Single cell type - RIPK2 - The Human Protein Atlas

RIPK2

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RIPK2
Gene descriptionⁱ Full gene name according to HGNC.	Receptor interacting serine/threonine kinase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Monocytes - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enriched (Monocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.59
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enriched (Monocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

RIPK2 is part of cluster 29 Monocytes - Innate immune response with confidenceⁱ 0.95
447 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZFAND5	Zinc finger AN1-type containing 5	0.8228	29
EREG	Epiregulin	0.8165	29
PLAUR	Plasminogen activator, urokinase receptor	0.8121	29
PNPLA8	Patatin like phospholipase domain containing 8	0.7986	29
IL1A	Interleukin 1 alpha	0.7871	29
IL1B	Interleukin 1 beta	0.7768	29
NLRP3	NLR family pyrin domain containing 3	0.7650	29
TP53BP2	Tumor protein p53 binding protein 2	0.7540	29
NOCT	Nocturnin	0.7537	29
LIPN	Lipase family member N	0.7502	29
ACOD1	Aconitate decarboxylase 1	0.7488	29
GPR132	G protein-coupled receptor 132	0.7426	29
NFKB1	Nuclear factor kappa B subunit 1	0.7373	29
SERPINB8	Serpin family B member 8	0.7268	29
C5AR1	Complement C5a receptor 1	0.7249	29

IMMUNE CELLS

RIPK2 is part of cluster 25 Non-specific - Unknown function with confidenceⁱ 0.89
355 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RING1	Ring finger protein 1	1.0000	25
GRK6	G protein-coupled receptor kinase 6	1.0000	25
GPR137B	G protein-coupled receptor 137B	1.0000	25
P2RY2	Purinergic receptor P2Y2	1.0000	25
MTIF2	Mitochondrial translational initiation factor 2	1.0000	25
ASCC2	Activating signal cointegrator 1 complex subunit 2	1.0000	25
ZNF668	Zinc finger protein 668	1.0000	25
MAPK7	Mitogen-activated protein kinase 7	1.0000	25
GPS2	G protein pathway suppressor 2	1.0000	25
SCLY	Selenocysteine lyase	1.0000	25
SNAPC2	Small nuclear RNA activating complex polypeptide 2	0.9762	25
CCDC170	Coiled-coil domain containing 170	0.9762	25
ZBTB45	Zinc finger and BTB domain containing 45	0.9762	25
PARP12	Poly(ADP-ribose) polymerase family member 12	0.9762	25
NUP93	Nucleoporin 93	0.9762	25

Adipocytes	18.7 nTPM
Adipose tissue	27.3 nTPM
Breast	10.2 nTPM

Alveolar cells type 1	16.2 nTPM
Lung	16.2 nTPM

Alveolar cells type 2	18.1 nTPM
Lung	18.1 nTPM

Astrocytes	24.2 nTPM
Brain	24.2 nTPM

B-cells	26.6 nTPM
Adipose tissue	80.7 nTPM
Spleen	39.0 nTPM
Stomach	38.8 nTPM
Lymph node	33.3 nTPM
Esophagus	29.5 nTPM
Thymus	26.6 nTPM
Skin	25.4 nTPM
Salivary gland	19.8 nTPM
Lung	17.4 nTPM
PBMC	10.8 nTPM
Bone marrow	10.4 nTPM
Liver	9.7 nTPM
Kidney	5.2 nTPM

Ciliated cells	27.9 nTPM
Endometrium	78.5 nTPM
Fallopian tube	15.1 nTPM
Bronchus	10.9 nTPM
Lung	7.0 nTPM

Club cells	14.7 nTPM
Bronchus	18.6 nTPM
Lung	14.9 nTPM
Prostate	10.5 nTPM

Dendritic cells	15.1 nTPM
Adipose tissue	19.5 nTPM
PBMC	10.8 nTPM

Endothelial cells	14.0 nTPM
Skeletal muscle	29.9 nTPM
Pancreas	28.4 nTPM
Skin	26.5 nTPM
Endometrium	21.9 nTPM
Heart muscle	17.1 nTPM
Fallopian tube	16.2 nTPM
Vascular	13.7 nTPM
Salivary gland	12.9 nTPM
Thymus	12.8 nTPM
Placenta	10.2 nTPM
Lung	8.7 nTPM
Prostate	8.5 nTPM
Tongue	8.3 nTPM
Esophagus	8.2 nTPM
Liver	7.6 nTPM
Ovary	7.3 nTPM
Testis	6.7 nTPM
Breast	6.2 nTPM

