Single cell type - AK9 - The Human Protein Atlas

AK9

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AK9
Gene descriptionⁱ Full gene name according to HGNC.	Adenylate kinase 9
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Ciliated cells - Cilium assembly (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Spermatocytes, Ciliated cells, Early spermatids)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.54
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Ependymal cell)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Spermatocytes, Ciliated cells, Early spermatids)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Ependymal cell)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

AK9 is part of cluster 42 Ciliated cells - Cilium assembly with confidenceⁱ 1
429 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FBXO15	F-box protein 15	0.7428	42
IFT81	Intraflagellar transport 81	0.7207	42
NEK4	NIMA related kinase 4	0.7091	31
CCDC191	Coiled-coil domain containing 191	0.7022	42
EFCAB2	EF-hand calcium binding domain 2	0.6920	42
TTC21A	Tetratricopeptide repeat domain 21A	0.6866	42
CFAP46	Cilia and flagella associated protein 46	0.6770	42
IFT122	Intraflagellar transport 122	0.6726	31
DZIP3	DAZ interacting zinc finger protein 3	0.6580	42
ENKD1	Enkurin domain containing 1	0.6558	42
TPTE	Transmembrane phosphatase with tensin homology	0.6488	31
SPEF1	Sperm flagellar 1	0.6440	42
CCP110	Centriolar coiled-coil protein 110	0.6332	31
DNAI1	Dynein axonemal intermediate chain 1	0.6322	42
STK36	Serine/threonine kinase 36	0.6290	42

IMMUNE CELLS

AK9 is part of cluster 32 Basophils - Transcription with confidenceⁱ 0.99
291 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MADD	MAP kinase activating death domain	1.0000	32
CAPN12	Calpain 12	1.0000	32
FANCB	FA complementation group B	1.0000	32
EPM2AIP1	EPM2A interacting protein 1	1.0000	32
MARCHF6	Membrane associated ring-CH-type finger 6	1.0000	32
FAM117A	Family with sequence similarity 117 member A	1.0000	32
RAB3GAP2	RAB3 GTPase activating non-catalytic protein subunit 2	1.0000	32
RBBP5	RB binding protein 5, histone lysine methyltransferase complex subunit	1.0000	32
ZNF684	Zinc finger protein 684	1.0000	32
ACTR8	Actin related protein 8	1.0000	32
ELP1	Elongator acetyltransferase complex subunit 1	1.0000	32
CBFB	Core-binding factor subunit beta	1.0000	32
BTK	Bruton tyrosine kinase	0.9762	32
HOXA9	Homeobox A9	0.9762	32
PTPN23	Protein tyrosine phosphatase non-receptor type 23	0.9762	32

Adipocytes	13.7 nTPM
Adipose tissue	14.8 nTPM
Breast	12.7 nTPM

Alveolar cells type 1	4.2 nTPM
Lung	4.2 nTPM

Alveolar cells type 2	5.3 nTPM
Lung	5.3 nTPM

Astrocytes	20.1 nTPM
Brain	20.1 nTPM

B-cells	14.3 nTPM
Liver	29.0 nTPM
PBMC	23.1 nTPM
Esophagus	17.7 nTPM
Salivary gland	17.1 nTPM
Lymph node	13.7 nTPM
Adipose tissue	13.2 nTPM
Thymus	12.6 nTPM
Bone marrow	12.2 nTPM
Kidney	10.4 nTPM
Spleen	10.2 nTPM
Lung	9.4 nTPM
Skin	8.5 nTPM
Stomach	8.4 nTPM

Ciliated cells	95.0 nTPM
Lung	132.2 nTPM
Bronchus	109.7 nTPM
Endometrium	78.1 nTPM
Fallopian tube	60.0 nTPM

Club cells	15.4 nTPM
Bronchus	21.5 nTPM
Prostate	14.8 nTPM
Lung	9.8 nTPM

Endothelial cells	10.9 nTPM
Skeletal muscle	21.5 nTPM
Breast	18.5 nTPM
Ovary	14.8 nTPM
Testis	14.7 nTPM
Heart muscle	14.1 nTPM
Prostate	13.3 nTPM
Esophagus	13.0 nTPM
Salivary gland	12.1 nTPM
Thymus	11.1 nTPM
Vascular	10.6 nTPM
Skin	9.4 nTPM
Lung	9.3 nTPM
Tongue	8.6 nTPM
Placenta	6.8 nTPM
Fallopian tube	6.2 nTPM
Endometrium	6.0 nTPM
Liver	3.8 nTPM
Pancreas	2.6 nTPM

