Single cell type - NFU1 - The Human Protein Atlas

NFU1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NFU1
Gene descriptionⁱ Full gene name according to HGNC.	NFU1 iron-sulfur cluster scaffold
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.27
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

NFU1 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 0.98
835 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LCMT1	Leucine carboxyl methyltransferase 1	0.5368	24
PEF1	Penta-EF-hand domain containing 1	0.5007	24
PDHB	Pyruvate dehydrogenase E1 subunit beta	0.4852	68
ISCU	Iron-sulfur cluster assembly enzyme	0.4646	39
MRPL44	Mitochondrial ribosomal protein L44	0.4590	39
SKP1	S-phase kinase associated protein 1	0.4582	39
ERAL1	Era like 12S mitochondrial rRNA chaperone 1	0.4575	24
DLD	Dihydrolipoamide dehydrogenase	0.4568	39
PMF1	Polyamine modulated factor 1	0.4499	39
ECH1	Enoyl-CoA hydratase 1	0.4381	24
PRPF31	Pre-mRNA processing factor 31	0.4366	39
ATP5F1A	ATP synthase F1 subunit alpha	0.4156	39
FN3KRP	Fructosamine 3 kinase related protein	0.4155	24
COX11	Cytochrome c oxidase copper chaperone COX11	0.4140	39
NDUFA10	NADH:ubiquinone oxidoreductase subunit A10	0.4125	39

IMMUNE CELLS

NFU1 is part of cluster 5 Non-specific - Cell proliferation with confidenceⁱ 1
689 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZRANB2	Zinc finger RANBP2-type containing 2	0.9524	5
CENPL	Centromere protein L	0.9286	5
VRK1	VRK serine/threonine kinase 1	0.9048	5
MRPL39	Mitochondrial ribosomal protein L39	0.9048	5
BET1	Bet1 golgi vesicular membrane trafficking protein	0.9048	5
ERLEC1	Endoplasmic reticulum lectin 1	0.9048	5
FNBP4	Formin binding protein 4	0.8810	22
KIF20B	Kinesin family member 20B	0.8810	5
CFAP298	Cilia and flagella associated protein 298	0.8810	12
YBEY	YbeY metalloendoribonuclease	0.8810	5
KDM4C	Lysine demethylase 4C	0.8571	5
ARHGEF7	Rho guanine nucleotide exchange factor 7	0.8571	22
SINHCAF	SIN3-HDAC complex associated factor	0.8571	5
MBNL2	Muscleblind like splicing regulator 2	0.8571	5
MGAT5	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	0.8571	22

Adipocytes	30.7 nTPM
Breast	33.7 nTPM
Adipose tissue	27.7 nTPM

Alveolar cells type 1	32.7 nTPM
Lung	32.7 nTPM

Alveolar cells type 2	33.1 nTPM
Lung	33.1 nTPM

Astrocytes	9.3 nTPM
Brain	9.3 nTPM

B-cells	29.7 nTPM
PBMC	58.5 nTPM
Kidney	36.4 nTPM
Liver	33.8 nTPM
Lung	32.2 nTPM
Stomach	32.1 nTPM
Adipose tissue	30.5 nTPM
Thymus	29.9 nTPM
Salivary gland	27.8 nTPM
Spleen	27.2 nTPM
Skin	27.1 nTPM
Lymph node	22.8 nTPM
Bone marrow	22.2 nTPM
Esophagus	5.9 nTPM

Ciliated cells	47.9 nTPM
Fallopian tube	52.9 nTPM
Bronchus	50.7 nTPM
Lung	47.1 nTPM
Endometrium	40.9 nTPM

Club cells	40.5 nTPM
Bronchus	58.2 nTPM
Lung	32.6 nTPM
Prostate	30.8 nTPM

Dendritic cells	21.2 nTPM
Adipose tissue	24.3 nTPM
PBMC	18.0 nTPM

Endothelial cells	31.9 nTPM
Placenta	68.1 nTPM
Ovary	47.3 nTPM
Testis	40.0 nTPM
Skeletal muscle	37.1 nTPM
Pancreas	36.2 nTPM
Breast	36.0 nTPM
Lung	33.4 nTPM
Fallopian tube	32.2 nTPM
Skin	31.7 nTPM
Thymus	29.9 nTPM
Heart muscle	28.9 nTPM
Vascular	26.8 nTPM
Liver	25.2 nTPM
Prostate	24.3 nTPM
Tongue	23.2 nTPM
Endometrium	20.3 nTPM
Salivary gland	18.4 nTPM
Esophagus	15.6 nTPM