Enteroendocrine cells	7.9 nTPM
Colon	11.7 nTPM
Small intestine	6.9 nTPM
Rectum	5.0 nTPM

Fibroblasts	20.2 nTPM
Skin	59.1 nTPM
Heart muscle	32.0 nTPM
Skeletal muscle	31.3 nTPM
Pancreas	29.2 nTPM
Adipose tissue	25.6 nTPM
Stomach	18.7 nTPM
Thymus	18.7 nTPM
Vascular	16.7 nTPM
Esophagus	14.5 nTPM
Fallopian tube	13.8 nTPM
Prostate	13.2 nTPM
Placenta	11.9 nTPM
Salivary gland	11.7 nTPM
Lung	11.4 nTPM
Breast	10.0 nTPM
Liver	4.7 nTPM

Granulocytes	41.8 nTPM
Fallopian tube	61.5 nTPM
Lung	44.4 nTPM
Tongue	19.4 nTPM

Intestinal goblet cells	5.7 nTPM
Colon	8.9 nTPM
Rectum	5.3 nTPM
Small intestine	2.9 nTPM

Lymphatic endothelial cells	9.7 nTPM
Fallopian tube	14.0 nTPM
Ovary	5.5 nTPM

Macrophages	98.9 nTPM
Fallopian tube	369.8 nTPM
Adipose tissue	367.1 nTPM
Stomach	159.5 nTPM
Skeletal muscle	146.6 nTPM
Endometrium	113.2 nTPM
Vascular	104.9 nTPM
Spleen	88.2 nTPM
Lung	80.5 nTPM
Tongue	64.4 nTPM
Salivary gland	63.9 nTPM
Esophagus	55.2 nTPM
Prostate	53.1 nTPM
Testis	50.2 nTPM
Breast	35.0 nTPM
Kidney	34.5 nTPM
Thymus	26.8 nTPM
Skin	23.4 nTPM
Pancreas	22.6 nTPM
Bone marrow	20.3 nTPM

Basal prostatic cells	11.0 nTPM
Prostate	11.0 nTPM

Basal respiratory cells	12.3 nTPM
Bronchus	12.3 nTPM

Basal squamous epithelial cells	16.0 nTPM
Esophagus	16.0 nTPM

Bipolar cells	1.7 nTPM
Eye	1.7 nTPM

Paneth cells	7.6 nTPM
Colon	14.5 nTPM
Rectum	8.3 nTPM
Small intestine	0.0 nTPM

Plasma cells	18.3 nTPM
Fallopian tube	27.7 nTPM
Stomach	20.9 nTPM
Spleen	20.2 nTPM
Salivary gland	18.4 nTPM
Thymus	16.1 nTPM
Esophagus	15.6 nTPM
Liver	15.5 nTPM
Bone marrow	12.1 nTPM

Schwann cells	41.1 nTPM
Adipose tissue	108.5 nTPM
Vascular	14.6 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	8.2 nTPM
Salivary gland	11.9 nTPM
Tongue	4.4 nTPM

Smooth muscle cells	16.0 nTPM
Adipose tissue	31.6 nTPM
Endometrium	30.7 nTPM
Skin	24.4 nTPM
Skeletal muscle	20.0 nTPM
Lung	17.6 nTPM
Tongue	16.8 nTPM
Placenta	14.7 nTPM
Esophagus	14.4 nTPM
Ovary	13.6 nTPM
Fallopian tube	13.4 nTPM
Salivary gland	13.0 nTPM
Thymus	12.1 nTPM
Vascular	11.2 nTPM
Breast	8.8 nTPM
Prostate	8.5 nTPM
Liver	4.7 nTPM

Suprabasal keratinocytes	29.0 nTPM
Skin	47.6 nTPM
Tongue	10.4 nTPM

T-cells	32.1 nTPM
Adipose tissue	149.8 nTPM
Thymus	65.7 nTPM
Vascular	49.8 nTPM
Tongue	36.6 nTPM
Stomach	35.9 nTPM
Endometrium	34.9 nTPM
Fallopian tube	33.8 nTPM
Spleen	32.2 nTPM
Salivary gland	31.8 nTPM
Lung	31.0 nTPM
Skeletal muscle	27.6 nTPM
Prostate	22.0 nTPM
Skin	21.4 nTPM
Colon	18.5 nTPM
Lymph node	17.9 nTPM
Bone marrow	15.2 nTPM
Liver	13.6 nTPM
PBMC	10.2 nTPM
Esophagus	9.7 nTPM
Breast	9.0 nTPM
Kidney	8.0 nTPM

