Single cell type - WWC1 - The Human Protein Atlas

WWC1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	WWC1
Gene descriptionⁱ Full gene name according to HGNC.	WW and C2 domain containing 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Serous glandular cells - Salivary secretion (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Astrocytes, Glandular and luminal cells, Alveolar cells type 1, Serous glandular cells, Mucus glandular cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.58
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Ependymal cell, Astrocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Astrocytes, Glandular and luminal cells, Alveolar cells type 1, Serous glandular cells, Mucus glandular cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Ependymal cell, Astrocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

WWC1 is part of cluster 75 Serous glandular cells - Salivary secretion with confidenceⁱ 1
145 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TCN1	Transcobalamin 1	0.6401	75
SHROOM3	Shroom family member 3	0.6365	37
MYO5C	Myosin VC	0.6200	72
GAREM1	GRB2 associated regulator of MAPK1 subtype 1	0.6173	47
TMPRSS5	Transmembrane serine protease 5	0.5919	75
OPRPN	Opiorphin prepropeptide	0.5905	75
GDF5	Growth differentiation factor 5	0.5814	75
BPIFA2	BPI fold containing family A member 2	0.5783	75
BSPRY	B-box and SPRY domain containing	0.5774	75
ZG16B	Zymogen granule protein 16B	0.5749	75
PRR27	Proline rich 27	0.5744	75
NXPE2	Neurexophilin and PC-esterase domain family member 2	0.5729	75
CA6	Carbonic anhydrase 6	0.5727	75
SMR3B	Submaxillary gland androgen regulated protein 3B	0.5723	75
ADGRG2	Adhesion G protein-coupled receptor G2	0.5701	75

Adipocytes	0.7 nTPM
Breast	1.5 nTPM
Adipose tissue	0.0 nTPM

Alveolar cells type 1	136.0 nTPM
Lung	136.0 nTPM

Alveolar cells type 2	73.7 nTPM
Lung	73.7 nTPM

B-cells	2.0 nTPM
Salivary gland	8.4 nTPM
Esophagus	5.9 nTPM
Kidney	5.2 nTPM
Skin	3.4 nTPM
Thymus	1.5 nTPM
Stomach	0.8 nTPM
Adipose tissue	0.4 nTPM
Spleen	0.4 nTPM
Lymph node	0.3 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM
Lung	0.0 nTPM

Basal keratinocytes	10.7 nTPM
Skin	15.1 nTPM
Tongue	6.3 nTPM

Ciliated cells	51.1 nTPM
Endometrium	77.8 nTPM
Fallopian tube	57.9 nTPM
Lung	41.9 nTPM
Bronchus	26.7 nTPM

Club cells	20.7 nTPM
Prostate	30.0 nTPM
Lung	17.8 nTPM
Bronchus	14.2 nTPM

Endothelial cells	2.8 nTPM
Pancreas	15.5 nTPM
Salivary gland	11.1 nTPM
Endometrium	7.2 nTPM
Prostate	4.1 nTPM
Lung	3.3 nTPM
Breast	2.6 nTPM
Tongue	2.0 nTPM
Heart muscle	1.9 nTPM
Skin	1.1 nTPM
Fallopian tube	0.8 nTPM
Placenta	0.6 nTPM
Thymus	0.2 nTPM
Ovary	0.1 nTPM
Testis	0.0 nTPM
Liver	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Vascular	0.0 nTPM

Enteroendocrine cells	6.0 nTPM
Rectum	11.7 nTPM
Colon	6.4 nTPM
Small intestine	0.0 nTPM

Fibroblasts	3.3 nTPM
Lung	17.2 nTPM
Placenta	13.9 nTPM
Salivary gland	7.3 nTPM
Pancreas	5.6 nTPM
Breast	2.0 nTPM
Fallopian tube	1.5 nTPM
Prostate	1.3 nTPM
Liver	1.2 nTPM
Skeletal muscle	0.9 nTPM
Skin	0.8 nTPM
Esophagus	0.3 nTPM
Vascular	0.3 nTPM
Thymus	0.2 nTPM
Heart muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Stomach	0.0 nTPM

