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RNF41
HPA
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                                          • RNF41
                                          TISSUE PRIMARY DATA KIDNEY Show tissue menu
                                          ADIPOSE TISSUE ADRENAL GLAND AMYGDALA APPENDIX BASAL GANGLIA BLOOD VESSEL BONE MARROW BREAST BRONCHUS CEREBELLUM CEREBRAL CORTEX CERVIX CHOROID PLEXUS COLON
                                          DUODENUM ENDOMETRIUM EPIDIDYMIS ESOPHAGUS FALLOPIAN TUBE GALLBLADDER HEART MUSCLE HIPPOCAMPAL FORMATION HYPOTHALAMUS KIDNEY LIVER LUNG LYMPH NODE MIDBRAIN
                                          NASOPHARYNX ORAL MUCOSA OVARY PANCREAS PARATHYROID GLAND PITUITARY GLAND PLACENTA PROSTATE RECTUM RETINA SALIVARY GLAND SEMINAL VESICLE SKELETAL MUSCLE SKIN
                                          SMALL INTESTINE SMOOTH MUSCLE SOFT TISSUE SPINAL CORD SPLEEN STOMACH TESTIS THYMUS THYROID GLAND TONGUE TONSIL URINARY BLADDER VAGINA
                                          ANTIBODIES
                                          AND
                                          VALIDATION
                                          Dictionary
                                          Kidney
                                          Tissue proteome
                                          Kidney
                                          Tissue methods
                                          KIDNEY - Expression summary
                                          Protein expression
                                          Kidneyi

                                          On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units. Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set. If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

                                          h
                                          m
                                          l
                                          n
                                          Cells in glomeruli: Not detected
                                          Cells in tubules: Low
                                          RNA expressioni

                                          A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas HPA, Genotype-Tissue Expression GTEx portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets. The mRNA expression levels in pig brain are based on RNA-seq data generated by the Human Protein Atlas, and for mouse brain HPA data and in situ hybridization generated by the Allen brain atlas dataset are reported.

                                          Scroll down to view mRNA expression data in more detail.

                                          Consensus:18.4 nTPM
                                          HPA:18.4 nTPM
                                          GTEx:16.6 nTPM
                                          FANTOM5:18.3 Scaled Tags Per Million
                                          KIDNEY - SINGLE CELL RNA EXPRESSION
                                          Explore single cell type data
                                          Renal collecting duct intercalated cellsRenal collecting duct principal cellsRenal connecting tubule cellsPodocytesProximal tubule cellsLoop of henle epithelial cellsPapillary tip epithelial cellsDistal convoluted tubule cellsVascular endothelial cellsLymphatic endothelial cellsPericytesVascular smooth muscle cellsFibroblastsMacrophagesT-cellsB-cellsNK-cells0510152025nCPM

                                          KIDNEY - Antibody stainingi

                                          Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.

                                          Ascending and descending describe two types of gradient, based on difference in staining intensity between enterocytes in crypts and apical enterocytes.

                                          Ascending - the staining intensity is stronger in apical enterocytes (towards the lumen) compared to enterocytes in the crypts (gland based)

                                          Descending - the staining is weaker in apical enterocytes compared to enterocytes in crypts

                                          Antibody HPA016812
                                          Cells in glomeruli Not detected
                                          Cells in tubules Low



                                          KIDNEY - HPA RNA-seqi

                                          The RNA-seq details section shows detailed information about the individual samples used for the transcript profiling and results of the RNA-seq analysis.

                                          Information about each individual sample is listed below, including gender, age, a tissue section image and estimated fractions of cell types. nTPM (normalized transcripts per million) values give a quantification of the gene abundance which is comparable between different genes and samples.

                                          Average nTPMi

                                          Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

                                          18.4
                                          overview
                                          Female, age 58
                                          Kidney sample 55
                                          nTPM: 18
                                          Cell types%
                                          Cells in tubules:
                                          60

                                          Cells in glomeruli:
                                          20

                                          Fibroblasts:
                                          5

                                          Other cell types:
                                          15

                                          overview
                                          Female, age 67
                                          Kidney sample 56
                                          nTPM: 19.7
                                          Cell types%
                                          Cells in tubules:
                                          70

                                          Cells in glomeruli:
                                          15

                                          Fibroblasts:
                                          10

                                          Other cell types:
                                          5

                                          overview
                                          Female, age 55
                                          Kidney sample 57
                                          nTPM: 15.8
                                          Cell types%
                                          Cells in tubules:
                                          80

                                          Cells in glomeruli:
                                          10

                                          Fibroblasts:
                                          5

                                          Other cell types:
                                          5

                                          overview
                                          Male, age 46
                                          Kidney sample 58
                                          nTPM: 17.8
                                          Cell types%
                                          Cells in tubules:
                                          60

