Single cell type - NUP188 - The Human Protein Atlas

NUP188

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NUP188
Gene descriptionⁱ Full gene name according to HGNC.	Nucleoporin 188
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Metabolic proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Spermatocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.42
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Spermatocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

NUP188 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
835 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IPO9	Importin 9	0.4638	39
ANAPC7	Anaphase promoting complex subunit 7	0.4595	12
NOM1	Nucleolar protein with MIF4G domain 1	0.4565	39
SUGP2	SURP and G-patch domain containing 2	0.4543	31
NKPD1	NTPase KAP family P-loop domain containing 1	0.4295	12
DYNC1H1	Dynein cytoplasmic 1 heavy chain 1	0.4253	55
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.4222	39
KPNB1	Karyopherin subunit beta 1	0.4211	39
WDR62	WD repeat domain 62	0.4147	31
ADNP2	ADNP homeobox 2	0.4143	29
FBXO45	F-box protein 45	0.4099	33
ZNF8	Zinc finger protein 8	0.4087	71
ANKLE2	Ankyrin repeat and LEM domain containing 2	0.4034	70
FAM193A	Family with sequence similarity 193 member A	0.3963	55
POLR1A	RNA polymerase I subunit A	0.3880	39

IMMUNE CELLS

NUP188 is part of cluster 33 Non-specific - ATP binding with confidenceⁱ 1
757 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MUTYH	MutY DNA glycosylase	1.0000	33
SYNJ2BP-COX16	SYNJ2BP-COX16 readthrough	0.9762	33
LIN9	Lin-9 DREAM MuvB core complex component	0.9762	33
TRAIP	TRAF interacting protein	0.9762	33
ZNF57	Zinc finger protein 57	0.9762	33
RCCD1	RCC1 domain containing 1	0.9762	33
PEX7	Peroxisomal biogenesis factor 7	0.9762	33
FAM50B	Family with sequence similarity 50 member B	0.9762	33
RECQL	RecQ like helicase	0.9762	33
DHX38	DEAH-box helicase 38	0.9762	33
WDR36	WD repeat domain 36	0.9524	33
TXNL4B	Thioredoxin like 4B	0.9524	33
TCF12	Transcription factor 12	0.9524	33
GBP1	Guanylate binding protein 1	0.9524	33
GLRX3	Glutaredoxin 3	0.9524	33

Adipocytes	9.0 nTPM
Adipose tissue	11.3 nTPM
Breast	6.8 nTPM

Alveolar cells type 1	18.7 nTPM
Lung	18.7 nTPM

Alveolar cells type 2	18.6 nTPM
Lung	18.6 nTPM

Astrocytes	14.9 nTPM
Brain	14.9 nTPM

B-cells	7.9 nTPM
Adipose tissue	14.0 nTPM
Salivary gland	13.7 nTPM
PBMC	12.3 nTPM
Spleen	10.7 nTPM
Stomach	10.1 nTPM
Lung	9.4 nTPM
Lymph node	8.5 nTPM
Thymus	8.0 nTPM
Bone marrow	7.0 nTPM
Esophagus	5.9 nTPM
Skin	3.4 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM

Ciliated cells	7.3 nTPM
Bronchus	9.9 nTPM
Lung	8.1 nTPM
Endometrium	6.1 nTPM
Fallopian tube	5.2 nTPM

Club cells	10.3 nTPM
Lung	11.7 nTPM
Prostate	9.7 nTPM
Bronchus	9.5 nTPM

Endothelial cells	9.4 nTPM
Lung	16.8 nTPM
Endometrium	14.8 nTPM
Fallopian tube	14.4 nTPM
Skeletal muscle	12.0 nTPM
Tongue	11.9 nTPM
Salivary gland	11.5 nTPM
Thymus	10.4 nTPM
Liver	10.1 nTPM
Testis	8.9 nTPM
Heart muscle	8.9 nTPM
Ovary	8.7 nTPM
Vascular	8.5 nTPM
Placenta	6.8 nTPM
Prostate	6.3 nTPM
Esophagus	6.0 nTPM
Skin	5.5 nTPM
Breast	4.4 nTPM
Pancreas	2.6 nTPM

Enteroendocrine cells	6.7 nTPM
Rectum	8.4 nTPM
Small intestine	6.9 nTPM
Colon	5.0 nTPM

