Single cell type - STX8 - The Human Protein Atlas

STX8

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	STX8
Gene descriptionⁱ Full gene name according to HGNC.	Syntaxin 8
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Late spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Oocytes, Late spermatids)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.44
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Group enriched (Oocytes, Late spermatids)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

STX8 is part of cluster 36 Late spermatids - Unknown function with confidenceⁱ 1
427 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NUP35	Nucleoporin 35	0.6702	36
ELOF1	Elongation factor 1	0.6574	36
LAS1L	LAS1 like ribosome biogenesis factor	0.6067	63
PHKG2	Phosphorylase kinase catalytic subunit gamma 2	0.6057	36
ENSG00000187186	Novel protein	0.6044	36
DCUN1D1	Defective in cullin neddylation 1 domain containing 1	0.6031	36
MORN3	MORN repeat containing 3	0.5988	36
THEG	Theg spermatid protein	0.5946	36
TSHB	Thyroid stimulating hormone subunit beta	0.5936	36
RANGAP1	Ran GTPase activating protein 1	0.5923	36
NUPR2	Nuclear protein 2, transcriptional regulator	0.5913	36
PDYN	Prodynorphin	0.5896	36
LRRC27	Leucine rich repeat containing 27	0.5886	63
UBXN11	UBX domain protein 11	0.5883	36
PCYT2	Phosphate cytidylyltransferase 2, ethanolamine	0.5882	36

IMMUNE CELLS

STX8 is part of cluster 12 Non-specific - Mitochondrial translation with confidenceⁱ 0.99
566 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
POLE3	DNA polymerase epsilon 3, accessory subunit	0.9762	12
FBXW5	F-box and WD repeat domain containing 5	0.9524	12
GFM1	G elongation factor mitochondrial 1	0.9524	12
UBE2V1	Ubiquitin conjugating enzyme E2 V1	0.9286	3
RANBP1	RAN binding protein 1	0.9286	12
PPP2R2A	Protein phosphatase 2 regulatory subunit Balpha	0.9048	12
NIF3L1	NGG1 interacting factor 3 like 1	0.9048	12
GOLT1B	Golgi transport 1B	0.9048	12
SNRPB2	Small nuclear ribonucleoprotein polypeptide B2	0.9048	3
MRPL13	Mitochondrial ribosomal protein L13	0.9048	12
DDX21	DExD-box helicase 21	0.9048	12
IFI27	Interferon alpha inducible protein 27	0.9048	12
CZIB	CXXC motif containing zinc binding protein	0.8810	12
STIP1	Stress induced phosphoprotein 1	0.8810	12
ACAA2	Acetyl-CoA acyltransferase 2	0.8810	12

Adipocytes	34.5 nTPM
Breast	42.0 nTPM
Adipose tissue	26.9 nTPM

Alveolar cells type 1	34.1 nTPM
Lung	34.1 nTPM

Alveolar cells type 2	26.1 nTPM
Lung	26.1 nTPM

Astrocytes	61.9 nTPM
Brain	61.9 nTPM

B-cells	38.0 nTPM
Skin	61.0 nTPM
PBMC	60.0 nTPM
Kidney	52.0 nTPM
Liver	43.5 nTPM
Lung	38.9 nTPM
Stomach	38.8 nTPM
Esophagus	35.4 nTPM
Thymus	32.0 nTPM
Adipose tissue	30.5 nTPM
Salivary gland	27.8 nTPM
Spleen	26.8 nTPM
Bone marrow	26.6 nTPM
Lymph node	21.2 nTPM

Ciliated cells	38.9 nTPM
Bronchus	49.7 nTPM
Fallopian tube	39.2 nTPM
Lung	33.7 nTPM
Endometrium	32.8 nTPM

Club cells	47.5 nTPM
Bronchus	64.4 nTPM
Prostate	43.1 nTPM
Lung	35.0 nTPM

Dendritic cells	24.9 nTPM
PBMC	28.8 nTPM
Adipose tissue	21.1 nTPM

Endothelial cells	33.1 nTPM
Pancreas	59.5 nTPM
Breast	55.4 nTPM
Skin	43.6 nTPM
Placenta	40.9 nTPM
Heart muscle	39.2 nTPM
Ovary	37.7 nTPM
Tongue	35.9 nTPM
Lung	33.6 nTPM
Testis	31.4 nTPM
Prostate	31.4 nTPM
Skeletal muscle	31.2 nTPM
Fallopian tube	29.5 nTPM
Liver	23.9 nTPM
Thymus	23.7 nTPM
Endometrium	22.7 nTPM
Salivary gland	21.0 nTPM
Vascular	20.4 nTPM
Esophagus	14.7 nTPM

