Single cell type - ZNF736 - The Human Protein Atlas

ZNF736

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZNF736
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger protein 736
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	B-cells - B-cell function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Late spermatids, Rod photoreceptor cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.49
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Late spermatids, Rod photoreceptor cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ZNF736 is part of cluster 73 B-cells - B-cell function with confidenceⁱ 1
195 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RALGPS2	Ral GEF with PH domain and SH3 binding motif 2	0.5567	73
ZNF432	Zinc finger protein 432	0.4717	66
ZMYM2	Zinc finger MYM-type containing 2	0.4636	36
GGA2	Golgi associated, gamma adaptin ear containing, ARF binding protein 2	0.4510	73
SERINC4	Serine incorporator 4	0.4421	11
WFDC10B	WAP four-disulfide core domain 10B	0.4359	36
PRDM4	PR/SET domain 4	0.4212	73
NIBAN3	Niban apoptosis regulator 3	0.4205	73
BCL11A	BAF chromatin remodeling complex subunit BCL11A	0.4161	28
ZNF585A	Zinc finger protein 585A	0.4139	49
POC1B	POC1 centriolar protein B	0.4129	37
OSBP2	Oxysterol binding protein 2	0.4116	66
ZNF549	Zinc finger protein 549	0.4037	55
RAB3IP	RAB3A interacting protein	0.3995	36
MECR	Mitochondrial trans-2-enoyl-CoA reductase	0.3957	66

IMMUNE CELLS

ZNF736 is part of cluster 22 Eosinophils - Transcription with confidenceⁱ 1
357 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NUTM2G	NUT family member 2G	1.0000	22
MYPOP	Myb related transcription factor, partner of profilin	1.0000	22
VPS28	VPS28 subunit of ESCRT-I	1.0000	22
LSM14B	LSM family member 14B	0.9762	22
MTA1	Metastasis associated 1	0.9762	22
NUDT4	Nudix hydrolase 4	0.9762	22
MFF	Mitochondrial fission factor	0.9762	22
CCDC88B	Coiled-coil domain containing 88B	0.9762	22
CENPV	Centromere protein V	0.9762	22
FRRS1	Ferric chelate reductase 1	0.9762	22
TFAP4	Transcription factor AP-4	0.9762	22
TLK2	Tousled like kinase 2	0.9762	22
RUBCN	Rubicon autophagy regulator	0.9762	22
HILPDA	Hypoxia inducible lipid droplet associated	0.9762	22
RBM17	RNA binding motif protein 17	0.9762	22

Adipocytes	6.9 nTPM
Adipose tissue	7.9 nTPM
Breast	6.0 nTPM

Alveolar cells type 1	3.8 nTPM
Lung	3.8 nTPM

Alveolar cells type 2	4.6 nTPM
Lung	4.6 nTPM

Astrocytes	27.2 nTPM
Brain	27.2 nTPM

B-cells	30.6 nTPM
Esophagus	53.1 nTPM
Lymph node	52.1 nTPM
Spleen	50.5 nTPM
Bone marrow	46.2 nTPM
Stomach	35.0 nTPM
Adipose tissue	31.7 nTPM
Kidney	26.0 nTPM
Salivary gland	21.0 nTPM
Thymus	19.3 nTPM
Lung	18.8 nTPM
PBMC	16.9 nTPM
Skin	16.9 nTPM
Liver	9.7 nTPM

Ciliated cells	7.1 nTPM
Endometrium	9.4 nTPM
Bronchus	9.0 nTPM
Lung	5.1 nTPM
Fallopian tube	4.9 nTPM

Club cells	6.5 nTPM
Bronchus	8.3 nTPM
Lung	6.5 nTPM
Prostate	4.6 nTPM

Endothelial cells	6.6 nTPM
Esophagus	13.8 nTPM
Liver	11.3 nTPM
Endometrium	9.0 nTPM
Heart muscle	8.9 nTPM
Prostate	8.9 nTPM
Salivary gland	7.3 nTPM
Ovary	7.3 nTPM
Fallopian tube	7.1 nTPM
Thymus	6.7 nTPM
Skeletal muscle	6.5 nTPM
Skin	6.3 nTPM
Vascular	6.1 nTPM
Testis	5.8 nTPM
Tongue	5.3 nTPM
Lung	4.4 nTPM
Placenta	4.0 nTPM
Breast	0.9 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	3.0 nTPM
Rectum	5.0 nTPM
Colon	3.9 nTPM
Small intestine	0.0 nTPM

