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The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
MDK is not prognostic in Pancreatic Adenocarcinoma (TCGA)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
382.8
Number of samples
176
Samples
Sample
Description
TPM
TCGA-IB-A6UF-01A
0 years, male, white, stage:Stage IIB, alive, 666 days
1239.6
TCGA-2L-AAQL-01A
0 years, male, white, stage:Stage IIB, dead, 292 days
1108.4
TCGA-3A-A9IU-01A
0 years, male, white, stage:Stage IIB, dead, 458 days
1032.2
TCGA-IB-A5SP-01A
0 years, male, white, stage:Stage IIA, alive, 482 days
1028.5
TCGA-HV-A7OL-01A
0 years, male, asian, stage:Stage IIA, alive, 252 days
959.9
TCGA-FB-AAPQ-01A
0 years, male, white, stage:Stage IIB, dead, 1130 days
951.9
TCGA-S4-A8RO-01A
0 years, female, white, stage:Stage IIB, alive, 525 days
928.3
TCGA-FB-A5VM-01A
0 years, male, white, stage:Stage IB, dead, 498 days
885.1
TCGA-3A-A9I5-01A
0 years, male, white, stage:'--, alive, 1794 days
884.6
TCGA-OE-A75W-01A
0 years, male, white, stage:Stage IIA, dead, 267 days
866.9
TCGA-YY-A8LH-01A
0 years, female, white, stage:Stage IIB, alive, 2016 days
813.3
TCGA-US-A77G-01A
0 years, male, white, stage:Stage IIB, dead, 12 days
797.0
TCGA-IB-AAUO-01A
0 years, female, white, stage:Stage IIB, dead, 239 days
733.1
TCGA-US-A779-01A
0 years, female, white, stage:Stage IIB, dead, 511 days
710.6
TCGA-2J-AAB6-01A
0 years, male, white, stage:Stage IIA, dead, 293 days
698.4
TCGA-F2-6879-01A
0 years, male, white, stage:Stage IIB, dead, 334 days
677.8
TCGA-IB-AAUU-01A
0 years, male, white, stage:Stage IIB, alive, 245 days
677.1
TCGA-HV-A5A3-01A
0 years, male, asian, stage:Stage IIA, dead, 128 days
667.2
TCGA-2J-AABA-01A
0 years, male, white, stage:Stage IIB, dead, 607 days
653.3
TCGA-F2-A8YN-01A
0 years, male, white, stage:Stage IIA, alive, 517 days
651.0
TCGA-IB-AAUQ-01A
0 years, male, white, stage:Stage IIB, dead, 183 days
648.1
TCGA-FB-A78T-01A
0 years, female, white, stage:Stage IIB, dead, 375 days
645.2
TCGA-FB-AAPP-01A
0 years, male, white, stage:Stage IIB, dead, 485 days
632.9
TCGA-HZ-A49I-01A
0 years, male, white, stage:Stage IIB, dead, 308 days
629.3
TCGA-HV-AA8X-01A
0 years, female, asian, stage:Stage IIB, dead, 532 days
627.3
TCGA-2J-AAB1-01A
0 years, male, white, stage:Stage IIB, dead, 66 days
598.4
TCGA-H6-A45N-01A
0 years, female, white, stage:Stage IIB, dead, 397 days
595.9
TCGA-FB-AAPU-01A
0 years, female, asian, stage:Stage IIA, dead, 381 days
576.9
TCGA-IB-8127-01A
0 years, male, white, stage:Stage IIB, alive, 522 days
568.5
TCGA-HZ-A4BH-01A
0 years, male, white, stage:Stage IIB, alive, 194 days
562.0
TCGA-HZ-A4BK-01A
0 years, male, white, stage:Stage IIB, alive, 657 days
560.8
TCGA-3A-A9IZ-01A
0 years, male, white, stage:Stage IIB, dead, 308 days
559.9
TCGA-FB-AAQ1-01A
0 years, male, white, stage:Stage IIB, dead, 123 days
558.0
TCGA-IB-A7M4-01A
0 years, male, white, stage:Stage IIB, alive, 483 days
548.4
TCGA-3A-A9IH-01A
0 years, female, white, stage:Stage IA, alive, 1021 days
546.3
TCGA-2J-AABH-01A
0 years, male, white, stage:Stage IIA, alive, 1287 days
536.2
TCGA-2L-AAQM-01A
0 years, male, white, stage:Stage IIB, alive, 1383 days
533.5
TCGA-M8-A5N4-01A
0 years, female, stage:Stage IIA, alive, 584 days
531.6
TCGA-PZ-A5RE-01A
0 years, female, white, stage:Stage IIB, dead, 470 days
491.3
TCGA-HZ-7925-01A
0 years, male, white, stage:Stage IIB, dead, 614 days
490.0
TCGA-IB-AAUN-01A
0 years, female, white, stage:Stage IB, dead, 144 days
486.6
TCGA-F2-A7TX-01A