                                          Cells in glomeruli:
                                          25

                                          Fibroblasts:
                                          5

                                          Other cell types:
                                          10

                                          overview
                                          Female, age 57
                                          Kidney sample 358
                                          nTPM: 17.3
                                          Cell types%
                                          Cells in tubules:
                                          60

                                          Cells in glomeruli:
                                          10

                                          Fibroblasts:
                                          10

                                          Other cell types:
                                          20

                                          overview
                                          Male, age 78
                                          Kidney sample 377
                                          nTPM: 19.4
                                          Cell types%
                                          Cells in tubules:
                                          65

                                          Cells in glomeruli:
                                          10

                                          Fibroblasts:
                                          5

                                          Other cell types:
                                          20

                                          overview
                                          Male, age 73
                                          Kidney sample 380
                                          nTPM: 22.7
                                          Cell types%
                                          Cells in tubules:
                                          60

                                          Cells in glomeruli:
                                          10

                                          Fibroblasts:
                                          10

                                          Other cell types:
                                          20

                                          overview
                                          Female, age 59
                                          Kidney sample 394
                                          nTPM: 19
                                          Cell types%
                                          Cells in tubules:
                                          65

                                          Cells in glomeruli:
                                          10

                                          Fibroblasts:
                                          10

                                          Other cell types:
                                          15

                                          overview
                                          Female, age 48
                                          Kidney sample 414
                                          nTPM: 15.8
                                          Cell types%
                                          Cells in tubules:
                                          60

                                          Cells in glomeruli:
                                          5

                                          Fibroblasts:
                                          10

                                          Other cell types:
                                          25


                                          KIDNEY - GTEx RNA-seqi

                                          RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

                                          Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.

                                          Max subtype nTPMi

                                          Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

                                          16.6
                                          GTEx sample id Sample description nTPM
                                          12.314.116.09.520.7024681012141618202224
                                          12.314.116.09.520.7024681012141618202224
                                          Kidney - Cortex
                                          Average nTPM: 14.5
                                          Samples: 104

