Single cell type - MRPS18A - The Human Protein Atlas

MRPS18A

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MRPS18A
Gene descriptionⁱ Full gene name according to HGNC.	Mitochondrial ribosomal protein S18A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Ribosomal proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Intestinal goblet cells - Mucin production (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.28
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

MRPS18A is part of cluster 16 Intestinal goblet cells - Mucin production with confidenceⁱ 1
268 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DNAJC17	DnaJ heat shock protein family (Hsp40) member C17	0.6072	35
ELF3	E74 like ETS transcription factor 3	0.5777	35
RNF25	Ring finger protein 25	0.5269	39
SH2D6	SH2 domain containing 6	0.5129	16
MUC5B	Mucin 5B, oligomeric mucus/gel-forming	0.5080	16
NOXO1	NADPH oxidase organizer 1	0.4913	16
BIK	BCL2 interacting killer	0.4883	35
DCTPP1	DCTP pyrophosphatase 1	0.4845	16
FASTK	Fas activated serine/threonine kinase	0.4807	39
PGLYRP4	Peptidoglycan recognition protein 4	0.4761	35
CLDN10	Claudin 10	0.4748	35
TAS2R41	Taste 2 receptor member 41	0.4715	16
HTR3E	5-hydroxytryptamine receptor 3E	0.4715	16
MRPL13	Mitochondrial ribosomal protein L13	0.4673	39
C1GALT1C1	C1GALT1 specific chaperone 1	0.4667	35

IMMUNE CELLS

MRPS18A is part of cluster 22 Eosinophils - Transcription with confidenceⁱ 0.78
357 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000288614	Novel protein	0.9286	22
SUB1	SUB1 regulator of transcription	0.9048	32
CFAP298	Cilia and flagella associated protein 298	0.9048	12
FMC1	Formation of mitochondrial complex V assembly factor 1 homolog	0.8810	22
KLHL6	Kelch like family member 6	0.8571	10
MPLKIP	M-phase specific PLK1 interacting protein	0.8571	10
OSBPL9	Oxysterol binding protein like 9	0.8571	32
CNST	Consortin, connexin sorting protein	0.8571	5
ANKRD10	Ankyrin repeat domain 10	0.8333	24
RCC1	Regulator of chromosome condensation 1	0.8333	22
HELQ	Helicase, POLQ like	0.8333	3
UPF3B	UPF3B regulator of nonsense mediated mRNA decay	0.8333	22
ZNF451	Zinc finger protein 451	0.8333	18
FNBP4	Formin binding protein 4	0.8333	22
SPPL2B	Signal peptide peptidase like 2B	0.8333	22

Adipocytes	25.4 nTPM
Adipose tissue	25.5 nTPM
Breast	25.3 nTPM

Alveolar cells type 1	33.0 nTPM
Lung	33.0 nTPM

Alveolar cells type 2	32.8 nTPM
Lung	32.8 nTPM

Astrocytes	5.0 nTPM
Brain	5.0 nTPM

B-cells	22.0 nTPM
Kidney	41.6 nTPM
Liver	33.8 nTPM
Stomach	30.8 nTPM
Bone marrow	26.9 nTPM
Spleen	26.8 nTPM
Salivary gland	26.4 nTPM
Lung	25.5 nTPM
Thymus	24.4 nTPM
Adipose tissue	17.3 nTPM
PBMC	13.9 nTPM
Skin	13.6 nTPM
Lymph node	5.2 nTPM
Esophagus	0.0 nTPM

Ciliated cells	30.0 nTPM
Bronchus	43.9 nTPM
Fallopian tube	31.3 nTPM
Endometrium	26.1 nTPM
Lung	18.9 nTPM

Club cells	57.8 nTPM
Bronchus	89.1 nTPM
Prostate	47.4 nTPM
Lung	36.9 nTPM

Endothelial cells	27.9 nTPM
Pancreas	51.7 nTPM
Skeletal muscle	51.7 nTPM
Placenta	39.2 nTPM
Fallopian tube	38.6 nTPM
Lung	34.8 nTPM
Testis	33.6 nTPM
Ovary	32.1 nTPM
Tongue	31.0 nTPM
Thymus	25.0 nTPM
Skin	24.1 nTPM
Salivary gland	21.8 nTPM
Breast	21.1 nTPM
Prostate	19.8 nTPM
Endometrium	19.7 nTPM
Vascular	19.2 nTPM
Liver	18.9 nTPM
Esophagus	16.9 nTPM
Heart muscle	3.5 nTPM