Enteroendocrine cells	18.8 nTPM
Small intestine	27.5 nTPM
Rectum	20.1 nTPM
Colon	8.7 nTPM

Fibroblasts	4.5 nTPM
Heart muscle	13.0 nTPM
Skeletal muscle	5.8 nTPM
Prostate	5.3 nTPM
Liver	4.7 nTPM
Stomach	4.3 nTPM
Breast	4.3 nTPM
Adipose tissue	4.1 nTPM
Salivary gland	4.0 nTPM
Placenta	3.9 nTPM
Esophagus	3.9 nTPM
Skin	3.8 nTPM
Vascular	3.8 nTPM
Lung	3.2 nTPM
Thymus	3.0 nTPM
Fallopian tube	2.9 nTPM
Pancreas	2.5 nTPM

Granulocytes	7.2 nTPM
Lung	9.6 nTPM
Fallopian tube	7.1 nTPM
Tongue	4.9 nTPM

Intestinal goblet cells	19.2 nTPM
Small intestine	30.5 nTPM
Colon	13.8 nTPM
Rectum	13.2 nTPM

Lymphatic endothelial cells	10.6 nTPM
Ovary	10.9 nTPM
Fallopian tube	10.3 nTPM

Macrophages	4.6 nTPM
Testis	9.3 nTPM
Breast	8.9 nTPM
Salivary gland	7.4 nTPM
Kidney	7.1 nTPM
Lung	6.9 nTPM
Spleen	6.0 nTPM
Skeletal muscle	5.2 nTPM
Prostate	5.1 nTPM
Tongue	4.7 nTPM
Vascular	4.3 nTPM
Adipose tissue	3.3 nTPM
Fallopian tube	3.3 nTPM
Endometrium	3.1 nTPM
Bone marrow	3.0 nTPM
Stomach	2.6 nTPM
Pancreas	2.1 nTPM
Thymus	2.1 nTPM
Esophagus	1.3 nTPM
Skin	1.1 nTPM

Paneth cells	8.2 nTPM
Small intestine	10.4 nTPM
Colon	7.2 nTPM
Rectum	7.0 nTPM

Basal prostatic cells	5.0 nTPM
Prostate	5.0 nTPM

Bipolar cells	15.9 nTPM
Eye	15.9 nTPM

Cholangiocytes	7.6 nTPM
Liver	7.6 nTPM

Collecting duct cells	7.8 nTPM
Kidney	7.8 nTPM

Plasma cells	5.1 nTPM
Stomach	8.0 nTPM
Fallopian tube	8.0 nTPM
Salivary gland	6.7 nTPM
Esophagus	5.2 nTPM
Liver	4.0 nTPM
Thymus	3.3 nTPM
Bone marrow	3.0 nTPM
Spleen	2.4 nTPM

Schwann cells	5.0 nTPM
Vascular	12.0 nTPM
Adipose tissue	3.1 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	11.4 nTPM
Salivary gland	18.4 nTPM
Tongue	4.4 nTPM

Smooth muscle cells	7.2 nTPM
Esophagus	15.6 nTPM
Salivary gland	12.7 nTPM
Vascular	12.7 nTPM
Ovary	10.8 nTPM
Skeletal muscle	8.7 nTPM
Liver	7.2 nTPM
Breast	7.0 nTPM
Thymus	6.0 nTPM
Skin	5.7 nTPM
Endometrium	5.2 nTPM
Adipose tissue	4.9 nTPM
Prostate	4.9 nTPM
Fallopian tube	4.8 nTPM
Placenta	3.4 nTPM
Tongue	3.0 nTPM
Lung	2.4 nTPM

T-cells	10.4 nTPM
Salivary gland	17.5 nTPM
PBMC	14.7 nTPM
Prostate	14.4 nTPM
Liver	13.6 nTPM
Vascular	12.9 nTPM
Bone marrow	12.6 nTPM
Skeletal muscle	12.5 nTPM
Colon	11.7 nTPM
Lung	11.0 nTPM
Endometrium	10.7 nTPM
Tongue	10.0 nTPM
Kidney	9.8 nTPM
Thymus	9.4 nTPM
Breast	9.2 nTPM
Lymph node	8.5 nTPM
Fallopian tube	8.3 nTPM
Stomach	7.9 nTPM
Esophagus	7.3 nTPM
Adipose tissue	6.5 nTPM
Spleen	5.6 nTPM
Skin	3.5 nTPM

Undifferentiated cells	10.0 nTPM
Small intestine	13.2 nTPM
Rectum	11.3 nTPM
Colon	5.6 nTPM

