Single cell type - ANKRD42 - The Human Protein Atlas

ANKRD42

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ANKRD42
Gene descriptionⁱ Full gene name according to HGNC.	Ankyrin repeat domain 42
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Ciliated cells - Cilium assembly (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Early spermatids, Late spermatids)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.60
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Early spermatids, Late spermatids)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ANKRD42 is part of cluster 42 Ciliated cells - Cilium assembly with confidenceⁱ 1
429 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CCDC138	Coiled-coil domain containing 138	0.6125	18
DNAI7	Dynein axonemal intermediate chain 7	0.5787	42
CLUAP1	Clusterin associated protein 1	0.5769	42
DNAAF11	Dynein axonemal assembly factor 11	0.5654	42
DYNC2LI1	Dynein cytoplasmic 2 light intermediate chain 1	0.5648	42
CCDC30	Coiled-coil domain containing 30	0.5332	42
ARMC3	Armadillo repeat containing 3	0.5229	42
CFAP91	Cilia and flagella associated protein 91	0.5197	42
C1orf87	Chromosome 1 open reading frame 87	0.5016	42
DNAI4	Dynein axonemal intermediate chain 4	0.5015	42
CFAP69	Cilia and flagella associated protein 69	0.5005	42
C4orf47	Chromosome 4 open reading frame 47	0.4994	42
ODAD2	Outer dynein arm docking complex subunit 2	0.4983	42
ZNF391	Zinc finger protein 391	0.4933	21
CFAP141	Cilia and flagella associated protein 141	0.4914	42

IMMUNE CELLS

ANKRD42 is part of cluster 32 Basophils - Transcription with confidenceⁱ 0.99
291 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KMT5A	Lysine methyltransferase 5A	1.0000	32
CNOT4	CCR4-NOT transcription complex subunit 4	1.0000	32
KIF21B	Kinesin family member 21B	0.9762	42
ISG20L2	Interferon stimulated exonuclease gene 20 like 2	0.9762	42
HACL1	2-hydroxyacyl-CoA lyase 1	0.9762	32
NAPB	NSF attachment protein beta	0.9762	42
FAM117A	Family with sequence similarity 117 member A	0.9762	32
SENP5	SUMO specific peptidase 5	0.9762	32
RAB3GAP2	RAB3 GTPase activating non-catalytic protein subunit 2	0.9762	32
RBBP5	RB binding protein 5, histone lysine methyltransferase complex subunit	0.9762	32
ZNF684	Zinc finger protein 684	0.9762	32
CBFB	Core-binding factor subunit beta	0.9762	32
ELMOD3	ELMO domain containing 3	0.9762	32
ACTR8	Actin related protein 8	0.9762	32
MADD	MAP kinase activating death domain	0.9762	32

Adipocytes	6.3 nTPM
Breast	6.4 nTPM
Adipose tissue	6.1 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	13.3 nTPM
Lung	13.3 nTPM

Astrocytes	7.1 nTPM
Brain	7.1 nTPM

B-cells	6.9 nTPM
Stomach	11.8 nTPM
PBMC	10.8 nTPM
Kidney	10.4 nTPM
Lymph node	10.3 nTPM
Adipose tissue	9.1 nTPM
Salivary gland	8.7 nTPM
Spleen	6.0 nTPM
Esophagus	5.9 nTPM
Bone marrow	5.5 nTPM
Thymus	5.5 nTPM
Lung	5.4 nTPM
Liver	0.0 nTPM
Skin	0.0 nTPM

Ciliated cells	47.9 nTPM
Lung	56.0 nTPM
Endometrium	52.1 nTPM
Fallopian tube	46.2 nTPM
Bronchus	37.0 nTPM

Club cells	7.6 nTPM
Prostate	8.7 nTPM
Bronchus	8.4 nTPM
Lung	5.7 nTPM

Endothelial cells	6.3 nTPM
Salivary gland	11.1 nTPM
Fallopian tube	11.1 nTPM
Prostate	10.4 nTPM
Endometrium	9.5 nTPM
Thymus	9.2 nTPM
Esophagus	8.2 nTPM
Vascular	7.2 nTPM
Testis	6.4 nTPM
Ovary	5.7 nTPM
Tongue	5.6 nTPM
Pancreas	5.2 nTPM
Skeletal muscle	4.7 nTPM
Lung	4.4 nTPM
Placenta	4.0 nTPM
Liver	3.8 nTPM
Skin	3.8 nTPM
Heart muscle	2.2 nTPM
Breast	0.9 nTPM

Enteroendocrine cells	3.4 nTPM
Colon	5.1 nTPM
Rectum	5.0 nTPM
Small intestine	0.0 nTPM

