Single cell type - MET - The Human Protein Atlas

MET

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MET
Gene descriptionⁱ Full gene name according to HGNC.	MET proto-oncogene, receptor tyrosine kinase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes Plasma proteins RAS pathway related proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted, Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Glandular & Luminal cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Glandular and luminal cells, Salivary duct cells, Alveolar cells type 2, Cytotrophoblasts, Mesothelial cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.61
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Choroid plexus epithelial cell, Hippocampal CA1-3, Oligodendrocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Glandular and luminal cells, Salivary duct cells, Alveolar cells type 2, Cytotrophoblasts, Mesothelial cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Choroid plexus epithelial cell, Hippocampal CA1-3, Oligodendrocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

MET is part of cluster 37 Glandular & Luminal cells - Unknown function with confidenceⁱ 1
334 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
APOL1	Apolipoprotein L1	0.7614	37
OCLN	Occludin	0.7285	37
TMEM101	Transmembrane protein 101	0.6963	37
MSX1	Msh homeobox 1	0.6958	37
ALPP	Alkaline phosphatase, placental	0.6914	72
LIF	LIF interleukin 6 family cytokine	0.6900	37
SLC7A4	Solute carrier family 7 member 4	0.6860	37
CLDN22	Claudin 22	0.6852	37
GABRP	Gamma-aminobutyric acid type A receptor subunit pi	0.6825	37
SCNN1G	Sodium channel epithelial 1 subunit gamma	0.6801	35
LIMS3	LIM zinc finger domain containing 3	0.6746	37
POU5F1	POU class 5 homeobox 1	0.6745	37
FZD6	Frizzled class receptor 6	0.6733	37
POU5F1B	POU class 5 homeobox 1B	0.6688	37
MYOF	Myoferlin	0.6649	37

Adipocytes	34.7 nTPM
Adipose tissue	36.8 nTPM
Breast	32.6 nTPM

Alveolar cells type 1	9.9 nTPM
Lung	9.9 nTPM

Alveolar cells type 2	95.5 nTPM
Lung	95.5 nTPM

Astrocytes	0.3 nTPM
Brain	0.3 nTPM

B-cells	1.1 nTPM
Esophagus	5.9 nTPM
Kidney	5.2 nTPM
Lung	1.3 nTPM
Thymus	1.1 nTPM
Salivary gland	0.6 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Ciliated cells	30.4 nTPM
Endometrium	48.8 nTPM
Bronchus	44.8 nTPM
Lung	21.8 nTPM
Fallopian tube	6.0 nTPM

Club cells	60.3 nTPM
Lung	83.4 nTPM
Bronchus	72.9 nTPM
Prostate	24.6 nTPM

Endothelial cells	27.4 nTPM
Thymus	66.9 nTPM
Salivary gland	56.9 nTPM
Vascular	55.4 nTPM
Esophagus	48.6 nTPM
Fallopian tube	34.0 nTPM
Tongue	31.5 nTPM
Skin	27.6 nTPM
Lung	25.1 nTPM
Endometrium	22.5 nTPM
Prostate	21.9 nTPM
Skeletal muscle	20.8 nTPM
Testis	18.6 nTPM
Breast	18.5 nTPM
Placenta	11.4 nTPM
Pancreas	10.3 nTPM
Heart muscle	9.9 nTPM
Ovary	8.8 nTPM
Liver	3.8 nTPM

Enteroendocrine cells	12.1 nTPM
Small intestine	20.6 nTPM
Colon	10.7 nTPM
Rectum	5.0 nTPM

Fibroblasts	4.5 nTPM
Placenta	30.7 nTPM
Heart muscle	10.0 nTPM
Lung	7.6 nTPM
Stomach	7.2 nTPM
Pancreas	3.2 nTPM
Vascular	3.1 nTPM
Thymus	2.7 nTPM
Prostate	2.0 nTPM
Salivary gland	1.8 nTPM
Skin	1.2 nTPM
Skeletal muscle	1.0 nTPM
Adipose tissue	0.5 nTPM
Esophagus	0.4 nTPM
Fallopian tube	0.4 nTPM
Breast	0.1 nTPM
Liver	0.0 nTPM

