Single cell type - CXCL8 - The Human Protein Atlas

CXCL8

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CXCL8
Gene descriptionⁱ Full gene name according to HGNC.	C-X-C motif chemokine ligand 8
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Candidate cardiovascular disease genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Monocytes - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Langerhans cells, Basal respiratory cells, Ionocytes, Monocytes, Macrophages)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.66
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Endothelial cell, Fibroblast, Central nervous system macrophage)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enriched (neutrophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Langerhans cells, Basal respiratory cells, Ionocytes, Monocytes, Macrophages)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Endothelial cell, Fibroblast, Central nervous system macrophage)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enriched (neutrophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

CXCL8 is part of cluster 29 Monocytes - Innate immune response with confidenceⁱ 0.95
447 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CXCL3	C-X-C motif chemokine ligand 3	0.8900	29
SAT1	Spermidine/spermine N1-acetyltransferase 1	0.7925	35
IRAK2	Interleukin 1 receptor associated kinase 2	0.7705	29
CXCL2	C-X-C motif chemokine ligand 2	0.7495	29
G0S2	G0/G1 switch 2	0.7478	29
IL1R2	Interleukin 1 receptor type 2	0.7290	28
CLEC10A	C-type lectin domain containing 10A	0.7196	28
NINJ1	Ninjurin 1	0.7182	29
ZNF267	Zinc finger protein 267	0.7150	29
VENTX	VENT homeobox	0.7037	29
OR2B11	Olfactory receptor family 2 subfamily B member 11	0.7004	29
NFKB1	Nuclear factor kappa B subunit 1	0.6956	29
PLAUR	Plasminogen activator, urokinase receptor	0.6855	29
VEGFA	Vascular endothelial growth factor A	0.6852	29
GNA13	G protein subunit alpha 13	0.6768	28

IMMUNE CELLS

CXCL8 is part of cluster 4 Neutrophils - Degranulation with confidenceⁱ 1
86 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ELAPOR1	Endosome-lysosome associated apoptosis and autophagy regulator 1	1.0000	4
SLPI	Secretory leukocyte peptidase inhibitor	1.0000	4
FAM209A	Family with sequence similarity 209 member A	1.0000	4
PI3	Peptidase inhibitor 3	1.0000	4
C4BPA	Complement component 4 binding protein alpha	1.0000	4
G0S2	G0/G1 switch 2	1.0000	4
TNFAIP6	TNF alpha induced protein 6	1.0000	4
CALD1	Caldesmon 1	1.0000	4
SPP1	Secreted phosphoprotein 1	1.0000	4
ARG1	Arginase 1	1.0000	4
PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	1.0000	4
IL1R2	Interleukin 1 receptor type 2	1.0000	4
OTX1	Orthodenticle homeobox 1	1.0000	4
ARRDC3	Arrestin domain containing 3	1.0000	4
MANSC1	MANSC domain containing 1	1.0000	4

Adipocytes	18.5 nTPM
Breast	23.6 nTPM
Adipose tissue	13.4 nTPM

Alveolar cells type 1	44.4 nTPM
Lung	44.4 nTPM

Alveolar cells type 2	466.2 nTPM
Lung	466.2 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	56.7 nTPM
Skin	640.3 nTPM
Adipose tissue	48.1 nTPM
Spleen	20.6 nTPM
Lung	9.4 nTPM
Esophagus	5.9 nTPM
Kidney	5.2 nTPM
Salivary gland	3.7 nTPM
Thymus	2.5 nTPM
Stomach	1.7 nTPM
Lymph node	0.2 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM

Basal squamous epithelial cells	196.1 nTPM
Esophagus	196.1 nTPM

Ciliated cells	431.9 nTPM
Endometrium	718.4 nTPM
Bronchus	712.9 nTPM
Fallopian tube	232.9 nTPM
Lung	63.5 nTPM