Undifferentiated cells	12.2 nTPM
Colon	21.2 nTPM
Rectum	8.3 nTPM
Small intestine	7.1 nTPM

Amygdala excitatory	24.2 nTPM
Hypothalamus	42.1 nTPM
Hippocampus	24.7 nTPM
Basal ganglia	23.9 nTPM
Cerebral cortex	22.5 nTPM
Amygdala	18.7 nTPM
Thalamus	13.6 nTPM

Astrocyte	79.1 nTPM
Spinal cord	224.6 nTPM
Hypothalamus	134.8 nTPM
Medulla oblongata	89.1 nTPM
Amygdala	72.2 nTPM
Pons	70.7 nTPM
Cerebellum	59.5 nTPM
Hippocampus	57.7 nTPM
Midbrain	44.7 nTPM
Cerebral cortex	42.9 nTPM
Basal ganglia	39.8 nTPM
Thalamus	34.3 nTPM

Bergmann glia	31.5 nTPM
Pons	40.3 nTPM
Medulla oblongata	27.7 nTPM
Cerebellum	26.4 nTPM

Central nervous system macrophage	61.7 nTPM
Hypothalamus	119.8 nTPM
Spinal cord	95.4 nTPM
Amygdala	65.1 nTPM
Pons	55.0 nTPM
Hippocampus	52.9 nTPM
Midbrain	51.1 nTPM
Basal ganglia	49.9 nTPM
Medulla oblongata	49.8 nTPM
Cerebellum	48.9 nTPM
Thalamus	48.6 nTPM
Cerebral cortex	42.3 nTPM

Cerebellar inhibitory	11.8 nTPM
Spinal cord	27.5 nTPM
Midbrain	10.0 nTPM
Cerebellum	7.4 nTPM
Pons	7.3 nTPM
Medulla oblongata	7.0 nTPM

Cge interneuron	9.2 nTPM
Amygdala	12.1 nTPM
Hypothalamus	10.1 nTPM
Hippocampus	9.3 nTPM
Basal ganglia	8.9 nTPM
Cerebral cortex	8.6 nTPM
Midbrain	7.8 nTPM
Thalamus	7.2 nTPM

Choroid plexus epithelial cell	13.0 nTPM
Basal ganglia	18.4 nTPM
Hippocampus	16.6 nTPM
Medulla oblongata	14.0 nTPM
Thalamus	2.7 nTPM

Committed oligodendrocyte precursor	16.8 nTPM
Hypothalamus	23.9 nTPM
Cerebral cortex	20.3 nTPM
Basal ganglia	19.7 nTPM
Cerebellum	19.0 nTPM
Amygdala	17.5 nTPM
Midbrain	16.8 nTPM
Thalamus	16.2 nTPM
Hippocampus	15.5 nTPM
Spinal cord	14.7 nTPM
Pons	10.6 nTPM
Medulla oblongata	10.3 nTPM

Deep-layer corticothalamic and 6b	14.8 nTPM
Amygdala	18.1 nTPM
Hypothalamus	17.8 nTPM
Cerebral cortex	15.4 nTPM
Hippocampus	14.7 nTPM
Basal ganglia	12.7 nTPM
Midbrain	10.0 nTPM

Deep-layer intratelencephalic	22.8 nTPM
Amygdala	26.4 nTPM
Hypothalamus	24.0 nTPM
Hippocampus	22.9 nTPM
Basal ganglia	20.7 nTPM
Cerebral cortex	19.8 nTPM

Deep-layer near-projecting	15.3 nTPM
Basal ganglia	17.4 nTPM
Amygdala	16.8 nTPM
Hippocampus	15.0 nTPM
Hypothalamus	15.0 nTPM
Cerebral cortex	12.2 nTPM

Eccentric medium spiny neuron	9.7 nTPM
Amygdala	11.4 nTPM
Thalamus	11.0 nTPM
Cerebral cortex	10.2 nTPM
Basal ganglia	9.6 nTPM
Hypothalamus	9.2 nTPM
Hippocampus	6.6 nTPM