Single cell type - POLE3 - The Human Protein Atlas

POLE3

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	POLE3
Gene descriptionⁱ Full gene name according to HGNC.	DNA polymerase epsilon 3, accessory subunit
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	FDA approved drug targets Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Cell proliferation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.26
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

POLE3 is part of cluster 52 Non-specific - Cell proliferation with confidenceⁱ 1
248 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HMGB1	High mobility group box 1	0.6772	52
UHRF1	Ubiquitin like with PHD and ring finger domains 1	0.6409	52
PARPBP	PARP1 binding protein	0.6305	52
MCM6	Minichromosome maintenance complex component 6	0.6284	52
ARHGAP11A	Rho GTPase activating protein 11A	0.6168	52
ASPM	Assembly factor for spindle microtubules	0.6151	52
TCF19	Transcription factor 19	0.6002	52
MKI67	Marker of proliferation Ki-67	0.5955	52
E2F8	E2F transcription factor 8	0.5949	52
CKAP2L	Cytoskeleton associated protein 2 like	0.5842	52
NEIL3	Nei like DNA glycosylase 3	0.5761	52
TFDP1	Transcription factor Dp-1	0.5743	1
KIF11	Kinesin family member 11	0.5718	52
KIF20B	Kinesin family member 20B	0.5710	52
GTSE1	G2 and S-phase expressed 1	0.5704	52

IMMUNE CELLS

POLE3 is part of cluster 12 Non-specific - Mitochondrial translation with confidenceⁱ 0.99
566 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
STX8	Syntaxin 8	0.9762	12
FBXW5	F-box and WD repeat domain containing 5	0.9286	12
UBE2V1	Ubiquitin conjugating enzyme E2 V1	0.9048	3
STIP1	Stress induced phosphoprotein 1	0.9048	12
SRP68	Signal recognition particle 68	0.9048	45
ACAA2	Acetyl-CoA acyltransferase 2	0.9048	12
DIAPH1	Diaphanous related formin 1	0.9048	25
RANBP1	RAN binding protein 1	0.9048	12
ABHD8	Abhydrolase domain containing 8	0.8810	25
COMMD10	COMM domain containing 10	0.8810	12
GOLT1B	Golgi transport 1B	0.8810	12
DDX21	DExD-box helicase 21	0.8810	12
IFI27	Interferon alpha inducible protein 27	0.8810	12
LMF2	Lipase maturation factor 2	0.8810	12
GGA1	Golgi associated, gamma adaptin ear containing, ARF binding protein 1	0.8810	3

Adipocytes	36.9 nTPM
Breast	39.3 nTPM
Adipose tissue	34.6 nTPM

Alveolar cells type 1	31.2 nTPM
Lung	31.2 nTPM

Alveolar cells type 2	45.7 nTPM
Lung	45.7 nTPM

Astrocytes	1.9 nTPM
Brain	1.9 nTPM

B-cells	53.1 nTPM
Lymph node	78.1 nTPM
Adipose tissue	73.3 nTPM
Liver	62.8 nTPM
Spleen	60.5 nTPM
Esophagus	59.0 nTPM
Salivary gland	57.1 nTPM
Skin	52.5 nTPM
Bone marrow	51.1 nTPM
Stomach	49.8 nTPM
Thymus	49.8 nTPM
PBMC	41.6 nTPM
Lung	33.5 nTPM
Kidney	20.8 nTPM

Ciliated cells	31.1 nTPM
Endometrium	45.7 nTPM
Fallopian tube	36.1 nTPM
Lung	26.2 nTPM
Bronchus	16.3 nTPM

Club cells	26.3 nTPM
Prostate	31.8 nTPM
Lung	27.3 nTPM
Bronchus	19.8 nTPM

Dendritic cells	82.3 nTPM
Adipose tissue	132.2 nTPM
PBMC	32.4 nTPM

Endothelial cells	33.4 nTPM
Fallopian tube	53.3 nTPM
Heart muscle	47.8 nTPM
Endometrium	47.5 nTPM
Skin	43.0 nTPM
Breast	41.3 nTPM
Pancreas	38.8 nTPM
Lung	37.2 nTPM
Thymus	32.4 nTPM
Ovary	32.1 nTPM
Placenta	31.8 nTPM
Tongue	29.8 nTPM
Esophagus	29.3 nTPM
Salivary gland	26.3 nTPM
Vascular	25.4 nTPM
Prostate	23.6 nTPM
Skeletal muscle	22.5 nTPM
Testis	21.7 nTPM
Liver	17.6 nTPM

