Single cell type - ADAM8 - The Human Protein Atlas

ADAM8

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ADAM8
Gene descriptionⁱ Full gene name according to HGNC.	ADAM metallopeptidase domain 8
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	CD markers Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Langerhans cells - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Langerhans cells, Extravillous trophoblasts, NK-cells, T-cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.75
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enriched (Leukocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (eosinophil, neutrophil, basophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Langerhans cells, Extravillous trophoblasts, NK-cells, T-cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enriched (Leukocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Group enriched (eosinophil, neutrophil, basophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ADAM8 is part of cluster 14 Langerhans cells - Innate immune response with confidenceⁱ 1
131 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MOB3A	MOB kinase activator 3A	0.7117	28
CYRIB	CYFIP related Rac1 interactor B	0.6203	19
LITAF	Lipopolysaccharide induced TNF factor	0.6112	74
ACTB	Actin beta	0.6109	14
FMNL1	Formin like 1	0.5991	19
IL1R2	Interleukin 1 receptor type 2	0.5915	28
CDC42SE1	CDC42 small effector 1	0.5897	19
IFNL1	Interferon lambda 1	0.5829	19
TRAF1	TNF receptor associated factor 1	0.5811	14
PFN1	Profilin 1	0.5770	14
SERPINB9	Serpin family B member 9	0.5754	28
VASP	Vasodilator stimulated phosphoprotein	0.5710	58
UBE2F	Ubiquitin conjugating enzyme E2 F (putative)	0.5694	4
ID2	Inhibitor of DNA binding 2	0.5688	14
IL23A	Interleukin 23 subunit alpha	0.5589	45

IMMUNE CELLS

ADAM8 is part of cluster 21 Neutrophils - Unknown function with confidenceⁱ 1
492 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SLC45A4	Solute carrier family 45 member 4	1.0000	21
BBIP1	BBSome interacting protein 1	1.0000	21
SEPTIN5	Septin 5	1.0000	21
ADGRG3	Adhesion G protein-coupled receptor G3	1.0000	21
C18orf32	Chromosome 18 open reading frame 32	1.0000	21
FRAT1	FRAT regulator of WNT signaling pathway 1	1.0000	21
RGL4	Ral guanine nucleotide dissociation stimulator like 4	1.0000	21
MCL1	MCL1 apoptosis regulator, BCL2 family member	0.9762	21
CAMK2G	Calcium/calmodulin dependent protein kinase II gamma	0.9762	21
RGS18	Regulator of G protein signaling 18	0.9762	21
XKR8	XK related 8	0.9762	21
F11R	F11 receptor	0.9762	21
ABHD12B	Abhydrolase domain containing 12B	0.9762	21
TREML1	Triggering receptor expressed on myeloid cells like 1	0.9762	21
ZNF436	Zinc finger protein 436	0.9762	21

Adipocytes	1.0 nTPM
Breast	1.3 nTPM
Adipose tissue	0.6 nTPM

Alveolar cells type 1	0.5 nTPM
Lung	0.5 nTPM

Alveolar cells type 2	0.8 nTPM
Lung	0.8 nTPM

Astrocytes	3.1 nTPM
Brain	3.1 nTPM

B-cells	28.5 nTPM
Skin	103.3 nTPM
Bone marrow	38.7 nTPM
Esophagus	35.4 nTPM
Stomach	31.2 nTPM
Lung	28.2 nTPM
PBMC	27.7 nTPM
Adipose tissue	23.0 nTPM
Lymph node	21.8 nTPM
Liver	19.3 nTPM
Thymus	18.4 nTPM
Spleen	17.3 nTPM
Salivary gland	5.6 nTPM
Kidney	0.0 nTPM

Ciliated cells	4.4 nTPM
Bronchus	13.3 nTPM
Fallopian tube	1.9 nTPM
Endometrium	1.2 nTPM
Lung	0.9 nTPM

Club cells	7.3 nTPM
Bronchus	13.0 nTPM
Prostate	5.9 nTPM
Lung	3.0 nTPM

Endothelial cells	0.8 nTPM
Liver	2.5 nTPM
Skin	2.4 nTPM
Salivary gland	1.6 nTPM
Tongue	1.2 nTPM
Placenta	1.1 nTPM
Endometrium	0.9 nTPM
Lung	0.9 nTPM
Skeletal muscle	0.8 nTPM
Thymus	0.6 nTPM
Prostate	0.5 nTPM
Vascular	0.3 nTPM
Fallopian tube	0.3 nTPM
Ovary	0.3 nTPM
Heart muscle	0.1 nTPM
Testis	0.0 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	1.9 nTPM
Small intestine	3.4 nTPM
Rectum	1.7 nTPM
Colon	0.5 nTPM

