Single cell type - PPP1R10 - The Human Protein Atlas

PPP1R10

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PPP1R10
Gene descriptionⁱ Full gene name according to HGNC.	Protein phosphatase 1 regulatory subunit 10
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.23
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (basophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (basophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

PPP1R10 is part of cluster 80 Non-specific - Transcription with confidenceⁱ 1
184 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
INTS6	Integrator complex subunit 6	0.8173	80
H2AX	H2A.X variant histone	0.8114	80
BRD2	Bromodomain containing 2	0.8098	80
RSRP1	Arginine and serine rich protein 1	0.7907	80
HEXIM1	HEXIM P-TEFb complex subunit 1	0.7811	80
ENSG00000268643	Novel protein	0.7744	80
NXF1	Nuclear RNA export factor 1	0.7554	80
IQCN	IQ motif containing N	0.7537	80
FUS	FUS RNA binding protein	0.7450	80
POLG2	DNA polymerase gamma 2, accessory subunit	0.7447	80
CBX4	Chromobox 4	0.7131	80
GADD45B	Growth arrest and DNA damage inducible beta	0.7127	80
IER2	Immediate early response 2	0.7092	80
UBE2S	Ubiquitin conjugating enzyme E2 S	0.6914	80
MTRFR	Mitochondrial translation release factor in rescue	0.6884	80

IMMUNE CELLS

PPP1R10 is part of cluster 42 Non-specific - Vesicular transport with confidenceⁱ 0.99
519 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PLPP6	Phospholipid phosphatase 6	1.0000	42
SRPK1	SRSF protein kinase 1	0.9762	42
BRPF3	Bromodomain and PHD finger containing 3	0.9762	42
PDCD1LG2	Programmed cell death 1 ligand 2	0.9762	42
MAF	MAF bZIP transcription factor	0.9762	42
JAGN1	Jagunal homolog 1	0.9762	42
CDKN2AIP	CDKN2A interacting protein	0.9762	42
MEAK7	MTOR associated protein, eak-7 homolog	0.9762	42
RHBDD2	Rhomboid domain containing 2	0.9762	42
FAM161B	FAM161 centrosomal protein B	0.9762	42
C18orf21	Chromosome 18 open reading frame 21	0.9524	42
SFR1	SWI5 dependent homologous recombination repair protein 1	0.9524	46
ADD3	Adducin 3	0.9524	42
HAX1	HCLS1 associated protein X-1	0.9524	42
SARAF	Store-operated calcium entry associated regulatory factor	0.9524	42

Adipocytes	212.0 nTPM
Breast	304.6 nTPM
Adipose tissue	119.4 nTPM

Alveolar cells type 1	38.6 nTPM
Lung	38.6 nTPM

Alveolar cells type 2	66.0 nTPM
Lung	66.0 nTPM

Astrocytes	19.5 nTPM
Brain	19.5 nTPM

B-cells	132.7 nTPM
Lymph node	512.1 nTPM
Esophagus	295.0 nTPM
Lung	135.5 nTPM
Adipose tissue	128.4 nTPM
Salivary gland	103.1 nTPM
Spleen	86.0 nTPM
Stomach	77.2 nTPM
Thymus	74.2 nTPM
Liver	72.5 nTPM
Skin	67.8 nTPM
PBMC	63.1 nTPM
Bone marrow	57.9 nTPM
Kidney	52.0 nTPM

Basal squamous epithelial cells	129.0 nTPM
Esophagus	129.0 nTPM

Ciliated cells	83.7 nTPM
Endometrium	137.3 nTPM
Fallopian tube	87.4 nTPM
Lung	65.9 nTPM
Bronchus	44.1 nTPM

Club cells	47.6 nTPM
Prostate	64.1 nTPM
Lung	43.5 nTPM
Bronchus	35.4 nTPM

Dendritic cells	149.1 nTPM
Adipose tissue	244.2 nTPM
PBMC	54.0 nTPM

Endothelial cells	91.8 nTPM
Esophagus	271.1 nTPM
Skeletal muscle	157.9 nTPM
Prostate	125.4 nTPM
Skin	122.3 nTPM
Tongue	101.2 nTPM
Ovary	98.7 nTPM
Salivary gland	96.3 nTPM
Thymus	88.8 nTPM
Fallopian tube	86.9 nTPM
Endometrium	85.4 nTPM
Heart muscle	81.2 nTPM
Breast	79.1 nTPM
Vascular	60.8 nTPM
Lung	58.3 nTPM
Testis	49.1 nTPM
Placenta	36.9 nTPM
Pancreas	33.6 nTPM
Liver	20.2 nTPM