0 years, male, white, stage:Stage IIB, dead, 95 days
483.6
TCGA-IB-7646-01A
0 years, male, white, stage:Stage IIB, dead, 145 days
482.6
TCGA-L1-A7W4-01A
0 years, female, white, stage:Stage IIB, dead, 278 days
481.3
TCGA-IB-A5SS-01A
0 years, female, white, stage:Stage IIB, dead, 460 days
479.3
TCGA-2J-AABI-01A
0 years, female, white, stage:Stage IIA, alive, 969 days
475.1
TCGA-HV-A5A4-01A
0 years, female, asian, stage:Stage IIA, alive, 232 days
473.8
TCGA-FB-AAPS-01A
0 years, female, white, stage:Stage IIB, alive, 228 days
470.7
TCGA-S4-A8RM-01A
0 years, male, white, stage:Stage IIB, alive, 737 days
467.4
TCGA-IB-AAUP-01A
0 years, male, white, stage:Stage IIB, alive, 431 days
454.6
TCGA-HZ-A77Q-01A
0 years, female, white, stage:Stage IIB, alive, 33 days
454.0
TCGA-XD-AAUI-01A
0 years, female, white, stage:Stage IIB, dead, 366 days
453.2
TCGA-3A-A9IC-01A
0 years, female, white, stage:Stage IIB, dead, 738 days
452.7
TCGA-2J-AABO-01A
0 years, male, white, stage:Stage IIB, alive, 440 days
447.6
TCGA-HZ-8636-01A
0 years, female, white, stage:Stage IV, dead, 545 days
446.2
TCGA-2J-AABE-01A
0 years, male, white, stage:Stage IIA, alive, 676 days
445.1
TCGA-YB-A89D-01A
0 years, male, white, stage:Stage IIB, alive, 350 days
443.3
TCGA-2L-AAQA-01A
0 years, male, white, stage:Stage IIB, dead, 143 days
441.8
TCGA-FB-AAQ3-01A
0 years, female, white, stage:Stage IIB, dead, 31 days
441.3
TCGA-3E-AAAY-01A
0 years, male, white, stage:Stage IIB, alive, 2285 days
435.2
TCGA-3A-A9IB-01A
0 years, female, white, stage:Stage IIB, dead, 224 days
434.9
TCGA-RB-AA9M-01A
0 years, male, white, stage:Stage IIB, alive, 286 days
427.1
TCGA-2J-AABP-01A
0 years, female, white, stage:Stage IIB, alive, 463 days
420.4
TCGA-2L-AAQE-01A
0 years, male, white, stage:Stage IIB, dead, 684 days
419.0
TCGA-2L-AAQJ-01A
0 years, female, white, stage:Stage III, dead, 394 days
417.5
TCGA-2J-AABF-01A
0 years, male, white, stage:Stage IIB, dead, 691 days
412.9
TCGA-HZ-A8P1-01A
0 years, male, white, stage:Stage IB, alive, 7 days
412.1
TCGA-3A-A9I7-01A
0 years, male, black or african american, stage:Stage IIB, alive, 1323 days
408.6
TCGA-FB-AAPY-01A
0 years, male, white, stage:Stage IIB, dead, 1059 days
403.0
TCGA-FB-AAQ0-01A
0 years, male, white, stage:Stage IIA, dead, 473 days
398.0
TCGA-IB-7645-01A
0 years, female, stage:Stage IIB, dead, 1502 days
398.0
TCGA-2J-AAB4-01A
0 years, male, white, stage:Stage IIB, alive, 729 days
395.9
TCGA-FB-AAQ6-01A
0 years, male, white, stage:Stage IA, dead, 244 days
390.0
TCGA-US-A77E-01A
0 years, male, white, stage:Stage IIB, dead, 430 days
389.7
TCGA-RL-AAAS-01A
0 years, female, white, stage:Stage IB, alive, 9 days
381.4
TCGA-HZ-7922-01A
0 years, female, white, stage:Stage IIB, alive, 4 days
378.8
TCGA-RB-A7B8-01A
0 years, female, white, stage:Stage IIB, dead, 466 days
378.6
TCGA-FB-A4P5-01A
0 years, female, white, stage:Stage IIB, dead, 179 days
378.3
TCGA-HZ-8005-01A
0 years, male, white, stage:Stage IIB, dead, 120 days
376.2
TCGA-IB-7885-01A
0 years, female, white, stage:Stage IIB, alive, 1257 days
374.3
TCGA-IB-A5SO-01A
0 years, male, white, stage:Stage IIB, dead, 365 days
373.0
TCGA-FB-A545-01A
0 years, female, white, stage:Stage IIB, dead, 732 days
371.6
TCGA-XN-A8T3-01A
0 years, male, white, stage:Stage IB, alive, 951 days
368.0
TCGA-HZ-7919-01A
0 years, female, white, stage:Stage IIB, dead, 593 days
364.9
TCGA-IB-A5ST-01A
0 years, female, white, stage:Stage IIB, alive, 635 days
359.2
TCGA-HV-AA8V-01A
0 years, male, asian, stage:Stage IIB, alive, 920 days
355.4