Enteroendocrine cells	28.7 nTPM
Colon	38.7 nTPM
Small intestine	24.0 nTPM
Rectum	23.5 nTPM

Fibroblasts	39.4 nTPM
Heart muscle	77.3 nTPM
Pancreas	56.4 nTPM
Lung	53.1 nTPM
Skin	45.5 nTPM
Placenta	45.3 nTPM
Adipose tissue	45.3 nTPM
Fallopian tube	40.0 nTPM
Breast	37.9 nTPM
Vascular	33.6 nTPM
Thymus	32.2 nTPM
Skeletal muscle	31.0 nTPM
Stomach	30.3 nTPM
Esophagus	29.3 nTPM
Salivary gland	28.2 nTPM
Prostate	24.4 nTPM
Liver	20.2 nTPM

Granulocytes	48.1 nTPM
Fallopian tube	82.8 nTPM
Lung	37.3 nTPM
Tongue	24.3 nTPM

Intestinal goblet cells	33.4 nTPM
Colon	44.8 nTPM
Rectum	31.1 nTPM
Small intestine	24.2 nTPM

Lymphatic endothelial cells	43.0 nTPM
Ovary	43.6 nTPM
Fallopian tube	42.3 nTPM

Macrophages	44.4 nTPM
Endometrium	79.9 nTPM
Adipose tissue	62.4 nTPM
Skin	52.4 nTPM
Testis	52.1 nTPM
Bone marrow	51.7 nTPM
Breast	47.3 nTPM
Thymus	46.3 nTPM
Pancreas	43.2 nTPM
Kidney	42.5 nTPM
Vascular	42.5 nTPM
Fallopian tube	39.8 nTPM
Skeletal muscle	39.1 nTPM
Prostate	39.0 nTPM
Tongue	38.9 nTPM
Spleen	37.1 nTPM
Salivary gland	36.4 nTPM
Esophagus	33.4 nTPM
Stomach	33.4 nTPM
Lung	27.1 nTPM

Basal keratinocytes	83.3 nTPM
Skin	98.5 nTPM
Tongue	68.0 nTPM

Basal respiratory cells	34.0 nTPM
Bronchus	34.0 nTPM

Basal squamous epithelial cells	70.7 nTPM
Esophagus	70.7 nTPM

Bipolar cells	12.1 nTPM
Eye	12.1 nTPM

Paneth cells	13.5 nTPM
Rectum	26.2 nTPM
Colon	7.2 nTPM
Small intestine	6.9 nTPM

Plasma cells	71.6 nTPM
Spleen	124.1 nTPM
Thymus	106.5 nTPM
Liver	101.1 nTPM
Bone marrow	93.6 nTPM
Fallopian tube	45.4 nTPM
Salivary gland	45.2 nTPM
Stomach	36.0 nTPM
Esophagus	20.8 nTPM

Schwann cells	51.0 nTPM
Adipose tissue	76.9 nTPM
Esophagus	47.9 nTPM
Vascular	28.2 nTPM

Serous glandular cells	44.2 nTPM
Tongue	48.6 nTPM
Salivary gland	39.9 nTPM

Smooth muscle cells	37.4 nTPM
Skin	51.5 nTPM
Endometrium	49.5 nTPM
Ovary	47.0 nTPM
Breast	41.2 nTPM
Lung	41.1 nTPM
Vascular	39.1 nTPM
Fallopian tube	38.7 nTPM
Adipose tissue	37.9 nTPM
Salivary gland	36.9 nTPM
Prostate	34.1 nTPM
Skeletal muscle	34.0 nTPM
Placenta	31.6 nTPM
Tongue	31.1 nTPM
Thymus	30.6 nTPM
Esophagus	30.0 nTPM
Liver	24.6 nTPM

Suprabasal keratinocytes	81.0 nTPM
Skin	97.9 nTPM
Tongue	64.1 nTPM

T-cells	62.4 nTPM
Adipose tissue	118.1 nTPM
Fallopian tube	84.4 nTPM
Endometrium	80.3 nTPM
Skin	74.7 nTPM
Breast	71.0 nTPM
Lymph node	65.7 nTPM
Spleen	63.3 nTPM
Tongue	61.0 nTPM
Kidney	60.3 nTPM
Thymus	60.2 nTPM
Esophagus	58.4 nTPM
Colon	57.5 nTPM
Skeletal muscle	55.2 nTPM
Vascular	55.1 nTPM
Liver	54.9 nTPM
Stomach	54.6 nTPM
PBMC	53.0 nTPM
Bone marrow	52.3 nTPM
Prostate	51.1 nTPM
Salivary gland	47.8 nTPM
Lung	31.5 nTPM

