Single cell type - ZNF30 - The Human Protein Atlas

ZNF30

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZNF30
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger protein 30
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Photoreceptor cells - Visual perception (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Cone photoreceptor cells, Excitatory neurons, Oligodendrocytes, Inhibitory neurons, Rod photoreceptor cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.66
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Cone photoreceptor cells, Excitatory neurons, Oligodendrocytes, Inhibitory neurons, Rod photoreceptor cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ZNF30 is part of cluster 66 Photoreceptor cells - Visual perception with confidenceⁱ 1
340 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
UBAP1L	Ubiquitin associated protein 1 like	0.5926	66
GABRA6	Gamma-aminobutyric acid type A receptor subunit alpha6	0.5698	65
NTNG2	Netrin G2	0.5666	66
ARHGEF9	Cdc42 guanine nucleotide exchange factor 9	0.5655	66
CALB1	Calbindin 1	0.5180	66
FRMPD1	FERM and PDZ domain containing 1	0.5170	66
PSKH2	Protein serine kinase H2	0.5144	66
GJD2	Gap junction protein delta 2	0.5027	66
PDE6C	Phosphodiesterase 6C	0.4982	66
GUCA1B	Guanylate cyclase activator 1B	0.4920	66
MPP4	MAGUK p55 scaffold protein 4	0.4898	66
RP1L1	RP1 like 1	0.4892	66
GRK7	G protein-coupled receptor kinase 7	0.4891	66
CPLX4	Complexin 4	0.4865	66
STXBP1	Syntaxin binding protein 1	0.4860	66

IMMUNE CELLS

ZNF30 is part of cluster 39 T-cells - T-cell receptor with confidenceⁱ 0.9
56 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SMIM20	Small integral membrane protein 20	0.9762	5
VMA21	Vacuolar ATPase assembly factor VMA21	0.9762	11
RALA	RAS like proto-oncogene A	0.9762	11
PRY2	PTPN13 like Y-linked 2	0.9524	39
TRAV30	T cell receptor alpha variable 30	0.9524	39
ABHD14A	Abhydrolase domain containing 14A	0.9524	11
TRAV18	T cell receptor alpha variable 18	0.9524	39
PRKAR1B	Protein kinase cAMP-dependent type I regulatory subunit beta	0.9524	39
KLHL34	Kelch like family member 34	0.9524	39
TMIE	Transmembrane inner ear	0.9524	11
SLC35G1	Solute carrier family 35 member G1	0.9524	39
CCDC144A	Coiled-coil domain containing 144A	0.9524	11
WNT7A	Wnt family member 7A	0.9524	39
MBIP	MAP3K12 binding inhibitory protein 1	0.9524	11
TRIM4	Tripartite motif containing 4	0.9524	11

Adipocytes	3.2 nTPM
Breast	3.7 nTPM
Adipose tissue	2.8 nTPM

Alveolar cells type 1	2.0 nTPM
Lung	2.0 nTPM

Alveolar cells type 2	1.2 nTPM
Lung	1.2 nTPM

Astrocytes	8.4 nTPM
Brain	8.4 nTPM

B-cells	1.7 nTPM
Esophagus	5.9 nTPM
PBMC	4.6 nTPM
Salivary gland	2.3 nTPM
Bone marrow	1.9 nTPM
Skin	1.7 nTPM
Thymus	1.3 nTPM
Adipose tissue	1.2 nTPM
Spleen	1.1 nTPM
Stomach	0.8 nTPM
Lymph node	0.7 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Lung	0.0 nTPM

Ciliated cells	0.8 nTPM
Lung	1.1 nTPM
Fallopian tube	0.9 nTPM
Endometrium	0.7 nTPM
Bronchus	0.5 nTPM

Club cells	0.8 nTPM
Lung	1.0 nTPM
Bronchus	0.7 nTPM
Prostate	0.6 nTPM

Endothelial cells	3.0 nTPM
Endometrium	5.7 nTPM
Skeletal muscle	5.1 nTPM
Testis	4.6 nTPM
Heart muscle	4.6 nTPM
Vascular	4.2 nTPM
Breast	3.5 nTPM
Prostate	3.1 nTPM
Thymus	3.1 nTPM
Salivary gland	2.8 nTPM
Skin	2.7 nTPM
Tongue	2.7 nTPM
Pancreas	2.6 nTPM
Placenta	2.3 nTPM
Ovary	2.2 nTPM
Esophagus	2.1 nTPM
Lung	1.5 nTPM
Fallopian tube	1.0 nTPM
Liver	0.0 nTPM

