Single cell type - IDNK - The Human Protein Atlas

IDNK

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IDNK
Gene descriptionⁱ Full gene name according to HGNC.	IDNK gluconokinase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Proximal tubular cells - Amino acid metabolism (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Proximal tubular cells, Proximal enterocytes, Hepatocytes, Distal tubular cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.58
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Proximal tubular cells, Proximal enterocytes, Hepatocytes, Distal tubular cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

IDNK is part of cluster 56 Proximal tubular cells - Amino acid metabolism with confidenceⁱ 1
204 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ACY3	Aminoacylase 3	0.8483	56
BPHL	Biphenyl hydrolase like	0.8438	56
GSTA2	Glutathione S-transferase alpha 2	0.8189	56
PEPD	Peptidase D	0.8135	22
PCK1	Phosphoenolpyruvate carboxykinase 1	0.8131	56
CRYL1	Crystallin lambda 1	0.7983	56
UGT2A1	UDP glucuronosyltransferase family 2 member A1 complex locus	0.7860	56
ASPDH	Aspartate dehydrogenase domain containing	0.7784	56
GGACT	Gamma-glutamylamine cyclotransferase	0.7770	56
SLC25A48	Solute carrier family 25 member 48	0.7754	56
NQO2	N-ribosyldihydronicotinamide:quinone reductase 2	0.7696	56
GLYATL1	Glycine-N-acyltransferase like 1	0.7688	56
GLYAT	Glycine-N-acyltransferase	0.7661	56
LYG1	Lysozyme g1	0.7644	56
PEBP1	Phosphatidylethanolamine binding protein 1	0.7636	56

IMMUNE CELLS

IDNK is part of cluster 32 Basophils - Transcription with confidenceⁱ 0.99
291 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ANKRD42	Ankyrin repeat domain 42	0.9762	32
KMT5A	Lysine methyltransferase 5A	0.9762	32
FAIM	Fas apoptotic inhibitory molecule	0.9762	32
CNOT4	CCR4-NOT transcription complex subunit 4	0.9762	32
CDKL1	Cyclin dependent kinase like 1	0.9524	32
ELMOD3	ELMO domain containing 3	0.9524	32
KIF21B	Kinesin family member 21B	0.9524	42
SENP5	SUMO specific peptidase 5	0.9524	32
NAPB	NSF attachment protein beta	0.9524	42
HACL1	2-hydroxyacyl-CoA lyase 1	0.9524	32
RASSF1	Ras association domain family member 1	0.9524	32
IPO11	Importin 11	0.9524	32
CGGBP1	CGG triplet repeat binding protein 1	0.9524	32
XRRA1	X-ray radiation resistance associated 1	0.9524	32
CCNDBP1	Cyclin D1 binding protein 1	0.9524	42

Adipocytes	6.5 nTPM
Breast	9.2 nTPM
Adipose tissue	3.8 nTPM

Alveolar cells type 1	6.1 nTPM
Lung	6.1 nTPM

Alveolar cells type 2	6.1 nTPM
Lung	6.1 nTPM

Astrocytes	13.9 nTPM
Brain	13.9 nTPM

B-cells	8.7 nTPM
Adipose tissue	17.3 nTPM
Kidney	15.6 nTPM
Spleen	11.1 nTPM
Stomach	11.0 nTPM
Lymph node	10.9 nTPM
Lung	8.0 nTPM
Salivary gland	8.0 nTPM
Bone marrow	7.9 nTPM
PBMC	7.7 nTPM
Thymus	5.4 nTPM
Skin	5.1 nTPM
Liver	4.8 nTPM
Esophagus	0.0 nTPM

Ciliated cells	30.9 nTPM
Lung	37.4 nTPM
Endometrium	36.1 nTPM
Fallopian tube	26.8 nTPM
Bronchus	23.4 nTPM

Club cells	6.4 nTPM
Bronchus	7.4 nTPM
Lung	6.4 nTPM
Prostate	5.5 nTPM

Endothelial cells	5.9 nTPM
Heart muscle	14.2 nTPM
Skin	13.6 nTPM
Breast	13.2 nTPM
Skeletal muscle	7.2 nTPM
Fallopian tube	6.9 nTPM
Esophagus	5.7 nTPM
Lung	5.5 nTPM
Thymus	4.7 nTPM
Placenta	4.5 nTPM
Salivary gland	4.4 nTPM
Tongue	4.4 nTPM
Ovary	4.3 nTPM
Vascular	4.0 nTPM
Testis	3.7 nTPM
Endometrium	3.4 nTPM
Pancreas	2.6 nTPM
Prostate	2.1 nTPM
Liver	1.3 nTPM