Enteroendocrine cells	64.8 nTPM
Colon	104.2 nTPM
Small intestine	65.2 nTPM
Rectum	25.2 nTPM

Fibroblasts	27.6 nTPM
Pancreas	57.1 nTPM
Placenta	56.1 nTPM
Adipose tissue	36.3 nTPM
Lung	31.8 nTPM
Fallopian tube	31.5 nTPM
Salivary gland	27.4 nTPM
Skeletal muscle	25.3 nTPM
Thymus	25.2 nTPM
Breast	23.0 nTPM
Liver	22.5 nTPM
Esophagus	22.2 nTPM
Stomach	21.6 nTPM
Skin	19.3 nTPM
Prostate	19.1 nTPM
Vascular	18.0 nTPM
Heart muscle	5.2 nTPM

Granulocytes	23.7 nTPM
Lung	28.7 nTPM
Fallopian tube	27.7 nTPM
Tongue	14.6 nTPM

Intestinal goblet cells	61.6 nTPM
Colon	80.2 nTPM
Small intestine	59.6 nTPM
Rectum	45.1 nTPM

Lymphatic endothelial cells	20.2 nTPM
Fallopian tube	29.4 nTPM
Ovary	10.9 nTPM

Macrophages	18.6 nTPM
Testis	31.6 nTPM
Lung	31.5 nTPM
Kidney	29.2 nTPM
Skin	29.0 nTPM
Pancreas	24.7 nTPM
Fallopian tube	21.8 nTPM
Prostate	19.5 nTPM
Thymus	18.3 nTPM
Salivary gland	16.8 nTPM
Stomach	15.4 nTPM
Tongue	14.7 nTPM
Adipose tissue	14.6 nTPM
Vascular	14.2 nTPM
Breast	13.8 nTPM
Bone marrow	13.2 nTPM
Spleen	13.0 nTPM
Endometrium	12.3 nTPM
Skeletal muscle	10.4 nTPM
Esophagus	10.3 nTPM

Paneth cells	86.0 nTPM
Small intestine	100.2 nTPM
Rectum	85.5 nTPM
Colon	72.4 nTPM

Basal keratinocytes	36.2 nTPM
Tongue	39.9 nTPM
Skin	32.4 nTPM

Basal prostatic cells	26.2 nTPM
Prostate	26.2 nTPM

Basal respiratory cells	98.8 nTPM
Bronchus	98.8 nTPM

Basal squamous epithelial cells	13.7 nTPM
Esophagus	13.7 nTPM

Plasma cells	52.5 nTPM
Liver	77.6 nTPM
Thymus	70.7 nTPM
Spleen	66.4 nTPM
Bone marrow	58.9 nTPM
Stomach	49.4 nTPM
Salivary gland	45.7 nTPM
Fallopian tube	35.7 nTPM
Esophagus	15.6 nTPM

Schwann cells	12.0 nTPM
Vascular	26.6 nTPM
Adipose tissue	9.4 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	31.8 nTPM
Salivary gland	46.0 nTPM
Tongue	17.7 nTPM

Smooth muscle cells	32.5 nTPM
Placenta	60.9 nTPM
Fallopian tube	57.3 nTPM
Ovary	39.7 nTPM
Skeletal muscle	35.0 nTPM
Thymus	34.2 nTPM
Liver	32.3 nTPM
Lung	31.7 nTPM
Prostate	31.6 nTPM
Breast	30.2 nTPM
Salivary gland	29.3 nTPM
Skin	28.2 nTPM
Vascular	24.1 nTPM
Tongue	24.0 nTPM
Endometrium	21.1 nTPM
Esophagus	20.4 nTPM
Adipose tissue	19.8 nTPM

Suprabasal keratinocytes	52.1 nTPM
Tongue	80.4 nTPM
Skin	23.7 nTPM

T-cells	19.7 nTPM
Kidney	38.1 nTPM
Colon	36.1 nTPM
Stomach	27.0 nTPM
Liver	26.8 nTPM
Fallopian tube	25.8 nTPM
PBMC	23.8 nTPM
Bone marrow	23.3 nTPM
Prostate	22.4 nTPM
Spleen	20.5 nTPM
Thymus	19.6 nTPM
Vascular	17.7 nTPM
Endometrium	17.4 nTPM
Lung	17.3 nTPM
Salivary gland	17.3 nTPM
Tongue	16.8 nTPM
Adipose tissue	14.7 nTPM
Skin	14.0 nTPM
Breast	11.5 nTPM
Esophagus	9.7 nTPM
Skeletal muscle	7.6 nTPM
Lymph node	5.3 nTPM