Granulocytes	0.6 nTPM
Lung	1.5 nTPM
Fallopian tube	0.2 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	19.5 nTPM
Small intestine	27.7 nTPM
Rectum	20.6 nTPM
Colon	10.3 nTPM

Lymphatic endothelial cells	8.1 nTPM
Fallopian tube	10.8 nTPM
Ovary	5.5 nTPM

Macrophages	3.3 nTPM
Pancreas	32.9 nTPM
Endometrium	6.1 nTPM
Adipose tissue	5.0 nTPM
Thymus	4.9 nTPM
Skeletal muscle	2.6 nTPM
Fallopian tube	2.3 nTPM
Vascular	2.0 nTPM
Prostate	1.4 nTPM
Salivary gland	1.4 nTPM
Tongue	1.4 nTPM
Skin	1.1 nTPM
Lung	1.0 nTPM
Kidney	0.9 nTPM
Breast	0.4 nTPM
Testis	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	4.2 nTPM
Small intestine	6.9 nTPM
Rectum	5.8 nTPM
Colon	0.0 nTPM

Basal keratinocytes	25.8 nTPM
Skin	47.9 nTPM
Tongue	3.7 nTPM

Basal prostatic cells	19.4 nTPM
Prostate	19.4 nTPM

Basal respiratory cells	56.5 nTPM
Bronchus	56.5 nTPM

Bipolar cells	6.2 nTPM
Eye	6.2 nTPM

Plasma cells	1.8 nTPM
Salivary gland	4.0 nTPM
Liver	3.0 nTPM
Fallopian tube	2.3 nTPM
Spleen	1.9 nTPM
Stomach	1.7 nTPM
Thymus	1.6 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Schwann cells	6.4 nTPM
Vascular	19.3 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	2.7 nTPM
Tongue	4.4 nTPM
Salivary gland	0.9 nTPM

Smooth muscle cells	3.5 nTPM
Salivary gland	15.8 nTPM
Tongue	10.8 nTPM
Skeletal muscle	5.7 nTPM
Liver	4.7 nTPM
Endometrium	4.5 nTPM
Vascular	3.6 nTPM
Placenta	3.3 nTPM
Thymus	2.2 nTPM
Esophagus	1.2 nTPM
Lung	1.2 nTPM
Prostate	1.2 nTPM
Breast	1.0 nTPM
Fallopian tube	0.8 nTPM
Skin	0.3 nTPM
Ovary	0.1 nTPM
Adipose tissue	0.0 nTPM

Suprabasal keratinocytes	10.7 nTPM
Skin	20.5 nTPM
Tongue	1.0 nTPM

T-cells	0.9 nTPM
Endometrium	9.4 nTPM
Skin	1.4 nTPM
Vascular	1.2 nTPM
Lung	1.1 nTPM
Colon	1.0 nTPM
Prostate	0.8 nTPM
Salivary gland	0.8 nTPM
Tongue	0.6 nTPM
Breast	0.5 nTPM
Skeletal muscle	0.4 nTPM
Fallopian tube	0.3 nTPM
Liver	0.2 nTPM
Adipose tissue	0.2 nTPM
Lymph node	0.2 nTPM
Thymus	0.2 nTPM
Stomach	0.1 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Undifferentiated cells	17.6 nTPM
Colon	22.4 nTPM
Rectum	18.8 nTPM
Small intestine	11.5 nTPM

Amygdala excitatory	7.3 nTPM
Cerebral cortex	19.3 nTPM
Hippocampus	16.9 nTPM
Hypothalamus	3.7 nTPM
Basal ganglia	2.3 nTPM
Amygdala	1.7 nTPM
Thalamus	0.0 nTPM