Undifferentiated cells	59.7 nTPM
Colon	76.0 nTPM
Small intestine	54.0 nTPM
Rectum	49.0 nTPM

Amygdala excitatory	5.1 nTPM
Hippocampus	6.6 nTPM
Cerebral cortex	5.6 nTPM
Amygdala	5.1 nTPM
Thalamus	5.0 nTPM
Basal ganglia	4.7 nTPM
Hypothalamus	3.8 nTPM

Astrocyte	3.1 nTPM
Medulla oblongata	5.1 nTPM
Cerebellum	3.6 nTPM
Pons	3.5 nTPM
Cerebral cortex	3.4 nTPM
Hippocampus	3.3 nTPM
Basal ganglia	3.2 nTPM
Thalamus	2.9 nTPM
Midbrain	2.8 nTPM
Amygdala	2.4 nTPM
Hypothalamus	2.1 nTPM
Spinal cord	1.8 nTPM

Bergmann glia	4.2 nTPM
Cerebellum	5.5 nTPM
Medulla oblongata	4.3 nTPM
Pons	2.9 nTPM

Central nervous system macrophage	9.1 nTPM
Medulla oblongata	13.1 nTPM
Basal ganglia	11.9 nTPM
Pons	11.3 nTPM
Thalamus	9.1 nTPM
Midbrain	8.7 nTPM
Hippocampus	8.6 nTPM
Cerebellum	8.4 nTPM
Cerebral cortex	8.2 nTPM
Amygdala	7.9 nTPM
Hypothalamus	6.8 nTPM
Spinal cord	5.9 nTPM

Cerebellar inhibitory	8.9 nTPM
Cerebellum	10.7 nTPM
Pons	10.0 nTPM
Medulla oblongata	9.2 nTPM
Midbrain	9.0 nTPM
Spinal cord	5.5 nTPM

Cge interneuron	8.9 nTPM
Thalamus	15.4 nTPM
Midbrain	11.6 nTPM
Hippocampus	8.7 nTPM
Basal ganglia	7.7 nTPM
Cerebral cortex	7.5 nTPM
Amygdala	7.1 nTPM
Hypothalamus	4.5 nTPM

Choroid plexus epithelial cell	4.9 nTPM
Thalamus	11.0 nTPM
Medulla oblongata	4.1 nTPM
Hippocampus	2.8 nTPM
Basal ganglia	1.8 nTPM

Committed oligodendrocyte precursor	5.3 nTPM
Pons	10.6 nTPM
Midbrain	10.1 nTPM
Medulla oblongata	9.0 nTPM
Spinal cord	7.4 nTPM
Basal ganglia	5.5 nTPM
Thalamus	3.8 nTPM
Hippocampus	3.4 nTPM
Cerebral cortex	2.5 nTPM
Amygdala	2.3 nTPM
Hypothalamus	2.0 nTPM
Cerebellum	1.6 nTPM

Deep-layer corticothalamic and 6b	7.4 nTPM
Midbrain	12.2 nTPM
Basal ganglia	7.6 nTPM
Cerebral cortex	7.6 nTPM
Hippocampus	7.5 nTPM
Amygdala	6.8 nTPM
Hypothalamus	3.0 nTPM

Deep-layer intratelencephalic	7.2 nTPM
Cerebral cortex	9.0 nTPM
Hippocampus	8.6 nTPM
Basal ganglia	7.9 nTPM
Amygdala	5.8 nTPM
Hypothalamus	4.4 nTPM

Deep-layer near-projecting	9.4 nTPM
Hippocampus	15.3 nTPM
Basal ganglia	10.9 nTPM
Cerebral cortex	10.0 nTPM
Amygdala	7.7 nTPM
Hypothalamus	3.4 nTPM

Eccentric medium spiny neuron	7.4 nTPM
Hypothalamus	8.8 nTPM
Cerebral cortex	8.5 nTPM
Basal ganglia	8.2 nTPM
Amygdala	6.7 nTPM
Thalamus	6.6 nTPM
Hippocampus	5.4 nTPM