Single cell type - SPPL2A - The Human Protein Atlas

SPPL2A

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SPPL2A
Gene descriptionⁱ Full gene name according to HGNC.	Signal peptide peptidase like 2A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Enzymes Human disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Skeletal myocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.30
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Skeletal myocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

SPPL2A is part of cluster 45 Non-specific - Mixed function with confidenceⁱ 1
349 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
P2RX4	Purinergic receptor P2X 4	0.5933	24
CFL1	Cofilin 1	0.5570	45
ANXA5	Annexin A5	0.5546	58
ABHD3	Abhydrolase domain containing 3, phospholipase	0.5485	5
POLD4	DNA polymerase delta 4, accessory subunit	0.5473	5
SERINC2	Serine incorporator 2	0.5367	5
CHMP4B	Charged multivesicular body protein 4B	0.5363	45
UBE2A	Ubiquitin conjugating enzyme E2 A	0.5342	5
PLGRKT	Plasminogen receptor with a C-terminal lysine	0.5325	5
CD164	CD164 molecule	0.5208	58
CASP7	Caspase 7	0.5162	5
FXYD3	FXYD domain containing ion transport regulator 3	0.5048	5
RAB7A	RAB7A, member RAS oncogene family	0.4949	45
PLS1	Plastin 1	0.4921	5
MTMR11	Myotubularin related protein 11	0.4858	45

IMMUNE CELLS

SPPL2A is part of cluster 25 Non-specific - Unknown function with confidenceⁱ 0.51
355 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GLRX2	Glutaredoxin 2	1.0000	25
RNF40	Ring finger protein 40	1.0000	25
UNC119	Unc-119 lipid binding chaperone	0.9762	25
ENSG00000241489	Novel protein	0.9762	25
ITSN1	Intersectin 1	0.9762	25
MAP3K11	Mitogen-activated protein kinase kinase kinase 11	0.9762	25
RAB24	RAB24, member RAS oncogene family	0.9762	7
ZFYVE1	Zinc finger FYVE-type containing 1	0.9762	25
PKN1	Protein kinase N1	0.9762	25
SASH3	SAM and SH3 domain containing 3	0.9762	25
CALB1	Calbindin 1	0.9762	7
RAB5IF	RAB5 interacting factor	0.9762	25
RIN3	Ras and Rab interactor 3	0.9762	25
ME2	Malic enzyme 2	0.9762	25
IFFO1	Intermediate filament family orphan 1	0.9762	25

Adipocytes	60.4 nTPM
Adipose tissue	74.1 nTPM
Breast	46.6 nTPM

Alveolar cells type 1	68.0 nTPM
Lung	68.0 nTPM

Alveolar cells type 2	51.9 nTPM
Lung	51.9 nTPM

Astrocytes	19.5 nTPM
Brain	19.5 nTPM

B-cells	47.5 nTPM
Adipose tissue	69.1 nTPM
Skin	62.7 nTPM
Stomach	57.4 nTPM
Spleen	53.8 nTPM
Lung	53.7 nTPM
Bone marrow	50.4 nTPM
Lymph node	49.7 nTPM
Kidney	46.8 nTPM
Esophagus	41.3 nTPM
PBMC	40.0 nTPM
Salivary gland	35.8 nTPM
Thymus	32.5 nTPM
Liver	24.2 nTPM

Ciliated cells	79.0 nTPM
Endometrium	107.3 nTPM
Bronchus	76.6 nTPM
Lung	73.1 nTPM
Fallopian tube	58.9 nTPM

Club cells	50.4 nTPM
Bronchus	54.9 nTPM
Prostate	51.5 nTPM
Lung	44.7 nTPM

Dendritic cells	51.7 nTPM
Adipose tissue	74.6 nTPM
PBMC	28.8 nTPM

Endothelial cells	57.4 nTPM
Pancreas	95.7 nTPM
Heart muscle	81.5 nTPM
Fallopian tube	74.1 nTPM
Salivary gland	71.1 nTPM
Lung	68.1 nTPM
Esophagus	64.6 nTPM
Skeletal muscle	61.2 nTPM
Breast	58.9 nTPM
Endometrium	57.9 nTPM
Thymus	54.4 nTPM
Skin	52.9 nTPM
Vascular	51.9 nTPM
Prostate	47.3 nTPM
Liver	46.6 nTPM
Tongue	42.5 nTPM
Placenta	38.0 nTPM
Testis	37.5 nTPM
Ovary	28.9 nTPM

