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SPRY2
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                                          • SPRY2
                                          TISSUE PRIMARY DATA SALIVARY GLAND Show tissue menu
                                          ADIPOSE TISSUE ADRENAL GLAND AMYGDALA APPENDIX BASAL GANGLIA BLOOD VESSEL BONE MARROW BREAST BRONCHUS CEREBELLUM CEREBRAL CORTEX CERVIX CHOROID PLEXUS COLON
                                          DUODENUM ENDOMETRIUM EPIDIDYMIS ESOPHAGUS FALLOPIAN TUBE GALLBLADDER HEART MUSCLE HIPPOCAMPAL FORMATION HYPOTHALAMUS KIDNEY LIVER LUNG LYMPH NODE MIDBRAIN
                                          NASOPHARYNX ORAL MUCOSA OVARY PANCREAS PARATHYROID GLAND PITUITARY GLAND PLACENTA PROSTATE RECTUM RETINA SALIVARY GLAND SEMINAL VESICLE SKELETAL MUSCLE SKIN
                                          SMALL INTESTINE SMOOTH MUSCLE SOFT TISSUE SPINAL CORD SPLEEN STOMACH TESTIS THYMUS THYROID GLAND TONGUE TONSIL URINARY BLADDER VAGINA
                                          ANTIBODIES
                                          AND
                                          VALIDATION
                                          Dictionary
                                          Salivary gland
                                          Tissue proteome
                                          Salivary gland
                                          Tissue methods
                                          SALIVARY GLAND - Expression summary
                                          Protein expression
                                          Salivary glandi

                                          On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units. Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set. If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

                                          h
                                          m
                                          l
                                          n
                                          Glandular cells: Medium
                                          RNA expressioni

                                          A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas HPA, Genotype-Tissue Expression GTEx portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets. The mRNA expression levels in pig brain are based on RNA-seq data generated by the Human Protein Atlas, and for mouse brain HPA data and in situ hybridization generated by the Allen brain atlas dataset are reported.

                                          Scroll down to view mRNA expression data in more detail.

                                          Consensus:32.8 nTPM
                                          HPA:32.8 nTPM
                                          GTEx:23.1 nTPM
                                          FANTOM5:52.5 Scaled Tags Per Million
                                          SALIVARY GLAND - SINGLE CELL RNA EXPRESSION
                                          Explore single cell type data
                                          Salivary ionocytesSalivary myoepithelial cellsSalivary duct cellsSalivary basal cellsSalivary acinar cellsVascular endothelial cellsLymphatic endothelial cellsPericytesVascular smooth muscle cellsFibroblastsMast cellsNeutrophilsMonocytesMacrophagesT-cellsInnate lymphoid cellsB-cellsPlasma cellsNK-cells050100150200nCPM

                                          SALIVARY GLAND - Antibody stainingi

                                          Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.

                                          Ascending and descending describe two types of gradient, based on difference in staining intensity between enterocytes in crypts and apical enterocytes.

                                          Ascending - the staining intensity is stronger in apical enterocytes (towards the lumen) compared to enterocytes in the crypts (gland based)

                                          Descending - the staining is weaker in apical enterocytes compared to enterocytes in crypts

                                          Antibody CAB037205
                                          Glandular cells Medium



                                          SALIVARY GLAND - HPA RNA-seqi

                                          The RNA-seq details section shows detailed information about the individual samples used for the transcript profiling and results of the RNA-seq analysis.

                                          Information about each individual sample is listed below, including gender, age, a tissue section image and estimated fractions of cell types. nTPM (normalized transcripts per million) values give a quantification of the gene abundance which is comparable between different genes and samples.

                                          Average nTPMi

                                          Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

                                          32.8
                                          overview
                                          Female, age 68
                                          Salivary gland sample 216
                                          nTPM: 35.7
                                          Cell types%
                                          Glandular cells:
                                          45

                                          Ductal cells:
                                          25

                                          Adipocytes:
                                          5

                                          Other cell types:
                                          25

                                          overview
                                          Male, age 60
                                          Salivary gland sample 217
                                          nTPM: 28.3
                                          Cell types%
                                          Glandular cells:
                                          55

                                          Ductal cells:
                                          20

                                          Adipocytes:
                                          5

                                          Endothelial cells:
                                          5

                                          Other cell types:
                                          15

                                          overview
                                          Female, age 21
                                          Salivary gland sample 218
                                          nTPM: 34.3
                                          Cell types%
                                          Glandular cells:
                                          55

                                          Ductal cells:
                                          15

                                          Adipocytes:
                                          5

                                          Endothelial cells:
                                          5

                                          Other cell types:
                                          20


                                          SALIVARY GLAND - GTEx RNA-seqi

                                          RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

                                          Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.

