Single cell type - WNT7A - The Human Protein Atlas

WNT7A

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	WNT7A
Gene descriptionⁱ Full gene name according to HGNC.	Wnt family member 7A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Extravillous trophoblasts - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Syncytiotrophoblasts, Extravillous trophoblasts, Cytotrophoblasts)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.86
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Eccentric medium spiny neuron, LAMP5-LHX6 and Chandelier, Astrocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (memory CD4 T-cell, naive CD4 T-cell)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Group enriched (Syncytiotrophoblasts, Extravillous trophoblasts, Cytotrophoblasts)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Eccentric medium spiny neuron, LAMP5-LHX6 and Chandelier, Astrocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Group enriched (memory CD4 T-cell, naive CD4 T-cell)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

WNT7A is part of cluster 4 Extravillous trophoblasts - Unknown function with confidenceⁱ 1
182 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CGB7	Chorionic gonadotropin subunit beta 7	0.7322	27
KRT7	Keratin 7	0.7085	45
FSTL3	Follistatin like 3	0.6750	4
KRT18	Keratin 18	0.6352	45
DDA1	DET1 and DDB1 associated 1	0.6350	39
RFK	Riboflavin kinase	0.6325	4
HMGB3	High mobility group box 3	0.6283	4
GCM1	Glial cells missing transcription factor 1	0.6141	4
QSOX1	Quiescin sulfhydryl oxidase 1	0.6137	4
NLRP2	NLR family pyrin domain containing 2	0.6098	4
CAPN6	Calpain 6	0.6046	4
XAGE2	X antigen family member 2	0.6003	4
FANCE	FA complementation group E	0.5980	4
HMGA1	High mobility group AT-hook 1	0.5971	45
ACKR2	Atypical chemokine receptor 2	0.5971	4

IMMUNE CELLS

WNT7A is part of cluster 39 T-cells - T-cell receptor with confidenceⁱ 0.9
56 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LEF1	Lymphoid enhancer binding factor 1	1.0000	39
TRAV30	T cell receptor alpha variable 30	1.0000	39
TRAV18	T cell receptor alpha variable 18	1.0000	39
PRKAR1B	Protein kinase cAMP-dependent type I regulatory subunit beta	1.0000	39
KLHL34	Kelch like family member 34	1.0000	39
SLC35G1	Solute carrier family 35 member G1	1.0000	39
PRY2	PTPN13 like Y-linked 2	1.0000	39
LDHB	Lactate dehydrogenase B	1.0000	39
ITK	IL2 inducible T cell kinase	0.9762	39
TRIM32	Tripartite motif containing 32	0.9762	39
LPAR2	Lysophosphatidic acid receptor 2	0.9762	39
RPL7	Ribosomal protein L7	0.9762	31
CIART	Circadian associated repressor of transcription	0.9762	31
ZFYVE28	Zinc finger FYVE-type containing 28	0.9762	39
ASF1A	Anti-silencing function 1A histone chaperone	0.9762	39

Adipocytes	0.0 nTPM
Adipose tissue	0.0 nTPM
Breast	0.0 nTPM

Alveolar cells type 1	32.5 nTPM
Lung	32.5 nTPM

Alveolar cells type 2	0.6 nTPM
Lung	0.6 nTPM

Astrocytes	8.1 nTPM
Brain	8.1 nTPM

B-cells	0.0 nTPM
Lymph node	0.1 nTPM
Salivary gland	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Thymus	0.0 nTPM

Ciliated cells	4.4 nTPM
Endometrium	16.0 nTPM
Fallopian tube	1.0 nTPM
Bronchus	0.7 nTPM
Lung	0.0 nTPM

Club cells	0.9 nTPM
Bronchus	1.4 nTPM
Lung	1.0 nTPM
Prostate	0.4 nTPM

Endothelial cells	0.4 nTPM
Placenta	1.7 nTPM
Lung	1.6 nTPM
Heart muscle	1.3 nTPM
Breast	0.9 nTPM
Endometrium	0.5 nTPM
Prostate	0.5 nTPM
Skin	0.2 nTPM
Thymus	0.2 nTPM
Fallopian tube	0.1 nTPM
Testis	0.0 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Salivary gland	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Ovary	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	2.7 nTPM
Placenta	39.9 nTPM
Pancreas	1.7 nTPM
Lung	1.2 nTPM
Skin	0.1 nTPM
Salivary gland	0.1 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Stomach	0.0 nTPM
Prostate	0.0 nTPM
Thymus	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

Granulocytes	0.1 nTPM
Fallopian tube	0.4 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	0.0 nTPM
Fallopian tube	0.1 nTPM
Ovary	0.0 nTPM

Macrophages	0.3 nTPM
Endometrium	2.5 nTPM
Pancreas	2.1 nTPM
Tongue	0.2 nTPM
Testis	0.0 nTPM
Kidney	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Basal respiratory cells	2.2 nTPM
Bronchus	2.2 nTPM

Cholangiocytes	11.4 nTPM
Liver	11.4 nTPM

Cytotrophoblasts	67.1 nTPM
Placenta	67.1 nTPM

Distal tubular cells	3.1 nTPM
Kidney	3.1 nTPM

Plasma cells	0.0 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Fallopian tube	0.0 nTPM

Schwann cells	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Vascular	0.0 nTPM

