Single cell type - FAM161B - The Human Protein Atlas

FAM161B

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FAM161B
Gene descriptionⁱ Full gene name according to HGNC.	FAM161 centrosomal protein B
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Late spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Late spermatids, Early spermatids)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.70
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Group enriched (Late spermatids, Early spermatids)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

FAM161B is part of cluster 63 Late spermatids - Spermatogenesis with confidenceⁱ 1
383 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FAM187B	Family with sequence similarity 187 member B	0.8195	63
CDRT4	CMT1A duplicated region transcript 4	0.8180	63
OXCT2	3-oxoacid CoA-transferase 2	0.8162	63
NFILZ	NFIL3 like basic leucine zipper	0.8109	63
CLCN1	Chloride voltage-gated channel 1	0.8039	63
CCDC54	Coiled-coil domain containing 54	0.7972	63
CXorf51B	Chromosome X open reading frame 51B	0.7874	63
C20orf141	Chromosome 20 open reading frame 141	0.7840	63
SLC6A5	Solute carrier family 6 member 5	0.7644	63
MOV10L1	Mov10 like RISC complex RNA helicase 1	0.7558	63
ENSG00000250803	Zinc finger protein 474-like (LOC100505841)	0.7515	63
TEX37	Testis expressed 37	0.7508	63
PFN3	Profilin 3	0.7498	63
C4orf36	Chromosome 4 open reading frame 36	0.7466	63
SPATA6	Spermatogenesis associated 6	0.7446	63

IMMUNE CELLS

FAM161B is part of cluster 42 Non-specific - Vesicular transport with confidenceⁱ 0.99
519 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SRPK1	SRSF protein kinase 1	1.0000	42
BRPF3	Bromodomain and PHD finger containing 3	1.0000	42
MAF	MAF bZIP transcription factor	1.0000	42
RHBDD2	Rhomboid domain containing 2	1.0000	42
ARL8B	ADP ribosylation factor like GTPase 8B	0.9762	42
ENSG00000187186	Novel protein	0.9762	42
SPATA21	Spermatogenesis associated 21	0.9762	46
EIF1	Eukaryotic translation initiation factor 1	0.9762	42
HPGD	15-hydroxyprostaglandin dehydrogenase	0.9762	42
SAFB	Scaffold attachment factor B	0.9762	42
SFR1	SWI5 dependent homologous recombination repair protein 1	0.9762	46
ADD3	Adducin 3	0.9762	42
C18orf21	Chromosome 18 open reading frame 21	0.9762	42
SARAF	Store-operated calcium entry associated regulatory factor	0.9762	42
ELF1	E74 like ETS transcription factor 1	0.9762	46

Adipocytes	3.6 nTPM
Adipose tissue	4.2 nTPM
Breast	3.2 nTPM

Alveolar cells type 1	1.5 nTPM
Lung	1.5 nTPM

Alveolar cells type 2	2.0 nTPM
Lung	2.0 nTPM

Astrocytes	4.6 nTPM
Brain	4.6 nTPM

B-cells	3.4 nTPM
Esophagus	11.8 nTPM
Spleen	5.4 nTPM
Thymus	4.7 nTPM
Salivary gland	4.6 nTPM
Stomach	4.2 nTPM
PBMC	3.1 nTPM
Bone marrow	2.8 nTPM
Lymph node	2.7 nTPM
Lung	2.7 nTPM
Adipose tissue	2.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Skin	0.0 nTPM

Ciliated cells	6.5 nTPM
Lung	8.4 nTPM
Fallopian tube	7.4 nTPM
Endometrium	6.1 nTPM
Bronchus	4.0 nTPM

Club cells	7.7 nTPM
Prostate	19.1 nTPM
Lung	2.4 nTPM
Bronchus	1.7 nTPM

Endothelial cells	3.0 nTPM
Prostate	4.4 nTPM
Salivary gland	4.4 nTPM
Breast	4.4 nTPM
Ovary	4.3 nTPM
Vascular	4.1 nTPM
Fallopian tube	4.0 nTPM
Liver	3.8 nTPM
Thymus	3.7 nTPM
Testis	3.1 nTPM
Tongue	2.9 nTPM
Esophagus	2.7 nTPM
Lung	2.5 nTPM
Endometrium	2.3 nTPM
Heart muscle	2.0 nTPM
Skeletal muscle	1.9 nTPM
Placenta	1.7 nTPM
Skin	1.3 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	0.4 nTPM
Colon	1.3 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	3.8 nTPM
Salivary gland	6.5 nTPM
Esophagus	6.3 nTPM
Stomach	5.8 nTPM
Breast	5.7 nTPM
Vascular	5.1 nTPM
Prostate	4.6 nTPM
Skeletal muscle	4.3 nTPM
Fallopian tube	4.0 nTPM
Lung	3.8 nTPM
Thymus	3.7 nTPM
Adipose tissue	3.1 nTPM
Skin	1.9 nTPM
Placenta	1.6 nTPM
Pancreas	1.4 nTPM
Liver	1.2 nTPM
Heart muscle	1.0 nTPM

