Single cell type - SASH3 - The Human Protein Atlas

SASH3

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SASH3
Gene descriptionⁱ Full gene name according to HGNC.	SAM and SH3 domain containing 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	T-cells - T-cell receptor (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (NK-cells, B-cells, T-cells, Kupffer cells, Hofbauer cells, Monocytes, Macrophages, Plasma cells, Dendritic cells, Langerhans cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.83
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Group enriched (Leukocyte, Central nervous system macrophage)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (NK-cells, B-cells, T-cells, Kupffer cells, Hofbauer cells, Monocytes, Macrophages, Plasma cells, Dendritic cells, Langerhans cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Group enriched (Leukocyte, Central nervous system macrophage)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

SASH3 is part of cluster 7 T-cells - T-cell receptor with confidenceⁱ 1
246 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CSK	C-terminal Src kinase	0.7567	73
CD244	CD244 molecule	0.7265	19
CORO1A	Coronin 1A	0.7223	19
FCRL3	Fc receptor like 3	0.7217	73
PVRIG	PVR related immunoglobulin domain containing	0.7068	7
DENND1C	DENN domain containing 1C	0.6831	7
TRAJ57	T cell receptor alpha joining 57	0.6804	7
OR1L6	Olfactory receptor family 1 subfamily L member 6	0.6721	19
RAC2	Rac family small GTPase 2	0.6620	19
ARPC4-TTLL3	ARPC4-TTLL3 readthrough	0.6550	7
ABI3	ABI family member 3	0.6493	19
TRAJ16	T cell receptor alpha joining 16	0.6490	7
DEFA1B	Defensin alpha 1B	0.6485	74
KIR2DS4	Killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4	0.6484	19
RCSD1	RCSD domain containing 1	0.6378	73

IMMUNE CELLS

SASH3 is part of cluster 25 Non-specific - Unknown function with confidenceⁱ 0.51
355 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ME2	Malic enzyme 2	1.0000	25
UNC119	Unc-119 lipid binding chaperone	1.0000	25
PPM1N	Protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)	0.9762	25
HYAL2	Hyaluronidase 2	0.9762	25
TMED1	Transmembrane p24 trafficking protein 1	0.9762	25
ZFYVE21	Zinc finger FYVE-type containing 21	0.9762	25
PPM1L	Protein phosphatase, Mg2+/Mn2+ dependent 1L	0.9762	25
RNF40	Ring finger protein 40	0.9762	25
GLRX2	Glutaredoxin 2	0.9762	25
SPPL2A	Signal peptide peptidase like 2A	0.9762	25
SORT1	Sortilin 1	0.9762	25
CALB1	Calbindin 1	0.9524	7
RAB24	RAB24, member RAS oncogene family	0.9524	7
SCGB3A1	Secretoglobin family 3A member 1	0.9524	25
PKN1	Protein kinase N1	0.9524	25

Adipocytes	0.5 nTPM
Breast	0.8 nTPM
Adipose tissue	0.2 nTPM

Alveolar cells type 1	0.1 nTPM
Lung	0.1 nTPM

Alveolar cells type 2	0.4 nTPM
Lung	0.4 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	64.2 nTPM
Lymph node	129.7 nTPM
Spleen	105.2 nTPM
Stomach	87.7 nTPM
Bone marrow	83.2 nTPM
Thymus	75.1 nTPM
Kidney	62.4 nTPM
Lung	57.7 nTPM
Salivary gland	56.8 nTPM
PBMC	49.3 nTPM
Esophagus	41.3 nTPM
Liver	38.6 nTPM
Adipose tissue	33.7 nTPM
Skin	13.6 nTPM

Ciliated cells	0.7 nTPM
Lung	2.4 nTPM
Fallopian tube	0.2 nTPM
Endometrium	0.1 nTPM
Bronchus	0.0 nTPM

