Single cell type - CRCP - The Human Protein Atlas

CRCP

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CRCP
Gene descriptionⁱ Full gene name according to HGNC.	CGRP receptor component
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	RNA polymerase related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	NK-cells & T-cells - Immune system & Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.26
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

CRCP is part of cluster 78 NK-cells & T-cells - Immune system & Transcription with confidenceⁱ 0.99
392 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRPF4B	Pre-mRNA processing factor 4B	0.6913	78
CENPC	Centromere protein C	0.6229	78
DDX24	DEAD-box helicase 24	0.6208	78
RPL7L1	Ribosomal protein L7 like 1	0.6022	39
CRNKL1	Crooked neck pre-mRNA splicing factor 1	0.5708	78
NCL	Nucleolin	0.5426	39
C2orf49	Chromosome 2 open reading frame 49	0.5392	78
ZNF721	Zinc finger protein 721	0.5297	55
PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1	0.5268	78
DDX39B	DExD-box helicase 39B	0.5254	80
OTULIN	OTU deubiquitinase with linear linkage specificity	0.5221	78
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.5206	55
SMC5	Structural maintenance of chromosomes 5	0.5189	55
CWC22	CWC22 spliceosome associated protein homolog	0.5183	55
BRD1	Bromodomain containing 1	0.5172	78

IMMUNE CELLS

CRCP is part of cluster 32 Basophils - Transcription with confidenceⁱ 0.99
291 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PGBD2	PiggyBac transposable element derived 2	1.0000	32
TCF7L1	Transcription factor 7 like 1	1.0000	32
FAM117A	Family with sequence similarity 117 member A	0.9762	32
ZNF587	Zinc finger protein 587	0.9762	32
CAPN12	Calpain 12	0.9762	32
FANCB	FA complementation group B	0.9762	32
EPM2AIP1	EPM2A interacting protein 1	0.9762	32
C2CD3	C2 domain containing 3 centriole elongation regulator	0.9762	32
AK9	Adenylate kinase 9	0.9762	32
MARCHF6	Membrane associated ring-CH-type finger 6	0.9762	32
CBFB	Core-binding factor subunit beta	0.9762	32
RAB3GAP2	RAB3 GTPase activating non-catalytic protein subunit 2	0.9762	32
RBBP5	RB binding protein 5, histone lysine methyltransferase complex subunit	0.9762	32
ZNF684	Zinc finger protein 684	0.9762	32
ACTR8	Actin related protein 8	0.9762	32

Adipocytes	23.9 nTPM
Breast	24.7 nTPM
Adipose tissue	23.1 nTPM

Alveolar cells type 1	21.5 nTPM
Lung	21.5 nTPM

Alveolar cells type 2	28.9 nTPM
Lung	28.9 nTPM

Astrocytes	11.5 nTPM
Brain	11.5 nTPM

B-cells	27.8 nTPM
Salivary gland	40.9 nTPM
PBMC	38.5 nTPM
Adipose tissue	37.9 nTPM
Lymph node	32.7 nTPM
Lung	30.9 nTPM
Bone marrow	30.5 nTPM
Esophagus	29.5 nTPM
Stomach	28.7 nTPM
Spleen	27.5 nTPM
Kidney	26.0 nTPM
Thymus	19.6 nTPM
Liver	9.7 nTPM
Skin	8.5 nTPM

Ciliated cells	19.7 nTPM
Endometrium	25.0 nTPM
Fallopian tube	23.8 nTPM
Lung	21.4 nTPM
Bronchus	8.6 nTPM

Club cells	23.1 nTPM
Prostate	32.9 nTPM
Lung	24.6 nTPM
Bronchus	12.0 nTPM

Dendritic cells	29.7 nTPM
Adipose tissue	41.4 nTPM
PBMC	18.0 nTPM

Endothelial cells	19.2 nTPM
Salivary gland	29.3 nTPM
Fallopian tube	28.1 nTPM
Breast	27.2 nTPM
Vascular	24.9 nTPM
Lung	24.6 nTPM
Tongue	22.1 nTPM
Ovary	20.4 nTPM
Testis	19.5 nTPM
Thymus	18.1 nTPM
Heart muscle	17.9 nTPM
Prostate	17.9 nTPM
Skeletal muscle	17.5 nTPM
Esophagus	16.0 nTPM
Endometrium	15.7 nTPM
Pancreas	15.5 nTPM
Skin	12.5 nTPM
Placenta	9.1 nTPM
Liver	8.8 nTPM