Fibroblasts	0.7 nTPM
Skin	2.7 nTPM
Placenta	1.7 nTPM
Liver	1.2 nTPM
Breast	1.1 nTPM
Esophagus	0.8 nTPM
Salivary gland	0.7 nTPM
Thymus	0.5 nTPM
Fallopian tube	0.5 nTPM
Skeletal muscle	0.4 nTPM
Vascular	0.4 nTPM
Lung	0.3 nTPM
Heart muscle	0.2 nTPM
Pancreas	0.2 nTPM
Adipose tissue	0.1 nTPM
Stomach	0.0 nTPM
Prostate	0.0 nTPM

Granulocytes	21.5 nTPM
Fallopian tube	45.2 nTPM
Tongue	9.7 nTPM
Lung	9.6 nTPM

Intestinal goblet cells	1.1 nTPM
Rectum	1.8 nTPM
Small intestine	1.3 nTPM
Colon	0.2 nTPM

Lymphatic endothelial cells	0.3 nTPM
Fallopian tube	0.6 nTPM
Ovary	0.0 nTPM

Macrophages	29.9 nTPM
Adipose tissue	83.7 nTPM
Skeletal muscle	49.6 nTPM
Pancreas	49.3 nTPM
Tongue	48.0 nTPM
Stomach	46.3 nTPM
Skin	43.5 nTPM
Fallopian tube	39.8 nTPM
Testis	37.2 nTPM
Endometrium	30.1 nTPM
Spleen	30.1 nTPM
Esophagus	20.6 nTPM
Kidney	20.4 nTPM
Breast	18.2 nTPM
Bone marrow	14.2 nTPM
Lung	10.3 nTPM
Salivary gland	8.0 nTPM
Vascular	7.1 nTPM
Prostate	6.5 nTPM
Thymus	4.9 nTPM

Paneth cells	0.2 nTPM
Rectum	0.7 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Basal keratinocytes	4.1 nTPM
Skin	6.2 nTPM
Tongue	2.1 nTPM

Basal respiratory cells	13.9 nTPM
Bronchus	13.9 nTPM

Bipolar cells	5.0 nTPM
Eye	5.0 nTPM

Cholangiocytes	3.8 nTPM
Liver	3.8 nTPM

Plasma cells	9.7 nTPM
Esophagus	31.2 nTPM
Fallopian tube	10.6 nTPM
Stomach	10.5 nTPM
Liver	8.0 nTPM
Salivary gland	7.2 nTPM
Thymus	5.6 nTPM
Spleen	2.6 nTPM
Bone marrow	1.5 nTPM

Schwann cells	35.3 nTPM
Adipose tissue	105.4 nTPM
Vascular	0.5 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	4.2 nTPM
Tongue	4.4 nTPM
Salivary gland	4.0 nTPM

Smooth muscle cells	0.7 nTPM
Liver	1.7 nTPM
Placenta	1.5 nTPM
Endometrium	1.2 nTPM
Skin	1.2 nTPM
Breast	1.1 nTPM
Skeletal muscle	0.8 nTPM
Thymus	0.8 nTPM
Tongue	0.6 nTPM
Adipose tissue	0.4 nTPM
Salivary gland	0.4 nTPM
Fallopian tube	0.4 nTPM
Ovary	0.4 nTPM
Vascular	0.2 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM

T-cells	36.5 nTPM
Skin	59.6 nTPM
Colon	54.6 nTPM
Bone marrow	54.0 nTPM
Skeletal muscle	53.3 nTPM
Kidney	53.2 nTPM
Breast	50.8 nTPM
Lung	48.3 nTPM
Liver	47.7 nTPM
Spleen	45.4 nTPM
Adipose tissue	41.9 nTPM
Stomach	37.9 nTPM
Endometrium	34.9 nTPM
Fallopian tube	31.0 nTPM
Esophagus	26.8 nTPM
PBMC	24.7 nTPM
Vascular	24.5 nTPM
Tongue	19.5 nTPM
Thymus	17.9 nTPM
Lymph node	17.0 nTPM
Prostate	15.4 nTPM
Salivary gland	7.3 nTPM

Undifferentiated cells	0.4 nTPM
Small intestine	0.6 nTPM
Rectum	0.5 nTPM
Colon	0.2 nTPM

