Single cell type - TET2 - The Human Protein Atlas

TET2

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TET2
Gene descriptionⁱ Full gene name according to HGNC.	Tet methylcytosine dioxygenase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes Enzymes Human disease related genes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Monocytes - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Monocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.51
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (neutrophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Monocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (neutrophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TET2 is part of cluster 29 Monocytes - Innate immune response with confidenceⁱ 0.95
447 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IL1B	Interleukin 1 beta	0.7772	29
NLRP3	NLR family pyrin domain containing 3	0.7727	29
CSGALNACT2	Chondroitin sulfate N-acetylgalactosaminyltransferase 2	0.7613	29
EREG	Epiregulin	0.7429	29
C9orf72	C9orf72-SMCR8 complex subunit	0.7423	29
ITGAX	Integrin subunit alpha X	0.7299	29
OR2B11	Olfactory receptor family 2 subfamily B member 11	0.7293	29
RILPL2	Rab interacting lysosomal protein like 2	0.7267	29
LIPN	Lipase family member N	0.7221	29
PPIF	Peptidylprolyl isomerase F	0.7206	29
DENND5A	DENN domain containing 5A	0.7103	29
C5AR1	Complement C5a receptor 1	0.7093	29
BCL2A1	BCL2 related protein A1	0.7084	29
PTPRE	Protein tyrosine phosphatase receptor type E	0.6934	29
RP2	RP2 activator of ARL3 GTPase	0.6903	29

IMMUNE CELLS

TET2 is part of cluster 21 Neutrophils - Unknown function with confidenceⁱ 0.79
492 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PIAS1	Protein inhibitor of activated STAT 1	1.0000	21
FAM200B	Family with sequence similarity 200 member B	1.0000	21
MPPE1	Metallophosphoesterase 1	0.9762	21
RRAGD	Ras related GTP binding D	0.9762	35
ANKRD34B	Ankyrin repeat domain 34B	0.9762	21
MTARC1	Mitochondrial amidoxime reducing component 1	0.9762	21
NOP10	NOP10 ribonucleoprotein	0.9762	35
SLC16A5	Solute carrier family 16 member 5	0.9762	35
HNRNPK	Heterogeneous nuclear ribonucleoprotein K	0.9762	35
F2RL1	F2R like trypsin receptor 1	0.9762	21
PADI4	Peptidyl arginine deiminase 4	0.9762	21
FBXL5	F-box and leucine rich repeat protein 5	0.9762	21
TMEM91	Transmembrane protein 91	0.9762	21
FLOT1	Flotillin 1	0.9762	35
AGO4	Argonaute RISC component 4	0.9762	21

Adipocytes	22.7 nTPM
Adipose tissue	23.1 nTPM
Breast	22.2 nTPM

Alveolar cells type 1	8.9 nTPM
Lung	8.9 nTPM

Alveolar cells type 2	16.0 nTPM
Lung	16.0 nTPM

Astrocytes	55.7 nTPM
Brain	55.7 nTPM

B-cells	26.7 nTPM
Adipose tissue	76.1 nTPM
Skin	59.3 nTPM
Salivary gland	30.6 nTPM
Stomach	27.0 nTPM
Spleen	26.7 nTPM
Esophagus	23.6 nTPM
PBMC	23.1 nTPM
Lymph node	20.6 nTPM
Thymus	16.8 nTPM
Lung	14.8 nTPM
Liver	14.5 nTPM
Bone marrow	9.1 nTPM
Kidney	5.2 nTPM

Ciliated cells	17.9 nTPM
Bronchus	20.8 nTPM
Endometrium	19.9 nTPM
Fallopian tube	16.0 nTPM
Lung	14.8 nTPM

Club cells	28.0 nTPM
Prostate	32.9 nTPM
Lung	25.8 nTPM
Bronchus	25.4 nTPM

Dendritic cells	109.6 nTPM
Adipose tissue	201.2 nTPM
PBMC	18.0 nTPM

Endothelial cells	19.7 nTPM
Heart muscle	43.8 nTPM
Endometrium	32.2 nTPM
Salivary gland	28.1 nTPM
Skeletal muscle	27.7 nTPM
Vascular	24.4 nTPM
Tongue	22.0 nTPM
Prostate	21.7 nTPM
Esophagus	21.1 nTPM
Liver	18.9 nTPM
Thymus	18.4 nTPM
Pancreas	18.1 nTPM
Ovary	15.4 nTPM
Lung	14.9 nTPM
Breast	13.2 nTPM
Skin	12.9 nTPM
Fallopian tube	10.3 nTPM
Testis	6.4 nTPM
Placenta	4.5 nTPM

