Single cell type - TLE1 - The Human Protein Atlas

TLE1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TLE1
Gene descriptionⁱ Full gene name according to HGNC.	TLE family member 1, transcriptional corepressor
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Glandular & Luminal cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Glandular and luminal cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.40
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Fibroblast)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Glandular and luminal cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Fibroblast)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TLE1 is part of cluster 37 Glandular & Luminal cells - Unknown function with confidenceⁱ 1
334 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MMP26	Matrix metallopeptidase 26	0.8138	37
SCGB1D2	Secretoglobin family 1D member 2	0.7269	37
CLDN22	Claudin 22	0.7241	37
POU5F1B	POU class 5 homeobox 1B	0.7226	37
CDSN	Corneodesmosin	0.7051	37
MSX1	Msh homeobox 1	0.7034	37
KRTAP4-7	Keratin associated protein 4-7	0.7009	37
PHACTR4	Phosphatase and actin regulator 4	0.6993	37
SCGB2A1	Secretoglobin family 2A member 1	0.6939	37
C2CD4A	C2 calcium dependent domain containing 4A	0.6938	37
LIMS3	LIM zinc finger domain containing 3	0.6936	37
POU5F1	POU class 5 homeobox 1	0.6877	37
TMEM101	Transmembrane protein 101	0.6760	37
KRTAP4-9	Keratin associated protein 4-9	0.6705	37
USP53	Ubiquitin specific peptidase 53	0.6681	37

IMMUNE CELLS

TLE1 is part of cluster 22 Eosinophils - Transcription with confidenceⁱ 1
357 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF582	Zinc finger protein 582	0.9524	22
USP22	Ubiquitin specific peptidase 22	0.9524	32
ARL16	ADP ribosylation factor like GTPase 16	0.9286	32
SPIN4	Spindlin family member 4	0.9286	42
PDE6G	Phosphodiesterase 6G	0.9286	42
ZNF75A	Zinc finger protein 75a	0.9286	22
BBX	BBX high mobility group box domain containing	0.9286	22
PLK2	Polo like kinase 2	0.9286	41
LPGAT1	Lysophosphatidylglycerol acyltransferase 1	0.9048	41
TVP23C-CDRT4	TVP23C-CDRT4 readthrough	0.9048	22
ZNF718	Zinc finger protein 718	0.9048	32
SLTM	SAFB like transcription modulator	0.9048	22
ZC3H13	Zinc finger CCCH-type containing 13	0.9048	41
CDC34	Cell division cycle 34, ubiqiutin conjugating enzyme	0.9048	42
USP48	Ubiquitin specific peptidase 48	0.9048	22

Adipocytes	93.0 nTPM
Adipose tissue	135.0 nTPM
Breast	51.0 nTPM

Alveolar cells type 1	3.1 nTPM
Lung	3.1 nTPM

Alveolar cells type 2	16.6 nTPM
Lung	16.6 nTPM

Astrocytes	115.2 nTPM
Brain	115.2 nTPM

B-cells	94.6 nTPM
Adipose tissue	327.6 nTPM
Salivary gland	166.6 nTPM
Thymus	162.4 nTPM
Stomach	111.8 nTPM
Esophagus	82.6 nTPM
PBMC	78.5 nTPM
Liver	77.3 nTPM
Lymph node	62.6 nTPM
Spleen	52.4 nTPM
Kidney	31.2 nTPM
Lung	30.9 nTPM
Bone marrow	30.6 nTPM
Skin	15.2 nTPM

Ciliated cells	47.2 nTPM
Endometrium	139.8 nTPM
Fallopian tube	21.4 nTPM
Bronchus	15.1 nTPM
Lung	12.6 nTPM

Club cells	34.4 nTPM
Prostate	60.5 nTPM
Lung	23.5 nTPM
Bronchus	19.4 nTPM

Endothelial cells	58.5 nTPM
Endometrium	139.6 nTPM
Breast	107.2 nTPM
Ovary	97.4 nTPM
Salivary gland	66.0 nTPM
Testis	63.5 nTPM
Skin	61.2 nTPM
Skeletal muscle	51.7 nTPM
Thymus	50.5 nTPM
Esophagus	49.9 nTPM
Vascular	49.6 nTPM
Placenta	49.4 nTPM
Heart muscle	47.8 nTPM
Tongue	44.3 nTPM
Fallopian tube	42.1 nTPM
Prostate	42.0 nTPM
Liver	39.0 nTPM
Lung	28.3 nTPM
Pancreas	23.3 nTPM