Amygdala excitatory	5.5 nTPM
Amygdala	6.5 nTPM
Cerebral cortex	6.1 nTPM
Thalamus	5.9 nTPM
Hippocampus	5.5 nTPM
Basal ganglia	4.5 nTPM
Hypothalamus	4.2 nTPM

Astrocyte	2.7 nTPM
Spinal cord	3.4 nTPM
Hippocampus	3.2 nTPM
Medulla oblongata	3.1 nTPM
Pons	3.1 nTPM
Thalamus	3.0 nTPM
Cerebral cortex	2.9 nTPM
Cerebellum	2.7 nTPM
Basal ganglia	2.6 nTPM
Midbrain	2.4 nTPM
Amygdala	2.2 nTPM
Hypothalamus	1.6 nTPM

Bergmann glia	1.8 nTPM
Medulla oblongata	4.3 nTPM
Cerebellum	1.0 nTPM
Pons	0.0 nTPM

Central nervous system macrophage	1.8 nTPM
Cerebellum	2.4 nTPM
Spinal cord	2.4 nTPM
Amygdala	2.2 nTPM
Midbrain	1.9 nTPM
Thalamus	1.9 nTPM
Hippocampus	1.8 nTPM
Basal ganglia	1.7 nTPM
Cerebral cortex	1.7 nTPM
Pons	1.4 nTPM
Hypothalamus	1.3 nTPM
Medulla oblongata	1.0 nTPM

Cerebellar inhibitory	4.9 nTPM
Spinal cord	8.2 nTPM
Cerebellum	4.4 nTPM
Medulla oblongata	4.1 nTPM
Midbrain	4.0 nTPM
Pons	3.9 nTPM

Cge interneuron	3.4 nTPM
Midbrain	4.4 nTPM
Thalamus	3.7 nTPM
Amygdala	3.5 nTPM
Cerebral cortex	3.3 nTPM
Hippocampus	3.1 nTPM
Hypothalamus	3.1 nTPM
Basal ganglia	2.8 nTPM

Choroid plexus epithelial cell	0.3 nTPM
Medulla oblongata	0.9 nTPM
Basal ganglia	0.3 nTPM
Hippocampus	0.0 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	2.3 nTPM
Hypothalamus	4.8 nTPM
Thalamus	3.8 nTPM
Cerebellum	3.2 nTPM
Hippocampus	2.8 nTPM
Medulla oblongata	2.6 nTPM
Cerebral cortex	1.9 nTPM
Pons	1.8 nTPM
Midbrain	1.7 nTPM
Basal ganglia	1.6 nTPM
Amygdala	1.1 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	5.2 nTPM
Midbrain	6.7 nTPM
Amygdala	6.3 nTPM
Hippocampus	6.2 nTPM
Cerebral cortex	4.9 nTPM
Basal ganglia	4.7 nTPM
Hypothalamus	2.2 nTPM

Deep-layer intratelencephalic	5.3 nTPM
Amygdala	6.6 nTPM
Basal ganglia	6.0 nTPM
Hippocampus	5.9 nTPM
Cerebral cortex	5.2 nTPM
Hypothalamus	3.0 nTPM

Deep-layer near-projecting	4.5 nTPM
Amygdala	5.5 nTPM
Cerebral cortex	4.9 nTPM
Hypothalamus	4.3 nTPM
Hippocampus	4.2 nTPM
Basal ganglia	3.7 nTPM

Eccentric medium spiny neuron	3.9 nTPM
Thalamus	4.7 nTPM
Cerebral cortex	4.4 nTPM
Basal ganglia	4.2 nTPM
Amygdala	3.8 nTPM
Hypothalamus	3.2 nTPM
Hippocampus	2.9 nTPM

Endothelial cell	0.8 nTPM
Amygdala	2.2 nTPM
Basal ganglia	1.9 nTPM
Pons	1.2 nTPM
Medulla oblongata	1.0 nTPM
Midbrain	0.9 nTPM
Cerebellum	0.8 nTPM
Hippocampus	0.6 nTPM
Thalamus	0.6 nTPM
Cerebral cortex	0.0 nTPM
Hypothalamus	0.0 nTPM
Spinal cord	0.0 nTPM

Ependymal cell	3.8 nTPM
Spinal cord	5.7 nTPM
Midbrain	4.4 nTPM
Basal ganglia	4.1 nTPM
Hippocampus	3.9 nTPM
Pons	3.9 nTPM
Hypothalamus	3.6 nTPM
Thalamus	3.6 nTPM
Medulla oblongata	3.5 nTPM
Amygdala	1.7 nTPM