Enteroendocrine cells	14.5 nTPM
Small intestine	24.0 nTPM
Rectum	11.7 nTPM
Colon	7.8 nTPM

Fibroblasts	8.0 nTPM
Heart muscle	30.0 nTPM
Skin	10.9 nTPM
Skeletal muscle	9.5 nTPM
Lung	8.2 nTPM
Fallopian tube	8.2 nTPM
Esophagus	8.1 nTPM
Adipose tissue	8.0 nTPM
Salivary gland	7.4 nTPM
Breast	7.4 nTPM
Vascular	6.5 nTPM
Thymus	6.2 nTPM
Placenta	4.5 nTPM
Stomach	4.3 nTPM
Liver	3.6 nTPM
Pancreas	2.8 nTPM
Prostate	2.0 nTPM

Granulocytes	27.4 nTPM
Lung	37.8 nTPM
Fallopian tube	29.8 nTPM
Tongue	14.6 nTPM

Intestinal goblet cells	11.5 nTPM
Small intestine	18.9 nTPM
Rectum	10.1 nTPM
Colon	5.7 nTPM

Lymphatic endothelial cells	4.6 nTPM
Fallopian tube	9.2 nTPM
Ovary	0.0 nTPM

Macrophages	7.1 nTPM
Lung	18.5 nTPM
Kidney	16.8 nTPM
Breast	11.0 nTPM
Pancreas	8.2 nTPM
Testis	8.1 nTPM
Stomach	7.7 nTPM
Fallopian tube	7.4 nTPM
Prostate	6.7 nTPM
Skeletal muscle	6.2 nTPM
Adipose tissue	6.0 nTPM
Skin	5.6 nTPM
Vascular	5.5 nTPM
Tongue	5.2 nTPM
Esophagus	5.1 nTPM
Salivary gland	4.5 nTPM
Thymus	3.9 nTPM
Endometrium	3.1 nTPM
Bone marrow	3.0 nTPM
Spleen	3.0 nTPM

Paneth cells	24.2 nTPM
Small intestine	48.4 nTPM
Colon	14.5 nTPM
Rectum	9.7 nTPM

Basal prostatic cells	4.1 nTPM
Prostate	4.1 nTPM

Bipolar cells	9.1 nTPM
Eye	9.1 nTPM

Cholangiocytes	11.4 nTPM
Liver	11.4 nTPM

Early spermatids	0.3 nTPM
Testis	0.3 nTPM

Plasma cells	10.8 nTPM
Fallopian tube	21.6 nTPM
Esophagus	20.8 nTPM
Stomach	11.7 nTPM
Liver	9.5 nTPM
Salivary gland	6.7 nTPM
Bone marrow	6.0 nTPM
Spleen	5.3 nTPM
Thymus	4.9 nTPM

Schwann cells	11.2 nTPM
Adipose tissue	13.7 nTPM
Esophagus	12.0 nTPM
Vascular	7.8 nTPM

Serous glandular cells	7.8 nTPM
Salivary gland	11.2 nTPM
Tongue	4.4 nTPM

Smooth muscle cells	6.1 nTPM
Breast	10.4 nTPM
Skin	9.7 nTPM
Fallopian tube	9.2 nTPM
Vascular	8.7 nTPM
Ovary	7.4 nTPM
Prostate	7.3 nTPM
Tongue	6.6 nTPM
Lung	5.9 nTPM
Placenta	5.1 nTPM
Skeletal muscle	5.1 nTPM
Salivary gland	4.8 nTPM
Thymus	4.5 nTPM
Adipose tissue	4.0 nTPM
Endometrium	3.3 nTPM
Liver	2.5 nTPM
Esophagus	2.4 nTPM

Suprabasal keratinocytes	10.0 nTPM
Tongue	15.7 nTPM
Skin	4.3 nTPM

T-cells	11.2 nTPM
Kidney	22.2 nTPM
Skin	18.9 nTPM
Stomach	17.6 nTPM
Liver	15.4 nTPM
Skeletal muscle	14.4 nTPM
PBMC	13.6 nTPM
Bone marrow	12.6 nTPM
Breast	12.5 nTPM
Lung	11.4 nTPM
Fallopian tube	10.8 nTPM
Spleen	10.0 nTPM
Lymph node	9.7 nTPM
Adipose tissue	9.2 nTPM
Prostate	9.2 nTPM
Salivary gland	9.1 nTPM
Colon	7.8 nTPM
Esophagus	7.3 nTPM
Tongue	7.2 nTPM
Vascular	6.0 nTPM
Endometrium	5.7 nTPM
Thymus	5.6 nTPM

