Single cell type - MNDA - The Human Protein Atlas

MNDA

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MNDA
Gene descriptionⁱ Full gene name according to HGNC.	Myeloid cell nuclear differentiation antigen
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neutrophils - Degranulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Hofbauer cells, Kupffer cells, Macrophages, Langerhans cells, Muller glia cells, Monocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.81
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Central nervous system macrophage, Vascular associated smooth muscle cell, Pericyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enriched (neutrophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Hofbauer cells, Kupffer cells, Macrophages, Langerhans cells, Muller glia cells, Monocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Central nervous system macrophage, Vascular associated smooth muscle cell, Pericyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enriched (neutrophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

MNDA is part of cluster 74 Neutrophils - Degranulation with confidenceⁱ 1
174 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
S100A12	S100 calcium binding protein A12	0.9543	74
CEACAM4	CEA cell adhesion molecule 4	0.9061	74
SIRPB1	Signal regulatory protein beta 1	0.8850	74
LILRB3	Leukocyte immunoglobulin like receptor B3	0.8685	74
CLEC4D	C-type lectin domain family 4 member D	0.8654	74
NLRP12	NLR family pyrin domain containing 12	0.8636	29
TLR8	Toll like receptor 8	0.8404	29
TLR1	Toll like receptor 1	0.8107	74
LILRA2	Leukocyte immunoglobulin like receptor A2	0.8036	29
SERPINB10	Serpin family B member 10	0.8006	74
GCA	Grancalcin	0.7822	74
FPR1	Formyl peptide receptor 1	0.7759	74
CEBPE	CCAAT enhancer binding protein epsilon	0.7690	74
IL17RA	Interleukin 17 receptor A	0.7608	74
NFAM1	NFAT activating protein with ITAM motif 1	0.7590	29

IMMUNE CELLS

MNDA is part of cluster 21 Neutrophils - Unknown function with confidenceⁱ 0.96
492 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GPX3	Glutathione peroxidase 3	1.0000	21
EYS	Eyes shut homolog	1.0000	21
FCAR	Fc alpha receptor	1.0000	21
QPCT	Glutaminyl-peptide cyclotransferase	1.0000	21
TMEM121B	Transmembrane protein 121B	1.0000	21
B3GNT5	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	1.0000	21
FPR1	Formyl peptide receptor 1	1.0000	21
SDC2	Syndecan 2	1.0000	21
PGS1	Phosphatidylglycerophosphate synthase 1	1.0000	21
CREB5	CAMP responsive element binding protein 5	1.0000	21
CLEC4E	C-type lectin domain family 4 member E	1.0000	21
TBC1D14	TBC1 domain family member 14	0.9762	21
TREM1	Triggering receptor expressed on myeloid cells 1	0.9762	21
FAM53C	Family with sequence similarity 53 member C	0.9762	21
FBXL5	F-box and leucine rich repeat protein 5	0.9762	21

Adipocytes	2.0 nTPM
Breast	4.0 nTPM
Adipose tissue	0.0 nTPM

Alveolar cells type 1	1.1 nTPM
Lung	1.1 nTPM

Alveolar cells type 2	1.4 nTPM
Lung	1.4 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	40.1 nTPM
Skin	120.3 nTPM
Bone marrow	47.4 nTPM
PBMC	46.2 nTPM
Stomach	38.8 nTPM
Thymus	36.5 nTPM
Kidney	36.4 nTPM
Spleen	36.3 nTPM
Lung	36.2 nTPM
Salivary gland	36.2 nTPM
Liver	24.2 nTPM
Lymph node	22.9 nTPM
Adipose tissue	22.6 nTPM
Esophagus	17.7 nTPM

Ciliated cells	4.4 nTPM
Lung	10.8 nTPM
Fallopian tube	6.7 nTPM
Endometrium	0.1 nTPM
Bronchus	0.0 nTPM

