Single cell type - ZFP62 - The Human Protein Atlas

ZFP62

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZFP62
Gene descriptionⁱ Full gene name according to HGNC.	ZFP62 zinc finger protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Oocytes - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.39
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ZFP62 is part of cluster 44 Oocytes - Unknown function with confidenceⁱ 1
133 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000275674	Novel protein	0.5371	44
TPRKB	TP53RK binding protein	0.4803	64
GDF9	Growth differentiation factor 9	0.4627	44
EBAG9	Estrogen receptor binding site associated antigen 9	0.4538	75
REC114	REC114 meiotic recombination protein	0.4488	44
PDCD5	Programmed cell death 5	0.4486	44
TRABD2A	TraB domain containing 2A	0.4423	11
TRPM5	Transient receptor potential cation channel subfamily M member 5	0.4403	44
C6orf52	Chromosome 6 open reading frame 52	0.4374	44
PSMG4	Proteasome assembly chaperone 4	0.4370	44
THYN1	Thymocyte nuclear protein 1	0.4366	44
LDHAL6A	Lactate dehydrogenase A like 6A	0.4345	44
BCL2L10	BCL2 like 10	0.4301	44
VRTN	Vertebrae development associated	0.4270	44
NKX2-6	NK2 homeobox 6	0.4264	36

IMMUNE CELLS

ZFP62 is part of cluster 43 Non-specific - Transcription & Translation with confidenceⁱ 0.52
433 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRPSAP2	Phosphoribosyl pyrophosphate synthetase associated protein 2	0.9762	43
ZNF726	Zinc finger protein 726	0.9762	43
ZNF256	Zinc finger protein 256	0.9524	43
GNB5	G protein subunit beta 5	0.9524	43
ARHGEF35	Rho guanine nucleotide exchange factor 35	0.9524	43
HLA-G	Major histocompatibility complex, class I, G	0.9524	43
ZNF805	Zinc finger protein 805	0.9524	16
RMI2	RecQ mediated genome instability 2	0.9524	43
AFAP1L2	Actin filament associated protein 1 like 2	0.9524	43
ASNS	Asparagine synthetase (glutamine-hydrolyzing)	0.9524	43
CARF	Calcium responsive transcription factor	0.9524	16
PASK	PAS domain containing serine/threonine kinase	0.9524	16
BIRC3	Baculoviral IAP repeat containing 3	0.9286	16
GRAP	GRB2 related adaptor protein	0.9286	43
SGCB	Sarcoglycan beta	0.9286	16

Adipocytes	10.2 nTPM
Breast	10.8 nTPM
Adipose tissue	9.7 nTPM

Alveolar cells type 1	10.9 nTPM
Lung	10.9 nTPM

Alveolar cells type 2	8.0 nTPM
Lung	8.0 nTPM

Astrocytes	5.3 nTPM
Brain	5.3 nTPM

B-cells	12.0 nTPM
Kidney	36.4 nTPM
PBMC	18.5 nTPM
Salivary gland	14.9 nTPM
Liver	14.5 nTPM
Bone marrow	13.4 nTPM
Adipose tissue	11.5 nTPM
Thymus	11.2 nTPM
Lung	10.7 nTPM
Lymph node	8.2 nTPM
Stomach	7.2 nTPM
Spleen	5.6 nTPM
Skin	3.4 nTPM
Esophagus	0.0 nTPM

Ciliated cells	10.1 nTPM
Lung	12.8 nTPM
Fallopian tube	10.2 nTPM
Endometrium	9.3 nTPM
Bronchus	8.2 nTPM

Club cells	10.8 nTPM
Prostate	13.4 nTPM
Lung	10.9 nTPM
Bronchus	8.2 nTPM

Endothelial cells	8.3 nTPM
Testis	15.0 nTPM
Skeletal muscle	12.6 nTPM
Heart muscle	11.6 nTPM
Prostate	11.4 nTPM
Liver	10.1 nTPM
Ovary	10.1 nTPM
Placenta	9.7 nTPM
Vascular	9.6 nTPM
Skin	8.3 nTPM
Tongue	8.1 nTPM
Lung	8.0 nTPM
Breast	7.0 nTPM
Salivary gland	6.3 nTPM
Fallopian tube	5.6 nTPM
Thymus	5.0 nTPM
Endometrium	4.6 nTPM
Esophagus	4.3 nTPM
Pancreas	2.6 nTPM

Enteroendocrine cells	16.4 nTPM
Rectum	20.1 nTPM
Colon	15.4 nTPM
Small intestine	13.7 nTPM