                                          Max nTPM: 25.8
                                          Min nTPM: 9.5
                                          Std nTPM: 2.8
                                          Median nTPM: 14.1
                                          GTEX-11TTK-1926-SM-5PNW8 60-69 years, female 25.8
                                          GTEX-1LH75-1326-SM-F2I1R 50-59 years, female 21.7
                                          GTEX-1117F-2126-SM-GIN9G 60-69 years, female 20.7
                                          GTEX-1GF9W-1326-SM-7P8PX 60-69 years, male 20.7
                                          GTEX-1O9I2-1926-SM-F2TBQ 50-59 years, male 20.4
                                          GTEX-14C5O-2026-SM-5YYB1 60-69 years, male 19.0
                                          GTEX-1JJE9-1026-SM-HL9TH 70-79 years, male 19.0
                                          GTEX-T6MN-1826-SM-EXOHN 50-59 years, male 19.0
                                          GTEX-WL46-1926-SM-GNIN6 50-59 years, male 18.5
                                          GTEX-15DCD-1926-SM-HAV33 70-79 years, female 18.0
                                          GTEX-1A3MW-2226-SM-73KUX 60-69 years, female 18.0
                                          GTEX-1N2DW-1826-SM-EAZ54 50-59 years, male 17.8
                                          GTEX-13NYB-1726-SM-5N9G2 40-49 years, male 17.6
                                          GTEX-1J1OQ-1426-SM-AHZ3P 40-49 years, female 17.6
                                          GTEX-1JMQJ-1726-SM-E9U4V 50-59 years, male 17.4
                                          GTEX-14E6D-2526-SM-5YYA9 50-59 years, male 17.0
                                          GTEX-16MT8-1926-SM-7EPGL 60-69 years, female 16.9
                                          GTEX-1GMR3-2426-SM-7MXV2 40-49 years, male 16.9
                                          GTEX-1PWST-2226-SM-EVR3G 70-79 years, male 16.5
                                          GTEX-REY6-1826-SM-EAZAT 60-69 years, male 16.5
                                          GTEX-1MUQO-2526-SM-E9TJN 60-69 years, male 16.4
                                          GTEX-1R9PO-1626-SM-E6CPT 60-69 years, female 16.4
                                          GTEX-1399S-0526-SM-5IJG8 30-39 years, female 16.2
                                          GTEX-11GS4-2326-SM-5A5KS 60-69 years, male 16.1
                                          GTEX-12696-0926-SM-5FQTV 60-69 years, male 16.1
                                          GTEX-1HB9E-1826-SM-D4P33 50-59 years, male 16.1
                                          GTEX-1CB4J-1926-SM-7MGX8 60-69 years, male 16.0
                                          GTEX-13OVI-1126-SM-5KLZF 60-69 years, female 15.9
                                          GTEX-1497J-0826-SM-5NQAJ 60-69 years, male 15.9
                                          GTEX-14C39-2126-SM-664OH 40-49 years, male 15.8
                                          GTEX-1JMQK-1926-SM-CJI3B 60-69 years, male 15.8
                                          GTEX-NFK9-1826-SM-HL9T3 40-49 years, male 15.8
                                          GTEX-O5YV-1226-SM-EV795 60-69 years, female 15.8
                                          GTEX-13RTJ-2226-SM-5S2Q1 60-69 years, male 15.7
                                          GTEX-17F97-1926-SM-7IGM4 50-59 years, male 15.7
                                          GTEX-1RQEC-2426-SM-F2I1J 60-69 years, male 15.7
                                          GTEX-ZVZP-0926-SM-5GIDB 50-59 years, male 15.6
                                          GTEX-ZYFG-1626-SM-5GZYY 60-69 years, female 15.5
                                          GTEX-16XZZ-2226-SM-HAV34 60-69 years, male 15.4
                                          GTEX-1K9T9-1826-SM-CXZK2 50-59 years, female 15.3
                                          GTEX-ZXG5-2026-SM-HAUZV 60-69 years, male 15.2
                                          GTEX-P4QS-1126-SM-3NMD5 60-69 years, male 15.1
                                          GTEX-1GTWX-1826-SM-9QEHG 60-69 years, male 15.0
                                          GTEX-17F96-1926-SM-7MGWY 70-79 years, male 14.8
                                          GTEX-1AX8Z-2326-SM-731CR 60-69 years, male 14.7
                                          GTEX-147F4-2626-SM-5Q5CS 50-59 years, male 14.6
                                          GTEX-1NV8Z-2226-SM-EXOJ2 60-69 years, male 14.5
                                          GTEX-W5X1-1626-SM-H7OGO 40-49 years, female 14.4
                                          GTEX-XPVG-0526-SM-4B65N 50-59 years, male 14.3
                                          GTEX-1GF9V-1926-SM-9JGHE 60-69 years, male 14.2
                                          GTEX-1N2EF-1426-SM-EXUSH 60-69 years, male 14.2
                                          GTEX-T5JC-1526-SM-4DM68 20-29 years, male 14.1
                                          GTEX-Y5V6-2026-SM-5IFHO 60-69 years, male 14.1
                                          GTEX-1EKGG-2226-SM-7IGOA 60-69 years, male 14.0
                                          GTEX-13O3O-1726-SM-GJ3RL 60-69 years, female 13.9
                                          GTEX-Y5V5-1226-SM-EYYVP 60-69 years, female 13.9
                                          GTEX-15CHQ-2126-SM-6871M 60-69 years, male 13.8
                                          GTEX-1IKK5-0926-SM-A9G2U 60-69 years, male 13.7
                                          GTEX-1H3VY-1926-SM-9JGHJ 50-59 years, male 13.6
                                          GTEX-RN64-1626-SM-48FD7 50-59 years, male 13.6
                                          GTEX-1BAJH-1826-SM-731DA 70-79 years, male 13.5
                                          GTEX-1JMPZ-1226-SM-ARU8Y 30-39 years, male 13.5
                                          GTEX-1LG7Y-2726-SM-D5OVW 50-59 years, male 13.5
                                          GTEX-S33H-1426-SM-EZ6L7 30-39 years, male 13.5
                                          GTEX-16XZY-1026-SM-HAV39 70-79 years, male 13.4
                                          GTEX-1JMLX-1526-SM-AHZ3N 50-59 years, male 13.4
                                          GTEX-QLQW-1626-SM-CMKFE 30-39 years, male 13.4
                                          GTEX-1ICLY-2026-SM-GA913 50-59 years, male 13.3
                                          GTEX-13112-2126-SM-5GCO4 50-59 years, male 13.2
                                          GTEX-1OJC4-2326-SM-DTXA5 50-59 years, female 13.2
                                          GTEX-ZE9C-1426-SM-4WKGM 60-69 years, male 13.0
                                          GTEX-1KWVE-0826-SM-CXZKO 30-39 years, male 12.9
                                          GTEX-145MN-0326-SM-5QGQI 30-39 years, male 12.8
                                          GTEX-14PJ2-1826-SM-HL9UB 50-59 years, male 12.8
                                          GTEX-1QAET-2126-SM-F2TBS 50-59 years, male 12.8
                                          GTEX-1F48J-2226-SM-7MXTN 50-59 years, female 12.7
                                          GTEX-QDT8-1726-SM-EYYV6 30-39 years, female 12.4
                                          GTEX-14JG1-2326-SM-HAUZ5 40-49 years, male 12.3
                                          GTEX-ZDXO-0226-SM-4WKH7 60-69 years, male 12.3
                                          GTEX-13FHP-2126-SM-GIN8J 50-59 years, male 12.2
                                          GTEX-1E2YA-1626-SM-7MGXS 50-59 years, male 12.2
                                          GTEX-12WSG-0826-SM-5EQ5A 50-59 years, female 12.1
                                          GTEX-1IL2V-1826-SM-ARU7R 70-79 years, male 12.1
                                          GTEX-1QP6S-1526-SM-EXUSG 40-49 years, male 12.1
                                          GTEX-QDVN-1726-SM-HL9TO 50-59 years, male 12.0
                                          GTEX-11OF3-1326-SM-5N9FJ 60-69 years, male 11.9
                                          GTEX-1A8FM-2026-SM-7P8RN 50-59 years, female 11.9
                                          GTEX-1H3NZ-2126-SM-9WPQ6 60-69 years, male 11.8
                                          GTEX-1HBPI-2026-SM-CE6RZ 50-59 years, male 11.8
                                          GTEX-1JJ6O-2526-SM-AHZ3J 60-69 years, male 11.8
                                          GTEX-17HHY-2326-SM-7KFSR 50-59 years, male 11.5
                                          GTEX-ZC5H-1726-SM-5HL7X 40-49 years, female 11.5
                                          GTEX-ZLFU-0926-SM-5P9F8 40-49 years, male 11.4
                                          GTEX-15DYW-2026-SM-6AJBD 60-69 years, female 11.1
                                          GTEX-1HCVE-2126-SM-HL9UO 50-59 years, male 11.0
                                          GTEX-ZYT6-2226-SM-5GIC9 30-39 years, male 10.9
                                          GTEX-13O1R-2526-SM-5N9FW 60-69 years, male 10.7
                                          GTEX-1HCU7-1826-SM-A9G2A 50-59 years, male 10.7
                                          GTEX-1I1GP-1926-SM-CNNQU 50-59 years, male 10.7
                                          GTEX-13OVL-1826-SM-5KLZR 50-59 years, male 10.3
                                          GTEX-16Z82-2826-SM-HAUZZ 60-69 years, male 10.1
                                          GTEX-1GN1U-2126-SM-AHZ4J 50-59 years, female 10.0
                                          GTEX-1C6VQ-2326-SM-7IGN1 50-59 years, male 9.9
                                          GTEX-13OW6-1826-SM-5N9F9 50-59 years, male 9.5
                                          Show allShow less
                                          13.815.217.611.422.10246810121416182022242628
                                          13.815.217.611.422.10246810121416182022242628
                                          Kidney - Medulla
                                          Average nTPM: 16.6
                                          Samples: 11