Enteroendocrine cells	17.5 nTPM
Colon	23.6 nTPM
Small intestine	20.6 nTPM
Rectum	8.4 nTPM

Fibroblasts	22.9 nTPM
Heart muscle	56.6 nTPM
Prostate	33.7 nTPM
Fallopian tube	33.6 nTPM
Salivary gland	31.0 nTPM
Adipose tissue	29.0 nTPM
Lung	24.8 nTPM
Skeletal muscle	24.2 nTPM
Vascular	22.9 nTPM
Breast	20.1 nTPM
Thymus	15.6 nTPM
Esophagus	14.9 nTPM
Stomach	14.4 nTPM
Liver	13.0 nTPM
Skin	12.8 nTPM
Pancreas	11.0 nTPM
Placenta	9.2 nTPM

Granulocytes	34.3 nTPM
Fallopian tube	42.9 nTPM
Tongue	38.8 nTPM
Lung	21.2 nTPM

Intestinal goblet cells	15.2 nTPM
Colon	20.2 nTPM
Rectum	14.4 nTPM
Small intestine	11.1 nTPM

Lymphatic endothelial cells	28.9 nTPM
Fallopian tube	36.0 nTPM
Ovary	21.8 nTPM

Macrophages	20.5 nTPM
Vascular	30.0 nTPM
Breast	29.5 nTPM
Salivary gland	28.2 nTPM
Adipose tissue	28.0 nTPM
Endometrium	26.4 nTPM
Thymus	25.3 nTPM
Lung	24.2 nTPM
Fallopian tube	23.5 nTPM
Prostate	22.4 nTPM
Testis	21.7 nTPM
Spleen	20.1 nTPM
Skeletal muscle	18.5 nTPM
Bone marrow	18.2 nTPM
Tongue	16.6 nTPM
Pancreas	16.4 nTPM
Esophagus	12.8 nTPM
Kidney	11.5 nTPM
Skin	11.1 nTPM
Stomach	5.1 nTPM

Basal prostatic cells	22.3 nTPM
Prostate	22.3 nTPM

Basal respiratory cells	13.4 nTPM
Bronchus	13.4 nTPM

Cholangiocytes	5.7 nTPM
Liver	5.7 nTPM

Cytotrophoblasts	13.3 nTPM
Placenta	13.3 nTPM

Paneth cells	8.9 nTPM
Rectum	15.8 nTPM
Colon	10.9 nTPM
Small intestine	0.0 nTPM

Plasma cells	23.3 nTPM
Fallopian tube	35.1 nTPM
Stomach	32.2 nTPM
Spleen	25.3 nTPM
Bone marrow	24.2 nTPM
Salivary gland	23.7 nTPM
Thymus	19.4 nTPM
Liver	16.0 nTPM
Esophagus	10.4 nTPM

Schwann cells	25.1 nTPM
Adipose tissue	49.2 nTPM
Vascular	26.1 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	23.0 nTPM
Salivary gland	28.4 nTPM
Tongue	17.7 nTPM

Smooth muscle cells	19.7 nTPM
Fallopian tube	30.3 nTPM
Salivary gland	28.6 nTPM
Vascular	27.1 nTPM
Ovary	24.3 nTPM
Prostate	23.7 nTPM
Lung	22.3 nTPM
Tongue	21.3 nTPM
Endometrium	21.2 nTPM
Breast	21.1 nTPM
Adipose tissue	17.8 nTPM
Skeletal muscle	16.9 nTPM
Esophagus	16.8 nTPM
Thymus	15.5 nTPM
Placenta	10.1 nTPM
Liver	8.9 nTPM
Skin	8.8 nTPM

Suprabasal keratinocytes	19.5 nTPM
Tongue	22.9 nTPM
Skin	16.2 nTPM

T-cells	26.0 nTPM
Adipose tissue	50.1 nTPM
Fallopian tube	43.7 nTPM
Endometrium	33.3 nTPM
Salivary gland	31.7 nTPM
Breast	31.3 nTPM
Skeletal muscle	30.2 nTPM
PBMC	29.5 nTPM
Tongue	26.1 nTPM
Prostate	26.0 nTPM
Vascular	25.7 nTPM
Lung	24.8 nTPM
Colon	24.4 nTPM
Bone marrow	22.6 nTPM
Liver	22.0 nTPM
Stomach	20.3 nTPM
Lymph node	18.6 nTPM
Thymus	18.3 nTPM
Spleen	17.9 nTPM
Skin	17.5 nTPM
Esophagus	17.0 nTPM
Kidney	14.2 nTPM