Club cells	1711.6 nTPM
Bronchus	3966.6 nTPM
Lung	1145.8 nTPM
Prostate	22.5 nTPM

Dendritic cells	146.8 nTPM
Adipose tissue	293.7 nTPM
PBMC	0.0 nTPM

Endothelial cells	97.3 nTPM
Pancreas	612.7 nTPM
Skin	429.1 nTPM
Endometrium	121.5 nTPM
Salivary gland	102.0 nTPM
Fallopian tube	90.6 nTPM
Lung	85.1 nTPM
Vascular	58.6 nTPM
Skeletal muscle	56.7 nTPM
Tongue	54.1 nTPM
Ovary	30.4 nTPM
Thymus	29.4 nTPM
Prostate	29.2 nTPM
Liver	23.9 nTPM
Heart muscle	10.0 nTPM
Placenta	8.5 nTPM
Esophagus	6.9 nTPM
Testis	1.2 nTPM
Breast	0.9 nTPM

Enteroendocrine cells	22.0 nTPM
Colon	52.7 nTPM
Rectum	13.4 nTPM
Small intestine	0.0 nTPM

Fibroblasts	116.9 nTPM
Pancreas	466.7 nTPM
Fallopian tube	434.3 nTPM
Skeletal muscle	377.7 nTPM
Skin	174.0 nTPM
Stomach	128.3 nTPM
Lung	91.7 nTPM
Vascular	61.6 nTPM
Salivary gland	37.3 nTPM
Esophagus	31.5 nTPM
Thymus	25.5 nTPM
Adipose tissue	20.1 nTPM
Heart muscle	9.5 nTPM
Liver	4.7 nTPM
Placenta	2.6 nTPM
Prostate	2.6 nTPM
Breast	2.4 nTPM

Glandular and luminal cells	1804.3 nTPM
Endometrium	1804.3 nTPM

Granulocytes	34.2 nTPM
Fallopian tube	63.2 nTPM
Lung	20.2 nTPM
Tongue	19.4 nTPM

Intestinal goblet cells	19.0 nTPM
Colon	52.4 nTPM
Rectum	3.4 nTPM
Small intestine	1.3 nTPM

Bipolar cells	3.2 nTPM
Eye	3.2 nTPM

Cholangiocytes	141.2 nTPM
Liver	141.2 nTPM

Collecting duct cells	3.9 nTPM
Kidney	3.9 nTPM

Cytotrophoblasts	2.2 nTPM
Placenta	2.2 nTPM

Lymphatic endothelial cells	63.5 nTPM
Fallopian tube	121.6 nTPM
Ovary	5.5 nTPM

Macrophages	3724.4 nTPM
Adipose tissue	15430.7 nTPM
Skin	14501.3 nTPM
Pancreas	9574.8 nTPM
Fallopian tube	7811.8 nTPM
Endometrium	3840.5 nTPM
Skeletal muscle	3002.8 nTPM
Testis	2360.1 nTPM
Vascular	2307.9 nTPM
Spleen	2034.1 nTPM
Tongue	2030.4 nTPM
Breast	1962.5 nTPM
Esophagus	1617.0 nTPM
Salivary gland	1588.2 nTPM
Stomach	1363.2 nTPM
Prostate	699.5 nTPM
Lung	265.0 nTPM
Kidney	197.4 nTPM
Thymus	163.3 nTPM
Bone marrow	12.2 nTPM

Paneth cells	1.4 nTPM
Colon	3.6 nTPM
Rectum	0.7 nTPM
Small intestine	0.0 nTPM

Plasma cells	16.1 nTPM
Salivary gland	97.1 nTPM
Fallopian tube	21.2 nTPM
Liver	4.0 nTPM
Spleen	3.4 nTPM
Thymus	1.5 nTPM
Stomach	1.3 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Schwann cells	388.5 nTPM
Adipose tissue	1159.8 nTPM
Vascular	5.7 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	126.9 nTPM
Salivary gland	143.3 nTPM
Tongue	110.5 nTPM

Smooth muscle cells	46.7 nTPM
Skeletal muscle	196.6 nTPM
Skin	117.6 nTPM
Endometrium	104.3 nTPM
Tongue	73.6 nTPM
Salivary gland	49.1 nTPM
Fallopian tube	45.9 nTPM
Adipose tissue	32.3 nTPM
Vascular	31.4 nTPM
Lung	29.4 nTPM
Placenta	19.6 nTPM
Liver	14.9 nTPM
Prostate	13.4 nTPM
Breast	9.3 nTPM
Ovary	4.3 nTPM
Thymus	2.7 nTPM
Esophagus	2.4 nTPM