Enteroendocrine cells	11.5 nTPM
Colon	14.1 nTPM
Rectum	13.4 nTPM
Small intestine	6.9 nTPM

Fibroblasts	15.4 nTPM
Heart muscle	36.5 nTPM
Fallopian tube	27.9 nTPM
Esophagus	23.8 nTPM
Salivary gland	21.8 nTPM
Stomach	21.6 nTPM
Prostate	16.5 nTPM
Vascular	14.6 nTPM
Skeletal muscle	13.9 nTPM
Breast	12.9 nTPM
Adipose tissue	12.2 nTPM
Thymus	10.1 nTPM
Liver	8.3 nTPM
Lung	7.0 nTPM
Skin	6.5 nTPM
Placenta	6.3 nTPM
Pancreas	6.3 nTPM

Granulocytes	37.6 nTPM
Fallopian tube	53.2 nTPM
Tongue	34.0 nTPM
Lung	25.7 nTPM

Intestinal goblet cells	16.6 nTPM
Small intestine	21.1 nTPM
Rectum	16.9 nTPM
Colon	11.8 nTPM

Lymphatic endothelial cells	13.3 nTPM
Fallopian tube	15.7 nTPM
Ovary	10.9 nTPM

Macrophages	109.4 nTPM
Adipose tissue	341.8 nTPM
Fallopian tube	269.6 nTPM
Skeletal muscle	264.7 nTPM
Spleen	149.4 nTPM
Stomach	141.5 nTPM
Tongue	125.4 nTPM
Endometrium	95.9 nTPM
Esophagus	91.2 nTPM
Salivary gland	81.0 nTPM
Vascular	74.5 nTPM
Breast	63.5 nTPM
Skin	60.2 nTPM
Kidney	56.6 nTPM
Prostate	54.0 nTPM
Thymus	53.1 nTPM
Testis	52.1 nTPM
Bone marrow	48.6 nTPM
Lung	37.0 nTPM
Pancreas	18.5 nTPM

Basal prostatic cells	20.1 nTPM
Prostate	20.1 nTPM

Basal respiratory cells	14.4 nTPM
Bronchus	14.4 nTPM

Basal squamous epithelial cells	19.5 nTPM
Esophagus	19.5 nTPM

Bipolar cells	17.0 nTPM
Eye	17.0 nTPM

Paneth cells	12.8 nTPM
Small intestine	17.3 nTPM
Rectum	13.8 nTPM
Colon	7.2 nTPM

Plasma cells	13.3 nTPM
Salivary gland	26.9 nTPM
Fallopian tube	25.1 nTPM
Thymus	12.8 nTPM
Spleen	12.5 nTPM
Stomach	11.3 nTPM
Bone marrow	10.6 nTPM
Liver	7.0 nTPM
Esophagus	0.0 nTPM

Schwann cells	85.1 nTPM
Adipose tissue	188.9 nTPM
Esophagus	35.9 nTPM
Vascular	30.3 nTPM

Serous glandular cells	23.9 nTPM
Salivary gland	30.1 nTPM
Tongue	17.7 nTPM

Smooth muscle cells	18.0 nTPM
Endometrium	38.6 nTPM
Salivary gland	32.0 nTPM
Tongue	25.7 nTPM
Adipose tissue	20.7 nTPM
Vascular	18.3 nTPM
Esophagus	18.0 nTPM
Skeletal muscle	17.9 nTPM
Ovary	17.8 nTPM
Prostate	15.8 nTPM
Breast	15.5 nTPM
Lung	15.3 nTPM
Thymus	13.5 nTPM
Fallopian tube	13.2 nTPM
Liver	11.9 nTPM
Placenta	7.2 nTPM
Skin	6.0 nTPM

Suprabasal keratinocytes	39.6 nTPM
Tongue	45.0 nTPM
Skin	34.3 nTPM

T-cells	20.6 nTPM
Adipose tissue	40.2 nTPM
Endometrium	36.0 nTPM
Tongue	34.7 nTPM
Skeletal muscle	34.0 nTPM
Fallopian tube	31.4 nTPM
Salivary gland	29.6 nTPM
Vascular	25.7 nTPM
Colon	19.5 nTPM
Lymph node	17.7 nTPM
Stomach	17.1 nTPM
Esophagus	17.0 nTPM
Prostate	16.4 nTPM
Breast	15.8 nTPM
Spleen	14.4 nTPM
Liver	14.1 nTPM
Bone marrow	14.0 nTPM
Thymus	13.5 nTPM
Lung	11.8 nTPM
Skin	11.2 nTPM
PBMC	10.5 nTPM
Kidney	8.0 nTPM

