Single cell type - DCTPP1 - The Human Protein Atlas

DCTPP1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DCTPP1
Gene descriptionⁱ Full gene name according to HGNC.	DCTP pyrophosphatase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Intestinal goblet cells - Mucin production (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.32
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

DCTPP1 is part of cluster 16 Intestinal goblet cells - Mucin production with confidenceⁱ 1
268 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MRPL12	Mitochondrial ribosomal protein L12	0.6702	39
TAS2R41	Taste 2 receptor member 41	0.6538	16
NOX1	NADPH oxidase 1	0.6451	16
HTR3E	5-hydroxytryptamine receptor 3E	0.6043	16
LEFTY1	Left-right determination factor 1	0.5925	16
CDX1	Caudal type homeobox 1	0.5833	16
GATD3	Glutamine amidotransferase class 1 domain containing 3	0.5746	16
TOMM40	Translocase of outer mitochondrial membrane 40	0.5590	39
PTGES2	Prostaglandin E synthase 2	0.5522	39
CYC1	Cytochrome c1	0.5465	39
METTL2A	Methyltransferase 2A, methylcytidine	0.5404	39
HES1	Hes family bHLH transcription factor 1	0.5402	16
PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B	0.5373	16
XRCC3	X-ray repair cross complementing 3	0.5363	52
NR2C2AP	Nuclear receptor 2C2 associated protein	0.5353	39

IMMUNE CELLS

DCTPP1 is part of cluster 12 Non-specific - Mitochondrial translation with confidenceⁱ 0.99
566 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000256514	Novel protein	0.9762	12
RAD23A	RAD23 homolog A, nucleotide excision repair protein	0.9762	12
HMGB3	High mobility group box 3	0.9524	25
NOL7	Nucleolar protein 7	0.9286	12
UMPS	Uridine monophosphate synthetase	0.9286	12
MRM2	Mitochondrial rRNA methyltransferase 2	0.9286	12
YDJC	YdjC chitooligosaccharide deacetylase homolog	0.9286	25
EFL1	Elongation factor like GTPase 1	0.9286	25
PDRG1	P53 and DNA damage regulated 1	0.9048	12
CRIP1	Cysteine rich protein 1	0.9048	12
MRPS16	Mitochondrial ribosomal protein S16	0.9048	12
DTYMK	Deoxythymidylate kinase	0.9048	12
HSCB	HscB mitochondrial iron-sulfur cluster cochaperone	0.9048	12
GEMIN2	Gem nuclear organelle associated protein 2	0.9048	12
HRK	Harakiri, BCL2 interacting protein	0.8810	12

Adipocytes	35.2 nTPM
Breast	43.5 nTPM
Adipose tissue	26.9 nTPM

Alveolar cells type 1	42.7 nTPM
Lung	42.7 nTPM

Alveolar cells type 2	46.9 nTPM
Lung	46.9 nTPM

Astrocytes	0.6 nTPM
Brain	0.6 nTPM

B-cells	38.0 nTPM
Skin	62.7 nTPM
Esophagus	53.1 nTPM
Lung	48.3 nTPM
PBMC	46.2 nTPM
Spleen	42.2 nTPM
Salivary gland	41.3 nTPM
Thymus	34.1 nTPM
Lymph node	32.0 nTPM
Liver	29.0 nTPM
Adipose tissue	28.8 nTPM
Bone marrow	28.8 nTPM
Stomach	27.4 nTPM
Kidney	20.8 nTPM

Ciliated cells	32.6 nTPM
Fallopian tube	35.5 nTPM
Lung	34.1 nTPM
Endometrium	33.7 nTPM
Bronchus	27.2 nTPM

Club cells	43.3 nTPM
Bronchus	46.6 nTPM
Lung	42.2 nTPM
Prostate	41.0 nTPM

Dendritic cells	19.1 nTPM
PBMC	25.2 nTPM
Adipose tissue	13.0 nTPM

Endothelial cells	45.9 nTPM
Breast	86.1 nTPM
Placenta	78.9 nTPM
Fallopian tube	66.0 nTPM
Skin	63.3 nTPM
Testis	62.6 nTPM
Pancreas	62.0 nTPM
Lung	52.2 nTPM
Thymus	43.5 nTPM
Tongue	41.1 nTPM
Skeletal muscle	40.4 nTPM
Esophagus	38.5 nTPM
Ovary	37.0 nTPM
Endometrium	36.3 nTPM
Vascular	31.9 nTPM
Prostate	25.1 nTPM
Salivary gland	22.0 nTPM
Liver	20.2 nTPM
Heart muscle	19.3 nTPM