Enteroendocrine cells	59.8 nTPM
Colon	86.0 nTPM
Small intestine	51.5 nTPM
Rectum	41.9 nTPM

Fibroblasts	74.0 nTPM
Adipose tissue	133.0 nTPM
Heart muscle	131.9 nTPM
Skeletal muscle	111.8 nTPM
Skin	78.1 nTPM
Salivary gland	75.2 nTPM
Fallopian tube	74.0 nTPM
Breast	71.4 nTPM
Vascular	68.8 nTPM
Stomach	67.7 nTPM
Pancreas	67.6 nTPM
Lung	63.6 nTPM
Thymus	58.7 nTPM
Esophagus	56.1 nTPM
Prostate	53.5 nTPM
Liver	47.4 nTPM
Placenta	24.6 nTPM

Granulocytes	43.8 nTPM
Fallopian tube	63.6 nTPM
Lung	48.4 nTPM
Tongue	19.4 nTPM

Intestinal goblet cells	111.1 nTPM
Small intestine	189.2 nTPM
Rectum	78.6 nTPM
Colon	65.4 nTPM

Lymphatic endothelial cells	66.0 nTPM
Fallopian tube	93.8 nTPM
Ovary	38.2 nTPM

Macrophages	82.9 nTPM
Pancreas	168.6 nTPM
Esophagus	107.9 nTPM
Lung	101.8 nTPM
Adipose tissue	96.9 nTPM
Spleen	91.2 nTPM
Stomach	90.0 nTPM
Vascular	89.2 nTPM
Thymus	84.4 nTPM
Fallopian tube	79.4 nTPM
Kidney	77.9 nTPM
Prostate	73.0 nTPM
Skeletal muscle	72.7 nTPM
Salivary gland	70.8 nTPM
Skin	68.0 nTPM
Bone marrow	67.9 nTPM
Tongue	64.6 nTPM
Testis	64.5 nTPM
Breast	55.5 nTPM
Endometrium	51.7 nTPM

Basal keratinocytes	53.2 nTPM
Skin	68.3 nTPM
Tongue	38.1 nTPM

Basal prostatic cells	52.2 nTPM
Prostate	52.2 nTPM

Basal respiratory cells	93.1 nTPM
Bronchus	93.1 nTPM

Basal squamous epithelial cells	37.9 nTPM
Esophagus	37.9 nTPM

Paneth cells	134.1 nTPM
Small intestine	162.3 nTPM
Colon	152.0 nTPM
Rectum	87.9 nTPM

Plasma cells	40.8 nTPM
Stomach	71.6 nTPM
Spleen	62.5 nTPM
Fallopian tube	38.6 nTPM
Salivary gland	38.5 nTPM
Thymus	34.1 nTPM
Esophagus	31.2 nTPM
Liver	30.5 nTPM
Bone marrow	19.6 nTPM

Schwann cells	72.8 nTPM
Esophagus	83.9 nTPM
Vascular	70.5 nTPM
Adipose tissue	64.0 nTPM

Serous glandular cells	55.1 nTPM
Salivary gland	79.3 nTPM
Tongue	30.9 nTPM

Smooth muscle cells	48.2 nTPM
Adipose tissue	75.3 nTPM
Skeletal muscle	58.6 nTPM
Vascular	55.9 nTPM
Endometrium	52.3 nTPM
Salivary gland	51.5 nTPM
Tongue	50.3 nTPM
Fallopian tube	49.6 nTPM
Esophagus	48.1 nTPM
Placenta	46.4 nTPM
Skin	45.4 nTPM
Lung	44.7 nTPM
Liver	42.5 nTPM
Prostate	42.0 nTPM
Thymus	40.7 nTPM
Breast	38.8 nTPM
Ovary	29.4 nTPM

Suprabasal keratinocytes	46.2 nTPM
Skin	54.9 nTPM
Tongue	37.5 nTPM

T-cells	54.1 nTPM
Adipose tissue	83.3 nTPM
Colon	82.9 nTPM
Stomach	75.9 nTPM
Spleen	70.8 nTPM
Bone marrow	67.0 nTPM
Endometrium	64.0 nTPM
Lung	60.7 nTPM
Skeletal muscle	60.5 nTPM
Fallopian tube	58.1 nTPM
Breast	56.6 nTPM
Esophagus	56.0 nTPM
Skin	51.2 nTPM
Kidney	49.7 nTPM
Tongue	48.3 nTPM
Liver	47.2 nTPM
Lymph node	41.9 nTPM
Prostate	38.5 nTPM
Salivary gland	32.8 nTPM
PBMC	31.8 nTPM
Vascular	31.0 nTPM
Thymus	28.2 nTPM