Fibroblasts	6.1 nTPM
Heart muscle	10.3 nTPM
Liver	9.5 nTPM
Prostate	9.2 nTPM
Breast	7.9 nTPM
Salivary gland	6.8 nTPM
Adipose tissue	6.4 nTPM
Esophagus	6.2 nTPM
Vascular	6.2 nTPM
Placenta	5.9 nTPM
Lung	5.5 nTPM
Fallopian tube	5.5 nTPM
Skeletal muscle	5.0 nTPM
Skin	4.7 nTPM
Pancreas	3.9 nTPM
Thymus	3.9 nTPM
Stomach	0.0 nTPM

Granulocytes	8.7 nTPM
Lung	10.1 nTPM
Tongue	9.7 nTPM
Fallopian tube	6.3 nTPM

Intestinal goblet cells	15.9 nTPM
Rectum	19.4 nTPM
Small intestine	17.3 nTPM
Colon	11.1 nTPM

Lymphatic endothelial cells	2.0 nTPM
Fallopian tube	4.1 nTPM
Ovary	0.0 nTPM

Macrophages	6.0 nTPM
Breast	10.7 nTPM
Prostate	10.4 nTPM
Testis	9.9 nTPM
Kidney	9.7 nTPM
Endometrium	8.6 nTPM
Salivary gland	7.2 nTPM
Tongue	7.0 nTPM
Lung	6.4 nTPM
Bone marrow	6.1 nTPM
Skeletal muscle	5.9 nTPM
Adipose tissue	5.9 nTPM
Spleen	5.0 nTPM
Fallopian tube	4.6 nTPM
Vascular	4.5 nTPM
Esophagus	2.6 nTPM
Stomach	2.6 nTPM
Thymus	2.3 nTPM
Skin	2.2 nTPM
Pancreas	2.1 nTPM

Paneth cells	12.7 nTPM
Rectum	20.6 nTPM
Small intestine	10.4 nTPM
Colon	7.2 nTPM

Basal prostatic cells	16.7 nTPM
Prostate	16.7 nTPM

Basal squamous epithelial cells	7.5 nTPM
Esophagus	7.5 nTPM

Bipolar cells	7.6 nTPM
Eye	7.6 nTPM

Cholangiocytes	7.6 nTPM
Liver	7.6 nTPM

Plasma cells	10.8 nTPM
Esophagus	15.6 nTPM
Bone marrow	13.6 nTPM
Fallopian tube	12.5 nTPM
Liver	10.0 nTPM
Salivary gland	9.8 nTPM
Stomach	8.8 nTPM
Spleen	8.2 nTPM
Thymus	7.7 nTPM

Schwann cells	4.9 nTPM
Vascular	9.9 nTPM
Adipose tissue	4.7 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	5.4 nTPM
Salivary gland	10.8 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	7.0 nTPM
Breast	11.3 nTPM
Lung	9.4 nTPM
Ovary	9.3 nTPM
Prostate	8.5 nTPM
Skeletal muscle	8.4 nTPM
Liver	8.1 nTPM
Salivary gland	7.8 nTPM
Fallopian tube	7.1 nTPM
Vascular	6.8 nTPM
Skin	6.4 nTPM
Tongue	6.0 nTPM
Adipose tissue	5.6 nTPM
Endometrium	5.5 nTPM
Esophagus	4.8 nTPM
Placenta	4.4 nTPM
Thymus	3.3 nTPM

T-cells	9.8 nTPM
PBMC	18.7 nTPM
Kidney	16.0 nTPM
Prostate	14.4 nTPM
Salivary gland	12.6 nTPM
Lung	11.8 nTPM
Colon	11.7 nTPM
Fallopian tube	11.2 nTPM
Lymph node	11.1 nTPM
Breast	10.6 nTPM
Skin	9.8 nTPM
Thymus	9.1 nTPM
Vascular	8.4 nTPM
Skeletal muscle	7.9 nTPM
Liver	7.8 nTPM
Adipose tissue	7.7 nTPM
Esophagus	7.3 nTPM
Stomach	6.9 nTPM
Bone marrow	6.8 nTPM
Endometrium	6.4 nTPM
Spleen	5.8 nTPM
Tongue	4.6 nTPM

Undifferentiated cells	17.4 nTPM
Small intestine	19.8 nTPM
Rectum	17.8 nTPM
Colon	14.6 nTPM

Amygdala excitatory	13.4 nTPM
Hypothalamus	15.6 nTPM
Hippocampus	14.4 nTPM
Amygdala	13.6 nTPM
Cerebral cortex	13.1 nTPM
Thalamus	12.7 nTPM
Basal ganglia	10.9 nTPM