Club cells	5.8 nTPM
Lung	16.6 nTPM
Prostate	0.8 nTPM
Bronchus	0.0 nTPM

Endothelial cells	2.1 nTPM
Liver	12.6 nTPM
Lung	5.8 nTPM
Heart muscle	4.7 nTPM
Tongue	2.3 nTPM
Skeletal muscle	2.2 nTPM
Thymus	2.2 nTPM
Vascular	1.5 nTPM
Salivary gland	1.4 nTPM
Placenta	1.1 nTPM
Prostate	1.0 nTPM
Fallopian tube	1.0 nTPM
Skin	0.9 nTPM
Testis	0.3 nTPM
Endometrium	0.1 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM
Breast	0.0 nTPM
Ovary	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	2.1 nTPM
Lung	9.3 nTPM
Fallopian tube	8.8 nTPM
Liver	4.7 nTPM
Salivary gland	2.6 nTPM
Thymus	2.2 nTPM
Skin	1.4 nTPM
Vascular	1.4 nTPM
Skeletal muscle	1.2 nTPM
Prostate	0.7 nTPM
Placenta	0.5 nTPM
Breast	0.5 nTPM
Heart muscle	0.2 nTPM
Pancreas	0.2 nTPM
Esophagus	0.2 nTPM
Adipose tissue	0.1 nTPM
Stomach	0.0 nTPM

Granulocytes	2.9 nTPM
Lung	5.5 nTPM
Fallopian tube	3.1 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	0.3 nTPM
Small intestine	0.7 nTPM
Colon	0.2 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	0.9 nTPM
Fallopian tube	1.9 nTPM
Ovary	0.0 nTPM

Macrophages	350.4 nTPM
Skeletal muscle	728.8 nTPM
Kidney	677.0 nTPM
Stomach	653.3 nTPM
Spleen	555.4 nTPM
Bone marrow	498.6 nTPM
Testis	474.3 nTPM
Fallopian tube	396.8 nTPM
Endometrium	362.8 nTPM
Breast	342.9 nTPM
Lung	316.2 nTPM
Tongue	273.0 nTPM
Adipose tissue	241.1 nTPM
Pancreas	197.3 nTPM
Salivary gland	195.9 nTPM
Thymus	180.6 nTPM
Vascular	146.7 nTPM
Prostate	140.1 nTPM
Esophagus	140.0 nTPM
Skin	137.1 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Cholangiocytes	9.5 nTPM
Liver	9.5 nTPM

Cytotrophoblasts	0.4 nTPM
Placenta	0.4 nTPM

Plasma cells	2.1 nTPM
Liver	5.0 nTPM
Fallopian tube	4.5 nTPM
Bone marrow	3.0 nTPM
Stomach	1.3 nTPM
Salivary gland	1.3 nTPM
Thymus	1.2 nTPM
Spleen	0.7 nTPM
Esophagus	0.0 nTPM

Schwann cells	36.0 nTPM
Adipose tissue	107.4 nTPM
Vascular	0.5 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	42.2 nTPM
Salivary gland	80.0 nTPM
Tongue	4.4 nTPM

Smooth muscle cells	6.2 nTPM
Skeletal muscle	30.2 nTPM
Breast	19.3 nTPM
Skin	8.9 nTPM
Esophagus	6.0 nTPM
Thymus	5.5 nTPM
Prostate	4.9 nTPM
Lung	4.7 nTPM
Adipose tissue	4.5 nTPM
Salivary gland	3.3 nTPM
Vascular	2.8 nTPM
Tongue	2.4 nTPM
Fallopian tube	2.2 nTPM
Ovary	1.5 nTPM
Liver	1.3 nTPM
Placenta	1.3 nTPM
Endometrium	0.3 nTPM

T-cells	4.1 nTPM
PBMC	20.6 nTPM
Lung	13.4 nTPM
Kidney	6.2 nTPM
Prostate	6.1 nTPM
Colon	5.8 nTPM
Bone marrow	5.4 nTPM
Spleen	4.4 nTPM
Vascular	4.4 nTPM
Liver	3.1 nTPM
Skeletal muscle	2.6 nTPM
Esophagus	2.4 nTPM
Fallopian tube	2.4 nTPM
Skin	2.1 nTPM
Breast	1.9 nTPM
Tongue	1.7 nTPM
Adipose tissue	0.8 nTPM
Salivary gland	0.8 nTPM
Stomach	0.6 nTPM
Endometrium	0.5 nTPM
Thymus	0.4 nTPM
Lymph node	0.3 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Amygdala excitatory	0.1 nTPM
Basal ganglia	0.3 nTPM
Amygdala	0.1 nTPM
Hippocampus	0.1 nTPM
Cerebral cortex	0.0 nTPM
Hypothalamus	0.0 nTPM
Thalamus	0.0 nTPM