Enteroendocrine cells	72.4 nTPM
Rectum	78.8 nTPM
Colon	69.7 nTPM
Small intestine	68.7 nTPM

Fibroblasts	95.3 nTPM
Esophagus	288.9 nTPM
Breast	183.0 nTPM
Fallopian tube	179.4 nTPM
Stomach	123.9 nTPM
Prostate	118.1 nTPM
Skeletal muscle	103.3 nTPM
Heart muscle	90.6 nTPM
Salivary gland	86.0 nTPM
Skin	62.5 nTPM
Lung	56.3 nTPM
Thymus	55.0 nTPM
Adipose tissue	54.8 nTPM
Liver	47.4 nTPM
Vascular	37.6 nTPM
Placenta	19.6 nTPM
Pancreas	18.1 nTPM

Granulocytes	199.2 nTPM
Tongue	261.9 nTPM
Fallopian tube	212.0 nTPM
Lung	123.5 nTPM

Intestinal goblet cells	89.5 nTPM
Small intestine	103.5 nTPM
Colon	92.3 nTPM
Rectum	72.7 nTPM

Lymphatic endothelial cells	112.0 nTPM
Fallopian tube	153.1 nTPM
Ovary	70.9 nTPM

Bipolar cells	77.7 nTPM
Eye	77.7 nTPM

Cholangiocytes	30.5 nTPM
Liver	30.5 nTPM

Collecting duct cells	29.2 nTPM
Kidney	29.2 nTPM

Cone photoreceptor cells	64.6 nTPM
Eye	64.6 nTPM

Macrophages	125.6 nTPM
Breast	537.5 nTPM
Esophagus	307.0 nTPM
Skeletal muscle	214.2 nTPM
Adipose tissue	169.9 nTPM
Fallopian tube	151.5 nTPM
Endometrium	151.3 nTPM
Prostate	119.6 nTPM
Salivary gland	109.9 nTPM
Tongue	91.5 nTPM
Spleen	81.2 nTPM
Skin	66.9 nTPM
Lung	58.8 nTPM
Thymus	58.1 nTPM
Testis	57.0 nTPM
Stomach	56.6 nTPM
Kidney	52.2 nTPM
Vascular	49.9 nTPM
Bone marrow	27.4 nTPM
Pancreas	26.7 nTPM

Paneth cells	51.8 nTPM
Colon	54.3 nTPM
Small intestine	51.8 nTPM
Rectum	49.3 nTPM

Plasma cells	145.0 nTPM
Fallopian tube	386.6 nTPM
Esophagus	254.7 nTPM
Stomach	129.0 nTPM
Salivary gland	121.3 nTPM
Spleen	105.4 nTPM
Thymus	68.5 nTPM
Bone marrow	55.9 nTPM
Liver	38.6 nTPM

Schwann cells	141.4 nTPM
Esophagus	239.6 nTPM
Adipose tissue	144.8 nTPM
Vascular	39.7 nTPM

Serous glandular cells	55.4 nTPM
Salivary gland	71.1 nTPM
Tongue	39.8 nTPM

Smooth muscle cells	107.5 nTPM
Esophagus	264.3 nTPM
Breast	234.4 nTPM
Skeletal muscle	191.3 nTPM
Ovary	155.9 nTPM
Endometrium	123.8 nTPM
Tongue	109.9 nTPM
Adipose tissue	97.8 nTPM
Salivary gland	90.3 nTPM
Skin	89.1 nTPM
Lung	69.4 nTPM
Fallopian tube	68.9 nTPM
Prostate	65.7 nTPM
Thymus	54.6 nTPM
Liver	40.8 nTPM
Vascular	35.9 nTPM
Placenta	28.9 nTPM