Granulocytes	3.9 nTPM
Tongue	4.9 nTPM
Fallopian tube	4.0 nTPM
Lung	3.0 nTPM

Intestinal goblet cells	4.7 nTPM
Small intestine	9.3 nTPM
Rectum	3.2 nTPM
Colon	1.7 nTPM

Lymphatic endothelial cells	5.2 nTPM
Ovary	5.5 nTPM
Fallopian tube	4.9 nTPM

Macrophages	1.5 nTPM
Endometrium	3.1 nTPM
Vascular	2.6 nTPM
Salivary gland	2.5 nTPM
Lung	2.4 nTPM
Fallopian tube	2.4 nTPM
Breast	2.3 nTPM
Adipose tissue	2.1 nTPM
Skeletal muscle	1.9 nTPM
Prostate	1.5 nTPM
Thymus	1.4 nTPM
Esophagus	1.3 nTPM
Testis	1.2 nTPM
Bone marrow	1.0 nTPM
Spleen	1.0 nTPM
Tongue	1.0 nTPM
Kidney	0.9 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	0.6 nTPM
Rectum	1.9 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Basal respiratory cells	1.1 nTPM
Bronchus	1.1 nTPM

Bipolar cells	7.8 nTPM
Eye	7.8 nTPM

Cone photoreceptor cells	6.8 nTPM
Eye	6.8 nTPM

Plasma cells	1.3 nTPM
Salivary gland	4.0 nTPM
Fallopian tube	1.9 nTPM
Stomach	1.7 nTPM
Thymus	1.3 nTPM
Liver	1.0 nTPM
Spleen	0.7 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Schwann cells	7.2 nTPM
Esophagus	12.0 nTPM
Vascular	7.3 nTPM
Adipose tissue	2.3 nTPM

Serous glandular cells	3.7 nTPM
Tongue	4.4 nTPM
Salivary gland	3.0 nTPM

Smooth muscle cells	4.9 nTPM
Prostate	9.7 nTPM
Salivary gland	7.3 nTPM
Fallopian tube	6.6 nTPM
Vascular	6.2 nTPM
Ovary	6.1 nTPM
Esophagus	6.0 nTPM
Thymus	5.6 nTPM
Breast	5.1 nTPM
Lung	4.7 nTPM
Endometrium	4.2 nTPM
Adipose tissue	3.8 nTPM
Skeletal muscle	3.1 nTPM
Liver	3.0 nTPM
Tongue	3.0 nTPM
Placenta	2.4 nTPM
Skin	2.3 nTPM

T-cells	3.6 nTPM
Prostate	7.6 nTPM
Colon	5.8 nTPM
Vascular	5.2 nTPM
Thymus	5.1 nTPM
Stomach	4.8 nTPM
Adipose tissue	4.7 nTPM
Fallopian tube	4.4 nTPM
PBMC	4.3 nTPM
Salivary gland	3.9 nTPM
Kidney	3.5 nTPM
Breast	3.2 nTPM
Bone marrow	3.1 nTPM
Spleen	2.7 nTPM
Skeletal muscle	2.6 nTPM
Lymph node	2.6 nTPM
Lung	2.6 nTPM
Esophagus	2.4 nTPM
Tongue	2.1 nTPM
Endometrium	1.9 nTPM
Liver	1.8 nTPM
Skin	1.4 nTPM

Undifferentiated cells	1.4 nTPM
Rectum	2.0 nTPM
Colon	1.7 nTPM
Small intestine	0.7 nTPM

Amygdala excitatory	11.4 nTPM
Cerebral cortex	12.6 nTPM
Hippocampus	12.6 nTPM
Thalamus	12.3 nTPM
Basal ganglia	10.9 nTPM
Hypothalamus	10.1 nTPM
Amygdala	10.0 nTPM