Undifferentiated cells	10.3 nTPM
Small intestine	12.4 nTPM
Rectum	10.0 nTPM
Colon	8.6 nTPM

Amygdala excitatory	92.7 nTPM
Thalamus	116.2 nTPM
Hypothalamus	101.3 nTPM
Amygdala	89.3 nTPM
Hippocampus	88.4 nTPM
Cerebral cortex	80.9 nTPM
Basal ganglia	80.2 nTPM

Astrocyte	164.3 nTPM
Amygdala	238.1 nTPM
Hypothalamus	190.4 nTPM
Midbrain	176.2 nTPM
Thalamus	175.3 nTPM
Pons	167.4 nTPM
Basal ganglia	158.8 nTPM
Cerebellum	154.6 nTPM
Medulla oblongata	146.5 nTPM
Spinal cord	140.1 nTPM
Hippocampus	139.3 nTPM
Cerebral cortex	120.9 nTPM

Bergmann glia	246.8 nTPM
Cerebellum	264.4 nTPM
Pons	246.0 nTPM
Medulla oblongata	230.2 nTPM

Central nervous system macrophage	419.9 nTPM
Amygdala	664.2 nTPM
Hypothalamus	483.1 nTPM
Midbrain	430.4 nTPM
Basal ganglia	414.4 nTPM
Thalamus	409.3 nTPM
Hippocampus	406.4 nTPM
Spinal cord	382.4 nTPM
Pons	373.4 nTPM
Cerebellum	367.9 nTPM
Cerebral cortex	356.3 nTPM
Medulla oblongata	331.3 nTPM

Cerebellar inhibitory	50.8 nTPM
Medulla oblongata	58.0 nTPM
Pons	52.9 nTPM
Midbrain	52.6 nTPM
Cerebellum	52.3 nTPM
Spinal cord	38.5 nTPM

Cge interneuron	128.1 nTPM
Thalamus	147.9 nTPM
Hypothalamus	144.0 nTPM
Amygdala	140.4 nTPM
Midbrain	128.3 nTPM
Basal ganglia	115.2 nTPM
Hippocampus	112.8 nTPM
Cerebral cortex	107.9 nTPM

Choroid plexus epithelial cell	178.3 nTPM
Basal ganglia	254.8 nTPM
Medulla oblongata	163.4 nTPM
Hippocampus	158.1 nTPM
Thalamus	137.0 nTPM

Committed oligodendrocyte precursor	154.0 nTPM
Amygdala	193.4 nTPM
Spinal cord	184.0 nTPM
Hippocampus	172.6 nTPM
Cerebellum	171.2 nTPM
Midbrain	168.8 nTPM
Hypothalamus	154.3 nTPM
Cerebral cortex	141.2 nTPM
Basal ganglia	136.9 nTPM
Thalamus	133.5 nTPM
Pons	123.1 nTPM
Medulla oblongata	114.9 nTPM

Deep-layer corticothalamic and 6b	80.5 nTPM
Amygdala	93.7 nTPM
Hypothalamus	85.8 nTPM
Hippocampus	81.8 nTPM
Basal ganglia	80.4 nTPM
Cerebral cortex	75.6 nTPM
Midbrain	65.5 nTPM

Deep-layer intratelencephalic	68.9 nTPM
Hypothalamus	82.5 nTPM
Hippocampus	76.1 nTPM
Amygdala	64.6 nTPM
Basal ganglia	61.3 nTPM
Cerebral cortex	59.8 nTPM

Deep-layer near-projecting	121.7 nTPM
Hypothalamus	149.8 nTPM
Amygdala	128.8 nTPM
Cerebral cortex	126.4 nTPM
Hippocampus	111.2 nTPM
Basal ganglia	92.4 nTPM

Eccentric medium spiny neuron	131.9 nTPM
Hippocampus	145.5 nTPM
Amygdala	139.2 nTPM
Thalamus	132.8 nTPM
Hypothalamus	127.7 nTPM
Cerebral cortex	123.7 nTPM
Basal ganglia	122.7 nTPM