                                          Max subtype nTPMi

                                          Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

                                          23.1
                                          GTEx sample id Sample description nTPM
                                          17.722.627.19.740.4051015202530354045505560
                                          17.722.627.19.740.4051015202530354045505560
                                          Minor Salivary Gland
                                          Average nTPM: 23.1
                                          Samples: 181

                                          Max nTPM: 63.4
                                          Min nTPM: 9.7
                                          Std nTPM: 7.4
                                          Median nTPM: 22.6
                                          GTEX-1QMI2-0426-SM-EWRND 60-69 years, male 63.4
                                          GTEX-1R9K4-0526-SM-E76P1 60-69 years, male 52.8
                                          GTEX-Y3I4-1926-SM-4TT8L 50-59 years, male 41.3
                                          GTEX-1I1HK-2526-SM-A96SM 60-69 years, male 40.4
                                          GTEX-11ZTT-2226-SM-5CVLP 60-69 years, female 37.3
                                          GTEX-1MCQQ-2226-SM-DLHC4 60-69 years, male 35.8
                                          GTEX-1LKK1-2926-SM-EVR4Z 50-59 years, female 35.7
                                          GTEX-1GTWX-2526-SM-9JGHG 60-69 years, male 35.5
                                          GTEX-X15G-2126-SM-4PQZR 50-59 years, female 34.8
                                          GTEX-1445S-2926-SM-5O993 60-69 years, male 34.5
                                          GTEX-146FR-1226-SM-5MR78 60-69 years, female 34.3
                                          GTEX-XGQ4-2626-SM-4AT6B 50-59 years, male 33.6
                                          GTEX-13CF2-2426-SM-5LZYL 60-69 years, male 33.4
                                          GTEX-1C64N-2926-SM-79OLM 50-59 years, male 33.1
                                          GTEX-1P4AB-2926-SM-EXOJR 50-59 years, male 33.1
                                          GTEX-14JIY-3026-SM-6EU1R 60-69 years, male 32.6
                                          GTEX-1OJC4-3126-SM-EXOJK 50-59 years, female 32.4
                                          GTEX-1117F-3026-SM-5GZYU 60-69 years, female 32.2
                                          GTEX-1LH75-2726-SM-HL11E 50-59 years, female 31.6
                                          GTEX-1R9PO-2626-SM-E6CPU 60-69 years, female 31.6
                                          GTEX-18A7B-2826-SM-7KFTK 70-79 years, male 31.3
                                          GTEX-1KANC-1326-SM-CYPT8 50-59 years, female 30.8
                                          GTEX-13O21-1926-SM-5MR39 50-59 years, male 30.7
                                          GTEX-1GMR2-2026-SM-7MKHK 50-59 years, male 30.7
                                          GTEX-14PN4-2526-SM-686ZG 50-59 years, male 30.5
                                          GTEX-1J8EW-2826-SM-A96T9 60-69 years, female 30.0
                                          GTEX-X5EB-1726-SM-4E3J7 40-49 years, male 29.6
                                          GTEX-ZC5H-2726-SM-5KLZW 40-49 years, female 29.5
                                          GTEX-1IE54-0826-SM-AHZ2Z 40-49 years, female 29.3
                                          GTEX-17KNJ-2726-SM-7KFRE 50-59 years, male 29.2
                                          GTEX-1AX8Z-0626-SM-731EH 60-69 years, male 29.1
                                          GTEX-YB5K-1726-SM-5IFIZ 40-49 years, female 29.1
                                          GTEX-W5X1-2426-SM-HPAGA 40-49 years, female 28.9
                                          GTEX-1KD5A-2226-SM-EV79U 50-59 years, male 28.8
                                          GTEX-1J8QM-1826-SM-A96TA 60-69 years, female 28.6
                                          GTEX-12WSM-1826-SM-5BC64 60-69 years, male 28.4
                                          GTEX-1NSGN-0626-SM-E9J35 50-59 years, male 28.4
                                          GTEX-13G51-2426-SM-5LZY8 60-69 years, male 28.3
                                          GTEX-13QJC-2326-SM-5Q5CD 60-69 years, female 28.3
                                          GTEX-1GF9X-0226-SM-7P8SM 40-49 years, female 28.2
                                          GTEX-1KD4Q-2526-SM-CXZKL 40-49 years, male 28.1
