Single cell type - ZNF57 - The Human Protein Atlas

ZNF57

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZNF57
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger protein 57
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Late spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oocytes, Early spermatids, Late spermatids, Squamous epithelial cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.71
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oocytes, Early spermatids, Late spermatids, Squamous epithelial cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ZNF57 is part of cluster 11 Late spermatids - Unknown function with confidenceⁱ 1
430 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KRTAP10-1	Keratin associated protein 10-1	0.6029	44
FAM47B	Family with sequence similarity 47 member B	0.5749	11
RPP38	Ribonuclease P/MRP subunit p38	0.5599	11
ENSG00000283205	Novel protein	0.5572	11
OR5AC2	Olfactory receptor family 5 subfamily AC member 2	0.5423	11
BARHL1	BarH like homeobox 1	0.5405	11
OR7E24	Olfactory receptor family 7 subfamily E member 24	0.5382	44
GSKIP	GSK3B interacting protein	0.5345	11
MBD3L1	Methyl-CpG binding domain protein 3 like 1	0.5340	11
MYO1H	Myosin IH	0.5312	44
FBXW12	F-box and WD repeat domain containing 12	0.5245	44
RAD21L1	RAD21 cohesin complex component like 1	0.5238	11
SPATA45	Spermatogenesis associated 45	0.5206	11
TTC23L	Tetratricopeptide repeat domain 23 like	0.5196	11
CARD18	Caspase recruitment domain family member 18	0.5137	11

IMMUNE CELLS

ZNF57 is part of cluster 33 Non-specific - ATP binding with confidenceⁱ 1
757 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NUP188	Nucleoporin 188	0.9762	33
KNOP1	Lysine rich nucleolar protein 1	0.9762	33
GLRX3	Glutaredoxin 3	0.9762	33
TCF12	Transcription factor 12	0.9762	33
MUTYH	MutY DNA glycosylase	0.9762	33
TULP4	TUB like protein 4	0.9524	33
TRAIP	TRAF interacting protein	0.9524	33
ATR	ATR serine/threonine kinase	0.9524	33
NUDT9	Nudix hydrolase 9	0.9524	33
RCCD1	RCC1 domain containing 1	0.9524	33
TRMT61A	TRNA methyltransferase 61A	0.9524	33
DHX38	DEAH-box helicase 38	0.9524	33
TRAF7	TNF receptor associated factor 7	0.9524	33
RECQL	RecQ like helicase	0.9524	33
PANK3	Pantothenate kinase 3	0.9524	33

Adipocytes	2.2 nTPM
Breast	2.4 nTPM
Adipose tissue	2.0 nTPM

Alveolar cells type 1	5.9 nTPM
Lung	5.9 nTPM

Alveolar cells type 2	5.0 nTPM
Lung	5.0 nTPM

Astrocytes	1.5 nTPM
Brain	1.5 nTPM

B-cells	1.1 nTPM
Liver	4.8 nTPM
Salivary gland	1.8 nTPM
Skin	1.7 nTPM
Thymus	1.6 nTPM
PBMC	1.5 nTPM
Lymph node	1.4 nTPM
Stomach	1.3 nTPM
Adipose tissue	0.4 nTPM
Spleen	0.4 nTPM
Kidney	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Lung	0.0 nTPM

Ciliated cells	6.0 nTPM
Lung	10.3 nTPM
Endometrium	6.4 nTPM
Fallopian tube	3.8 nTPM
Bronchus	3.7 nTPM

Club cells	4.6 nTPM
Prostate	5.4 nTPM
Bronchus	4.9 nTPM
Lung	3.5 nTPM

Endothelial cells	1.9 nTPM
Tongue	3.5 nTPM
Esophagus	3.4 nTPM
Prostate	3.2 nTPM
Endometrium	2.7 nTPM
Skin	2.7 nTPM
Breast	2.6 nTPM
Fallopian tube	2.2 nTPM
Testis	2.1 nTPM
Skeletal muscle	2.1 nTPM
Placenta	1.7 nTPM
Ovary	1.6 nTPM
Thymus	1.5 nTPM
Vascular	1.5 nTPM
Salivary gland	1.4 nTPM
Lung	1.1 nTPM
Heart muscle	0.4 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	5.2 nTPM
Colon	8.7 nTPM
Small intestine	6.9 nTPM
Rectum	0.0 nTPM