Enteroendocrine cells	45.8 nTPM
Colon	66.2 nTPM
Small intestine	37.8 nTPM
Rectum	33.5 nTPM

Fibroblasts	38.9 nTPM
Fallopian tube	97.1 nTPM
Placenta	84.4 nTPM
Prostate	77.9 nTPM
Skin	45.0 nTPM
Heart muscle	42.1 nTPM
Breast	40.2 nTPM
Esophagus	39.0 nTPM
Skeletal muscle	33.9 nTPM
Vascular	28.3 nTPM
Thymus	27.3 nTPM
Lung	22.8 nTPM
Pancreas	20.1 nTPM
Salivary gland	20.1 nTPM
Stomach	17.3 nTPM
Adipose tissue	15.3 nTPM
Liver	11.9 nTPM

Granulocytes	10.2 nTPM
Tongue	14.6 nTPM
Fallopian tube	10.6 nTPM
Lung	5.5 nTPM

Intestinal goblet cells	23.2 nTPM
Rectum	31.0 nTPM
Colon	19.4 nTPM
Small intestine	19.2 nTPM

Lymphatic endothelial cells	121.6 nTPM
Ovary	125.5 nTPM
Fallopian tube	117.8 nTPM

Macrophages	18.1 nTPM
Adipose tissue	73.2 nTPM
Skin	54.6 nTPM
Endometrium	31.4 nTPM
Tongue	23.9 nTPM
Salivary gland	22.0 nTPM
Skeletal muscle	19.7 nTPM
Testis	18.6 nTPM
Thymus	17.3 nTPM
Fallopian tube	16.6 nTPM
Esophagus	14.1 nTPM
Vascular	10.2 nTPM
Prostate	9.9 nTPM
Breast	8.7 nTPM
Stomach	7.7 nTPM
Lung	5.5 nTPM
Spleen	5.0 nTPM
Pancreas	4.1 nTPM
Bone marrow	1.0 nTPM
Kidney	0.0 nTPM

Paneth cells	48.8 nTPM
Rectum	58.3 nTPM
Small intestine	51.8 nTPM
Colon	36.2 nTPM

Basal keratinocytes	61.8 nTPM
Skin	81.3 nTPM
Tongue	42.3 nTPM

Basal prostatic cells	26.8 nTPM
Prostate	26.8 nTPM

Basal respiratory cells	12.2 nTPM
Bronchus	12.2 nTPM

Basal squamous epithelial cells	48.5 nTPM
Esophagus	48.5 nTPM

Plasma cells	66.0 nTPM
Fallopian tube	132.2 nTPM
Thymus	77.0 nTPM
Salivary gland	64.9 nTPM
Spleen	63.5 nTPM
Stomach	62.0 nTPM
Liver	55.6 nTPM
Esophagus	36.4 nTPM
Bone marrow	36.2 nTPM

Schwann cells	73.3 nTPM
Vascular	135.3 nTPM
Adipose tissue	48.8 nTPM
Esophagus	35.9 nTPM

Serous glandular cells	75.5 nTPM
Salivary gland	106.8 nTPM
Tongue	44.2 nTPM

Smooth muscle cells	66.2 nTPM
Skeletal muscle	110.4 nTPM
Ovary	109.7 nTPM
Adipose tissue	84.4 nTPM
Endometrium	79.9 nTPM
Salivary gland	77.9 nTPM
Lung	71.7 nTPM
Esophagus	70.9 nTPM
Fallopian tube	61.9 nTPM
Prostate	60.2 nTPM
Skin	57.4 nTPM
Thymus	54.1 nTPM
Vascular	53.5 nTPM
Tongue	47.0 nTPM
Liver	45.4 nTPM
Breast	44.0 nTPM
Placenta	30.5 nTPM

Suprabasal keratinocytes	68.3 nTPM
Tongue	75.2 nTPM
Skin	61.4 nTPM

T-cells	29.0 nTPM
Liver	80.3 nTPM
Fallopian tube	65.8 nTPM
Vascular	64.3 nTPM
Prostate	62.3 nTPM
Salivary gland	56.0 nTPM
Endometrium	54.6 nTPM
Adipose tissue	49.8 nTPM
Thymus	33.3 nTPM
Skeletal muscle	22.3 nTPM
Lung	21.3 nTPM
Tongue	15.7 nTPM
Stomach	14.0 nTPM
Breast	13.8 nTPM
Skin	12.3 nTPM
Colon	11.7 nTPM
Spleen	9.4 nTPM
PBMC	7.5 nTPM
Kidney	7.1 nTPM
Bone marrow	4.7 nTPM
Lymph node	3.7 nTPM
Esophagus	0.0 nTPM