                                          GTEX-1QEPI-0626-SM-E76QE 60-69 years, female 28.0
                                          GTEX-1LC47-2426-SM-DHXKK 60-69 years, male 27.8
                                          GTEX-1HSMQ-0926-SM-A96SI 50-59 years, male 27.5
                                          GTEX-1I6K7-0926-SM-A96SV 40-49 years, male 27.3
                                          GTEX-1AMEY-1126-SM-72D79 30-39 years, female 27.1
                                          GTEX-1GN1W-2526-SM-9JGHX 50-59 years, female 27.1
                                          GTEX-1HFI7-2426-SM-B2LXV 50-59 years, female 26.8
                                          GTEX-1LVA9-2526-SM-EVR5H 50-59 years, male 26.6
                                          GTEX-1S5VW-1026-SM-HK797 60-69 years, male 26.6
                                          GTEX-13113-1526-SM-5EGHV 60-69 years, female 26.4
                                          GTEX-1B97J-2126-SM-79OL6 50-59 years, female 26.4
                                          GTEX-1QP28-2026-SM-F2I3M 50-59 years, female 26.3
                                          GTEX-1IDJC-1626-SM-AHZ2R 50-59 years, male 26.1
                                          GTEX-131XH-2626-SM-5GCNP 50-59 years, male 26.0
                                          GTEX-1LVAM-0626-SM-HPAFZ 50-59 years, female 25.7
                                          GTEX-145ME-1626-SM-5RQI3 40-49 years, female 25.5
                                          GTEX-1HSGN-0626-SM-A9G2E 40-49 years, female 25.5
                                          GTEX-1AX9K-2126-SM-72D7K 50-59 years, male 25.3
                                          GTEX-WHSB-2326-SM-4M1XK 50-59 years, male 25.3
                                          GTEX-ZG7Y-2426-SM-DO11H 50-59 years, male 25.1
                                          GTEX-1R9K5-0626-SM-DPRZB 50-59 years, male 24.9
                                          GTEX-1RNSC-2926-SM-EV79L 60-69 years, male 24.9
                                          GTEX-13QBU-2126-SM-5KLZN 40-49 years, female 24.8
                                          GTEX-ZE7O-2926-SM-51MSG 50-59 years, female 24.6
                                          GTEX-1B8KZ-1726-SM-73KV7 50-59 years, male 24.5
                                          GTEX-1IOXB-2826-SM-AHZ32 50-59 years, male 24.5
                                          GTEX-1HSMP-1926-SM-GA8Z5 70-79 years, male 24.2
                                          GTEX-1I6K6-0626-SM-ARU7J 30-39 years, male 24.2
                                          GTEX-Y5V6-2226-SM-4VDTC 60-69 years, male 24.2
                                          GTEX-1H4P4-2026-SM-9WPNV 50-59 years, male 24.1
                                          GTEX-1HR9M-2526-SM-A9G3J 60-69 years, male 24.1
                                          GTEX-1HSEH-1826-SM-A96SA 60-69 years, male 24.1
                                          GTEX-13NYC-2626-SM-5K7VN 60-69 years, male 24.0
                                          GTEX-1RAZA-0626-SM-EAZ4H 20-29 years, male 24.0
                                          GTEX-131XF-2826-SM-5EGKH 60-69 years, male 23.9
                                          GTEX-1MCC2-2226-SM-EV7AJ 30-39 years, female 23.9
                                          GTEX-14PJN-1726-SM-69LO7 30-39 years, male 23.8
                                          GTEX-1GN1V-2926-SM-9JGI3 60-69 years, male 23.8
                                          GTEX-15CHC-1226-SM-686ZH 60-69 years, female 23.6
                                          GTEX-1LVAO-2626-SM-EVR4S 60-69 years, male 23.6
                                          GTEX-13111-2326-SM-5LZUQ 50-59 years, male 23.5
                                          GTEX-WYVS-2026-SM-4RGNS 40-49 years, female 23.5
                                          GTEX-15SHV-2226-SM-6M464 60-69 years, male 23.4
                                          GTEX-11WQK-2926-SM-5EQKT 50-59 years, male 23.2
                                          GTEX-1J1R8-1826-SM-AHZ3B 40-49 years, male 23.2
                                          GTEX-1HFI6-2826-SM-GA91I 40-49 years, male 23.0
                                          GTEX-1HGF4-2326-SM-GA91Q 60-69 years, male 23.0
                                          GTEX-1IY9M-2926-SM-A96TH 60-69 years, male 22.7
                                          GTEX-1QCLZ-2526-SM-EXUST 60-69 years, female 22.7
                                          GTEX-1JN6P-2526-SM-CNNPX 60-69 years, male 22.6
                                          GTEX-ZQUD-2126-SM-51MSY 30-39 years, male 22.5