Enteroendocrine cells	1.2 nTPM
Colon	1.8 nTPM
Rectum	1.7 nTPM
Small intestine	0.0 nTPM

Fibroblasts	1.8 nTPM
Liver	8.3 nTPM
Stomach	4.3 nTPM
Thymus	1.9 nTPM
Vascular	1.9 nTPM
Breast	1.6 nTPM
Placenta	1.5 nTPM
Skeletal muscle	1.4 nTPM
Salivary gland	1.4 nTPM
Prostate	1.3 nTPM
Fallopian tube	1.2 nTPM
Pancreas	1.0 nTPM
Skin	1.0 nTPM
Lung	0.9 nTPM
Adipose tissue	0.8 nTPM
Esophagus	0.8 nTPM
Heart muscle	0.3 nTPM

Granulocytes	0.5 nTPM
Lung	1.0 nTPM
Fallopian tube	0.4 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	2.1 nTPM
Small intestine	2.6 nTPM
Colon	2.0 nTPM
Rectum	1.7 nTPM

Lymphatic endothelial cells	6.1 nTPM
Ovary	10.9 nTPM
Fallopian tube	1.4 nTPM

Macrophages	0.7 nTPM
Breast	3.9 nTPM
Prostate	2.1 nTPM
Testis	1.2 nTPM
Salivary gland	1.2 nTPM
Skin	1.1 nTPM
Lung	0.9 nTPM
Vascular	0.8 nTPM
Endometrium	0.6 nTPM
Thymus	0.6 nTPM
Adipose tissue	0.5 nTPM
Fallopian tube	0.5 nTPM
Tongue	0.2 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	0.6 nTPM
Rectum	1.7 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Bipolar cells	5.3 nTPM
Eye	5.3 nTPM

Cone photoreceptor cells	15.3 nTPM
Eye	15.3 nTPM

Plasma cells	1.1 nTPM
Bone marrow	3.0 nTPM
Liver	2.0 nTPM
Fallopian tube	1.0 nTPM
Salivary gland	0.9 nTPM
Thymus	0.8 nTPM
Spleen	0.7 nTPM
Stomach	0.4 nTPM
Esophagus	0.0 nTPM

Schwann cells	1.6 nTPM
Vascular	4.7 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	1.2 nTPM
Salivary gland	2.4 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	1.6 nTPM
Esophagus	4.8 nTPM
Endometrium	3.4 nTPM
Vascular	2.1 nTPM
Skin	2.0 nTPM
Ovary	1.9 nTPM
Liver	1.7 nTPM
Thymus	1.7 nTPM
Skeletal muscle	1.3 nTPM
Salivary gland	1.3 nTPM
Prostate	1.2 nTPM
Adipose tissue	0.9 nTPM
Placenta	0.8 nTPM
Fallopian tube	0.8 nTPM
Tongue	0.6 nTPM
Breast	0.6 nTPM
Lung	0.0 nTPM

T-cells	2.0 nTPM
PBMC	6.8 nTPM
Liver	4.1 nTPM
Salivary gland	3.1 nTPM
Endometrium	2.9 nTPM
Lymph node	2.8 nTPM
Prostate	2.7 nTPM
Breast	2.4 nTPM
Thymus	2.3 nTPM
Bone marrow	2.1 nTPM
Colon	1.9 nTPM
Skeletal muscle	1.9 nTPM
Skin	1.8 nTPM
Adipose tissue	1.3 nTPM
Tongue	1.3 nTPM
Vascular	1.2 nTPM
Fallopian tube	1.2 nTPM
Kidney	0.9 nTPM
Spleen	0.9 nTPM
Stomach	0.7 nTPM
Lung	0.5 nTPM
Esophagus	0.0 nTPM

Undifferentiated cells	1.4 nTPM
Rectum	1.6 nTPM
Colon	1.5 nTPM
Small intestine	1.2 nTPM

Amygdala excitatory	21.2 nTPM
Amygdala	22.2 nTPM
Cerebral cortex	22.1 nTPM
Thalamus	21.8 nTPM
Hippocampus	21.3 nTPM
Hypothalamus	20.1 nTPM
Basal ganglia	19.4 nTPM