Granulocytes	3.1 nTPM
Tongue	4.9 nTPM
Fallopian tube	2.3 nTPM
Lung	2.0 nTPM

Intestinal goblet cells	6.7 nTPM
Rectum	8.5 nTPM
Small intestine	6.0 nTPM
Colon	5.7 nTPM

Lymphatic endothelial cells	0.3 nTPM
Fallopian tube	0.6 nTPM
Ovary	0.0 nTPM

Macrophages	2.7 nTPM
Salivary gland	17.5 nTPM
Kidney	9.7 nTPM
Endometrium	8.6 nTPM
Pancreas	8.2 nTPM
Prostate	2.1 nTPM
Tongue	1.6 nTPM
Breast	1.3 nTPM
Skin	1.1 nTPM
Fallopian tube	0.8 nTPM
Lung	0.6 nTPM
Adipose tissue	0.1 nTPM
Vascular	0.1 nTPM
Testis	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Thymus	0.0 nTPM

Paneth cells	4.9 nTPM
Rectum	7.8 nTPM
Colon	3.6 nTPM
Small intestine	3.5 nTPM

Astrocytes	153.9 nTPM
Brain	153.9 nTPM

Bipolar cells	4.3 nTPM
Eye	4.3 nTPM

Cholangiocytes	28.6 nTPM
Liver	28.6 nTPM

Collecting duct cells	58.3 nTPM
Kidney	58.3 nTPM

Plasma cells	1.9 nTPM
Salivary gland	13.0 nTPM
Liver	1.5 nTPM
Thymus	0.7 nTPM
Fallopian tube	0.3 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Schwann cells	0.2 nTPM
Vascular	0.5 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	108.3 nTPM
Salivary gland	167.9 nTPM
Tongue	48.6 nTPM

Smooth muscle cells	4.9 nTPM
Salivary gland	54.6 nTPM
Endometrium	7.2 nTPM
Prostate	6.7 nTPM
Lung	3.5 nTPM
Placenta	3.1 nTPM
Fallopian tube	1.2 nTPM
Skin	0.6 nTPM
Tongue	0.6 nTPM
Breast	0.3 nTPM
Thymus	0.2 nTPM
Ovary	0.2 nTPM
Liver	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Vascular	0.0 nTPM

Suprabasal keratinocytes	19.8 nTPM
Tongue	23.2 nTPM
Skin	16.5 nTPM

T-cells	2.0 nTPM
Salivary gland	12.0 nTPM
Endometrium	8.9 nTPM
Kidney	8.0 nTPM
Prostate	4.7 nTPM
Tongue	1.7 nTPM
Breast	1.5 nTPM
Lung	1.3 nTPM
Fallopian tube	1.2 nTPM
Adipose tissue	0.6 nTPM
Thymus	0.6 nTPM
Skin	0.4 nTPM
Stomach	0.3 nTPM
PBMC	0.2 nTPM
Lymph node	0.2 nTPM
Colon	0.0 nTPM
Liver	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Vascular	0.0 nTPM

Undifferentiated cells	10.9 nTPM
Rectum	12.7 nTPM
Small intestine	10.3 nTPM
Colon	9.5 nTPM

Amygdala excitatory	104.0 nTPM
Hypothalamus	183.0 nTPM
Amygdala	111.7 nTPM
Hippocampus	98.1 nTPM
Cerebral cortex	94.4 nTPM
Basal ganglia	90.0 nTPM
Thalamus	47.2 nTPM

