Single cell type - TJP2 - The Human Protein Atlas

TJP2

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TJP2
Gene descriptionⁱ Full gene name according to HGNC.	Tight junction protein 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	17

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oligodendrocytes, Astrocytes, Rod photoreceptor cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.58
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Bergmann glia, Astrocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (non-classical monocyte)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Astrocytes, Rod photoreceptor cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Bergmann glia, Astrocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (non-classical monocyte)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TJP2 is part of cluster 45 Non-specific - Mixed function with confidenceⁱ 1
349 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MYRF	Myelin regulatory factor	0.6185	45
MYO6	Myosin VI	0.5752	45
VNN1	Vanin 1	0.5491	45
DUOXA2	Dual oxidase maturation factor 2	0.5418	45
RND1	Rho family GTPase 1	0.5339	45
ITGA2	Integrin subunit alpha 2	0.5266	45
MMP7	Matrix metallopeptidase 7	0.5238	45
CDC42EP1	CDC42 effector protein 1	0.5185	45
GTF2IRD1	GTF2I repeat domain containing 1	0.5143	47
ANKRD36C	Ankyrin repeat domain 36C	0.5142	45
PLEKHA7	Pleckstrin homology domain containing A7	0.5132	47
KRTAP1-1	Keratin associated protein 1-1	0.5088	45
UBD	Ubiquitin D	0.5068	45
FGD6	FYVE, RhoGEF and PH domain containing 6	0.5061	45
DUOX2	Dual oxidase 2	0.4963	45

IMMUNE CELLS

TJP2 is part of cluster 40 Monocytes - Innate immune response with confidenceⁱ 1
228 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SLC24A4	Solute carrier family 24 member 4	1.0000	40
PGA5	Pepsinogen A5	1.0000	40
LIPN	Lipase family member N	1.0000	40
AP2A1	Adaptor related protein complex 2 subunit alpha 1	1.0000	40
CD300E	CD300e molecule	1.0000	40
PENK	Proenkephalin	1.0000	40
CDC42EP4	CDC42 effector protein 4	1.0000	40
FLII	FLII actin remodeling protein	1.0000	40
CXCL16	C-X-C motif chemokine ligand 16	1.0000	40
ATG3	Autophagy related 3	1.0000	40
SLC31A1	Solute carrier family 31 member 1	1.0000	40
SAT1	Spermidine/spermine N1-acetyltransferase 1	1.0000	40
CALML4	Calmodulin like 4	1.0000	40
LOXL3	Lysyl oxidase like 3	1.0000	40
ABHD11	Abhydrolase domain containing 11	1.0000	40

Adipocytes	5.3 nTPM
Adipose tissue	6.9 nTPM
Breast	3.6 nTPM

Alveolar cells type 1	10.4 nTPM
Lung	10.4 nTPM

Alveolar cells type 2	5.0 nTPM
Lung	5.0 nTPM

B-cells	1.5 nTPM
Skin	11.9 nTPM
Esophagus	5.9 nTPM
Adipose tissue	0.4 nTPM
Stomach	0.4 nTPM
Salivary gland	0.4 nTPM
Thymus	0.4 nTPM
Spleen	0.2 nTPM
Lymph node	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM
Lung	0.0 nTPM

Basal keratinocytes	6.6 nTPM
Skin	7.0 nTPM
Tongue	6.3 nTPM

Ciliated cells	9.9 nTPM
Fallopian tube	14.7 nTPM
Endometrium	10.8 nTPM
Bronchus	8.3 nTPM
Lung	5.9 nTPM

Club cells	8.0 nTPM
Prostate	10.1 nTPM
Bronchus	7.3 nTPM
Lung	6.7 nTPM

Endothelial cells	7.2 nTPM
Thymus	15.4 nTPM
Pancreas	12.9 nTPM
Fallopian tube	12.4 nTPM
Esophagus	10.3 nTPM
Lung	9.8 nTPM
Skeletal muscle	8.9 nTPM
Salivary gland	7.9 nTPM
Liver	7.6 nTPM
Endometrium	7.3 nTPM
Breast	6.2 nTPM
Heart muscle	5.6 nTPM
Tongue	5.6 nTPM
Vascular	5.3 nTPM
Skin	4.6 nTPM
Prostate	4.3 nTPM
Ovary	2.8 nTPM
Testis	1.5 nTPM
Placenta	1.1 nTPM

Enteroendocrine cells	8.4 nTPM
Rectum	11.7 nTPM
Colon	10.2 nTPM
Small intestine	3.4 nTPM