Enteroendocrine cells	94.9 nTPM
Colon	179.2 nTPM
Small intestine	58.4 nTPM
Rectum	47.0 nTPM

Fibroblasts	27.9 nTPM
Pancreas	83.4 nTPM
Lung	48.2 nTPM
Placenta	38.0 nTPM
Fallopian tube	28.2 nTPM
Breast	27.6 nTPM
Skin	27.5 nTPM
Thymus	25.5 nTPM
Heart muscle	24.3 nTPM
Adipose tissue	24.3 nTPM
Skeletal muscle	23.7 nTPM
Liver	21.3 nTPM
Vascular	18.0 nTPM
Prostate	17.8 nTPM
Salivary gland	16.2 nTPM
Stomach	11.5 nTPM
Esophagus	10.5 nTPM

Granulocytes	29.6 nTPM
Lung	39.3 nTPM
Fallopian tube	35.0 nTPM
Tongue	14.6 nTPM

Intestinal goblet cells	118.0 nTPM
Colon	185.3 nTPM
Rectum	115.9 nTPM
Small intestine	52.6 nTPM

Lymphatic endothelial cells	37.9 nTPM
Fallopian tube	48.5 nTPM
Ovary	27.3 nTPM

Macrophages	27.9 nTPM
Pancreas	63.7 nTPM
Lung	51.7 nTPM
Kidney	44.3 nTPM
Endometrium	42.4 nTPM
Prostate	32.5 nTPM
Breast	31.1 nTPM
Thymus	28.2 nTPM
Vascular	24.8 nTPM
Tongue	24.1 nTPM
Esophagus	21.8 nTPM
Bone marrow	21.3 nTPM
Skin	21.2 nTPM
Stomach	20.6 nTPM
Testis	20.5 nTPM
Skeletal muscle	19.4 nTPM
Fallopian tube	18.6 nTPM
Salivary gland	16.6 nTPM
Spleen	15.0 nTPM
Adipose tissue	13.2 nTPM

Basal keratinocytes	71.6 nTPM
Skin	90.8 nTPM
Tongue	52.4 nTPM

Basal prostatic cells	44.1 nTPM
Prostate	44.1 nTPM

Basal respiratory cells	88.8 nTPM
Bronchus	88.8 nTPM

Bipolar cells	18.2 nTPM
Eye	18.2 nTPM

Paneth cells	125.5 nTPM
Rectum	168.3 nTPM
Small intestine	110.5 nTPM
Colon	97.7 nTPM

Plasma cells	35.7 nTPM
Liver	69.6 nTPM
Thymus	68.6 nTPM
Bone marrow	49.8 nTPM
Spleen	42.6 nTPM
Salivary gland	26.0 nTPM
Fallopian tube	14.5 nTPM
Stomach	9.2 nTPM
Esophagus	5.2 nTPM

Schwann cells	32.0 nTPM
Adipose tissue	65.2 nTPM
Vascular	18.8 nTPM
Esophagus	12.0 nTPM

Serous glandular cells	36.9 nTPM
Tongue	48.6 nTPM
Salivary gland	25.2 nTPM

Smooth muscle cells	28.1 nTPM
Skin	42.1 nTPM
Placenta	39.2 nTPM
Fallopian tube	36.8 nTPM
Liver	35.2 nTPM
Ovary	34.3 nTPM
Lung	34.1 nTPM
Prostate	32.2 nTPM
Skeletal muscle	30.2 nTPM
Thymus	28.5 nTPM
Breast	28.4 nTPM
Endometrium	25.6 nTPM
Vascular	20.1 nTPM
Adipose tissue	18.5 nTPM
Esophagus	16.8 nTPM
Salivary gland	15.0 nTPM
Tongue	12.9 nTPM

Suprabasal keratinocytes	49.4 nTPM
Skin	73.6 nTPM
Tongue	25.2 nTPM

T-cells	25.8 nTPM
Kidney	41.7 nTPM
Skin	38.2 nTPM
Liver	37.5 nTPM
Esophagus	36.5 nTPM
Endometrium	31.6 nTPM
Colon	30.2 nTPM
PBMC	28.0 nTPM
Prostate	27.1 nTPM
Lung	27.0 nTPM
Breast	24.2 nTPM
Bone marrow	23.1 nTPM
Fallopian tube	22.6 nTPM
Spleen	21.8 nTPM
Skeletal muscle	21.5 nTPM
Thymus	21.3 nTPM
Lymph node	21.0 nTPM
Tongue	20.2 nTPM
Vascular	19.7 nTPM
Stomach	18.7 nTPM
Salivary gland	18.5 nTPM
Adipose tissue	11.8 nTPM