                                          GTEX-1339X-2326-SM-5HL5B 40-49 years, male 22.4
                                          GTEX-Y111-2626-SM-4TT24 50-59 years, male 22.4
                                          GTEX-YF7O-2226-SM-5CVN8 50-59 years, male 22.4
                                          GTEX-13OVL-2926-SM-5IFG3 50-59 years, male 22.3
                                          GTEX-15EU6-2626-SM-7KUN4 50-59 years, male 22.1
                                          GTEX-1GZ2Q-2526-SM-9KNVW 40-49 years, male 21.9
                                          GTEX-111FC-2926-SM-5GZY7 60-69 years, male 21.8
                                          GTEX-1LSNL-2626-SM-EV7AT 50-59 years, male 21.7
                                          GTEX-1S82P-0726-SM-EVR4O 60-69 years, female 21.7
                                          GTEX-1EH9U-2926-SM-7DHLX 60-69 years, male 21.6
                                          GTEX-1C64O-0626-SM-7DHL1 60-69 years, male 21.5
                                          GTEX-1LBAC-0626-SM-D3L9T 20-29 years, male 21.5
                                          GTEX-X3Y1-1926-SM-4PQZO 40-49 years, male 21.5
                                          GTEX-Z9EW-1426-SM-HPAG9 40-49 years, male 21.4
                                          GTEX-1R9PM-1726-SM-E76T2 20-29 years, male 21.3
                                          GTEX-1B8SF-1826-SM-731DJ 60-69 years, male 21.2
                                          GTEX-1QP9N-2026-SM-DPRZT 30-39 years, male 21.2
                                          GTEX-X261-2426-SM-4PQZU 50-59 years, male 20.9
                                          GTEX-14B4R-1426-SM-5Q5CG 30-39 years, male 20.8
                                          GTEX-14PJ3-1526-SM-664O9 50-59 years, male 20.8
                                          GTEX-15RJE-2726-SM-6LPJ1 40-49 years, male 20.8
                                          GTEX-1C4CL-2026-SM-731EB 30-39 years, male 20.3
                                          GTEX-1H1CY-2326-SM-9OSXW 60-69 years, female 20.3
                                          GTEX-1ICLY-0626-SM-GA915 50-59 years, male 20.2
                                          GTEX-14E1K-2626-SM-664OJ 50-59 years, male 20.0
                                          GTEX-15SDE-1226-SM-HAV36 50-59 years, female 20.0
                                          GTEX-13OVI-2326-SM-5KM47 60-69 years, female 19.9
                                          GTEX-1I4MK-1326-SM-B2LWT 50-59 years, female 19.9
                                          GTEX-1IKJJ-2826-SM-GA8ZM 60-69 years, male 19.9
                                          GTEX-11EMC-2526-SM-5PNVU 60-69 years, female 19.8
                                          GTEX-13OVK-1826-SM-6PALE 40-49 years, male 19.8
                                          GTEX-WFJO-2026-SM-4LVM3 30-39 years, male 19.8
                                          GTEX-1B932-0626-SM-731EM 40-49 years, female 19.5
                                          GTEX-11EQ9-2026-SM-5P9JI 30-39 years, male 19.4
                                          GTEX-11NV4-1926-SM-5N9D4 60-69 years, male 19.2
                                          GTEX-11ZTS-3026-SM-5EQM7 60-69 years, female 19.0
                                          GTEX-WH7G-2126-SM-4M1XU 40-49 years, male 19.0
                                          GTEX-12WSL-2126-SM-5GCNG 50-59 years, male 18.8
                                          GTEX-ZF29-2126-SM-DNZYX 60-69 years, female 18.5
                                          GTEX-1MGNQ-1926-SM-DTX8L 40-49 years, male 18.4
                                          GTEX-13JVG-2926-SM-5J2N9 60-69 years, male 18.3
                                          GTEX-13NYB-2426-SM-5IFF4 40-49 years, male 18.2
                                          GTEX-178AV-1426-SM-6LLID 40-49 years, male 18.1
                                          GTEX-1A3MV-1726-SM-72D68 30-39 years, male 17.7
                                          GTEX-11TUW-2426-SM-5EQKB 60-69 years, male 17.6
                                          GTEX-1S5ZU-0926-SM-HPAEX 20-29 years, female 17.6
                                          GTEX-WOFM-2126-SM-4M9R4 20-29 years, male 17.5
                                          GTEX-1CB4I-2526-SM-7MKG1 50-59 years, male 17.4
                                          GTEX-1POEN-2226-SM-DPRXV 30-39 years, female 17.4
                                          GTEX-13VXT-1726-SM-5IFF5 20-29 years, female 17.3
                                          GTEX-18A67-0626-SM-7KFSL 50-59 years, male 17.3