Suprabasal keratinocytes	75.8 nTPM
Skin	86.5 nTPM
Tongue	65.1 nTPM

T-cells	156.6 nTPM
Breast	534.7 nTPM
Lymph node	421.5 nTPM
Esophagus	226.3 nTPM
Endometrium	220.8 nTPM
Fallopian tube	205.0 nTPM
Skeletal muscle	180.7 nTPM
Tongue	155.7 nTPM
Salivary gland	135.2 nTPM
Adipose tissue	133.5 nTPM
Vascular	133.1 nTPM
Lung	131.6 nTPM
Spleen	122.2 nTPM
Prostate	119.4 nTPM
Thymus	104.4 nTPM
Colon	88.7 nTPM
Kidney	84.2 nTPM
Stomach	75.6 nTPM
Liver	64.3 nTPM
Skin	51.9 nTPM
PBMC	50.6 nTPM
Bone marrow	48.9 nTPM

Undifferentiated cells	57.1 nTPM
Small intestine	63.7 nTPM
Rectum	58.9 nTPM
Colon	48.6 nTPM

Amygdala excitatory	44.6 nTPM
Hippocampus	50.2 nTPM
Amygdala	48.5 nTPM
Cerebral cortex	46.6 nTPM
Basal ganglia	45.7 nTPM
Hypothalamus	40.1 nTPM
Thalamus	36.8 nTPM

Astrocyte	68.8 nTPM
Spinal cord	99.8 nTPM
Amygdala	82.2 nTPM
Cerebellum	72.6 nTPM
Midbrain	69.0 nTPM
Medulla oblongata	67.4 nTPM
Pons	64.0 nTPM
Hippocampus	63.3 nTPM
Cerebral cortex	62.8 nTPM
Basal ganglia	61.2 nTPM
Thalamus	59.4 nTPM
Hypothalamus	55.1 nTPM

Bergmann glia	75.2 nTPM
Pons	93.5 nTPM
Cerebellum	76.5 nTPM
Medulla oblongata	55.4 nTPM

Central nervous system macrophage	130.8 nTPM
Basal ganglia	166.5 nTPM
Medulla oblongata	145.9 nTPM
Cerebellum	142.3 nTPM
Midbrain	138.6 nTPM
Pons	129.9 nTPM
Amygdala	127.7 nTPM
Hypothalamus	126.9 nTPM
Thalamus	123.2 nTPM
Spinal cord	119.2 nTPM
Hippocampus	115.5 nTPM
Cerebral cortex	102.4 nTPM

Cerebellar inhibitory	54.5 nTPM
Spinal cord	60.5 nTPM
Cerebellum	58.4 nTPM
Medulla oblongata	58.0 nTPM
Pons	53.0 nTPM
Midbrain	42.6 nTPM

Cge interneuron	54.3 nTPM
Hippocampus	59.3 nTPM
Thalamus	57.9 nTPM
Midbrain	55.5 nTPM
Amygdala	54.1 nTPM
Cerebral cortex	53.1 nTPM
Basal ganglia	50.9 nTPM
Hypothalamus	49.4 nTPM

Choroid plexus epithelial cell	82.4 nTPM
Hippocampus	113.7 nTPM
Basal ganglia	87.8 nTPM
Medulla oblongata	73.3 nTPM
Thalamus	54.8 nTPM

Committed oligodendrocyte precursor	57.3 nTPM
Cerebellum	68.2 nTPM
Hippocampus	65.2 nTPM
Pons	64.6 nTPM
Medulla oblongata	59.4 nTPM
Amygdala	58.1 nTPM
Midbrain	56.3 nTPM
Spinal cord	55.2 nTPM
Cerebral cortex	54.5 nTPM
Thalamus	52.9 nTPM
Hypothalamus	48.5 nTPM
Basal ganglia	47.6 nTPM

Deep-layer corticothalamic and 6b	45.3 nTPM
Hippocampus	49.3 nTPM
Amygdala	46.7 nTPM
Cerebral cortex	46.2 nTPM
Hypothalamus	45.7 nTPM
Basal ganglia	43.2 nTPM
Midbrain	41.0 nTPM

Deep-layer intratelencephalic	49.0 nTPM
Hippocampus	57.7 nTPM
Cerebral cortex	49.3 nTPM
Hypothalamus	47.4 nTPM
Basal ganglia	46.7 nTPM
Amygdala	43.8 nTPM

Deep-layer near-projecting	49.3 nTPM
Hippocampus	55.3 nTPM
Cerebral cortex	51.4 nTPM
Basal ganglia	49.2 nTPM
Amygdala	46.8 nTPM
Hypothalamus	43.9 nTPM