Fibroblasts	5.3 nTPM
Esophagus	11.2 nTPM
Liver	10.7 nTPM
Breast	7.0 nTPM
Fallopian tube	6.4 nTPM
Prostate	5.9 nTPM
Adipose tissue	5.6 nTPM
Salivary gland	5.3 nTPM
Placenta	5.2 nTPM
Vascular	4.6 nTPM
Lung	4.4 nTPM
Stomach	4.3 nTPM
Skeletal muscle	4.2 nTPM
Thymus	4.0 nTPM
Skin	3.5 nTPM
Pancreas	1.9 nTPM
Heart muscle	0.2 nTPM

Granulocytes	12.0 nTPM
Fallopian tube	15.2 nTPM
Lung	11.1 nTPM
Tongue	9.7 nTPM

Intestinal goblet cells	4.6 nTPM
Small intestine	6.8 nTPM
Rectum	4.2 nTPM
Colon	2.7 nTPM

Lymphatic endothelial cells	5.4 nTPM
Ovary	5.5 nTPM
Fallopian tube	5.3 nTPM

Macrophages	10.4 nTPM
Esophagus	21.8 nTPM
Adipose tissue	17.0 nTPM
Endometrium	12.9 nTPM
Fallopian tube	12.9 nTPM
Testis	12.4 nTPM
Spleen	12.0 nTPM
Prostate	12.0 nTPM
Bone marrow	10.1 nTPM
Breast	10.1 nTPM
Lung	9.8 nTPM
Thymus	9.3 nTPM
Salivary gland	8.8 nTPM
Skeletal muscle	8.2 nTPM
Tongue	8.0 nTPM
Skin	7.8 nTPM
Stomach	7.7 nTPM
Vascular	7.3 nTPM
Kidney	4.4 nTPM
Pancreas	4.1 nTPM

Paneth cells	3.0 nTPM
Rectum	5.3 nTPM
Colon	3.6 nTPM
Small intestine	0.0 nTPM

Basal respiratory cells	4.8 nTPM
Bronchus	4.8 nTPM

Basal squamous epithelial cells	12.2 nTPM
Esophagus	12.2 nTPM

Bipolar cells	19.0 nTPM
Eye	19.0 nTPM

Cone photoreceptor cells	18.7 nTPM
Eye	18.7 nTPM

Plasma cells	5.1 nTPM
Liver	7.5 nTPM
Stomach	6.3 nTPM
Esophagus	5.2 nTPM
Fallopian tube	5.1 nTPM
Bone marrow	4.5 nTPM
Thymus	4.5 nTPM
Spleen	3.8 nTPM
Salivary gland	3.6 nTPM

Schwann cells	9.9 nTPM
Adipose tissue	23.4 nTPM
Vascular	6.3 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	2.0 nTPM
Salivary gland	4.0 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	5.9 nTPM
Adipose tissue	10.5 nTPM
Lung	8.2 nTPM
Prostate	7.3 nTPM
Endometrium	7.2 nTPM
Esophagus	7.2 nTPM
Ovary	7.1 nTPM
Liver	5.9 nTPM
Salivary gland	5.9 nTPM
Skeletal muscle	5.7 nTPM
Tongue	5.1 nTPM
Thymus	4.6 nTPM
Vascular	4.5 nTPM
Placenta	4.3 nTPM
Breast	4.1 nTPM
Fallopian tube	4.0 nTPM
Skin	3.2 nTPM

T-cells	10.5 nTPM
Lymph node	23.3 nTPM
Spleen	19.1 nTPM
Bone marrow	15.0 nTPM
Adipose tissue	13.3 nTPM
Colon	12.7 nTPM
Esophagus	12.2 nTPM
Salivary gland	12.0 nTPM
Fallopian tube	11.3 nTPM
Thymus	11.1 nTPM
Prostate	11.0 nTPM
Vascular	10.5 nTPM
Endometrium	9.9 nTPM
Stomach	9.1 nTPM
Skeletal muscle	8.7 nTPM
Lung	8.4 nTPM
Tongue	6.8 nTPM
Breast	6.6 nTPM
Skin	6.3 nTPM
PBMC	5.8 nTPM
Liver	3.6 nTPM
Kidney	3.5 nTPM

Undifferentiated cells	5.7 nTPM
Rectum	7.1 nTPM
Small intestine	5.4 nTPM
Colon	4.5 nTPM

Amygdala excitatory	60.9 nTPM
Hypothalamus	70.3 nTPM
Thalamus	65.3 nTPM
Amygdala	62.7 nTPM
Basal ganglia	56.8 nTPM
Hippocampus	56.5 nTPM
Cerebral cortex	53.8 nTPM

