Single cell type - DNAI7 - The Human Protein Atlas

DNAI7

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DNAI7
Gene descriptionⁱ Full gene name according to HGNC.	Dynein axonemal intermediate chain 7
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Ciliated cells - Cilium assembly (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Early spermatids, Late spermatids, Ciliated cells, Spermatocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.82
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Group enriched (Ependymal cell, Choroid plexus epithelial cell)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Early spermatids, Late spermatids, Ciliated cells, Spermatocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Group enriched (Ependymal cell, Choroid plexus epithelial cell)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

DNAI7 is part of cluster 42 Ciliated cells - Cilium assembly with confidenceⁱ 1
429 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ARMC3	Armadillo repeat containing 3	0.8430	42
DNAH3	Dynein axonemal heavy chain 3	0.7635	42
TEKT2	Tektin 2	0.7452	42
DNAAF6	Dynein axonemal assembly factor 6	0.7399	42
CFAP45	Cilia and flagella associated protein 45	0.7396	42
TEKT1	Tektin 1	0.7364	42
C11orf97	Chromosome 11 open reading frame 97	0.7203	42
DNAI4	Dynein axonemal intermediate chain 4	0.7143	42
PPIL6	Peptidylprolyl isomerase like 6	0.7050	42
OSCP1	Organic solute carrier partner 1	0.6745	42
GON7	GON7 subunit of KEOPS complex	0.6639	42
CFAP141	Cilia and flagella associated protein 141	0.6620	42
ODAD4	Outer dynein arm docking complex subunit 4	0.6589	42
CFAP43	Cilia and flagella associated protein 43	0.6526	42
ODAD2	Outer dynein arm docking complex subunit 2	0.6472	42

IMMUNE CELLS

DNAI7 is part of cluster 24 Non-specific - Transcription with confidenceⁱ 0.8
516 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
H2AC7	H2A clustered histone 7	0.9524	20
RFX3	Regulatory factor X3	0.9286	21
RGPD6	RANBP2 like and GRIP domain containing 6	0.9286	20
PNN	Pinin, desmosome associated protein	0.9048	24
TTC9	Tetratricopeptide repeat domain 9	0.9048	21
PPIG	Peptidylprolyl isomerase G	0.9048	24
PRELID3A	PRELI domain containing 3A	0.9048	21
GPR160	G protein-coupled receptor 160	0.9048	24
SPDYE2B	Speedy/RINGO cell cycle regulator family member E2B	0.9048	24
RYK	Receptor like tyrosine kinase	0.8810	21
H4C14	H4 clustered histone 14	0.8810	24
H4C15	H4 clustered histone 15	0.8810	24
DYNC1H1	Dynein cytoplasmic 1 heavy chain 1	0.8810	21
MFN1	Mitofusin 1	0.8810	21
CEP295	Centrosomal protein 295	0.8810	21

Adipocytes	0.3 nTPM
Adipose tissue	0.4 nTPM
Breast	0.2 nTPM

Alveolar cells type 1	1.0 nTPM
Lung	1.0 nTPM

Alveolar cells type 2	0.5 nTPM
Lung	0.5 nTPM

Astrocytes	15.2 nTPM
Brain	15.2 nTPM

B-cells	0.4 nTPM
Stomach	1.7 nTPM
Lung	1.3 nTPM
Thymus	0.9 nTPM
Bone marrow	0.7 nTPM
Salivary gland	0.6 nTPM
Adipose tissue	0.4 nTPM
Lymph node	0.2 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Spleen	0.0 nTPM

Ciliated cells	96.3 nTPM
Lung	104.6 nTPM
Fallopian tube	101.4 nTPM
Endometrium	99.7 nTPM
Bronchus	79.5 nTPM