Fibroblasts	9.4 nTPM
Lung	16.9 nTPM
Liver	15.4 nTPM
Stomach	13.0 nTPM
Thymus	12.7 nTPM
Fallopian tube	12.0 nTPM
Vascular	11.8 nTPM
Skeletal muscle	10.2 nTPM
Salivary gland	8.6 nTPM
Pancreas	8.3 nTPM
Prostate	7.9 nTPM
Skin	7.4 nTPM
Breast	6.5 nTPM
Adipose tissue	6.4 nTPM
Placenta	6.2 nTPM
Esophagus	5.2 nTPM
Heart muscle	2.5 nTPM

Granulocytes	10.2 nTPM
Fallopian tube	14.0 nTPM
Tongue	9.7 nTPM
Lung	7.1 nTPM

Intestinal goblet cells	7.0 nTPM
Rectum	7.7 nTPM
Small intestine	7.3 nTPM
Colon	5.9 nTPM

Lymphatic endothelial cells	12.7 nTPM
Ovary	16.4 nTPM
Fallopian tube	9.1 nTPM

Macrophages	9.4 nTPM
Lung	15.3 nTPM
Tongue	14.0 nTPM
Bone marrow	13.2 nTPM
Salivary gland	11.8 nTPM
Adipose tissue	11.7 nTPM
Thymus	11.1 nTPM
Fallopian tube	11.1 nTPM
Pancreas	10.3 nTPM
Vascular	9.7 nTPM
Spleen	9.0 nTPM
Kidney	8.9 nTPM
Prostate	8.9 nTPM
Testis	8.1 nTPM
Endometrium	8.0 nTPM
Esophagus	6.4 nTPM
Skin	5.6 nTPM
Breast	5.5 nTPM
Skeletal muscle	5.3 nTPM
Stomach	5.1 nTPM

Paneth cells	3.3 nTPM
Rectum	6.3 nTPM
Colon	3.6 nTPM
Small intestine	0.0 nTPM

Basal prostatic cells	7.5 nTPM
Prostate	7.5 nTPM

Basal squamous epithelial cells	6.6 nTPM
Esophagus	6.6 nTPM

Bipolar cells	17.6 nTPM
Eye	17.6 nTPM

Collecting duct cells	5.8 nTPM
Kidney	5.8 nTPM

Plasma cells	9.5 nTPM
Thymus	17.1 nTPM
Spleen	15.2 nTPM
Salivary gland	10.7 nTPM
Liver	10.5 nTPM
Bone marrow	9.1 nTPM
Fallopian tube	9.0 nTPM
Stomach	4.6 nTPM
Esophagus	0.0 nTPM

Schwann cells	18.3 nTPM
Esophagus	24.0 nTPM
Vascular	23.0 nTPM
Adipose tissue	7.8 nTPM

Serous glandular cells	8.5 nTPM
Tongue	8.8 nTPM
Salivary gland	8.2 nTPM

Smooth muscle cells	7.8 nTPM
Thymus	11.2 nTPM
Liver	11.0 nTPM
Vascular	10.5 nTPM
Skeletal muscle	9.8 nTPM
Placenta	9.7 nTPM
Endometrium	8.9 nTPM
Tongue	8.4 nTPM
Salivary gland	8.3 nTPM
Fallopian tube	8.3 nTPM
Lung	7.1 nTPM
Ovary	5.9 nTPM
Adipose tissue	5.6 nTPM
Skin	5.5 nTPM
Prostate	5.5 nTPM
Esophagus	4.8 nTPM
Breast	4.0 nTPM

Suprabasal keratinocytes	16.6 nTPM
Tongue	22.3 nTPM
Skin	10.9 nTPM

T-cells	10.0 nTPM
Tongue	14.3 nTPM
Spleen	13.9 nTPM
Skeletal muscle	12.9 nTPM
Salivary gland	12.6 nTPM
Thymus	12.0 nTPM
Adipose tissue	11.9 nTPM
Lung	11.6 nTPM
Fallopian tube	11.1 nTPM
Bone marrow	10.7 nTPM
Liver	10.3 nTPM
Lymph node	9.8 nTPM
PBMC	9.1 nTPM
Skin	9.1 nTPM
Stomach	9.1 nTPM
Breast	8.6 nTPM
Endometrium	8.0 nTPM
Vascular	7.6 nTPM
Esophagus	7.3 nTPM
Kidney	7.1 nTPM
Prostate	6.3 nTPM
Colon	5.8 nTPM

Undifferentiated cells	9.3 nTPM
Colon	11.0 nTPM
Rectum	10.2 nTPM
Small intestine	6.8 nTPM