Enteroendocrine cells	45.0 nTPM
Colon	60.5 nTPM
Rectum	43.6 nTPM
Small intestine	30.9 nTPM

Fibroblasts	32.2 nTPM
Pancreas	64.8 nTPM
Fallopian tube	40.5 nTPM
Skeletal muscle	38.1 nTPM
Breast	36.5 nTPM
Adipose tissue	36.4 nTPM
Liver	35.6 nTPM
Placenta	31.6 nTPM
Thymus	31.3 nTPM
Prostate	31.0 nTPM
Skin	28.6 nTPM
Lung	28.0 nTPM
Vascular	27.6 nTPM
Salivary gland	26.8 nTPM
Heart muscle	26.3 nTPM
Esophagus	18.9 nTPM
Stomach	13.0 nTPM

Granulocytes	36.7 nTPM
Fallopian tube	49.0 nTPM
Lung	36.8 nTPM
Tongue	24.3 nTPM

Intestinal goblet cells	46.2 nTPM
Colon	53.6 nTPM
Rectum	48.0 nTPM
Small intestine	36.9 nTPM

Lymphatic endothelial cells	45.4 nTPM
Ovary	49.1 nTPM
Fallopian tube	41.7 nTPM

Macrophages	27.4 nTPM
Lung	54.2 nTPM
Testis	47.7 nTPM
Pancreas	47.3 nTPM
Kidney	42.5 nTPM
Spleen	32.1 nTPM
Prostate	28.7 nTPM
Breast	27.0 nTPM
Fallopian tube	25.4 nTPM
Vascular	24.3 nTPM
Thymus	22.7 nTPM
Adipose tissue	20.9 nTPM
Tongue	20.6 nTPM
Skeletal muscle	20.2 nTPM
Esophagus	19.3 nTPM
Bone marrow	19.3 nTPM
Skin	18.9 nTPM
Endometrium	17.8 nTPM
Salivary gland	16.8 nTPM
Stomach	15.4 nTPM

Basal keratinocytes	17.0 nTPM
Tongue	21.3 nTPM
Skin	12.6 nTPM

Basal respiratory cells	90.1 nTPM
Bronchus	90.1 nTPM

Basal squamous epithelial cells	16.2 nTPM
Esophagus	16.2 nTPM

Bipolar cells	21.5 nTPM
Eye	21.5 nTPM

Paneth cells	41.0 nTPM
Rectum	49.3 nTPM
Small intestine	44.9 nTPM
Colon	28.9 nTPM

Plasma cells	31.1 nTPM
Liver	49.1 nTPM
Spleen	45.0 nTPM
Thymus	43.3 nTPM
Fallopian tube	31.8 nTPM
Stomach	21.8 nTPM
Esophagus	20.8 nTPM
Salivary gland	18.8 nTPM
Bone marrow	18.1 nTPM

Schwann cells	25.4 nTPM
Adipose tissue	26.2 nTPM
Vascular	26.1 nTPM
Esophagus	24.0 nTPM

Serous glandular cells	17.4 nTPM
Salivary gland	25.9 nTPM
Tongue	8.8 nTPM

Smooth muscle cells	47.9 nTPM
Fallopian tube	73.5 nTPM
Ovary	73.2 nTPM
Placenta	72.2 nTPM
Skeletal muscle	57.6 nTPM
Breast	51.7 nTPM
Skin	50.8 nTPM
Esophagus	49.3 nTPM
Thymus	48.7 nTPM
Adipose tissue	47.9 nTPM
Vascular	45.3 nTPM
Prostate	38.9 nTPM
Lung	37.6 nTPM
Liver	35.7 nTPM
Salivary gland	32.9 nTPM
Tongue	26.9 nTPM
Endometrium	24.3 nTPM

Suprabasal keratinocytes	21.2 nTPM
Tongue	28.1 nTPM
Skin	14.3 nTPM

T-cells	32.7 nTPM
Colon	79.9 nTPM
Fallopian tube	70.5 nTPM
Adipose tissue	42.3 nTPM
Kidney	39.9 nTPM
Skin	35.7 nTPM
Stomach	35.3 nTPM
PBMC	33.9 nTPM
Spleen	31.9 nTPM
Liver	30.6 nTPM
Prostate	29.3 nTPM
Skeletal muscle	28.7 nTPM
Breast	28.7 nTPM
Lung	28.5 nTPM
Thymus	26.4 nTPM
Tongue	25.4 nTPM
Lymph node	22.4 nTPM
Bone marrow	22.3 nTPM
Endometrium	20.5 nTPM
Salivary gland	19.5 nTPM
Vascular	19.3 nTPM
Esophagus	14.6 nTPM