Suprabasal keratinocytes	98.4 nTPM
Skin	121.4 nTPM
Tongue	75.3 nTPM

T-cells	61.2 nTPM
Colon	670.8 nTPM
Endometrium	201.0 nTPM
Skin	154.9 nTPM
Fallopian tube	52.7 nTPM
Vascular	52.3 nTPM
Adipose tissue	35.2 nTPM
Lung	29.7 nTPM
Tongue	19.3 nTPM
Salivary gland	19.0 nTPM
Skeletal muscle	16.3 nTPM
Prostate	9.7 nTPM
Spleen	8.2 nTPM
Esophagus	7.3 nTPM
Breast	4.4 nTPM
Liver	3.2 nTPM
Stomach	1.3 nTPM
Thymus	0.5 nTPM
Lymph node	0.3 nTPM
Bone marrow	0.1 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM

Undifferentiated cells	10.6 nTPM
Colon	26.5 nTPM
Rectum	4.6 nTPM
Small intestine	0.7 nTPM

Amygdala excitatory	0.0 nTPM
Amygdala	0.0 nTPM
Basal ganglia	0.0 nTPM
Cerebral cortex	0.0 nTPM
Hippocampus	0.0 nTPM
Hypothalamus	0.0 nTPM
Thalamus	0.0 nTPM

Astrocyte	0.0 nTPM
Medulla oblongata	0.1 nTPM
Amygdala	0.0 nTPM
Basal ganglia	0.0 nTPM
Cerebellum	0.0 nTPM
Cerebral cortex	0.0 nTPM
Hippocampus	0.0 nTPM
Hypothalamus	0.0 nTPM
Midbrain	0.0 nTPM
Pons	0.0 nTPM
Spinal cord	0.0 nTPM
Thalamus	0.0 nTPM

Bergmann glia	0.0 nTPM
Cerebellum	0.0 nTPM
Medulla oblongata	0.0 nTPM
Pons	0.0 nTPM

Central nervous system macrophage	2.4 nTPM
Hypothalamus	17.7 nTPM
Medulla oblongata	3.0 nTPM
Pons	1.4 nTPM
Thalamus	1.3 nTPM
Spinal cord	1.2 nTPM
Cerebellum	0.5 nTPM
Cerebral cortex	0.4 nTPM
Midbrain	0.4 nTPM
Basal ganglia	0.2 nTPM
Amygdala	0.1 nTPM
Hippocampus	0.1 nTPM

Cerebellar inhibitory	0.0 nTPM
Cerebellum	0.0 nTPM
Medulla oblongata	0.0 nTPM
Midbrain	0.0 nTPM
Pons	0.0 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	0.0 nTPM
Amygdala	0.0 nTPM
Basal ganglia	0.0 nTPM
Cerebral cortex	0.0 nTPM
Hippocampus	0.0 nTPM
Hypothalamus	0.0 nTPM
Midbrain	0.0 nTPM
Thalamus	0.0 nTPM

Choroid plexus epithelial cell	0.0 nTPM
Medulla oblongata	0.1 nTPM
Basal ganglia	0.0 nTPM
Hippocampus	0.0 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	0.0 nTPM
Thalamus	0.0 nTPM
Amygdala	0.0 nTPM
Basal ganglia	0.0 nTPM
Cerebellum	0.0 nTPM
Cerebral cortex	0.0 nTPM
Hippocampus	0.0 nTPM
Hypothalamus	0.0 nTPM
Medulla oblongata	0.0 nTPM
Midbrain	0.0 nTPM
Pons	0.0 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	0.0 nTPM
Amygdala	0.0 nTPM
Basal ganglia	0.0 nTPM
Cerebral cortex	0.0 nTPM
Hippocampus	0.0 nTPM
Hypothalamus	0.0 nTPM
Midbrain	0.0 nTPM

Deep-layer intratelencephalic	0.1 nTPM
Basal ganglia	0.1 nTPM
Cerebral cortex	0.1 nTPM
Hippocampus	0.1 nTPM
Hypothalamus	0.1 nTPM
Amygdala	0.0 nTPM