Club cells	0.7 nTPM
Lung	2.0 nTPM
Bronchus	0.0 nTPM
Prostate	0.0 nTPM

Dendritic cells	30.3 nTPM
PBMC	46.8 nTPM
Adipose tissue	13.8 nTPM

Endothelial cells	1.0 nTPM
Liver	8.8 nTPM
Tongue	1.8 nTPM
Thymus	1.5 nTPM
Placenta	1.1 nTPM
Lung	1.1 nTPM
Prostate	0.9 nTPM
Skin	0.6 nTPM
Salivary gland	0.6 nTPM
Esophagus	0.5 nTPM
Endometrium	0.4 nTPM
Vascular	0.4 nTPM
Heart muscle	0.1 nTPM
Skeletal muscle	0.1 nTPM
Fallopian tube	0.1 nTPM
Testis	0.0 nTPM
Pancreas	0.0 nTPM
Breast	0.0 nTPM
Ovary	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	0.9 nTPM
Liver	4.7 nTPM
Stomach	2.9 nTPM
Salivary gland	1.9 nTPM
Thymus	1.7 nTPM
Lung	1.2 nTPM
Breast	1.0 nTPM
Vascular	0.4 nTPM
Skin	0.3 nTPM
Esophagus	0.3 nTPM
Skeletal muscle	0.1 nTPM
Fallopian tube	0.1 nTPM
Heart muscle	0.0 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM
Adipose tissue	0.0 nTPM
Prostate	0.0 nTPM

Granulocytes	6.6 nTPM
Lung	10.1 nTPM
Tongue	4.9 nTPM
Fallopian tube	4.8 nTPM

Intestinal goblet cells	0.1 nTPM
Colon	0.2 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	0.1 nTPM
Fallopian tube	0.1 nTPM
Ovary	0.0 nTPM

Macrophages	40.4 nTPM
Bone marrow	92.2 nTPM
Spleen	83.2 nTPM
Stomach	59.2 nTPM
Kidney	57.5 nTPM
Thymus	52.5 nTPM
Fallopian tube	45.3 nTPM
Testis	42.8 nTPM
Lung	41.6 nTPM
Salivary gland	39.9 nTPM
Prostate	39.5 nTPM
Vascular	35.3 nTPM
Esophagus	30.8 nTPM
Breast	28.0 nTPM
Pancreas	26.7 nTPM
Skeletal muscle	25.5 nTPM
Tongue	22.5 nTPM
Endometrium	22.1 nTPM
Adipose tissue	18.7 nTPM
Skin	3.3 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Plasma cells	35.9 nTPM
Bone marrow	64.9 nTPM
Spleen	48.4 nTPM
Liver	43.6 nTPM
Stomach	39.8 nTPM
Thymus	37.6 nTPM
Fallopian tube	19.3 nTPM
Salivary gland	18.4 nTPM
Esophagus	15.6 nTPM

Schwann cells	4.7 nTPM
Adipose tissue	14.1 nTPM
Esophagus	0.0 nTPM
Vascular	0.0 nTPM

Serous glandular cells	2.1 nTPM
Salivary gland	4.1 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	0.7 nTPM
Liver	3.0 nTPM
Breast	2.6 nTPM
Thymus	2.4 nTPM
Skin	1.2 nTPM
Salivary gland	0.8 nTPM
Placenta	0.4 nTPM
Endometrium	0.2 nTPM
Vascular	0.2 nTPM
Fallopian tube	0.1 nTPM
Ovary	0.1 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Tongue	0.0 nTPM

T-cells	53.0 nTPM
Bone marrow	135.9 nTPM
Liver	103.8 nTPM
Spleen	101.1 nTPM
Stomach	91.4 nTPM
Kidney	85.1 nTPM
Esophagus	80.3 nTPM
Lymph node	53.3 nTPM
Breast	50.2 nTPM
Thymus	47.7 nTPM
PBMC	47.4 nTPM
Lung	42.2 nTPM
Endometrium	37.4 nTPM
Colon	37.0 nTPM
Salivary gland	28.2 nTPM
Fallopian tube	28.1 nTPM
Prostate	27.8 nTPM
Skin	27.3 nTPM
Tongue	27.3 nTPM
Vascular	26.1 nTPM
Skeletal muscle	21.2 nTPM
Adipose tissue	14.5 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.1 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Amygdala excitatory	0.2 nTPM
Basal ganglia	0.4 nTPM
Amygdala	0.2 nTPM
Cerebral cortex	0.2 nTPM
Hippocampus	0.2 nTPM
Hypothalamus	0.1 nTPM
Thalamus	0.0 nTPM