Astrocyte	393.8 nTPM
Midbrain	447.9 nTPM
Thalamus	437.3 nTPM
Hypothalamus	420.2 nTPM
Amygdala	419.7 nTPM
Pons	418.7 nTPM
Cerebellum	417.6 nTPM
Hippocampus	401.2 nTPM
Spinal cord	365.8 nTPM
Basal ganglia	353.9 nTPM
Cerebral cortex	330.1 nTPM
Medulla oblongata	319.4 nTPM

Bergmann glia	251.5 nTPM
Cerebellum	279.8 nTPM
Medulla oblongata	238.7 nTPM
Pons	235.9 nTPM

Central nervous system macrophage	3.0 nTPM
Spinal cord	5.0 nTPM
Hippocampus	4.7 nTPM
Cerebral cortex	3.5 nTPM
Amygdala	3.4 nTPM
Thalamus	3.3 nTPM
Basal ganglia	2.8 nTPM
Hypothalamus	2.8 nTPM
Pons	2.3 nTPM
Cerebellum	1.8 nTPM
Medulla oblongata	1.8 nTPM
Midbrain	1.8 nTPM

Cerebellar inhibitory	42.3 nTPM
Midbrain	59.4 nTPM
Cerebellum	47.1 nTPM
Medulla oblongata	43.3 nTPM
Pons	42.4 nTPM
Spinal cord	19.2 nTPM

Cge interneuron	59.1 nTPM
Hypothalamus	78.6 nTPM
Midbrain	62.3 nTPM
Amygdala	55.8 nTPM
Thalamus	55.3 nTPM
Hippocampus	55.0 nTPM
Basal ganglia	53.2 nTPM
Cerebral cortex	53.2 nTPM

Choroid plexus epithelial cell	313.8 nTPM
Basal ganglia	543.3 nTPM
Thalamus	276.8 nTPM
Medulla oblongata	224.3 nTPM
Hippocampus	210.8 nTPM

Committed oligodendrocyte precursor	37.0 nTPM
Medulla oblongata	59.4 nTPM
Basal ganglia	58.6 nTPM
Hippocampus	51.7 nTPM
Cerebellum	49.2 nTPM
Cerebral cortex	32.3 nTPM
Hypothalamus	31.4 nTPM
Amygdala	28.8 nTPM
Midbrain	26.9 nTPM
Pons	23.9 nTPM
Thalamus	23.2 nTPM
Spinal cord	22.1 nTPM

Deep-layer corticothalamic and 6b	71.9 nTPM
Amygdala	96.0 nTPM
Hypothalamus	78.7 nTPM
Hippocampus	77.7 nTPM
Cerebral cortex	66.4 nTPM
Basal ganglia	58.7 nTPM
Midbrain	54.4 nTPM

Deep-layer intratelencephalic	103.4 nTPM
Hypothalamus	137.8 nTPM
Amygdala	108.6 nTPM
Basal ganglia	93.1 nTPM
Hippocampus	92.0 nTPM
Cerebral cortex	85.7 nTPM

Deep-layer near-projecting	23.9 nTPM
Amygdala	28.2 nTPM
Cerebral cortex	27.2 nTPM
Hypothalamus	27.2 nTPM
Basal ganglia	19.0 nTPM
Hippocampus	17.9 nTPM

Eccentric medium spiny neuron	96.3 nTPM
Amygdala	118.8 nTPM
Thalamus	105.1 nTPM
Hippocampus	99.9 nTPM
Cerebral cortex	99.3 nTPM
Hypothalamus	78.8 nTPM
Basal ganglia	76.0 nTPM

Endothelial cell	11.6 nTPM
Basal ganglia	17.7 nTPM
Cerebral cortex	17.3 nTPM
Hypothalamus	13.6 nTPM
Hippocampus	13.5 nTPM
Amygdala	13.4 nTPM
Medulla oblongata	12.3 nTPM
Spinal cord	12.1 nTPM
Cerebellum	10.8 nTPM
Midbrain	7.6 nTPM
Pons	6.2 nTPM
Thalamus	2.8 nTPM