Fibroblasts	1.9 nTPM
Fallopian tube	5.0 nTPM
Prostate	4.6 nTPM
Skin	2.6 nTPM
Esophagus	2.6 nTPM
Liver	2.4 nTPM
Breast	2.3 nTPM
Adipose tissue	1.8 nTPM
Pancreas	1.6 nTPM
Thymus	1.5 nTPM
Stomach	1.4 nTPM
Salivary gland	1.4 nTPM
Vascular	1.4 nTPM
Placenta	1.0 nTPM
Skeletal muscle	1.0 nTPM
Heart muscle	0.3 nTPM
Lung	0.3 nTPM

Granulocytes	2.3 nTPM
Lung	4.5 nTPM
Fallopian tube	2.3 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	8.3 nTPM
Colon	12.1 nTPM
Small intestine	7.7 nTPM
Rectum	5.2 nTPM

Lymphatic endothelial cells	1.3 nTPM
Fallopian tube	2.5 nTPM
Ovary	0.0 nTPM

Macrophages	1.5 nTPM
Prostate	4.1 nTPM
Lung	4.0 nTPM
Tongue	3.3 nTPM
Breast	3.3 nTPM
Endometrium	3.1 nTPM
Skin	2.2 nTPM
Testis	1.9 nTPM
Thymus	1.9 nTPM
Salivary gland	1.2 nTPM
Fallopian tube	1.1 nTPM
Adipose tissue	0.9 nTPM
Vascular	0.9 nTPM
Skeletal muscle	0.7 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	6.5 nTPM
Rectum	12.6 nTPM
Small intestine	6.9 nTPM
Colon	0.0 nTPM

Basal keratinocytes	19.6 nTPM
Skin	25.4 nTPM
Tongue	13.8 nTPM

Basal prostatic cells	8.4 nTPM
Prostate	8.4 nTPM

Basal respiratory cells	7.4 nTPM
Bronchus	7.4 nTPM

Distal enterocytes	14.5 nTPM
Colon	17.3 nTPM
Rectum	11.6 nTPM

Plasma cells	0.5 nTPM
Liver	1.5 nTPM
Salivary gland	1.3 nTPM
Thymus	0.9 nTPM
Stomach	0.4 nTPM
Spleen	0.2 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Fallopian tube	0.0 nTPM

Schwann cells	1.6 nTPM
Vascular	4.7 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	2.9 nTPM
Tongue	4.4 nTPM
Salivary gland	1.3 nTPM

Smooth muscle cells	2.0 nTPM
Skin	4.2 nTPM
Tongue	3.3 nTPM
Ovary	3.2 nTPM
Breast	2.6 nTPM
Esophagus	2.4 nTPM
Fallopian tube	2.3 nTPM
Placenta	2.2 nTPM
Endometrium	2.0 nTPM
Liver	1.7 nTPM
Skeletal muscle	1.4 nTPM
Salivary gland	1.3 nTPM
Lung	1.2 nTPM
Prostate	1.2 nTPM
Vascular	1.2 nTPM
Thymus	1.1 nTPM
Adipose tissue	0.7 nTPM

Suprabasal keratinocytes	28.8 nTPM
Tongue	29.3 nTPM
Skin	28.3 nTPM

T-cells	1.8 nTPM
Skin	3.9 nTPM
Prostate	3.0 nTPM
Breast	3.0 nTPM
Colon	2.9 nTPM
Lung	2.6 nTPM
Esophagus	2.4 nTPM
Tongue	2.4 nTPM
Liver	2.2 nTPM
Fallopian tube	2.1 nTPM
Endometrium	2.0 nTPM
PBMC	1.7 nTPM
Skeletal muscle	1.5 nTPM
Thymus	1.3 nTPM
Adipose tissue	1.2 nTPM
Bone marrow	1.1 nTPM
Kidney	0.9 nTPM
Spleen	0.9 nTPM
Vascular	0.8 nTPM
Lymph node	0.7 nTPM
Salivary gland	0.7 nTPM
Stomach	0.6 nTPM

Undifferentiated cells	7.5 nTPM
Colon	11.0 nTPM
Small intestine	6.3 nTPM
Rectum	5.3 nTPM