Amygdala excitatory	45.4 nTPM
Hypothalamus	49.1 nTPM
Hippocampus	47.5 nTPM
Thalamus	46.3 nTPM
Cerebral cortex	45.2 nTPM
Basal ganglia	44.0 nTPM
Amygdala	40.2 nTPM

Astrocyte	57.6 nTPM
Hypothalamus	81.9 nTPM
Medulla oblongata	74.2 nTPM
Spinal cord	72.2 nTPM
Cerebellum	68.1 nTPM
Amygdala	57.0 nTPM
Hippocampus	53.9 nTPM
Thalamus	50.2 nTPM
Pons	49.4 nTPM
Basal ganglia	46.1 nTPM
Midbrain	43.1 nTPM
Cerebral cortex	37.9 nTPM

Bergmann glia	32.4 nTPM
Medulla oblongata	36.2 nTPM
Cerebellum	32.3 nTPM
Pons	28.8 nTPM

Central nervous system macrophage	61.8 nTPM
Amygdala	81.6 nTPM
Hypothalamus	74.9 nTPM
Cerebral cortex	68.9 nTPM
Hippocampus	65.7 nTPM
Basal ganglia	62.7 nTPM
Thalamus	61.6 nTPM
Midbrain	58.1 nTPM
Medulla oblongata	54.8 nTPM
Pons	53.6 nTPM
Cerebellum	50.3 nTPM
Spinal cord	47.7 nTPM

Cerebellar inhibitory	41.9 nTPM
Midbrain	49.5 nTPM
Cerebellum	46.2 nTPM
Pons	40.9 nTPM
Medulla oblongata	40.1 nTPM
Spinal cord	33.0 nTPM

Cge interneuron	36.6 nTPM
Amygdala	41.9 nTPM
Hypothalamus	39.1 nTPM
Hippocampus	39.0 nTPM
Basal ganglia	36.8 nTPM
Cerebral cortex	35.5 nTPM
Midbrain	34.8 nTPM
Thalamus	29.4 nTPM

Choroid plexus epithelial cell	177.4 nTPM
Basal ganglia	269.8 nTPM
Thalamus	189.1 nTPM
Hippocampus	127.6 nTPM
Medulla oblongata	123.3 nTPM

Committed oligodendrocyte precursor	44.9 nTPM
Thalamus	60.6 nTPM
Cerebral cortex	55.7 nTPM
Hippocampus	54.3 nTPM
Hypothalamus	51.2 nTPM
Medulla oblongata	47.8 nTPM
Amygdala	47.4 nTPM
Basal ganglia	46.0 nTPM
Cerebellum	44.4 nTPM
Pons	38.1 nTPM
Midbrain	30.2 nTPM
Spinal cord	18.4 nTPM

Deep-layer corticothalamic and 6b	39.2 nTPM
Hypothalamus	60.1 nTPM
Amygdala	47.6 nTPM
Hippocampus	37.3 nTPM
Cerebral cortex	34.7 nTPM
Basal ganglia	31.5 nTPM
Midbrain	24.4 nTPM

Deep-layer intratelencephalic	50.2 nTPM
Hypothalamus	58.0 nTPM
Amygdala	55.4 nTPM
Hippocampus	50.4 nTPM
Cerebral cortex	44.0 nTPM
Basal ganglia	43.1 nTPM

Deep-layer near-projecting	35.6 nTPM
Hypothalamus	48.8 nTPM
Cerebral cortex	34.5 nTPM
Basal ganglia	32.3 nTPM
Amygdala	31.6 nTPM
Hippocampus	30.9 nTPM

Eccentric medium spiny neuron	24.3 nTPM
Hippocampus	31.1 nTPM
Amygdala	24.6 nTPM
Basal ganglia	24.1 nTPM
Thalamus	24.0 nTPM
Hypothalamus	21.8 nTPM
Cerebral cortex	20.3 nTPM

Endothelial cell	59.4 nTPM
Amygdala	90.5 nTPM
Hippocampus	76.0 nTPM
Basal ganglia	71.8 nTPM
Cerebellum	59.6 nTPM
Pons	56.2 nTPM
Thalamus	55.9 nTPM
Cerebral cortex	55.6 nTPM
Hypothalamus	53.3 nTPM
Midbrain	47.3 nTPM
Spinal cord	46.6 nTPM
Medulla oblongata	41.0 nTPM

Ependymal cell	370.2 nTPM
Amygdala	530.1 nTPM
Hippocampus	459.2 nTPM
Basal ganglia	396.4 nTPM
Hypothalamus	378.4 nTPM
Midbrain	332.7 nTPM
Thalamus	319.1 nTPM
Spinal cord	308.6 nTPM
Pons	307.6 nTPM
Medulla oblongata	299.9 nTPM