Undifferentiated cells	15.0 nTPM
Colon	21.2 nTPM
Small intestine	12.3 nTPM
Rectum	11.4 nTPM

Amygdala excitatory	34.9 nTPM
Hypothalamus	45.9 nTPM
Hippocampus	36.4 nTPM
Amygdala	34.7 nTPM
Cerebral cortex	33.8 nTPM
Basal ganglia	31.5 nTPM
Thalamus	26.8 nTPM

Astrocyte	29.6 nTPM
Thalamus	33.4 nTPM
Amygdala	32.3 nTPM
Pons	31.3 nTPM
Cerebellum	31.1 nTPM
Midbrain	31.1 nTPM
Hypothalamus	30.8 nTPM
Cerebral cortex	29.5 nTPM
Basal ganglia	28.8 nTPM
Hippocampus	27.3 nTPM
Medulla oblongata	27.1 nTPM
Spinal cord	22.9 nTPM

Bergmann glia	25.9 nTPM
Pons	33.1 nTPM
Cerebellum	27.5 nTPM
Medulla oblongata	17.0 nTPM

Central nervous system macrophage	44.7 nTPM
Cerebellum	53.5 nTPM
Amygdala	49.5 nTPM
Thalamus	49.0 nTPM
Midbrain	47.8 nTPM
Hypothalamus	47.0 nTPM
Pons	46.5 nTPM
Basal ganglia	43.4 nTPM
Hippocampus	43.1 nTPM
Cerebral cortex	42.1 nTPM
Medulla oblongata	40.0 nTPM
Spinal cord	30.3 nTPM

Cerebellar inhibitory	34.9 nTPM
Cerebellum	39.8 nTPM
Midbrain	38.3 nTPM
Medulla oblongata	35.7 nTPM
Pons	33.0 nTPM
Spinal cord	27.5 nTPM

Cge interneuron	35.0 nTPM
Hypothalamus	46.9 nTPM
Amygdala	35.7 nTPM
Cerebral cortex	35.5 nTPM
Hippocampus	35.0 nTPM
Basal ganglia	33.9 nTPM
Thalamus	30.2 nTPM
Midbrain	28.0 nTPM

Choroid plexus epithelial cell	26.1 nTPM
Basal ganglia	43.9 nTPM
Medulla oblongata	27.4 nTPM
Hippocampus	16.6 nTPM
Thalamus	16.4 nTPM

Committed oligodendrocyte precursor	29.6 nTPM
Hypothalamus	47.1 nTPM
Hippocampus	36.5 nTPM
Amygdala	35.5 nTPM
Thalamus	31.5 nTPM
Midbrain	30.2 nTPM
Pons	29.2 nTPM
Basal ganglia	27.4 nTPM
Cerebral cortex	26.6 nTPM
Cerebellum	23.8 nTPM
Medulla oblongata	19.4 nTPM
Spinal cord	18.4 nTPM

Deep-layer corticothalamic and 6b	34.4 nTPM
Hypothalamus	47.8 nTPM
Amygdala	32.4 nTPM
Cerebral cortex	32.4 nTPM
Basal ganglia	31.9 nTPM
Hippocampus	31.6 nTPM
Midbrain	30.0 nTPM

Deep-layer intratelencephalic	35.8 nTPM
Hypothalamus	49.8 nTPM
Amygdala	33.7 nTPM
Hippocampus	32.6 nTPM
Cerebral cortex	32.4 nTPM
Basal ganglia	30.7 nTPM

Deep-layer near-projecting	44.2 nTPM
Hypothalamus	57.1 nTPM
Amygdala	43.7 nTPM
Cerebral cortex	42.6 nTPM
Hippocampus	40.0 nTPM
Basal ganglia	37.7 nTPM

Eccentric medium spiny neuron	30.0 nTPM
Hypothalamus	33.7 nTPM
Cerebral cortex	31.2 nTPM
Amygdala	30.1 nTPM
Hippocampus	29.8 nTPM
Basal ganglia	28.6 nTPM
Thalamus	26.5 nTPM