Fibroblasts	3.7 nTPM
Stomach	11.5 nTPM
Placenta	9.0 nTPM
Lung	6.4 nTPM
Thymus	6.3 nTPM
Skin	3.9 nTPM
Vascular	3.7 nTPM
Pancreas	3.5 nTPM
Salivary gland	2.7 nTPM
Fallopian tube	2.6 nTPM
Esophagus	2.5 nTPM
Liver	2.4 nTPM
Prostate	2.0 nTPM
Adipose tissue	1.0 nTPM
Skeletal muscle	0.9 nTPM
Heart muscle	0.8 nTPM
Breast	0.6 nTPM

Granulocytes	4.9 nTPM
Tongue	9.7 nTPM
Fallopian tube	4.0 nTPM
Lung	1.0 nTPM

Intestinal goblet cells	19.7 nTPM
Small intestine	30.3 nTPM
Rectum	18.4 nTPM
Colon	10.3 nTPM

Lymphatic endothelial cells	7.0 nTPM
Ovary	10.9 nTPM
Fallopian tube	3.2 nTPM

Macrophages	3.7 nTPM
Fallopian tube	12.5 nTPM
Pancreas	8.2 nTPM
Endometrium	8.0 nTPM
Stomach	7.7 nTPM
Adipose tissue	6.5 nTPM
Spleen	4.0 nTPM
Tongue	3.3 nTPM
Bone marrow	3.0 nTPM
Skeletal muscle	2.3 nTPM
Thymus	2.3 nTPM
Skin	2.2 nTPM
Kidney	1.8 nTPM
Prostate	1.5 nTPM
Vascular	1.5 nTPM
Breast	1.4 nTPM
Esophagus	1.3 nTPM
Salivary gland	1.1 nTPM
Lung	1.0 nTPM
Testis	0.6 nTPM

Paneth cells	22.2 nTPM
Rectum	24.0 nTPM
Colon	21.7 nTPM
Small intestine	20.7 nTPM

Astrocytes	72.5 nTPM
Brain	72.5 nTPM

Bipolar cells	27.7 nTPM
Eye	27.7 nTPM

Collecting duct cells	7.8 nTPM
Kidney	7.8 nTPM

Distal enterocytes	20.5 nTPM
Rectum	21.1 nTPM
Colon	20.0 nTPM

Plasma cells	1.8 nTPM
Esophagus	5.2 nTPM
Salivary gland	3.6 nTPM
Fallopian tube	2.6 nTPM
Stomach	1.3 nTPM
Liver	1.0 nTPM
Spleen	0.2 nTPM
Thymus	0.2 nTPM
Bone marrow	0.0 nTPM

Schwann cells	3.6 nTPM
Adipose tissue	10.1 nTPM
Vascular	0.5 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	4.1 nTPM
Tongue	4.4 nTPM
Salivary gland	3.8 nTPM

Smooth muscle cells	3.1 nTPM
Thymus	7.8 nTPM
Skin	5.4 nTPM
Adipose tissue	5.3 nTPM
Vascular	4.7 nTPM
Fallopian tube	4.6 nTPM
Tongue	4.2 nTPM
Esophagus	3.6 nTPM
Skeletal muscle	3.3 nTPM
Lung	2.4 nTPM
Endometrium	2.2 nTPM
Salivary gland	1.8 nTPM
Liver	1.7 nTPM
Ovary	1.0 nTPM
Placenta	0.9 nTPM
Breast	0.8 nTPM
Prostate	0.6 nTPM

T-cells	0.7 nTPM
Tongue	2.7 nTPM
Colon	1.9 nTPM
Skin	1.8 nTPM
Endometrium	1.0 nTPM
Stomach	0.9 nTPM
Skeletal muscle	0.8 nTPM
Lung	0.8 nTPM
Vascular	0.8 nTPM
Lymph node	0.7 nTPM
Liver	0.6 nTPM
PBMC	0.6 nTPM
Bone marrow	0.5 nTPM
Spleen	0.5 nTPM
Prostate	0.4 nTPM
Thymus	0.4 nTPM
Breast	0.4 nTPM
Adipose tissue	0.2 nTPM
Salivary gland	0.2 nTPM
Fallopian tube	0.2 nTPM
Kidney	0.0 nTPM
Esophagus	0.0 nTPM

Undifferentiated cells	13.3 nTPM
Small intestine	17.2 nTPM
Rectum	15.0 nTPM
Colon	7.8 nTPM

Amygdala excitatory	7.0 nTPM
Amygdala	8.0 nTPM
Hippocampus	7.9 nTPM
Basal ganglia	7.2 nTPM
Cerebral cortex	6.8 nTPM
Hypothalamus	6.2 nTPM
Thalamus	5.9 nTPM