Club cells	4.4 nTPM
Bronchus	12.2 nTPM
Prostate	0.8 nTPM
Lung	0.3 nTPM

Endothelial cells	0.4 nTPM
Breast	1.8 nTPM
Testis	1.2 nTPM
Fallopian tube	0.9 nTPM
Prostate	0.7 nTPM
Skeletal muscle	0.6 nTPM
Ovary	0.6 nTPM
Endometrium	0.5 nTPM
Skin	0.4 nTPM
Salivary gland	0.4 nTPM
Tongue	0.3 nTPM
Thymus	0.2 nTPM
Vascular	0.2 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	0.7 nTPM
Prostate	3.3 nTPM
Fallopian tube	1.6 nTPM
Skin	0.9 nTPM
Lung	0.9 nTPM
Breast	0.9 nTPM
Skeletal muscle	0.6 nTPM
Adipose tissue	0.6 nTPM
Vascular	0.5 nTPM
Esophagus	0.4 nTPM
Salivary gland	0.4 nTPM
Thymus	0.3 nTPM
Heart muscle	0.2 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM
Stomach	0.0 nTPM

Granulocytes	0.6 nTPM
Fallopian tube	1.3 nTPM
Lung	0.5 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	0.6 nTPM
Fallopian tube	1.3 nTPM
Ovary	0.0 nTPM

Macrophages	0.3 nTPM
Endometrium	1.8 nTPM
Kidney	0.9 nTPM
Fallopian tube	0.7 nTPM
Testis	0.6 nTPM
Prostate	0.3 nTPM
Adipose tissue	0.2 nTPM
Salivary gland	0.2 nTPM
Tongue	0.2 nTPM
Lung	0.1 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Thymus	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Basal prostatic cells	1.9 nTPM
Prostate	1.9 nTPM

Basal respiratory cells	5.9 nTPM
Bronchus	5.9 nTPM

Bipolar cells	2.2 nTPM
Eye	2.2 nTPM

Collecting duct cells	5.8 nTPM
Kidney	5.8 nTPM

Plasma cells	0.8 nTPM
Stomach	3.8 nTPM
Fallopian tube	1.0 nTPM
Spleen	0.7 nTPM
Thymus	0.5 nTPM
Salivary gland	0.4 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Schwann cells	0.9 nTPM
Vascular	2.6 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	2.4 nTPM
Tongue	4.4 nTPM
Salivary gland	0.4 nTPM

Smooth muscle cells	0.6 nTPM
Fallopian tube	2.8 nTPM
Esophagus	1.2 nTPM
Ovary	1.1 nTPM
Liver	0.8 nTPM
Endometrium	0.8 nTPM
Salivary gland	0.8 nTPM
Adipose tissue	0.7 nTPM
Prostate	0.6 nTPM
Vascular	0.5 nTPM
Breast	0.5 nTPM
Skeletal muscle	0.3 nTPM
Placenta	0.2 nTPM
Thymus	0.1 nTPM
Skin	0.0 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM

T-cells	0.8 nTPM
Endometrium	2.7 nTPM
Stomach	2.7 nTPM
Thymus	2.2 nTPM
Lymph node	1.4 nTPM
Spleen	1.3 nTPM
Fallopian tube	1.2 nTPM
Kidney	0.9 nTPM
Liver	0.8 nTPM
Vascular	0.8 nTPM
Prostate	0.6 nTPM
Salivary gland	0.6 nTPM
Skin	0.4 nTPM
Adipose tissue	0.4 nTPM
Lung	0.3 nTPM
PBMC	0.2 nTPM
Breast	0.2 nTPM
Bone marrow	0.1 nTPM
Colon	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Tongue	0.0 nTPM

Undifferentiated cells	0.0 nTPM
Rectum	0.1 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Amygdala excitatory	33.9 nTPM
Thalamus	44.0 nTPM
Hypothalamus	35.5 nTPM
Basal ganglia	34.9 nTPM
Amygdala	32.7 nTPM
Cerebral cortex	28.2 nTPM
Hippocampus	27.9 nTPM

Astrocyte	45.2 nTPM
Hypothalamus	56.4 nTPM
Medulla oblongata	56.3 nTPM
Amygdala	53.4 nTPM
Cerebellum	49.7 nTPM
Basal ganglia	45.5 nTPM
Spinal cord	44.7 nTPM
Midbrain	41.7 nTPM
Thalamus	40.0 nTPM
Pons	37.5 nTPM
Hippocampus	36.3 nTPM
Cerebral cortex	35.6 nTPM