Astrocyte	16.0 nTPM
Cerebral cortex	18.2 nTPM
Midbrain	17.5 nTPM
Hippocampus	17.2 nTPM
Amygdala	16.7 nTPM
Thalamus	16.6 nTPM
Hypothalamus	16.3 nTPM
Medulla oblongata	16.2 nTPM
Basal ganglia	14.9 nTPM
Cerebellum	14.9 nTPM
Pons	14.7 nTPM
Spinal cord	13.3 nTPM

Bergmann glia	34.1 nTPM
Medulla oblongata	40.5 nTPM
Cerebellum	31.6 nTPM
Pons	30.2 nTPM

Central nervous system macrophage	17.4 nTPM
Cerebral cortex	19.5 nTPM
Hippocampus	18.9 nTPM
Medulla oblongata	18.6 nTPM
Cerebellum	18.5 nTPM
Pons	18.3 nTPM
Amygdala	17.5 nTPM
Basal ganglia	17.4 nTPM
Midbrain	17.1 nTPM
Hypothalamus	16.9 nTPM
Thalamus	16.9 nTPM
Spinal cord	11.8 nTPM

Cerebellar inhibitory	24.0 nTPM
Cerebellum	28.3 nTPM
Spinal cord	27.5 nTPM
Medulla oblongata	22.6 nTPM
Midbrain	21.5 nTPM
Pons	19.9 nTPM

Cge interneuron	19.4 nTPM
Cerebral cortex	22.3 nTPM
Hippocampus	21.5 nTPM
Amygdala	20.8 nTPM
Basal ganglia	19.7 nTPM
Thalamus	18.2 nTPM
Hypothalamus	16.6 nTPM
Midbrain	16.6 nTPM

Choroid plexus epithelial cell	12.2 nTPM
Basal ganglia	16.5 nTPM
Hippocampus	11.1 nTPM
Thalamus	11.0 nTPM
Medulla oblongata	10.3 nTPM

Committed oligodendrocyte precursor	20.4 nTPM
Cerebral cortex	29.8 nTPM
Hippocampus	24.8 nTPM
Spinal cord	22.1 nTPM
Pons	21.2 nTPM
Midbrain	21.0 nTPM
Medulla oblongata	20.7 nTPM
Cerebellum	20.6 nTPM
Amygdala	16.9 nTPM
Thalamus	16.2 nTPM
Basal ganglia	15.9 nTPM
Hypothalamus	15.0 nTPM

Deep-layer corticothalamic and 6b	20.4 nTPM
Cerebral cortex	24.4 nTPM
Hippocampus	23.6 nTPM
Basal ganglia	22.6 nTPM
Amygdala	19.7 nTPM
Midbrain	16.6 nTPM
Hypothalamus	15.3 nTPM

Deep-layer intratelencephalic	20.5 nTPM
Basal ganglia	22.7 nTPM
Cerebral cortex	22.4 nTPM
Hippocampus	22.2 nTPM
Amygdala	19.4 nTPM
Hypothalamus	15.9 nTPM

Deep-layer near-projecting	14.7 nTPM
Hippocampus	18.5 nTPM
Amygdala	14.6 nTPM
Basal ganglia	14.6 nTPM
Cerebral cortex	13.2 nTPM
Hypothalamus	12.6 nTPM

Eccentric medium spiny neuron	22.3 nTPM
Basal ganglia	24.5 nTPM
Hypothalamus	24.5 nTPM
Cerebral cortex	23.9 nTPM
Thalamus	22.5 nTPM
Amygdala	21.4 nTPM
Hippocampus	17.4 nTPM

Endothelial cell	19.3 nTPM
Spinal cord	25.9 nTPM
Cerebral cortex	23.7 nTPM
Hippocampus	23.1 nTPM
Pons	21.8 nTPM
Basal ganglia	21.4 nTPM
Amygdala	21.2 nTPM
Midbrain	18.9 nTPM
Thalamus	16.4 nTPM
Medulla oblongata	15.4 nTPM
Hypothalamus	14.9 nTPM
Cerebellum	10.1 nTPM

Ependymal cell	9.5 nTPM
Amygdala	18.8 nTPM
Basal ganglia	12.7 nTPM
Hippocampus	11.0 nTPM
Medulla oblongata	10.3 nTPM
Thalamus	9.7 nTPM
Hypothalamus	8.9 nTPM
Pons	7.5 nTPM
Midbrain	4.4 nTPM
Spinal cord	1.9 nTPM