Undifferentiated cells	34.4 nTPM
Rectum	40.8 nTPM
Colon	36.5 nTPM
Small intestine	26.0 nTPM

Amygdala excitatory	88.5 nTPM
Cerebral cortex	129.5 nTPM
Hippocampus	113.1 nTPM
Amygdala	110.1 nTPM
Basal ganglia	79.6 nTPM
Hypothalamus	55.3 nTPM
Thalamus	43.1 nTPM

Astrocyte	168.7 nTPM
Amygdala	365.1 nTPM
Hippocampus	314.7 nTPM
Cerebral cortex	275.6 nTPM
Basal ganglia	189.6 nTPM
Thalamus	153.2 nTPM
Hypothalamus	145.1 nTPM
Midbrain	109.4 nTPM
Pons	97.2 nTPM
Cerebellum	92.6 nTPM
Medulla oblongata	68.2 nTPM
Spinal cord	45.3 nTPM

Bergmann glia	198.8 nTPM
Cerebellum	218.0 nTPM
Medulla oblongata	213.1 nTPM
Pons	165.4 nTPM

Central nervous system macrophage	3.6 nTPM
Hippocampus	6.8 nTPM
Cerebral cortex	4.7 nTPM
Hypothalamus	4.5 nTPM
Thalamus	3.8 nTPM
Amygdala	3.7 nTPM
Cerebellum	2.8 nTPM
Midbrain	2.8 nTPM
Medulla oblongata	2.7 nTPM
Pons	2.7 nTPM
Basal ganglia	2.6 nTPM
Spinal cord	2.1 nTPM

Cerebellar inhibitory	43.6 nTPM
Cerebellum	65.4 nTPM
Medulla oblongata	42.7 nTPM
Midbrain	39.2 nTPM
Spinal cord	35.7 nTPM
Pons	35.2 nTPM

Cge interneuron	17.2 nTPM
Cerebral cortex	25.7 nTPM
Hippocampus	20.1 nTPM
Hypothalamus	17.6 nTPM
Basal ganglia	16.5 nTPM
Amygdala	15.2 nTPM
Midbrain	14.5 nTPM
Thalamus	11.2 nTPM

Choroid plexus epithelial cell	11.5 nTPM
Medulla oblongata	22.9 nTPM
Basal ganglia	17.6 nTPM
Hippocampus	2.8 nTPM
Thalamus	2.7 nTPM

Committed oligodendrocyte precursor	15.8 nTPM
Thalamus	22.5 nTPM
Cerebellum	22.2 nTPM
Basal ganglia	21.4 nTPM
Amygdala	19.2 nTPM
Hippocampus	17.1 nTPM
Hypothalamus	16.4 nTPM
Medulla oblongata	15.5 nTPM
Pons	12.4 nTPM
Cerebral cortex	10.1 nTPM
Midbrain	10.1 nTPM
Spinal cord	7.4 nTPM

Deep-layer corticothalamic and 6b	2.9 nTPM
Hippocampus	3.9 nTPM
Cerebral cortex	3.4 nTPM
Hypothalamus	3.3 nTPM
Amygdala	2.9 nTPM
Basal ganglia	2.6 nTPM
Midbrain	1.1 nTPM

Deep-layer intratelencephalic	65.2 nTPM
Hippocampus	84.8 nTPM
Amygdala	68.3 nTPM
Hypothalamus	67.5 nTPM
Cerebral cortex	58.4 nTPM
Basal ganglia	46.7 nTPM

Deep-layer near-projecting	2.2 nTPM
Basal ganglia	2.6 nTPM
Hippocampus	2.3 nTPM
Amygdala	2.1 nTPM
Hypothalamus	2.1 nTPM
Cerebral cortex	1.8 nTPM

Eccentric medium spiny neuron	59.4 nTPM
Cerebral cortex	70.8 nTPM
Amygdala	70.6 nTPM
Hypothalamus	61.7 nTPM
Thalamus	55.3 nTPM
Hippocampus	54.7 nTPM
Basal ganglia	43.6 nTPM

Endothelial cell	270.7 nTPM
Hypothalamus	442.9 nTPM
Amygdala	300.7 nTPM
Midbrain	291.1 nTPM
Medulla oblongata	282.0 nTPM
Cerebral cortex	256.4 nTPM
Spinal cord	248.5 nTPM
Basal ganglia	247.9 nTPM
Cerebellum	236.9 nTPM
Thalamus	225.9 nTPM
Hippocampus	223.4 nTPM
Pons	221.6 nTPM