Astrocyte	0.7 nTPM
Cerebral cortex	1.1 nTPM
Spinal cord	1.1 nTPM
Hippocampus	0.9 nTPM
Hypothalamus	0.8 nTPM
Thalamus	0.8 nTPM
Medulla oblongata	0.7 nTPM
Basal ganglia	0.6 nTPM
Midbrain	0.6 nTPM
Cerebellum	0.5 nTPM
Amygdala	0.4 nTPM
Pons	0.3 nTPM

Bergmann glia	0.1 nTPM
Cerebellum	0.3 nTPM
Medulla oblongata	0.0 nTPM
Pons	0.0 nTPM

Central nervous system macrophage	0.7 nTPM
Hippocampus	1.5 nTPM
Cerebral cortex	1.3 nTPM
Basal ganglia	0.9 nTPM
Spinal cord	0.9 nTPM
Amygdala	0.6 nTPM
Midbrain	0.6 nTPM
Cerebellum	0.4 nTPM
Medulla oblongata	0.4 nTPM
Thalamus	0.4 nTPM
Hypothalamus	0.2 nTPM
Pons	0.1 nTPM

Cerebellar inhibitory	11.2 nTPM
Pons	23.6 nTPM
Midbrain	11.5 nTPM
Medulla oblongata	10.5 nTPM
Spinal cord	5.5 nTPM
Cerebellum	5.1 nTPM

Cge interneuron	2.4 nTPM
Hippocampus	8.6 nTPM
Midbrain	1.8 nTPM
Cerebral cortex	1.7 nTPM
Thalamus	1.6 nTPM
Basal ganglia	1.5 nTPM
Hypothalamus	1.0 nTPM
Amygdala	0.8 nTPM

Choroid plexus epithelial cell	64.5 nTPM
Basal ganglia	101.4 nTPM
Thalamus	85.0 nTPM
Hippocampus	44.4 nTPM
Medulla oblongata	27.4 nTPM

Committed oligodendrocyte precursor	21.9 nTPM
Hypothalamus	64.9 nTPM
Thalamus	51.1 nTPM
Amygdala	35.5 nTPM
Spinal cord	18.4 nTPM
Basal ganglia	17.0 nTPM
Cerebral cortex	15.2 nTPM
Medulla oblongata	12.9 nTPM
Hippocampus	11.9 nTPM
Pons	7.1 nTPM
Midbrain	6.7 nTPM
Cerebellum	0.0 nTPM

Deep-layer corticothalamic and 6b	0.7 nTPM
Cerebral cortex	1.3 nTPM
Hippocampus	1.1 nTPM
Amygdala	0.7 nTPM
Basal ganglia	0.5 nTPM
Hypothalamus	0.3 nTPM
Midbrain	0.0 nTPM

Deep-layer intratelencephalic	1.5 nTPM
Cerebral cortex	3.1 nTPM
Hypothalamus	1.4 nTPM
Hippocampus	1.3 nTPM
Amygdala	0.8 nTPM
Basal ganglia	0.7 nTPM

Deep-layer near-projecting	9.3 nTPM
Hypothalamus	14.8 nTPM
Basal ganglia	10.1 nTPM
Cerebral cortex	10.1 nTPM
Hippocampus	7.5 nTPM
Amygdala	3.7 nTPM

Eccentric medium spiny neuron	2.5 nTPM
Hippocampus	5.8 nTPM
Thalamus	3.8 nTPM
Cerebral cortex	2.3 nTPM
Amygdala	1.9 nTPM
Basal ganglia	0.7 nTPM
Hypothalamus	0.7 nTPM

Endothelial cell	42.2 nTPM
Hypothalamus	111.7 nTPM
Medulla oblongata	67.7 nTPM
Cerebral cortex	48.6 nTPM
Basal ganglia	45.7 nTPM
Amygdala	31.3 nTPM
Cerebellum	31.0 nTPM
Thalamus	30.5 nTPM
Pons	28.1 nTPM
Midbrain	27.4 nTPM
Hippocampus	27.2 nTPM
Spinal cord	15.5 nTPM