Astrocyte	8.1 nTPM
Amygdala	9.7 nTPM
Midbrain	8.9 nTPM
Hypothalamus	8.5 nTPM
Cerebral cortex	8.4 nTPM
Thalamus	8.3 nTPM
Cerebellum	8.1 nTPM
Spinal cord	8.1 nTPM
Basal ganglia	7.6 nTPM
Medulla oblongata	7.6 nTPM
Hippocampus	7.4 nTPM
Pons	7.0 nTPM

Bergmann glia	10.7 nTPM
Pons	12.9 nTPM
Cerebellum	12.7 nTPM
Medulla oblongata	6.4 nTPM

Central nervous system macrophage	3.0 nTPM
Medulla oblongata	3.9 nTPM
Midbrain	3.5 nTPM
Amygdala	3.4 nTPM
Cerebellum	3.4 nTPM
Hypothalamus	3.4 nTPM
Thalamus	3.2 nTPM
Cerebral cortex	2.8 nTPM
Basal ganglia	2.7 nTPM
Hippocampus	2.7 nTPM
Pons	2.7 nTPM
Spinal cord	1.8 nTPM

Cerebellar inhibitory	12.4 nTPM
Spinal cord	16.5 nTPM
Medulla oblongata	12.5 nTPM
Midbrain	12.1 nTPM
Cerebellum	11.5 nTPM
Pons	9.3 nTPM

Cge interneuron	13.6 nTPM
Cerebral cortex	16.2 nTPM
Basal ganglia	15.8 nTPM
Hippocampus	15.0 nTPM
Amygdala	13.2 nTPM
Hypothalamus	12.4 nTPM
Thalamus	12.3 nTPM
Midbrain	10.4 nTPM

Choroid plexus epithelial cell	12.2 nTPM
Thalamus	21.9 nTPM
Basal ganglia	13.6 nTPM
Medulla oblongata	10.6 nTPM
Hippocampus	2.8 nTPM

Committed oligodendrocyte precursor	6.6 nTPM
Basal ganglia	11.5 nTPM
Hypothalamus	8.9 nTPM
Thalamus	8.6 nTPM
Amygdala	8.5 nTPM
Cerebellum	7.9 nTPM
Midbrain	7.6 nTPM
Spinal cord	7.4 nTPM
Hippocampus	5.2 nTPM
Cerebral cortex	3.2 nTPM
Medulla oblongata	2.6 nTPM
Pons	1.8 nTPM

Deep-layer corticothalamic and 6b	12.2 nTPM
Basal ganglia	15.7 nTPM
Cerebral cortex	12.7 nTPM
Amygdala	12.1 nTPM
Hippocampus	11.5 nTPM
Midbrain	11.1 nTPM
Hypothalamus	10.2 nTPM

Deep-layer intratelencephalic	12.6 nTPM
Basal ganglia	13.6 nTPM
Cerebral cortex	13.2 nTPM
Hippocampus	12.9 nTPM
Hypothalamus	12.2 nTPM
Amygdala	11.2 nTPM

Deep-layer near-projecting	13.4 nTPM
Hippocampus	15.9 nTPM
Basal ganglia	14.7 nTPM
Amygdala	14.1 nTPM
Cerebral cortex	13.5 nTPM
Hypothalamus	8.8 nTPM

Eccentric medium spiny neuron	11.3 nTPM
Hypothalamus	13.7 nTPM
Basal ganglia	11.2 nTPM
Cerebral cortex	11.0 nTPM
Thalamus	11.0 nTPM
Hippocampus	10.4 nTPM
Amygdala	10.2 nTPM

Endothelial cell	3.4 nTPM
Amygdala	6.7 nTPM
Cerebral cortex	5.8 nTPM
Hypothalamus	5.0 nTPM
Midbrain	4.7 nTPM
Hippocampus	3.8 nTPM
Thalamus	3.4 nTPM
Basal ganglia	2.8 nTPM
Cerebellum	2.3 nTPM
Medulla oblongata	2.1 nTPM
Pons	1.2 nTPM
Spinal cord	0.0 nTPM

Ependymal cell	13.3 nTPM
Hypothalamus	16.1 nTPM
Amygdala	15.9 nTPM
Spinal cord	15.3 nTPM
Thalamus	13.8 nTPM
Pons	13.4 nTPM
Hippocampus	12.7 nTPM
Basal ganglia	11.9 nTPM
Medulla oblongata	10.5 nTPM
Midbrain	10.2 nTPM