Astrocyte	211.9 nTPM
Spinal cord	590.3 nTPM
Cerebellum	287.7 nTPM
Medulla oblongata	253.2 nTPM
Pons	218.0 nTPM
Hypothalamus	198.0 nTPM
Hippocampus	188.9 nTPM
Midbrain	147.0 nTPM
Amygdala	131.9 nTPM
Thalamus	126.5 nTPM
Cerebral cortex	104.4 nTPM
Basal ganglia	85.1 nTPM

Bergmann glia	370.8 nTPM
Cerebellum	395.2 nTPM
Pons	387.0 nTPM
Medulla oblongata	330.3 nTPM

Central nervous system macrophage	6.5 nTPM
Spinal cord	11.5 nTPM
Cerebellum	8.4 nTPM
Hippocampus	8.2 nTPM
Midbrain	7.2 nTPM
Amygdala	7.0 nTPM
Basal ganglia	5.7 nTPM
Hypothalamus	5.4 nTPM
Thalamus	5.4 nTPM
Cerebral cortex	4.9 nTPM
Pons	4.7 nTPM
Medulla oblongata	3.4 nTPM

Cerebellar inhibitory	13.8 nTPM
Cerebellum	15.8 nTPM
Medulla oblongata	14.4 nTPM
Spinal cord	13.7 nTPM
Pons	13.1 nTPM
Midbrain	11.8 nTPM

Cge interneuron	4.7 nTPM
Midbrain	6.7 nTPM
Cerebral cortex	4.8 nTPM
Amygdala	4.7 nTPM
Hippocampus	4.7 nTPM
Hypothalamus	4.3 nTPM
Basal ganglia	4.1 nTPM
Thalamus	3.3 nTPM

Choroid plexus epithelial cell	19.4 nTPM
Medulla oblongata	21.7 nTPM
Basal ganglia	19.8 nTPM
Hippocampus	19.4 nTPM
Thalamus	16.4 nTPM

Committed oligodendrocyte precursor	35.5 nTPM
Hypothalamus	65.5 nTPM
Thalamus	54.3 nTPM
Amygdala	49.1 nTPM
Basal ganglia	41.1 nTPM
Cerebral cortex	38.6 nTPM
Hippocampus	34.4 nTPM
Midbrain	28.6 nTPM
Pons	26.6 nTPM
Medulla oblongata	24.5 nTPM
Cerebellum	20.6 nTPM
Spinal cord	7.4 nTPM

Deep-layer corticothalamic and 6b	3.8 nTPM
Hippocampus	4.7 nTPM
Hypothalamus	4.2 nTPM
Cerebral cortex	4.1 nTPM
Amygdala	3.7 nTPM
Basal ganglia	3.7 nTPM
Midbrain	2.2 nTPM

Deep-layer intratelencephalic	4.8 nTPM
Hippocampus	5.7 nTPM
Amygdala	5.0 nTPM
Hypothalamus	5.0 nTPM
Cerebral cortex	4.4 nTPM
Basal ganglia	3.9 nTPM

Deep-layer near-projecting	4.4 nTPM
Amygdala	5.7 nTPM
Cerebral cortex	5.6 nTPM
Basal ganglia	4.4 nTPM
Hippocampus	3.6 nTPM
Hypothalamus	2.8 nTPM

Eccentric medium spiny neuron	6.3 nTPM
Amygdala	7.2 nTPM
Cerebral cortex	7.1 nTPM
Thalamus	6.3 nTPM
Basal ganglia	6.0 nTPM
Hypothalamus	5.9 nTPM
Hippocampus	5.4 nTPM

Endothelial cell	87.8 nTPM
Basal ganglia	111.9 nTPM
Midbrain	104.0 nTPM
Pons	91.8 nTPM
Hypothalamus	90.6 nTPM
Spinal cord	86.3 nTPM
Cerebral cortex	85.7 nTPM
Amygdala	84.9 nTPM
Hippocampus	82.1 nTPM
Thalamus	81.3 nTPM
Cerebellum	76.7 nTPM
Medulla oblongata	70.8 nTPM

Ependymal cell	17.2 nTPM
Spinal cord	32.6 nTPM
Midbrain	21.6 nTPM
Hippocampus	19.1 nTPM
Thalamus	17.8 nTPM
Medulla oblongata	17.1 nTPM
Pons	16.9 nTPM
Amygdala	14.2 nTPM
Basal ganglia	9.6 nTPM
Hypothalamus	6.2 nTPM