Single cell type - TEAD1 - The Human Protein Atlas

TEAD1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TEAD1
Gene descriptionⁱ Full gene name according to HGNC.	TEA domain transcription factor 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Glandular & Luminal cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Astrocytes, Alveolar cells type 1, Skeletal myocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.41
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Astrocytes, Alveolar cells type 1, Skeletal myocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TEAD1 is part of cluster 37 Glandular & Luminal cells - Unknown function with confidenceⁱ 1
334 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FRS2	Fibroblast growth factor receptor substrate 2	0.5526	47
GRAMD2B	GRAM domain containing 2B	0.5178	37
SHROOM3	Shroom family member 3	0.5092	37
MFHAS1	Multifunctional ROCO family signaling regulator 1	0.5077	37
CABLES1	Cdk5 and Abl enzyme substrate 1	0.5037	47
XPR1	Xenotropic and polytropic retrovirus receptor 1	0.5030	34
SGMS2	Sphingomyelin synthase 2	0.5014	37
NUP153	Nucleoporin 153	0.4971	37
ROR1	Receptor tyrosine kinase like orphan receptor 1	0.4958	8
FREM2	FRAS1 related extracellular matrix 2	0.4847	37
YAP1	Yes1 associated transcriptional regulator	0.4843	32
MTR	5-methyltetrahydrofolate-homocysteine methyltransferase	0.4762	37
WLS	Wnt ligand secretion mediator	0.4759	37
ALPP	Alkaline phosphatase, placental	0.4634	72
ITGB8	Integrin subunit beta 8	0.4631	37

Adipocytes	41.7 nTPM
Adipose tissue	56.5 nTPM
Breast	26.8 nTPM

Alveolar cells type 1	188.9 nTPM
Lung	188.9 nTPM

Alveolar cells type 2	78.9 nTPM
Lung	78.9 nTPM

B-cells	1.1 nTPM
Kidney	5.2 nTPM
Skin	5.1 nTPM
Thymus	1.9 nTPM
Salivary gland	1.0 nTPM
Adipose tissue	0.8 nTPM
Stomach	0.4 nTPM
Lymph node	0.3 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Lung	0.0 nTPM

Basal keratinocytes	68.5 nTPM
Skin	121.0 nTPM
Tongue	16.0 nTPM

Ciliated cells	75.0 nTPM
Lung	97.1 nTPM
Endometrium	92.7 nTPM
Fallopian tube	68.0 nTPM
Bronchus	42.4 nTPM

Club cells	32.4 nTPM
Prostate	39.5 nTPM
Lung	35.4 nTPM
Bronchus	22.2 nTPM

Endothelial cells	38.9 nTPM
Skin	102.9 nTPM
Endometrium	61.5 nTPM
Salivary gland	48.1 nTPM
Thymus	44.1 nTPM
Breast	43.9 nTPM
Liver	39.0 nTPM
Fallopian tube	37.9 nTPM
Vascular	37.8 nTPM
Tongue	36.8 nTPM
Prostate	35.9 nTPM
Lung	35.2 nTPM
Heart muscle	34.4 nTPM
Skeletal muscle	33.6 nTPM
Esophagus	25.4 nTPM
Ovary	24.6 nTPM
Placenta	23.3 nTPM
Testis	22.3 nTPM
Pancreas	12.9 nTPM

Enteroendocrine cells	47.8 nTPM
Rectum	78.8 nTPM
Small intestine	51.5 nTPM
Colon	13.2 nTPM

Fibroblasts	51.5 nTPM
Salivary gland	75.5 nTPM
Placenta	69.2 nTPM
Adipose tissue	61.9 nTPM
Heart muscle	61.8 nTPM
Skin	60.5 nTPM
Breast	57.9 nTPM
Fallopian tube	55.6 nTPM
Vascular	55.2 nTPM
Esophagus	50.9 nTPM
Skeletal muscle	50.7 nTPM
Lung	50.2 nTPM
Thymus	46.9 nTPM
Pancreas	36.3 nTPM
Prostate	36.3 nTPM
Stomach	33.1 nTPM
Liver	21.3 nTPM