Fibroblasts	9.2 nTPM
Heart muscle	23.3 nTPM
Stomach	15.9 nTPM
Fallopian tube	13.1 nTPM
Vascular	10.6 nTPM
Lung	9.9 nTPM
Salivary gland	9.4 nTPM
Prostate	9.2 nTPM
Thymus	7.8 nTPM
Esophagus	7.5 nTPM
Skin	7.3 nTPM
Breast	6.8 nTPM
Pancreas	6.5 nTPM
Skeletal muscle	6.3 nTPM
Liver	5.9 nTPM
Adipose tissue	5.8 nTPM
Placenta	1.2 nTPM

Granulocytes	18.3 nTPM
Tongue	24.3 nTPM
Fallopian tube	20.0 nTPM
Lung	10.6 nTPM

Intestinal goblet cells	3.7 nTPM
Small intestine	5.1 nTPM
Rectum	4.6 nTPM
Colon	1.5 nTPM

Lymphatic endothelial cells	5.9 nTPM
Fallopian tube	11.9 nTPM
Ovary	0.0 nTPM

Macrophages	8.4 nTPM
Skin	13.4 nTPM
Esophagus	12.8 nTPM
Lung	10.5 nTPM
Stomach	10.3 nTPM
Adipose tissue	10.1 nTPM
Spleen	10.0 nTPM
Skeletal muscle	9.6 nTPM
Vascular	9.2 nTPM
Salivary gland	8.7 nTPM
Endometrium	8.0 nTPM
Fallopian tube	8.0 nTPM
Prostate	7.5 nTPM
Thymus	7.2 nTPM
Kidney	7.1 nTPM
Breast	6.9 nTPM
Testis	6.8 nTPM
Bone marrow	5.1 nTPM
Tongue	4.5 nTPM
Pancreas	4.1 nTPM

Paneth cells	7.4 nTPM
Colon	10.9 nTPM
Small intestine	6.9 nTPM
Rectum	4.4 nTPM

Basal squamous epithelial cells	4.2 nTPM
Esophagus	4.2 nTPM

Bipolar cells	3.6 nTPM
Eye	3.6 nTPM

Cholangiocytes	1.9 nTPM
Liver	1.9 nTPM

Cone photoreceptor cells	18.7 nTPM
Eye	18.7 nTPM

Plasma cells	5.6 nTPM
Stomach	12.6 nTPM
Salivary gland	10.3 nTPM
Fallopian tube	8.0 nTPM
Esophagus	5.2 nTPM
Bone marrow	3.0 nTPM
Liver	2.5 nTPM
Spleen	1.7 nTPM
Thymus	1.7 nTPM

Schwann cells	12.7 nTPM
Vascular	19.9 nTPM
Esophagus	12.0 nTPM
Adipose tissue	6.2 nTPM

Serous glandular cells	4.3 nTPM
Salivary gland	8.7 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	7.7 nTPM
Salivary gland	15.6 nTPM
Endometrium	9.4 nTPM
Prostate	9.1 nTPM
Vascular	8.9 nTPM
Lung	8.2 nTPM
Liver	7.6 nTPM
Skeletal muscle	7.6 nTPM
Tongue	7.2 nTPM
Breast	6.9 nTPM
Skin	6.7 nTPM
Ovary	6.7 nTPM
Adipose tissue	6.5 nTPM
Esophagus	6.0 nTPM
Fallopian tube	5.9 nTPM
Placenta	5.5 nTPM
Thymus	5.4 nTPM

T-cells	6.2 nTPM
Stomach	12.2 nTPM
Endometrium	12.1 nTPM
Prostate	8.0 nTPM
Thymus	7.5 nTPM
Lung	7.3 nTPM
Salivary gland	7.3 nTPM
Breast	7.2 nTPM
Adipose tissue	7.1 nTPM
Fallopian tube	6.7 nTPM
Vascular	6.4 nTPM
Skin	5.6 nTPM
Lymph node	5.6 nTPM
Tongue	5.2 nTPM
Skeletal muscle	4.9 nTPM
Esophagus	4.9 nTPM
Bone marrow	4.6 nTPM
Spleen	4.5 nTPM
Kidney	4.4 nTPM
Liver	3.2 nTPM
Colon	2.9 nTPM
PBMC	2.2 nTPM

Undifferentiated cells	2.9 nTPM
Rectum	3.2 nTPM
Colon	3.0 nTPM
Small intestine	2.4 nTPM