Undifferentiated cells	11.8 nTPM
Small intestine	20.0 nTPM
Rectum	8.3 nTPM
Colon	7.0 nTPM

Amygdala excitatory	13.0 nTPM
Hypothalamus	17.6 nTPM
Basal ganglia	14.2 nTPM
Amygdala	13.0 nTPM
Cerebral cortex	12.4 nTPM
Thalamus	10.9 nTPM
Hippocampus	9.7 nTPM

Astrocyte	40.1 nTPM
Amygdala	47.5 nTPM
Hypothalamus	46.4 nTPM
Hippocampus	44.5 nTPM
Spinal cord	41.4 nTPM
Medulla oblongata	41.2 nTPM
Cerebellum	41.1 nTPM
Cerebral cortex	36.9 nTPM
Basal ganglia	36.2 nTPM
Midbrain	35.9 nTPM
Thalamus	35.4 nTPM
Pons	34.4 nTPM

Bergmann glia	30.4 nTPM
Medulla oblongata	32.0 nTPM
Cerebellum	30.5 nTPM
Pons	28.8 nTPM

Central nervous system macrophage	25.5 nTPM
Amygdala	32.4 nTPM
Basal ganglia	29.9 nTPM
Hippocampus	27.3 nTPM
Medulla oblongata	26.8 nTPM
Midbrain	26.5 nTPM
Hypothalamus	25.4 nTPM
Cerebellum	24.8 nTPM
Cerebral cortex	24.1 nTPM
Thalamus	23.9 nTPM
Pons	23.8 nTPM
Spinal cord	15.9 nTPM

Cerebellar inhibitory	13.4 nTPM
Medulla oblongata	16.4 nTPM
Cerebellum	15.6 nTPM
Pons	13.6 nTPM
Midbrain	13.4 nTPM
Spinal cord	8.2 nTPM

Cge interneuron	12.3 nTPM
Basal ganglia	14.5 nTPM
Midbrain	13.0 nTPM
Amygdala	12.4 nTPM
Cerebral cortex	12.4 nTPM
Hypothalamus	12.0 nTPM
Thalamus	10.9 nTPM
Hippocampus	10.8 nTPM

Choroid plexus epithelial cell	26.4 nTPM
Basal ganglia	39.5 nTPM
Medulla oblongata	33.0 nTPM
Thalamus	19.2 nTPM
Hippocampus	13.9 nTPM

Committed oligodendrocyte precursor	13.9 nTPM
Hypothalamus	25.9 nTPM
Medulla oblongata	23.2 nTPM
Amygdala	19.2 nTPM
Basal ganglia	18.6 nTPM
Thalamus	18.5 nTPM
Cerebellum	11.1 nTPM
Hippocampus	9.8 nTPM
Midbrain	8.4 nTPM
Pons	8.0 nTPM
Cerebral cortex	7.0 nTPM
Spinal cord	3.7 nTPM

Deep-layer corticothalamic and 6b	12.5 nTPM
Basal ganglia	15.7 nTPM
Hypothalamus	14.9 nTPM
Midbrain	13.3 nTPM
Amygdala	10.7 nTPM
Cerebral cortex	10.5 nTPM
Hippocampus	9.7 nTPM

Deep-layer intratelencephalic	12.8 nTPM
Hypothalamus	15.8 nTPM
Basal ganglia	14.5 nTPM
Amygdala	13.5 nTPM
Hippocampus	10.2 nTPM
Cerebral cortex	9.9 nTPM

Deep-layer near-projecting	14.4 nTPM
Hippocampus	16.3 nTPM
Hypothalamus	16.3 nTPM
Basal ganglia	15.9 nTPM
Amygdala	12.7 nTPM
Cerebral cortex	10.8 nTPM

Eccentric medium spiny neuron	17.5 nTPM
Hypothalamus	20.2 nTPM
Basal ganglia	18.5 nTPM
Thalamus	18.3 nTPM
Amygdala	17.7 nTPM
Cerebral cortex	17.2 nTPM
Hippocampus	12.8 nTPM

Endothelial cell	11.7 nTPM
Amygdala	16.8 nTPM
Hippocampus	15.4 nTPM
Pons	13.7 nTPM
Medulla oblongata	13.3 nTPM
Spinal cord	12.1 nTPM
Midbrain	11.3 nTPM
Thalamus	10.2 nTPM
Cerebellum	10.1 nTPM
Cerebral cortex	9.6 nTPM
Basal ganglia	8.4 nTPM
Hypothalamus	7.4 nTPM