Amygdala excitatory	3.5 nTPM
Amygdala	4.0 nTPM
Hippocampus	3.9 nTPM
Basal ganglia	3.6 nTPM
Cerebral cortex	3.6 nTPM
Hypothalamus	3.0 nTPM
Thalamus	2.7 nTPM

Astrocyte	3.4 nTPM
Spinal cord	4.2 nTPM
Amygdala	4.1 nTPM
Hypothalamus	3.9 nTPM
Hippocampus	3.8 nTPM
Cerebral cortex	3.4 nTPM
Thalamus	3.3 nTPM
Pons	3.2 nTPM
Basal ganglia	3.0 nTPM
Cerebellum	2.9 nTPM
Midbrain	2.9 nTPM
Medulla oblongata	2.6 nTPM

Bergmann glia	3.6 nTPM
Medulla oblongata	6.4 nTPM
Cerebellum	2.8 nTPM
Pons	1.4 nTPM

Central nervous system macrophage	2.6 nTPM
Amygdala	3.2 nTPM
Cerebral cortex	3.1 nTPM
Medulla oblongata	3.1 nTPM
Thalamus	2.9 nTPM
Basal ganglia	2.8 nTPM
Hippocampus	2.6 nTPM
Cerebellum	2.5 nTPM
Hypothalamus	2.5 nTPM
Midbrain	2.4 nTPM
Pons	2.4 nTPM
Spinal cord	1.5 nTPM

Cerebellar inhibitory	5.4 nTPM
Medulla oblongata	6.8 nTPM
Midbrain	6.2 nTPM
Cerebellum	6.0 nTPM
Pons	5.5 nTPM
Spinal cord	2.7 nTPM

Cge interneuron	3.3 nTPM
Hippocampus	3.6 nTPM
Amygdala	3.4 nTPM
Midbrain	3.4 nTPM
Cerebral cortex	3.3 nTPM
Thalamus	3.3 nTPM
Hypothalamus	3.2 nTPM
Basal ganglia	3.0 nTPM

Choroid plexus epithelial cell	3.3 nTPM
Basal ganglia	4.4 nTPM
Medulla oblongata	3.3 nTPM
Hippocampus	2.8 nTPM
Thalamus	2.7 nTPM

Committed oligodendrocyte precursor	2.1 nTPM
Hippocampus	4.1 nTPM
Basal ganglia	3.8 nTPM
Spinal cord	3.7 nTPM
Midbrain	3.4 nTPM
Amygdala	2.3 nTPM
Hypothalamus	2.0 nTPM
Thalamus	1.8 nTPM
Cerebral cortex	1.3 nTPM
Pons	0.9 nTPM
Cerebellum	0.0 nTPM
Medulla oblongata	0.0 nTPM

Deep-layer corticothalamic and 6b	2.9 nTPM
Cerebral cortex	3.5 nTPM
Basal ganglia	3.4 nTPM
Hippocampus	2.9 nTPM
Amygdala	2.8 nTPM
Hypothalamus	2.7 nTPM
Midbrain	2.2 nTPM

Deep-layer intratelencephalic	3.5 nTPM
Amygdala	3.8 nTPM
Cerebral cortex	3.7 nTPM
Hippocampus	3.7 nTPM
Basal ganglia	3.4 nTPM
Hypothalamus	2.9 nTPM

Deep-layer near-projecting	2.3 nTPM
Cerebral cortex	2.7 nTPM
Hippocampus	2.6 nTPM
Hypothalamus	2.6 nTPM
Basal ganglia	1.9 nTPM
Amygdala	1.8 nTPM

Eccentric medium spiny neuron	3.0 nTPM
Hippocampus	4.1 nTPM
Basal ganglia	3.1 nTPM
Thalamus	2.9 nTPM
Cerebral cortex	2.8 nTPM
Amygdala	2.7 nTPM
Hypothalamus	2.5 nTPM

Endothelial cell	2.2 nTPM
Midbrain	5.7 nTPM
Thalamus	3.4 nTPM
Hippocampus	3.2 nTPM
Pons	3.1 nTPM
Hypothalamus	2.5 nTPM
Amygdala	2.2 nTPM
Cerebellum	1.5 nTPM
Medulla oblongata	1.0 nTPM
Basal ganglia	0.9 nTPM
Cerebral cortex	0.6 nTPM
Spinal cord	0.0 nTPM