Enteroendocrine cells	21.1 nTPM
Colon	32.7 nTPM
Small intestine	17.2 nTPM
Rectum	13.4 nTPM

Fibroblasts	48.6 nTPM
Heart muscle	87.0 nTPM
Skin	76.4 nTPM
Adipose tissue	71.2 nTPM
Pancreas	65.7 nTPM
Breast	49.4 nTPM
Skeletal muscle	48.0 nTPM
Lung	47.0 nTPM
Fallopian tube	45.6 nTPM
Placenta	44.0 nTPM
Prostate	42.9 nTPM
Vascular	40.4 nTPM
Salivary gland	38.9 nTPM
Esophagus	37.4 nTPM
Thymus	35.1 nTPM
Liver	28.5 nTPM
Stomach	20.2 nTPM

Granulocytes	51.0 nTPM
Fallopian tube	53.2 nTPM
Lung	51.4 nTPM
Tongue	48.5 nTPM

Intestinal goblet cells	43.3 nTPM
Colon	44.3 nTPM
Rectum	43.2 nTPM
Small intestine	42.4 nTPM

Lymphatic endothelial cells	35.1 nTPM
Fallopian tube	37.5 nTPM
Ovary	32.7 nTPM

Macrophages	44.7 nTPM
Lung	70.6 nTPM
Pancreas	59.6 nTPM
Adipose tissue	58.5 nTPM
Kidney	58.4 nTPM
Skin	57.9 nTPM
Testis	57.7 nTPM
Breast	51.8 nTPM
Bone marrow	47.6 nTPM
Fallopian tube	45.9 nTPM
Endometrium	44.3 nTPM
Skeletal muscle	42.8 nTPM
Prostate	40.2 nTPM
Vascular	38.2 nTPM
Thymus	38.1 nTPM
Salivary gland	31.7 nTPM
Stomach	30.9 nTPM
Tongue	30.2 nTPM
Esophagus	23.1 nTPM
Spleen	21.1 nTPM

Basal prostatic cells	43.4 nTPM
Prostate	43.4 nTPM

Basal respiratory cells	79.1 nTPM
Bronchus	79.1 nTPM

Bipolar cells	16.7 nTPM
Eye	16.7 nTPM

Cholangiocytes	26.7 nTPM
Liver	26.7 nTPM

Paneth cells	49.8 nTPM
Colon	65.1 nTPM
Rectum	46.4 nTPM
Small intestine	38.0 nTPM

Plasma cells	30.5 nTPM
Fallopian tube	50.2 nTPM
Liver	44.6 nTPM
Stomach	33.9 nTPM
Thymus	27.4 nTPM
Bone marrow	27.2 nTPM
Spleen	23.1 nTPM
Salivary gland	22.4 nTPM
Esophagus	15.6 nTPM

Schwann cells	24.4 nTPM
Adipose tissue	39.8 nTPM
Vascular	33.4 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	28.0 nTPM
Salivary gland	47.2 nTPM
Tongue	8.8 nTPM

Smooth muscle cells	46.6 nTPM
Fallopian tube	67.2 nTPM
Skin	62.5 nTPM
Breast	58.1 nTPM
Placenta	56.5 nTPM
Ovary	54.9 nTPM
Prostate	53.5 nTPM
Lung	48.2 nTPM
Vascular	45.3 nTPM
Thymus	43.7 nTPM
Esophagus	42.0 nTPM
Adipose tissue	39.6 nTPM
Salivary gland	38.8 nTPM
Liver	36.5 nTPM
Skeletal muscle	36.3 nTPM
Tongue	33.5 nTPM
Endometrium	28.4 nTPM

Suprabasal keratinocytes	49.6 nTPM
Tongue	61.2 nTPM
Skin	37.9 nTPM

T-cells	48.6 nTPM
Skin	77.5 nTPM
Kidney	73.6 nTPM
Breast	63.5 nTPM
Colon	63.4 nTPM
Fallopian tube	62.1 nTPM
Liver	58.8 nTPM
Adipose tissue	57.0 nTPM
Lung	56.7 nTPM
Prostate	52.7 nTPM
Skeletal muscle	50.3 nTPM
PBMC	47.0 nTPM
Bone marrow	43.1 nTPM
Spleen	41.2 nTPM
Stomach	41.0 nTPM
Endometrium	39.6 nTPM
Tongue	38.6 nTPM
Vascular	35.8 nTPM
Thymus	35.4 nTPM
Esophagus	34.1 nTPM
Salivary gland	32.2 nTPM
Lymph node	17.7 nTPM