Granulocytes	3.8 nTPM
Lung	8.1 nTPM
Fallopian tube	3.3 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	16.3 nTPM
Rectum	27.1 nTPM
Colon	11.8 nTPM
Small intestine	10.0 nTPM

Lymphatic endothelial cells	35.9 nTPM
Fallopian tube	44.6 nTPM
Ovary	27.3 nTPM

Macrophages	3.0 nTPM
Endometrium	16.0 nTPM
Skin	6.7 nTPM
Prostate	4.8 nTPM
Thymus	3.9 nTPM
Vascular	3.9 nTPM
Skeletal muscle	3.6 nTPM
Salivary gland	3.5 nTPM
Tongue	3.3 nTPM
Kidney	2.7 nTPM
Fallopian tube	2.7 nTPM
Breast	1.8 nTPM
Esophagus	1.3 nTPM
Testis	1.2 nTPM
Lung	1.0 nTPM
Adipose tissue	0.2 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	7.4 nTPM
Small intestine	10.4 nTPM
Rectum	8.3 nTPM
Colon	3.6 nTPM

Astrocytes	218.9 nTPM
Brain	218.9 nTPM

Bipolar cells	14.6 nTPM
Eye	14.6 nTPM

Cholangiocytes	34.3 nTPM
Liver	34.3 nTPM

Collecting duct cells	54.5 nTPM
Kidney	54.5 nTPM

Plasma cells	2.9 nTPM
Salivary gland	8.5 nTPM
Fallopian tube	6.1 nTPM
Esophagus	5.2 nTPM
Liver	1.5 nTPM
Thymus	1.3 nTPM
Stomach	0.8 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Schwann cells	100.0 nTPM
Vascular	203.7 nTPM
Esophagus	95.8 nTPM
Adipose tissue	0.4 nTPM

Serous glandular cells	21.4 nTPM
Tongue	26.5 nTPM
Salivary gland	16.2 nTPM

Smooth muscle cells	53.5 nTPM
Adipose tissue	97.1 nTPM
Endometrium	95.5 nTPM
Tongue	88.9 nTPM
Vascular	62.3 nTPM
Salivary gland	51.9 nTPM
Lung	51.7 nTPM
Thymus	50.3 nTPM
Fallopian tube	48.7 nTPM
Placenta	45.5 nTPM
Liver	45.0 nTPM
Esophagus	44.4 nTPM
Skeletal muscle	43.2 nTPM
Skin	42.8 nTPM
Prostate	32.8 nTPM
Breast	27.6 nTPM
Ovary	27.4 nTPM

Suprabasal keratinocytes	45.8 nTPM
Skin	62.3 nTPM
Tongue	29.2 nTPM

T-cells	1.9 nTPM
Endometrium	15.9 nTPM
Skin	5.3 nTPM
Tongue	4.1 nTPM
Skeletal muscle	2.6 nTPM
Prostate	2.0 nTPM
Fallopian tube	1.9 nTPM
Kidney	1.8 nTPM
Liver	1.2 nTPM
Vascular	1.2 nTPM
Salivary gland	1.0 nTPM
Breast	0.8 nTPM
Thymus	0.4 nTPM
Lymph node	0.3 nTPM
Lung	0.3 nTPM
PBMC	0.2 nTPM
Adipose tissue	0.2 nTPM
Stomach	0.2 nTPM
Colon	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Undifferentiated cells	20.7 nTPM
Rectum	24.2 nTPM
Small intestine	20.2 nTPM
Colon	17.6 nTPM

Amygdala excitatory	187.7 nTPM
Basal ganglia	242.3 nTPM
Hypothalamus	215.0 nTPM
Thalamus	187.4 nTPM
Hippocampus	175.2 nTPM
Amygdala	161.0 nTPM
Cerebral cortex	145.1 nTPM