                                          Max nTPM: 29.2
                                          Min nTPM: 11.4
                                          Std nTPM: 4.9
                                          Median nTPM: 15.2
                                          GTEX-N7MS-1526-SM-HAUZP 60-69 years, male 29.2
                                          GTEX-QEG5-2026-SM-H6Q6I 20-29 years, male 22.1
                                          GTEX-T5JC-1626-SM-EZ6KW 20-29 years, male 18.7
                                          GTEX-T6MN-1926-SM-GOQYD 50-59 years, male 16.5
                                          GTEX-R55E-2026-SM-EZ6L1 20-29 years, male 15.4
                                          GTEX-S33H-1526-SM-GQ1CB 30-39 years, male 15.2
                                          GTEX-QEG4-1526-SM-GPRWK 30-39 years, male 14.7
                                          GTEX-P4QS-1226-SM-HPAG8 60-69 years, male 14.0
                                          GTEX-RU72-1926-SM-EAZ3F 50-59 years, female 13.6
                                          GTEX-SIU8-1926-SM-H7OG4 50-59 years, male 11.8
                                          GTEX-TKQ2-0626-SM-EZ6LB 50-59 years, male 11.4
                                          Show allShow less

                                          KIDNEY - FANTOM5 CAGEi

                                          RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

                                          Max subtype Scaled Tags Per Millioni

                                          Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.

                                          18.3
                                          FANTOM5 sample id Sample description Scaled Tags Per Million
                                          Kidney
                                          Scaled Tags Per Million: 18.3
                                          FF:10017-101C8 60,62,63 years, female 18.3

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