Undifferentiated cells	49.9 nTPM
Small intestine	71.9 nTPM
Colon	39.1 nTPM
Rectum	38.8 nTPM

Amygdala excitatory	46.1 nTPM
Hypothalamus	63.8 nTPM
Cerebral cortex	48.7 nTPM
Amygdala	45.0 nTPM
Hippocampus	41.6 nTPM
Basal ganglia	41.3 nTPM
Thalamus	36.3 nTPM

Astrocyte	67.8 nTPM
Amygdala	81.6 nTPM
Hypothalamus	75.5 nTPM
Cerebral cortex	73.6 nTPM
Basal ganglia	72.0 nTPM
Hippocampus	71.9 nTPM
Thalamus	66.8 nTPM
Midbrain	66.3 nTPM
Cerebellum	62.7 nTPM
Medulla oblongata	61.7 nTPM
Pons	61.0 nTPM
Spinal cord	53.2 nTPM

Bergmann glia	75.4 nTPM
Medulla oblongata	93.8 nTPM
Cerebellum	69.3 nTPM
Pons	63.3 nTPM

Central nervous system macrophage	104.6 nTPM
Amygdala	120.4 nTPM
Thalamus	112.1 nTPM
Basal ganglia	110.5 nTPM
Hypothalamus	109.8 nTPM
Midbrain	106.3 nTPM
Cerebral cortex	102.4 nTPM
Pons	102.4 nTPM
Hippocampus	98.4 nTPM
Cerebellum	97.7 nTPM
Medulla oblongata	96.7 nTPM
Spinal cord	93.9 nTPM

Cerebellar inhibitory	43.0 nTPM
Medulla oblongata	51.0 nTPM
Midbrain	45.1 nTPM
Cerebellum	43.5 nTPM
Pons	39.8 nTPM
Spinal cord	35.7 nTPM

Cge interneuron	51.9 nTPM
Hypothalamus	58.2 nTPM
Amygdala	56.6 nTPM
Thalamus	53.5 nTPM
Basal ganglia	50.0 nTPM
Cerebral cortex	49.5 nTPM
Hippocampus	48.8 nTPM
Midbrain	46.6 nTPM

Choroid plexus epithelial cell	145.9 nTPM
Basal ganglia	181.4 nTPM
Hippocampus	152.5 nTPM
Medulla oblongata	134.4 nTPM
Thalamus	115.1 nTPM

Committed oligodendrocyte precursor	52.9 nTPM
Hypothalamus	71.7 nTPM
Hippocampus	62.3 nTPM
Thalamus	59.9 nTPM
Amygdala	59.2 nTPM
Cerebral cortex	57.0 nTPM
Pons	53.1 nTPM
Midbrain	52.1 nTPM
Basal ganglia	50.4 nTPM
Medulla oblongata	42.6 nTPM
Spinal cord	40.5 nTPM
Cerebellum	33.3 nTPM

Deep-layer corticothalamic and 6b	39.9 nTPM
Hypothalamus	48.0 nTPM
Cerebral cortex	42.7 nTPM
Basal ganglia	39.4 nTPM
Hippocampus	38.6 nTPM
Amygdala	37.7 nTPM
Midbrain	33.3 nTPM

Deep-layer intratelencephalic	55.9 nTPM
Hypothalamus	66.1 nTPM
Basal ganglia	56.8 nTPM
Cerebral cortex	56.1 nTPM
Amygdala	52.5 nTPM
Hippocampus	47.8 nTPM

Deep-layer near-projecting	64.3 nTPM
Cerebral cortex	72.1 nTPM
Hippocampus	68.6 nTPM
Amygdala	65.8 nTPM
Hypothalamus	58.6 nTPM
Basal ganglia	56.2 nTPM

Eccentric medium spiny neuron	35.7 nTPM
Thalamus	37.4 nTPM
Cerebral cortex	37.3 nTPM
Basal ganglia	36.8 nTPM
Hypothalamus	34.9 nTPM
Amygdala	34.8 nTPM
Hippocampus	33.2 nTPM