Undifferentiated cells	167.8 nTPM
Colon	232.8 nTPM
Rectum	141.2 nTPM
Small intestine	129.3 nTPM

Amygdala excitatory	2.6 nTPM
Thalamus	4.5 nTPM
Cerebral cortex	2.5 nTPM
Basal ganglia	2.3 nTPM
Hippocampus	2.3 nTPM
Amygdala	1.9 nTPM
Hypothalamus	1.8 nTPM

Astrocyte	1.9 nTPM
Thalamus	2.6 nTPM
Medulla oblongata	2.4 nTPM
Pons	2.3 nTPM
Cerebral cortex	2.1 nTPM
Midbrain	2.1 nTPM
Basal ganglia	2.0 nTPM
Cerebellum	1.9 nTPM
Hippocampus	1.9 nTPM
Hypothalamus	1.5 nTPM
Amygdala	1.1 nTPM
Spinal cord	0.8 nTPM

Bergmann glia	2.6 nTPM
Cerebellum	2.9 nTPM
Pons	2.9 nTPM
Medulla oblongata	2.1 nTPM

Central nervous system macrophage	3.0 nTPM
Cerebral cortex	4.6 nTPM
Cerebellum	3.6 nTPM
Medulla oblongata	3.5 nTPM
Midbrain	3.4 nTPM
Basal ganglia	3.3 nTPM
Thalamus	2.9 nTPM
Hippocampus	2.8 nTPM
Pons	2.7 nTPM
Hypothalamus	2.5 nTPM
Spinal cord	2.1 nTPM
Amygdala	1.5 nTPM

Cerebellar inhibitory	9.3 nTPM
Spinal cord	11.0 nTPM
Midbrain	9.6 nTPM
Pons	9.6 nTPM
Medulla oblongata	8.7 nTPM
Cerebellum	7.6 nTPM

Cge interneuron	5.7 nTPM
Thalamus	7.4 nTPM
Midbrain	6.8 nTPM
Basal ganglia	6.1 nTPM
Cerebral cortex	5.8 nTPM
Hippocampus	5.7 nTPM
Amygdala	4.8 nTPM
Hypothalamus	3.4 nTPM

Choroid plexus epithelial cell	1.8 nTPM
Hippocampus	2.8 nTPM
Medulla oblongata	2.8 nTPM
Basal ganglia	1.8 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	4.7 nTPM
Spinal cord	7.4 nTPM
Basal ganglia	7.1 nTPM
Medulla oblongata	6.5 nTPM
Pons	6.2 nTPM
Cerebellum	4.8 nTPM
Midbrain	4.2 nTPM
Hippocampus	4.1 nTPM
Amygdala	3.9 nTPM
Thalamus	3.4 nTPM
Cerebral cortex	3.2 nTPM
Hypothalamus	0.7 nTPM

Deep-layer corticothalamic and 6b	3.1 nTPM
Midbrain	5.5 nTPM
Basal ganglia	4.2 nTPM
Cerebral cortex	3.0 nTPM
Hippocampus	2.4 nTPM
Amygdala	2.3 nTPM
Hypothalamus	1.0 nTPM

Deep-layer intratelencephalic	3.9 nTPM
Basal ganglia	5.5 nTPM
Cerebral cortex	4.7 nTPM
Hippocampus	3.7 nTPM
Amygdala	3.1 nTPM
Hypothalamus	2.6 nTPM

Deep-layer near-projecting	4.1 nTPM
Hippocampus	6.2 nTPM
Cerebral cortex	4.8 nTPM
Basal ganglia	4.4 nTPM
Amygdala	3.2 nTPM
Hypothalamus	2.1 nTPM

Eccentric medium spiny neuron	3.3 nTPM
Hippocampus	4.6 nTPM
Hypothalamus	3.4 nTPM
Basal ganglia	3.2 nTPM
Cerebral cortex	3.2 nTPM
Amygdala	2.7 nTPM
Thalamus	2.5 nTPM