                                          GTEX-1IDJD-2526-SM-C1YSA 30-39 years, male 17.0
                                          GTEX-11P81-2026-SM-5P9GT 30-39 years, female 16.8
                                          GTEX-1GPI7-0326-SM-7MKH6 20-29 years, male 16.7
                                          GTEX-WY7C-1426-SM-4OND1 50-59 years, male 16.7
                                          GTEX-1192X-2926-SM-5N9BA 50-59 years, male 16.5
                                          GTEX-XV7Q-2426-SM-4BRV8 40-49 years, female 16.5
                                          GTEX-1S83E-0626-SM-E9TKC 40-49 years, male 16.4
                                          GTEX-1JN1M-2426-SM-ARU93 60-69 years, female 16.3
                                          GTEX-1OJC3-1026-SM-E6CQK 20-29 years, male 16.3
                                          GTEX-1RQED-2926-SM-HPAFT 60-69 years, male 15.9
                                          GTEX-ZXG5-2826-SM-5NQ8T 60-69 years, male 15.9
                                          GTEX-ZLWG-2026-SM-DO11F 50-59 years, female 15.7
                                          GTEX-12WSN-2226-SM-5DUXT 40-49 years, male 15.5
                                          GTEX-1C6VR-0726-SM-7P8OV 60-69 years, male 15.5
                                          GTEX-ZAB5-2326-SM-5IJFR 50-59 years, male 15.4
                                          GTEX-1314G-2026-SM-5LZUM 30-39 years, male 15.3
                                          GTEX-11P82-0926-SM-5986X 20-29 years, male 15.0
                                          GTEX-12BJ1-2226-SM-5BC6G 60-69 years, male 14.9
                                          GTEX-18D9U-2226-SM-7KFTN 40-49 years, male 14.9
                                          GTEX-1AYD5-2726-SM-7MXVG 50-59 years, male 14.8
                                          GTEX-1JKYR-0726-SM-AHZ3K 20-29 years, male 14.6
                                          GTEX-17MFQ-1626-SM-7938Z 20-29 years, male 14.4
                                          GTEX-ZLFU-2226-SM-EXUS7 40-49 years, male 14.3
                                          GTEX-1PIEJ-0626-SM-DTX99 20-29 years, female 14.1
                                          GTEX-XMK1-2626-SM-4B65R 40-49 years, male 13.8
                                          GTEX-YJ8A-1826-SM-GNTAB 20-29 years, male 13.6
                                          GTEX-1IDJV-2326-SM-GA8ZL 60-69 years, male 13.1
                                          GTEX-ZPU1-2326-SM-57WEP 40-49 years, male 13.1
                                          GTEX-Y5LM-1826-SM-4VDT9 40-49 years, female 12.3
                                          GTEX-ZT9W-2126-SM-51MSF 50-59 years, male 12.2
                                          GTEX-ZP4G-1926-SM-57WDZ 20-29 years, female 11.9
                                          GTEX-1NHNU-2226-SM-GRR2I 50-59 years, male 11.5
                                          GTEX-18QFQ-0626-SM-718AW 30-39 years, male 11.3
                                          GTEX-1O97I-2826-SM-HPAEO 60-69 years, male 10.5
                                          GTEX-1PPH8-1526-SM-E6CQO 20-29 years, male 10.3
                                          GTEX-1HCU7-0126-SM-C1YR3 50-59 years, male 10.2
                                          GTEX-ZA64-1726-SM-5CVMF 20-29 years, male 10.0
                                          GTEX-1PDJ9-2126-SM-HPAFH 20-29 years, male 9.7
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                                          SALIVARY GLAND - FANTOM5 CAGEi

                                          RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

                                          Max subtype Scaled Tags Per Millioni

                                          Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.

                                          52.5
                                          FANTOM5 sample id Sample description Scaled Tags Per Million
                                          Parotid gland
                                          Scaled Tags Per Million: 40.7
                                          FF:10199-103F1 23 years, male 40.7
                                          Salivary gland
                                          Scaled Tags Per Million: 52.5
                                          FF:10093-102C3 16-60 years, mixed 52.5
                                          Submaxillary gland
                                          Scaled Tags Per Million: 49.9
                                          FF:10202-103F4 24 years, male 49.9

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