Amygdala excitatory	48.5 nTPM
Hypothalamus	57.0 nTPM
Hippocampus	52.4 nTPM
Basal ganglia	50.6 nTPM
Amygdala	49.5 nTPM
Cerebral cortex	48.2 nTPM
Thalamus	33.6 nTPM

Astrocyte	20.6 nTPM
Amygdala	26.9 nTPM
Hypothalamus	23.9 nTPM
Basal ganglia	22.5 nTPM
Midbrain	21.9 nTPM
Medulla oblongata	20.8 nTPM
Hippocampus	19.8 nTPM
Spinal cord	19.4 nTPM
Thalamus	19.4 nTPM
Pons	18.0 nTPM
Cerebral cortex	17.9 nTPM
Cerebellum	16.2 nTPM

Bergmann glia	14.2 nTPM
Cerebellum	16.1 nTPM
Medulla oblongata	14.9 nTPM
Pons	11.5 nTPM

Central nervous system macrophage	18.5 nTPM
Amygdala	23.0 nTPM
Hypothalamus	22.8 nTPM
Thalamus	19.4 nTPM
Midbrain	19.3 nTPM
Hippocampus	18.8 nTPM
Spinal cord	17.4 nTPM
Basal ganglia	17.1 nTPM
Pons	16.7 nTPM
Cerebellum	16.4 nTPM
Cerebral cortex	16.3 nTPM
Medulla oblongata	16.2 nTPM

Cerebellar inhibitory	31.8 nTPM
Pons	35.9 nTPM
Midbrain	34.2 nTPM
Medulla oblongata	31.5 nTPM
Cerebellum	30.0 nTPM
Spinal cord	27.5 nTPM

Cge interneuron	24.5 nTPM
Thalamus	29.1 nTPM
Amygdala	26.9 nTPM
Hypothalamus	25.5 nTPM
Hippocampus	24.8 nTPM
Cerebral cortex	23.9 nTPM
Basal ganglia	20.9 nTPM
Midbrain	20.7 nTPM

Choroid plexus epithelial cell	55.0 nTPM
Basal ganglia	63.9 nTPM
Thalamus	57.5 nTPM
Hippocampus	55.5 nTPM
Medulla oblongata	43.0 nTPM

Committed oligodendrocyte precursor	12.0 nTPM
Medulla oblongata	21.9 nTPM
Hypothalamus	17.1 nTPM
Basal ganglia	14.8 nTPM
Hippocampus	12.4 nTPM
Thalamus	11.9 nTPM
Amygdala	11.8 nTPM
Cerebellum	9.5 nTPM
Pons	8.9 nTPM
Cerebral cortex	8.2 nTPM
Midbrain	7.6 nTPM
Spinal cord	7.4 nTPM

Deep-layer corticothalamic and 6b	26.0 nTPM
Cerebral cortex	29.4 nTPM
Amygdala	27.0 nTPM
Hypothalamus	26.8 nTPM
Hippocampus	26.7 nTPM
Midbrain	23.3 nTPM
Basal ganglia	22.8 nTPM

Deep-layer intratelencephalic	33.1 nTPM
Hippocampus	37.9 nTPM
Amygdala	34.1 nTPM
Hypothalamus	34.0 nTPM
Cerebral cortex	31.4 nTPM
Basal ganglia	27.8 nTPM

Deep-layer near-projecting	26.4 nTPM
Cerebral cortex	29.2 nTPM
Amygdala	28.6 nTPM
Hypothalamus	27.2 nTPM
Hippocampus	24.4 nTPM
Basal ganglia	22.7 nTPM

Eccentric medium spiny neuron	31.1 nTPM
Amygdala	34.5 nTPM
Hypothalamus	33.1 nTPM
Thalamus	31.3 nTPM
Cerebral cortex	30.8 nTPM
Basal ganglia	29.7 nTPM
Hippocampus	26.9 nTPM

Endothelial cell	13.7 nTPM
Cerebral cortex	18.5 nTPM
Amygdala	17.9 nTPM
Hippocampus	17.3 nTPM
Hypothalamus	16.1 nTPM
Spinal cord	13.8 nTPM
Medulla oblongata	13.3 nTPM
Thalamus	13.0 nTPM
Basal ganglia	12.1 nTPM
Pons	10.0 nTPM
Midbrain	9.5 nTPM
Cerebellum	9.3 nTPM

Ependymal cell	110.4 nTPM
Basal ganglia	126.9 nTPM
Hypothalamus	124.9 nTPM
Midbrain	111.7 nTPM
Pons	111.2 nTPM
Thalamus	106.1 nTPM
Hippocampus	105.1 nTPM
Amygdala	103.5 nTPM
Spinal cord	103.5 nTPM
Medulla oblongata	100.5 nTPM