Bergmann glia	25.8 nTPM
Cerebellum	30.2 nTPM
Pons	30.2 nTPM
Medulla oblongata	17.0 nTPM

Central nervous system macrophage	1.5 nTPM
Basal ganglia	2.3 nTPM
Medulla oblongata	2.3 nTPM
Hypothalamus	2.1 nTPM
Thalamus	1.9 nTPM
Amygdala	1.6 nTPM
Cerebral cortex	1.6 nTPM
Pons	1.6 nTPM
Hippocampus	1.3 nTPM
Cerebellum	1.0 nTPM
Midbrain	0.8 nTPM
Spinal cord	0.6 nTPM

Cerebellar inhibitory	30.1 nTPM
Spinal cord	41.2 nTPM
Midbrain	28.6 nTPM
Medulla oblongata	28.4 nTPM
Pons	26.5 nTPM
Cerebellum	25.5 nTPM

Cge interneuron	15.9 nTPM
Amygdala	18.2 nTPM
Hypothalamus	17.3 nTPM
Basal ganglia	17.0 nTPM
Hippocampus	16.4 nTPM
Cerebral cortex	15.7 nTPM
Midbrain	14.8 nTPM
Thalamus	11.8 nTPM

Choroid plexus epithelial cell	317.6 nTPM
Basal ganglia	449.9 nTPM
Thalamus	334.3 nTPM
Medulla oblongata	244.8 nTPM
Hippocampus	241.3 nTPM

Committed oligodendrocyte precursor	11.3 nTPM
Medulla oblongata	38.7 nTPM
Basal ganglia	20.3 nTPM
Cerebral cortex	10.1 nTPM
Thalamus	9.9 nTPM
Pons	8.9 nTPM
Hypothalamus	7.5 nTPM
Spinal cord	7.4 nTPM
Hippocampus	6.7 nTPM
Amygdala	6.2 nTPM
Cerebellum	4.8 nTPM
Midbrain	4.2 nTPM

Deep-layer corticothalamic and 6b	27.7 nTPM
Hypothalamus	31.1 nTPM
Amygdala	29.2 nTPM
Cerebral cortex	28.5 nTPM
Hippocampus	27.7 nTPM
Midbrain	27.7 nTPM
Basal ganglia	21.9 nTPM

Deep-layer intratelencephalic	28.4 nTPM
Hypothalamus	34.2 nTPM
Hippocampus	27.8 nTPM
Basal ganglia	27.3 nTPM
Cerebral cortex	27.2 nTPM
Amygdala	25.7 nTPM

Deep-layer near-projecting	41.1 nTPM
Hypothalamus	52.9 nTPM
Amygdala	46.2 nTPM
Basal ganglia	39.5 nTPM
Cerebral cortex	34.9 nTPM
Hippocampus	31.9 nTPM

Eccentric medium spiny neuron	35.2 nTPM
Hypothalamus	38.3 nTPM
Hippocampus	37.3 nTPM
Amygdala	37.0 nTPM
Cerebral cortex	33.3 nTPM
Basal ganglia	32.7 nTPM
Thalamus	32.4 nTPM

Endothelial cell	2.0 nTPM
Hypothalamus	5.0 nTPM
Cerebellum	4.6 nTPM
Midbrain	3.8 nTPM
Pons	1.9 nTPM
Spinal cord	1.7 nTPM
Thalamus	1.7 nTPM
Hippocampus	1.0 nTPM
Medulla oblongata	1.0 nTPM
Basal ganglia	0.9 nTPM
Amygdala	0.0 nTPM
Cerebral cortex	0.0 nTPM

Ependymal cell	660.9 nTPM
Basal ganglia	800.7 nTPM
Hypothalamus	790.6 nTPM
Amygdala	717.8 nTPM
Hippocampus	640.5 nTPM
Midbrain	635.5 nTPM
Thalamus	616.7 nTPM
Pons	595.2 nTPM
Spinal cord	580.7 nTPM
Medulla oblongata	570.3 nTPM