Undifferentiated cells	56.4 nTPM
Rectum	58.6 nTPM
Colon	57.6 nTPM
Small intestine	52.9 nTPM

Amygdala excitatory	28.2 nTPM
Thalamus	35.4 nTPM
Hypothalamus	31.4 nTPM
Amygdala	27.8 nTPM
Basal ganglia	27.6 nTPM
Cerebral cortex	24.1 nTPM
Hippocampus	23.1 nTPM

Astrocyte	25.3 nTPM
Amygdala	29.4 nTPM
Hypothalamus	27.8 nTPM
Cerebellum	26.5 nTPM
Thalamus	26.5 nTPM
Basal ganglia	26.4 nTPM
Pons	25.3 nTPM
Hippocampus	24.8 nTPM
Medulla oblongata	24.6 nTPM
Midbrain	24.1 nTPM
Cerebral cortex	23.1 nTPM
Spinal cord	20.1 nTPM

Bergmann glia	24.3 nTPM
Cerebellum	25.7 nTPM
Medulla oblongata	25.6 nTPM
Pons	21.6 nTPM

Central nervous system macrophage	33.7 nTPM
Amygdala	37.3 nTPM
Medulla oblongata	34.9 nTPM
Cerebellum	34.7 nTPM
Hippocampus	34.4 nTPM
Basal ganglia	34.2 nTPM
Thalamus	34.0 nTPM
Cerebral cortex	33.4 nTPM
Pons	33.4 nTPM
Midbrain	33.0 nTPM
Hypothalamus	31.5 nTPM
Spinal cord	30.0 nTPM

Cerebellar inhibitory	30.4 nTPM
Spinal cord	49.5 nTPM
Medulla oblongata	27.3 nTPM
Pons	26.9 nTPM
Cerebellum	24.8 nTPM
Midbrain	23.3 nTPM

Cge interneuron	30.5 nTPM
Hypothalamus	34.1 nTPM
Thalamus	32.9 nTPM
Amygdala	31.0 nTPM
Basal ganglia	30.5 nTPM
Hippocampus	28.7 nTPM
Midbrain	28.3 nTPM
Cerebral cortex	28.0 nTPM

Choroid plexus epithelial cell	40.3 nTPM
Thalamus	60.3 nTPM
Basal ganglia	50.5 nTPM
Medulla oblongata	36.7 nTPM
Hippocampus	13.9 nTPM

Committed oligodendrocyte precursor	33.1 nTPM
Cerebral cortex	40.5 nTPM
Amygdala	37.2 nTPM
Hippocampus	37.0 nTPM
Thalamus	34.9 nTPM
Pons	34.5 nTPM
Hypothalamus	33.5 nTPM
Cerebellum	31.7 nTPM
Medulla oblongata	31.0 nTPM
Midbrain	29.4 nTPM
Basal ganglia	29.0 nTPM
Spinal cord	25.8 nTPM

Deep-layer corticothalamic and 6b	26.9 nTPM
Hypothalamus	33.5 nTPM
Amygdala	26.6 nTPM
Hippocampus	26.6 nTPM
Midbrain	25.5 nTPM
Basal ganglia	25.3 nTPM
Cerebral cortex	23.7 nTPM

Deep-layer intratelencephalic	30.1 nTPM
Hypothalamus	35.6 nTPM
Basal ganglia	31.9 nTPM
Amygdala	28.5 nTPM
Hippocampus	27.8 nTPM
Cerebral cortex	26.9 nTPM

Deep-layer near-projecting	27.8 nTPM
Hypothalamus	35.3 nTPM
Amygdala	28.4 nTPM
Basal ganglia	26.6 nTPM
Hippocampus	25.4 nTPM
Cerebral cortex	23.4 nTPM

Eccentric medium spiny neuron	22.6 nTPM
Amygdala	24.4 nTPM
Hypothalamus	23.5 nTPM
Cerebral cortex	22.6 nTPM
Thalamus	22.6 nTPM
Hippocampus	22.0 nTPM
Basal ganglia	20.6 nTPM