Astrocyte	0.3 nTPM
Basal ganglia	0.5 nTPM
Midbrain	0.5 nTPM
Spinal cord	0.5 nTPM
Cerebellum	0.4 nTPM
Amygdala	0.3 nTPM
Hippocampus	0.3 nTPM
Medulla oblongata	0.2 nTPM
Pons	0.2 nTPM
Thalamus	0.2 nTPM
Cerebral cortex	0.1 nTPM
Hypothalamus	0.1 nTPM

Bergmann glia	0.1 nTPM
Cerebellum	0.3 nTPM
Medulla oblongata	0.0 nTPM
Pons	0.0 nTPM

Central nervous system macrophage	159.8 nTPM
Basal ganglia	222.0 nTPM
Spinal cord	174.9 nTPM
Thalamus	161.7 nTPM
Amygdala	158.5 nTPM
Medulla oblongata	157.2 nTPM
Pons	156.5 nTPM
Cerebral cortex	156.3 nTPM
Midbrain	153.6 nTPM
Hypothalamus	143.6 nTPM
Hippocampus	141.1 nTPM
Cerebellum	132.0 nTPM

Cerebellar inhibitory	0.1 nTPM
Midbrain	0.3 nTPM
Pons	0.3 nTPM
Cerebellum	0.1 nTPM
Medulla oblongata	0.0 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	0.2 nTPM
Basal ganglia	0.4 nTPM
Hypothalamus	0.2 nTPM
Midbrain	0.2 nTPM
Thalamus	0.2 nTPM
Amygdala	0.1 nTPM
Cerebral cortex	0.1 nTPM
Hippocampus	0.1 nTPM

Choroid plexus epithelial cell	1.6 nTPM
Hippocampus	5.5 nTPM
Medulla oblongata	0.7 nTPM
Basal ganglia	0.1 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	0.5 nTPM
Midbrain	1.7 nTPM
Basal ganglia	1.6 nTPM
Hippocampus	0.8 nTPM
Cerebral cortex	0.6 nTPM
Thalamus	0.5 nTPM
Amygdala	0.0 nTPM
Cerebellum	0.0 nTPM
Hypothalamus	0.0 nTPM
Medulla oblongata	0.0 nTPM
Pons	0.0 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	0.0 nTPM
Amygdala	0.1 nTPM
Hippocampus	0.1 nTPM
Basal ganglia	0.0 nTPM
Cerebral cortex	0.0 nTPM
Hypothalamus	0.0 nTPM
Midbrain	0.0 nTPM

Deep-layer intratelencephalic	0.1 nTPM
Amygdala	0.1 nTPM
Basal ganglia	0.1 nTPM
Hippocampus	0.1 nTPM
Cerebral cortex	0.0 nTPM
Hypothalamus	0.0 nTPM

Deep-layer near-projecting	0.1 nTPM
Amygdala	0.4 nTPM
Cerebral cortex	0.1 nTPM
Basal ganglia	0.0 nTPM
Hippocampus	0.0 nTPM
Hypothalamus	0.0 nTPM

Eccentric medium spiny neuron	0.0 nTPM
Amygdala	0.1 nTPM
Basal ganglia	0.1 nTPM
Cerebral cortex	0.0 nTPM
Hippocampus	0.0 nTPM
Hypothalamus	0.0 nTPM
Thalamus	0.0 nTPM

Endothelial cell	1.1 nTPM
Medulla oblongata	3.1 nTPM
Hypothalamus	2.5 nTPM
Basal ganglia	1.9 nTPM
Pons	1.2 nTPM
Amygdala	1.1 nTPM
Cerebral cortex	0.6 nTPM
Hippocampus	0.6 nTPM
Thalamus	0.6 nTPM
Cerebellum	0.0 nTPM
Midbrain	0.0 nTPM
Spinal cord	0.0 nTPM

Ependymal cell	0.1 nTPM
Medulla oblongata	0.4 nTPM
Pons	0.4 nTPM
Thalamus	0.4 nTPM
Hippocampus	0.1 nTPM
Amygdala	0.0 nTPM
Basal ganglia	0.0 nTPM
Hypothalamus	0.0 nTPM
Midbrain	0.0 nTPM
Spinal cord	0.0 nTPM