Undifferentiated cells	34.1 nTPM
Rectum	37.7 nTPM
Colon	32.7 nTPM
Small intestine	32.0 nTPM

Amygdala excitatory	95.8 nTPM
Hypothalamus	139.4 nTPM
Amygdala	104.1 nTPM
Basal ganglia	98.5 nTPM
Cerebral cortex	80.4 nTPM
Thalamus	77.1 nTPM
Hippocampus	75.4 nTPM

Astrocyte	156.2 nTPM
Spinal cord	174.4 nTPM
Amygdala	172.9 nTPM
Hypothalamus	172.3 nTPM
Hippocampus	162.9 nTPM
Cerebellum	162.4 nTPM
Basal ganglia	157.8 nTPM
Thalamus	149.9 nTPM
Midbrain	146.3 nTPM
Cerebral cortex	145.7 nTPM
Medulla oblongata	137.0 nTPM
Pons	136.9 nTPM

Bergmann glia	125.0 nTPM
Cerebellum	149.8 nTPM
Medulla oblongata	121.5 nTPM
Pons	103.6 nTPM

Central nervous system macrophage	233.4 nTPM
Amygdala	286.5 nTPM
Hypothalamus	266.2 nTPM
Hippocampus	256.9 nTPM
Basal ganglia	240.8 nTPM
Cerebral cortex	237.4 nTPM
Midbrain	231.9 nTPM
Cerebellum	225.3 nTPM
Pons	220.1 nTPM
Thalamus	218.0 nTPM
Medulla oblongata	197.7 nTPM
Spinal cord	186.6 nTPM

Cerebellar inhibitory	111.1 nTPM
Medulla oblongata	123.2 nTPM
Spinal cord	118.2 nTPM
Cerebellum	112.7 nTPM
Pons	103.3 nTPM
Midbrain	98.0 nTPM

Cge interneuron	89.9 nTPM
Hypothalamus	117.0 nTPM
Amygdala	92.3 nTPM
Midbrain	86.6 nTPM
Cerebral cortex	86.4 nTPM
Thalamus	84.9 nTPM
Hippocampus	82.0 nTPM
Basal ganglia	80.3 nTPM

Choroid plexus epithelial cell	159.0 nTPM
Basal ganglia	271.8 nTPM
Medulla oblongata	157.2 nTPM
Hippocampus	110.9 nTPM
Thalamus	95.9 nTPM

Committed oligodendrocyte precursor	140.8 nTPM
Hypothalamus	177.5 nTPM
Amygdala	175.4 nTPM
Cerebellum	166.5 nTPM
Hippocampus	144.9 nTPM
Thalamus	142.7 nTPM
Midbrain	138.6 nTPM
Cerebral cortex	131.7 nTPM
Basal ganglia	126.5 nTPM
Spinal cord	125.1 nTPM
Pons	120.4 nTPM
Medulla oblongata	99.4 nTPM

Deep-layer corticothalamic and 6b	101.6 nTPM
Hypothalamus	157.6 nTPM
Cerebral cortex	103.9 nTPM
Amygdala	96.7 nTPM
Basal ganglia	88.8 nTPM
Midbrain	84.3 nTPM
Hippocampus	78.4 nTPM

Deep-layer intratelencephalic	117.1 nTPM
Hypothalamus	172.6 nTPM
Cerebral cortex	111.1 nTPM
Amygdala	109.2 nTPM
Basal ganglia	97.6 nTPM
Hippocampus	95.0 nTPM

Deep-layer near-projecting	86.5 nTPM
Hypothalamus	110.0 nTPM
Amygdala	92.4 nTPM
Cerebral cortex	86.6 nTPM
Hippocampus	74.2 nTPM
Basal ganglia	69.5 nTPM

Eccentric medium spiny neuron	79.6 nTPM
Thalamus	86.8 nTPM
Basal ganglia	82.5 nTPM
Amygdala	79.9 nTPM
Cerebral cortex	79.7 nTPM
Hypothalamus	77.3 nTPM
Hippocampus	71.3 nTPM