Serous glandular cells	0.0 nTPM
Salivary gland	0.0 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	0.2 nTPM
Liver	1.7 nTPM
Placenta	1.0 nTPM
Endometrium	0.5 nTPM
Ovary	0.1 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

T-cells	1.8 nTPM
Thymus	7.8 nTPM
Lymph node	4.4 nTPM
Salivary gland	4.4 nTPM
PBMC	3.7 nTPM
Kidney	3.5 nTPM
Spleen	3.4 nTPM
Endometrium	2.0 nTPM
Adipose tissue	2.0 nTPM
Lung	1.9 nTPM
Bone marrow	1.0 nTPM
Tongue	0.9 nTPM
Stomach	0.7 nTPM
Breast	0.6 nTPM
Skeletal muscle	0.4 nTPM
Vascular	0.4 nTPM
Liver	0.3 nTPM
Fallopian tube	0.3 nTPM
Colon	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Prostate	0.0 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Amygdala excitatory	4.5 nTPM
Hypothalamus	16.6 nTPM
Basal ganglia	4.6 nTPM
Amygdala	2.6 nTPM
Cerebral cortex	2.4 nTPM
Thalamus	0.5 nTPM
Hippocampus	0.4 nTPM

Astrocyte	18.2 nTPM
Amygdala	26.7 nTPM
Medulla oblongata	24.4 nTPM
Pons	22.9 nTPM
Basal ganglia	18.3 nTPM
Cerebral cortex	18.0 nTPM
Spinal cord	17.8 nTPM
Thalamus	17.4 nTPM
Midbrain	16.9 nTPM
Hippocampus	15.9 nTPM
Hypothalamus	11.6 nTPM
Cerebellum	10.5 nTPM

Bergmann glia	14.9 nTPM
Pons	17.3 nTPM
Medulla oblongata	17.0 nTPM
Cerebellum	10.5 nTPM

Central nervous system macrophage	0.3 nTPM
Amygdala	0.8 nTPM
Cerebral cortex	0.6 nTPM
Hippocampus	0.4 nTPM
Basal ganglia	0.3 nTPM
Spinal cord	0.3 nTPM
Hypothalamus	0.2 nTPM
Midbrain	0.2 nTPM
Cerebellum	0.1 nTPM
Medulla oblongata	0.1 nTPM
Pons	0.1 nTPM
Thalamus	0.1 nTPM

Cerebellar inhibitory	0.0 nTPM
Pons	0.1 nTPM
Cerebellum	0.0 nTPM
Medulla oblongata	0.0 nTPM
Midbrain	0.0 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	6.1 nTPM
Hypothalamus	8.3 nTPM
Amygdala	7.7 nTPM
Hippocampus	7.7 nTPM
Midbrain	5.4 nTPM
Cerebral cortex	5.1 nTPM
Basal ganglia	4.5 nTPM
Thalamus	4.2 nTPM

Choroid plexus epithelial cell	0.1 nTPM
Medulla oblongata	0.4 nTPM
Basal ganglia	0.0 nTPM
Hippocampus	0.0 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	0.5 nTPM
Basal ganglia	2.7 nTPM
Cerebellum	1.6 nTPM
Amygdala	0.6 nTPM
Cerebral cortex	0.6 nTPM
Hippocampus	0.3 nTPM
Thalamus	0.2 nTPM
Hypothalamus	0.0 nTPM
Medulla oblongata	0.0 nTPM
Midbrain	0.0 nTPM
Pons	0.0 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	8.5 nTPM
Hypothalamus	11.8 nTPM
Basal ganglia	11.7 nTPM
Amygdala	9.9 nTPM
Cerebral cortex	9.8 nTPM
Midbrain	4.4 nTPM
Hippocampus	3.4 nTPM

Deep-layer intratelencephalic	6.4 nTPM
Hypothalamus	11.7 nTPM
Cerebral cortex	5.9 nTPM
Amygdala	5.2 nTPM
Basal ganglia	4.7 nTPM
Hippocampus	4.6 nTPM

Deep-layer near-projecting	1.4 nTPM
Basal ganglia	3.2 nTPM
Hypothalamus	1.7 nTPM
Amygdala	1.2 nTPM
Cerebral cortex	0.5 nTPM
Hippocampus	0.3 nTPM

Eccentric medium spiny neuron	19.9 nTPM
Amygdala	24.5 nTPM
Hippocampus	24.5 nTPM
Hypothalamus	22.5 nTPM
Cerebral cortex	22.1 nTPM
Thalamus	15.4 nTPM
Basal ganglia	10.8 nTPM

Endothelial cell	0.3 nTPM
Spinal cord	1.7 nTPM
Amygdala	1.1 nTPM
Hippocampus	0.3 nTPM
Basal ganglia	0.0 nTPM
Cerebellum	0.0 nTPM
Cerebral cortex	0.0 nTPM
Hypothalamus	0.0 nTPM
Medulla oblongata	0.0 nTPM
Midbrain	0.0 nTPM
Pons	0.0 nTPM
Thalamus	0.0 nTPM

Ependymal cell	1.0 nTPM
Medulla oblongata	3.5 nTPM
Amygdala	2.8 nTPM
Pons	1.2 nTPM
Thalamus	0.8 nTPM
Basal ganglia	0.3 nTPM
Hippocampus	0.0 nTPM
Hypothalamus	0.0 nTPM
Midbrain	0.0 nTPM
Spinal cord	0.0 nTPM