Astrocyte	55.6 nTPM
Amygdala	69.9 nTPM
Spinal cord	66.6 nTPM
Basal ganglia	61.4 nTPM
Hypothalamus	60.3 nTPM
Hippocampus	55.2 nTPM
Cerebral cortex	51.8 nTPM
Midbrain	50.7 nTPM
Thalamus	50.6 nTPM
Pons	50.1 nTPM
Medulla oblongata	48.0 nTPM
Cerebellum	46.9 nTPM

Bergmann glia	51.0 nTPM
Medulla oblongata	55.4 nTPM
Cerebellum	51.7 nTPM
Pons	46.0 nTPM

Central nervous system macrophage	80.4 nTPM
Amygdala	118.2 nTPM
Basal ganglia	86.0 nTPM
Midbrain	82.1 nTPM
Hippocampus	81.5 nTPM
Hypothalamus	78.2 nTPM
Thalamus	77.8 nTPM
Pons	77.3 nTPM
Spinal cord	76.0 nTPM
Cerebral cortex	71.8 nTPM
Cerebellum	69.2 nTPM
Medulla oblongata	66.6 nTPM

Cerebellar inhibitory	47.4 nTPM
Midbrain	55.7 nTPM
Medulla oblongata	51.9 nTPM
Pons	51.9 nTPM
Cerebellum	47.3 nTPM
Spinal cord	30.2 nTPM

Cge interneuron	65.9 nTPM
Midbrain	72.8 nTPM
Amygdala	72.6 nTPM
Thalamus	71.0 nTPM
Hypothalamus	67.9 nTPM
Hippocampus	61.5 nTPM
Basal ganglia	58.8 nTPM
Cerebral cortex	56.9 nTPM

Choroid plexus epithelial cell	60.6 nTPM
Hippocampus	74.9 nTPM
Basal ganglia	69.1 nTPM
Thalamus	49.3 nTPM
Medulla oblongata	49.1 nTPM

Committed oligodendrocyte precursor	57.8 nTPM
Pons	72.6 nTPM
Amygdala	68.2 nTPM
Spinal cord	62.5 nTPM
Cerebral cortex	60.8 nTPM
Hippocampus	59.2 nTPM
Midbrain	58.8 nTPM
Hypothalamus	56.0 nTPM
Basal ganglia	55.8 nTPM
Cerebellum	53.9 nTPM
Thalamus	48.2 nTPM
Medulla oblongata	40.0 nTPM

Deep-layer corticothalamic and 6b	68.4 nTPM
Amygdala	79.1 nTPM
Cerebral cortex	71.6 nTPM
Hippocampus	71.4 nTPM
Basal ganglia	67.6 nTPM
Hypothalamus	65.2 nTPM
Midbrain	55.5 nTPM

Deep-layer intratelencephalic	58.5 nTPM
Amygdala	62.1 nTPM
Hypothalamus	61.0 nTPM
Hippocampus	57.3 nTPM
Cerebral cortex	56.6 nTPM
Basal ganglia	55.5 nTPM

Deep-layer near-projecting	50.3 nTPM
Amygdala	55.7 nTPM
Hypothalamus	52.4 nTPM
Cerebral cortex	48.6 nTPM
Basal ganglia	48.1 nTPM
Hippocampus	46.5 nTPM

Eccentric medium spiny neuron	66.7 nTPM
Amygdala	68.7 nTPM
Basal ganglia	67.9 nTPM
Thalamus	67.6 nTPM
Hippocampus	67.2 nTPM
Hypothalamus	66.6 nTPM
Cerebral cortex	62.5 nTPM

Endothelial cell	44.6 nTPM
Basal ganglia	53.1 nTPM
Hippocampus	51.9 nTPM
Hypothalamus	49.6 nTPM
Midbrain	48.2 nTPM
Medulla oblongata	47.2 nTPM
Thalamus	44.1 nTPM
Pons	42.4 nTPM
Cerebellum	41.0 nTPM
Amygdala	40.2 nTPM
Cerebral cortex	38.4 nTPM
Spinal cord	34.5 nTPM

Ependymal cell	42.7 nTPM
Amygdala	51.2 nTPM
Basal ganglia	50.8 nTPM
Hippocampus	48.7 nTPM
Thalamus	44.5 nTPM
Medulla oblongata	42.8 nTPM
Hypothalamus	40.2 nTPM
Midbrain	37.5 nTPM
Pons	35.7 nTPM
Spinal cord	32.6 nTPM