Undifferentiated cells	75.5 nTPM
Colon	87.8 nTPM
Rectum	69.7 nTPM
Small intestine	69.1 nTPM

Amygdala excitatory	6.7 nTPM
Basal ganglia	8.3 nTPM
Thalamus	7.3 nTPM
Cerebral cortex	6.8 nTPM
Amygdala	6.2 nTPM
Hippocampus	6.2 nTPM
Hypothalamus	5.6 nTPM

Astrocyte	8.7 nTPM
Pons	11.1 nTPM
Cerebral cortex	9.6 nTPM
Amygdala	9.1 nTPM
Hippocampus	8.9 nTPM
Midbrain	8.8 nTPM
Cerebellum	8.5 nTPM
Medulla oblongata	8.4 nTPM
Spinal cord	8.3 nTPM
Thalamus	8.3 nTPM
Basal ganglia	8.2 nTPM
Hypothalamus	6.2 nTPM

Bergmann glia	8.8 nTPM
Medulla oblongata	10.7 nTPM
Cerebellum	8.5 nTPM
Pons	7.2 nTPM

Central nervous system macrophage	8.6 nTPM
Medulla oblongata	9.9 nTPM
Amygdala	9.4 nTPM
Spinal cord	9.1 nTPM
Hypothalamus	9.0 nTPM
Cerebellum	8.8 nTPM
Pons	8.6 nTPM
Basal ganglia	8.4 nTPM
Cerebral cortex	8.0 nTPM
Midbrain	7.9 nTPM
Hippocampus	7.6 nTPM
Thalamus	7.5 nTPM

Cerebellar inhibitory	9.1 nTPM
Midbrain	10.0 nTPM
Medulla oblongata	9.6 nTPM
Cerebellum	9.2 nTPM
Pons	8.7 nTPM
Spinal cord	8.2 nTPM

Cge interneuron	7.6 nTPM
Thalamus	9.4 nTPM
Midbrain	8.8 nTPM
Basal ganglia	8.3 nTPM
Cerebral cortex	7.6 nTPM
Hippocampus	7.1 nTPM
Amygdala	6.6 nTPM
Hypothalamus	5.7 nTPM

Choroid plexus epithelial cell	21.0 nTPM
Hippocampus	27.7 nTPM
Basal ganglia	24.5 nTPM
Thalamus	19.2 nTPM
Medulla oblongata	12.7 nTPM

Committed oligodendrocyte precursor	7.5 nTPM
Spinal cord	11.0 nTPM
Basal ganglia	9.9 nTPM
Cerebellum	9.5 nTPM
Cerebral cortex	9.5 nTPM
Pons	8.9 nTPM
Thalamus	7.9 nTPM
Medulla oblongata	6.5 nTPM
Hippocampus	6.2 nTPM
Amygdala	5.1 nTPM
Midbrain	5.0 nTPM
Hypothalamus	3.4 nTPM

Deep-layer corticothalamic and 6b	7.1 nTPM
Midbrain	8.9 nTPM
Basal ganglia	8.0 nTPM
Cerebral cortex	7.0 nTPM
Amygdala	6.5 nTPM
Hippocampus	6.3 nTPM
Hypothalamus	6.1 nTPM

Deep-layer intratelencephalic	7.7 nTPM
Basal ganglia	8.6 nTPM
Cerebral cortex	8.4 nTPM
Hippocampus	7.5 nTPM
Hypothalamus	7.2 nTPM
Amygdala	6.8 nTPM

Deep-layer near-projecting	7.1 nTPM
Hippocampus	9.1 nTPM
Basal ganglia	7.8 nTPM
Cerebral cortex	7.3 nTPM
Hypothalamus	6.8 nTPM
Amygdala	4.6 nTPM

Eccentric medium spiny neuron	8.7 nTPM
Hippocampus	10.8 nTPM
Hypothalamus	9.2 nTPM
Cerebral cortex	8.7 nTPM
Basal ganglia	8.6 nTPM
Amygdala	7.7 nTPM
Thalamus	7.4 nTPM

Endothelial cell	11.9 nTPM
Thalamus	18.1 nTPM
Cerebral cortex	17.3 nTPM
Spinal cord	15.5 nTPM
Pons	15.0 nTPM
Hippocampus	13.1 nTPM
Cerebellum	12.4 nTPM
Medulla oblongata	11.3 nTPM
Hypothalamus	9.9 nTPM
Midbrain	8.5 nTPM
Amygdala	5.6 nTPM
Basal ganglia	3.7 nTPM