Amygdala excitatory	16.8 nTPM
Thalamus	19.5 nTPM
Hypothalamus	17.9 nTPM
Amygdala	16.5 nTPM
Hippocampus	16.1 nTPM
Basal ganglia	15.8 nTPM
Cerebral cortex	15.1 nTPM

Astrocyte	44.3 nTPM
Spinal cord	66.6 nTPM
Midbrain	51.1 nTPM
Thalamus	49.8 nTPM
Pons	48.7 nTPM
Cerebellum	47.7 nTPM
Medulla oblongata	42.1 nTPM
Amygdala	40.9 nTPM
Hippocampus	37.9 nTPM
Hypothalamus	37.4 nTPM
Cerebral cortex	34.5 nTPM
Basal ganglia	30.4 nTPM

Bergmann glia	72.8 nTPM
Medulla oblongata	89.5 nTPM
Cerebellum	74.2 nTPM
Pons	54.7 nTPM

Central nervous system macrophage	27.6 nTPM
Hippocampus	31.8 nTPM
Amygdala	31.7 nTPM
Midbrain	29.3 nTPM
Spinal cord	29.1 nTPM
Pons	28.1 nTPM
Cerebellum	27.9 nTPM
Hypothalamus	27.3 nTPM
Thalamus	26.4 nTPM
Basal ganglia	25.8 nTPM
Cerebral cortex	24.6 nTPM
Medulla oblongata	22.2 nTPM

Cerebellar inhibitory	21.4 nTPM
Cerebellum	24.7 nTPM
Spinal cord	22.0 nTPM
Medulla oblongata	20.6 nTPM
Midbrain	20.2 nTPM
Pons	19.5 nTPM

Cge interneuron	20.3 nTPM
Hypothalamus	22.1 nTPM
Amygdala	21.6 nTPM
Thalamus	21.4 nTPM
Cerebral cortex	20.8 nTPM
Basal ganglia	19.6 nTPM
Midbrain	18.6 nTPM
Hippocampus	17.9 nTPM

Choroid plexus epithelial cell	20.9 nTPM
Basal ganglia	24.8 nTPM
Thalamus	24.7 nTPM
Medulla oblongata	23.1 nTPM
Hippocampus	11.1 nTPM

Committed oligodendrocyte precursor	20.9 nTPM
Cerebral cortex	27.2 nTPM
Amygdala	25.9 nTPM
Hypothalamus	25.3 nTPM
Thalamus	24.3 nTPM
Cerebellum	22.2 nTPM
Spinal cord	22.1 nTPM
Hippocampus	22.0 nTPM
Midbrain	21.0 nTPM
Basal ganglia	17.5 nTPM
Pons	11.5 nTPM
Medulla oblongata	10.3 nTPM

Deep-layer corticothalamic and 6b	17.2 nTPM
Cerebral cortex	19.8 nTPM
Hypothalamus	18.7 nTPM
Basal ganglia	17.3 nTPM
Amygdala	17.1 nTPM
Hippocampus	15.8 nTPM
Midbrain	14.4 nTPM

Deep-layer intratelencephalic	15.3 nTPM
Hypothalamus	16.9 nTPM
Amygdala	15.7 nTPM
Cerebral cortex	15.3 nTPM
Basal ganglia	14.9 nTPM
Hippocampus	13.5 nTPM

Deep-layer near-projecting	17.8 nTPM
Amygdala	24.3 nTPM
Cerebral cortex	18.4 nTPM
Hippocampus	15.6 nTPM
Basal ganglia	15.5 nTPM
Hypothalamus	15.2 nTPM

Eccentric medium spiny neuron	18.9 nTPM
Hypothalamus	20.4 nTPM
Thalamus	19.4 nTPM
Basal ganglia	19.3 nTPM
Hippocampus	18.7 nTPM
Cerebral cortex	18.0 nTPM
Amygdala	17.7 nTPM

Endothelial cell	22.8 nTPM
Hypothalamus	33.5 nTPM
Basal ganglia	29.8 nTPM
Midbrain	26.5 nTPM
Medulla oblongata	25.6 nTPM
Pons	25.0 nTPM
Cerebral cortex	23.0 nTPM
Spinal cord	20.7 nTPM
Hippocampus	20.2 nTPM
Cerebellum	17.0 nTPM
Thalamus	16.9 nTPM
Amygdala	12.3 nTPM