nTPM
Hippocampus	7.8 nTPM
Cerebral cortex	6.3 nTPM
Amygdala	6.2 nTPM
Basal ganglia	6.0 nTPM
Hypothalamus	3.4 nTPM

Deep-layer near-projecting	7.5 nTPM
Hippocampus	13.7 nTPM
Basal ganglia	7.9 nTPM
Cerebral cortex	6.7 nTPM
Amygdala	6.1 nTPM
Hypothalamus	3.0 nTPM

Eccentric medium spiny neuron	5.4 nTPM
Amygdala	6.5 nTPM
Basal ganglia	6.0 nTPM
Cerebral cortex	5.8 nTPM
Hypothalamus	5.7 nTPM
Thalamus	4.6 nTPM
Hippocampus	3.7 nTPM

Endothelial cell	9.6 nTPM
Amygdala	15.6 nTPM
Thalamus	13.6 nTPM
Cerebral cortex	12.8 nTPM
Cerebellum	11.6 nTPM
Medulla oblongata	11.3 nTPM
Pons	8.1 nTPM
Basal ganglia	7.5 nTPM
Hippocampus	7.4 nTPM
Spinal cord	6.9 nTPM
Midbrain	5.7 nTPM
Hypothalamus	5.0 nTPM

Ependymal cell	15.6 nTPM
Midbrain	21.0 nTPM
Amygdala	19.9 nTPM
Medulla oblongata	18.2 nTPM
Hippocampus	16.8 nTPM
Pons	14.9 nTPM
Hypothalamus	14.3 nTPM
Basal ganglia	14.2 nTPM
Thalamus	13.4 nTPM
Spinal cord	7.7 nTPM