Astrocyte	10.6 nTPM
Amygdala	13.2 nTPM
Cerebral cortex	12.4 nTPM
Hippocampus	11.9 nTPM
Midbrain	11.6 nTPM
Basal ganglia	11.0 nTPM
Thalamus	10.7 nTPM
Cerebellum	10.5 nTPM
Hypothalamus	9.2 nTPM
Spinal cord	9.0 nTPM
Pons	8.6 nTPM
Medulla oblongata	8.4 nTPM

Bergmann glia	14.4 nTPM
Pons	18.7 nTPM
Cerebellum	18.2 nTPM
Medulla oblongata	6.4 nTPM

Central nervous system macrophage	18.8 nTPM
Amygdala	23.5 nTPM
Midbrain	20.9 nTPM
Hippocampus	20.6 nTPM
Spinal cord	20.0 nTPM
Thalamus	19.7 nTPM
Basal ganglia	18.2 nTPM
Cerebellum	17.8 nTPM
Pons	17.6 nTPM
Hypothalamus	17.4 nTPM
Cerebral cortex	16.6 nTPM
Medulla oblongata	14.5 nTPM

Cerebellar inhibitory	9.0 nTPM
Cerebellum	11.5 nTPM
Medulla oblongata	9.2 nTPM
Spinal cord	8.2 nTPM
Midbrain	8.1 nTPM
Pons	8.1 nTPM

Cge interneuron	12.8 nTPM
Cerebral cortex	14.1 nTPM
Hypothalamus	14.1 nTPM
Hippocampus	13.8 nTPM
Basal ganglia	13.1 nTPM
Amygdala	12.4 nTPM
Thalamus	12.2 nTPM
Midbrain	10.1 nTPM

Choroid plexus epithelial cell	9.8 nTPM
Basal ganglia	14.2 nTPM
Hippocampus	11.1 nTPM
Medulla oblongata	8.6 nTPM
Thalamus	5.5 nTPM

Committed oligodendrocyte precursor	11.8 nTPM
Midbrain	16.0 nTPM
Amygdala	15.2 nTPM
Spinal cord	14.7 nTPM
Hippocampus	14.2 nTPM
Medulla oblongata	14.2 nTPM
Thalamus	12.4 nTPM
Cerebral cortex	10.1 nTPM
Cerebellum	9.5 nTPM
Basal ganglia	8.8 nTPM
Hypothalamus	7.5 nTPM
Pons	7.1 nTPM

Deep-layer corticothalamic and 6b	10.5 nTPM
Hypothalamus	12.6 nTPM
Basal ganglia	12.3 nTPM
Cerebral cortex	12.2 nTPM
Amygdala	9.6 nTPM
Hippocampus	9.4 nTPM
Midbrain	6.7 nTPM

Deep-layer intratelencephalic	13.2 nTPM
Hypothalamus	14.6 nTPM
Hippocampus	14.2 nTPM
Cerebral cortex	12.9 nTPM
Basal ganglia	12.5 nTPM
Amygdala	11.9 nTPM

Deep-layer near-projecting	14.0 nTPM
Hypothalamus	16.1 nTPM
Hippocampus	14.6 nTPM
Basal ganglia	13.4 nTPM
Cerebral cortex	13.3 nTPM
Amygdala	12.5 nTPM

Eccentric medium spiny neuron	14.3 nTPM
Hippocampus	15.8 nTPM
Hypothalamus	15.4 nTPM
Basal ganglia	14.2 nTPM
Thalamus	14.2 nTPM
Amygdala	13.0 nTPM
Cerebral cortex	13.0 nTPM

Endothelial cell	13.0 nTPM
Cerebellum	21.7 nTPM
Amygdala	17.9 nTPM
Hippocampus	17.0 nTPM
Pons	16.9 nTPM
Midbrain	15.1 nTPM
Spinal cord	13.8 nTPM
Cerebral cortex	10.2 nTPM
Basal ganglia	9.3 nTPM
Thalamus	9.0 nTPM
Hypothalamus	6.2 nTPM
Medulla oblongata	6.2 nTPM

Ependymal cell	7.6 nTPM
Amygdala	10.8 nTPM
Hippocampus	9.7 nTPM
Pons	9.0 nTPM
Medulla oblongata	8.1 nTPM
Thalamus	7.7 nTPM
Basal ganglia	6.6 nTPM
Midbrain	5.7 nTPM
Spinal cord	5.7 nTPM
Hypothalamus	5.4 nTPM