Astrocyte	483.4 nTPM
Amygdala	636.9 nTPM
Spinal cord	628.3 nTPM
Hippocampus	526.5 nTPM
Hypothalamus	486.4 nTPM
Basal ganglia	485.2 nTPM
Cerebral cortex	478.1 nTPM
Medulla oblongata	444.1 nTPM
Midbrain	436.2 nTPM
Thalamus	429.5 nTPM
Pons	401.8 nTPM
Cerebellum	364.9 nTPM

Bergmann glia	489.7 nTPM
Cerebellum	536.7 nTPM
Pons	493.4 nTPM
Medulla oblongata	439.0 nTPM

Central nervous system macrophage	12.9 nTPM
Hypothalamus	23.9 nTPM
Pons	16.0 nTPM
Medulla oblongata	15.6 nTPM
Spinal cord	15.3 nTPM
Thalamus	14.0 nTPM
Hippocampus	11.8 nTPM
Cerebellum	10.7 nTPM
Midbrain	9.9 nTPM
Basal ganglia	9.5 nTPM
Cerebral cortex	8.7 nTPM
Amygdala	6.8 nTPM

Cerebellar inhibitory	128.1 nTPM
Spinal cord	220.0 nTPM
Medulla oblongata	138.3 nTPM
Midbrain	97.7 nTPM
Cerebellum	92.6 nTPM
Pons	92.1 nTPM

Cge interneuron	107.1 nTPM
Thalamus	136.2 nTPM
Hypothalamus	114.8 nTPM
Midbrain	113.8 nTPM
Amygdala	110.3 nTPM
Basal ganglia	98.6 nTPM
Cerebral cortex	90.8 nTPM
Hippocampus	85.6 nTPM

Choroid plexus epithelial cell	435.6 nTPM
Basal ganglia	606.8 nTPM
Medulla oblongata	452.0 nTPM
Thalamus	348.0 nTPM
Hippocampus	335.6 nTPM

Committed oligodendrocyte precursor	139.2 nTPM
Hippocampus	173.6 nTPM
Hypothalamus	158.4 nTPM
Medulla oblongata	154.9 nTPM
Midbrain	149.5 nTPM
Amygdala	147.2 nTPM
Basal ganglia	141.3 nTPM
Spinal cord	139.8 nTPM
Thalamus	127.4 nTPM
Cerebellum	120.5 nTPM
Cerebral cortex	110.2 nTPM
Pons	108.9 nTPM

Deep-layer corticothalamic and 6b	152.5 nTPM
Cerebral cortex	215.4 nTPM
Hypothalamus	199.3 nTPM
Amygdala	152.9 nTPM
Midbrain	147.6 nTPM
Basal ganglia	105.8 nTPM
Hippocampus	94.1 nTPM

Deep-layer intratelencephalic	178.7 nTPM
Hypothalamus	248.6 nTPM
Hippocampus	233.1 nTPM
Cerebral cortex	164.0 nTPM
Basal ganglia	133.4 nTPM
Amygdala	114.3 nTPM

Deep-layer near-projecting	90.6 nTPM
Hypothalamus	131.8 nTPM
Amygdala	108.7 nTPM
Cerebral cortex	73.1 nTPM
Hippocampus	71.2 nTPM
Basal ganglia	68.4 nTPM

Eccentric medium spiny neuron	213.9 nTPM
Hypothalamus	276.3 nTPM
Amygdala	233.8 nTPM
Hippocampus	220.9 nTPM
Cerebral cortex	210.2 nTPM
Thalamus	180.4 nTPM
Basal ganglia	161.9 nTPM

Endothelial cell	475.8 nTPM
Basal ganglia	611.5 nTPM
Hypothalamus	584.3 nTPM
Midbrain	509.4 nTPM
Hippocampus	494.0 nTPM
Amygdala	492.9 nTPM
Spinal cord	464.3 nTPM
Pons	451.3 nTPM
Cerebral cortex	426.4 nTPM
Cerebellum	422.0 nTPM
Medulla oblongata	400.0 nTPM
Thalamus	377.9 nTPM