Astrocyte	0.2 nTPM
Medulla oblongata	0.4 nTPM
Cerebral cortex	0.3 nTPM
Spinal cord	0.3 nTPM
Basal ganglia	0.2 nTPM
Hippocampus	0.2 nTPM
Hypothalamus	0.2 nTPM
Midbrain	0.2 nTPM
Amygdala	0.1 nTPM
Cerebellum	0.1 nTPM
Pons	0.1 nTPM
Thalamus	0.1 nTPM

Bergmann glia	0.1 nTPM
Cerebellum	0.2 nTPM
Medulla oblongata	0.0 nTPM
Pons	0.0 nTPM

Central nervous system macrophage	51.7 nTPM
Hippocampus	54.7 nTPM
Medulla oblongata	54.5 nTPM
Midbrain	54.3 nTPM
Thalamus	54.2 nTPM
Cerebellum	53.9 nTPM
Basal ganglia	53.4 nTPM
Hypothalamus	52.4 nTPM
Pons	51.0 nTPM
Cerebral cortex	50.8 nTPM
Amygdala	48.6 nTPM
Spinal cord	41.2 nTPM

Cerebellar inhibitory	0.1 nTPM
Cerebellum	0.2 nTPM
Medulla oblongata	0.2 nTPM
Midbrain	0.0 nTPM
Pons	0.0 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	0.2 nTPM
Amygdala	0.2 nTPM
Cerebral cortex	0.2 nTPM
Hypothalamus	0.2 nTPM
Midbrain	0.2 nTPM
Basal ganglia	0.1 nTPM
Hippocampus	0.1 nTPM
Thalamus	0.1 nTPM

Choroid plexus epithelial cell	0.0 nTPM
Basal ganglia	0.1 nTPM
Hippocampus	0.0 nTPM
Medulla oblongata	0.0 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	0.4 nTPM
Basal ganglia	1.6 nTPM
Hippocampus	1.6 nTPM
Midbrain	0.8 nTPM
Cerebral cortex	0.6 nTPM
Amygdala	0.0 nTPM
Cerebellum	0.0 nTPM
Hypothalamus	0.0 nTPM
Medulla oblongata	0.0 nTPM
Pons	0.0 nTPM
Spinal cord	0.0 nTPM
Thalamus	0.0 nTPM

Deep-layer corticothalamic and 6b	0.2 nTPM
Amygdala	0.2 nTPM
Basal ganglia	0.2 nTPM
Cerebral cortex	0.2 nTPM
Hippocampus	0.2 nTPM
Hypothalamus	0.2 nTPM
Midbrain	0.0 nTPM

Deep-layer intratelencephalic	0.2 nTPM
Amygdala	0.2 nTPM
Basal ganglia	0.2 nTPM
Cerebral cortex	0.2 nTPM
Hippocampus	0.1 nTPM
Hypothalamus	0.1 nTPM

Deep-layer near-projecting	0.3 nTPM
Hippocampus	0.7 nTPM
Amygdala	0.4 nTPM
Basal ganglia	0.3 nTPM
Cerebral cortex	0.2 nTPM
Hypothalamus	0.0 nTPM

Eccentric medium spiny neuron	0.1 nTPM
Thalamus	0.2 nTPM
Amygdala	0.1 nTPM
Basal ganglia	0.1 nTPM
Cerebral cortex	0.1 nTPM
Hypothalamus	0.1 nTPM
Hippocampus	0.0 nTPM

Endothelial cell	0.3 nTPM
Pons	1.2 nTPM
Cerebellum	0.8 nTPM
Thalamus	0.6 nTPM
Hippocampus	0.3 nTPM
Amygdala	0.0 nTPM
Basal ganglia	0.0 nTPM
Cerebral cortex	0.0 nTPM
Hypothalamus	0.0 nTPM
Medulla oblongata	0.0 nTPM
Midbrain	0.0 nTPM
Spinal cord	0.0 nTPM