TCGA-YH-A8SY-01A
0 years, female, white, stage:'--, alive, 388 days
342.8
TCGA-HZ-A77P-01A
0 years, male, white, stage:Stage IIB, alive, 330 days
340.5
TCGA-2J-AABT-01A
0 years, female, white, stage:Stage IIB, alive, 319 days
340.1
TCGA-XD-AAUG-01A
0 years, female, white, stage:Stage IV, alive, 420 days
338.2
TCGA-IB-7888-01A
0 years, female, black or african american, stage:Stage IIA, dead, 1332 days
330.7
TCGA-IB-7654-01A
0 years, male, white, stage:Stage IIB, dead, 476 days
326.1
TCGA-3A-A9IS-01A
0 years, male, white, stage:Stage IB, alive, 998 days
325.0
TCGA-HV-A5A6-01A
0 years, female, asian, stage:Stage IIB, dead, 2036 days
325.0
TCGA-FB-A7DR-01A
0 years, male, asian, stage:Stage IIA, dead, 353 days
325.0
TCGA-2J-AABR-01A
0 years, female, white, stage:Stage IIA, alive, 438 days
323.4
TCGA-S4-A8RP-01A
0 years, female, white, stage:Stage IIB, dead, 702 days
317.9
TCGA-IB-AAUV-01A
0 years, male, white, stage:Stage IIB, alive, 404 days
317.4
TCGA-IB-7889-01A
0 years, female, white, stage:Stage IIB, dead, 481 days
307.7
TCGA-HV-A5A5-01A
0 years, female, asian, stage:Stage IIB, alive, 289 days
304.8
TCGA-IB-7890-01A
0 years, male, stage:Stage IB, dead, 598 days
303.5
TCGA-2J-AAB8-01A
0 years, male, white, stage:Stage IIB, alive, 80 days
300.7
TCGA-HZ-8002-01A
0 years, male, white, stage:Stage IIB, dead, 366 days
299.8
TCGA-HZ-7289-01A
0 years, male, white, stage:Stage IIB, dead, 661 days
298.1
TCGA-HZ-8001-01A
0 years, male, white, stage:Stage III, alive, 706 days
293.6
TCGA-H6-8124-01A
0 years, female, white, stage:Stage IIB, alive, 392 days
291.3
TCGA-IB-7886-01A
0 years, male, white, stage:Stage IIB, dead, 123 days
290.0
TCGA-2J-AABK-01A
0 years, male, white, stage:Stage IIB, alive, 484 days
284.3
TCGA-IB-AAUT-01A
0 years, male, white, stage:Stage IIB, alive, 287 days
283.9
TCGA-IB-7644-01A
0 years, female, white, stage:Stage IV, dead, 394 days
278.3
TCGA-HZ-7920-01A
0 years, male, white, stage:Stage IB, dead, 236 days
274.1
TCGA-3E-AAAZ-01A
0 years, male, white, stage:Stage IIA, dead, 2182 days
269.5
TCGA-HZ-8315-01A
0 years, female, white, stage:Stage IIA, dead, 299 days
267.5
TCGA-IB-AAUS-01A
0 years, female, white, stage:Stage IIB, alive, 225 days
267.2
TCGA-LB-A8F3-01A
0 years, female, black or african american, stage:Stage IIA, alive, 379 days
266.8
TCGA-US-A77J-01A
0 years, female, white, stage:Stage IIB, dead, 568 days
264.7
TCGA-IB-A7LX-01A
0 years, male, white, stage:Stage IIB, dead, 250 days
264.1
TCGA-HZ-A49G-01A
0 years, female, white, stage:Stage IIB, alive, 660 days
260.4
TCGA-XN-A8T5-01A
0 years, female, white, stage:Stage IB, alive, 720 days
258.5
TCGA-HZ-8519-01A
0 years, male, white, stage:Stage IA, alive, 454 days
254.5
TCGA-3A-A9I9-01A
0 years, male, white, stage:Stage IIA, dead, 634 days
253.8
TCGA-3A-A9J0-01A
0 years, male, white, stage:Stage IIB, alive, 743 days
252.2
TCGA-F2-7273-01A
0 years, male, black or african american, stage:Stage IIB, dead, 592 days
246.9
TCGA-IB-7887-01A
0 years, female, white, stage:Stage IIB, dead, 110 days
246.9
TCGA-US-A774-01A
0 years, female, white, stage:Stage IIB, dead, 695 days
245.0
TCGA-XD-AAUL-01A
0 years, male, white, stage:Stage IIA, alive, 498 days
238.6
TCGA-IB-AAUR-01A
0 years, male, white, stage:Stage IIB, alive, 338 days
237.5
TCGA-IB-A5SQ-01A
0 years, female, white, stage:Stage IB, dead, 219 days
234.1
TCGA-Q3-A5QY-01A
0 years, male, white, stage:Stage IIB, alive, 416 days
230.5
TCGA-3A-A9IX-01A
0 years, male, white, stage:Stage IA, alive, 1037 days
227.5
TCGA-Q3-AA2A-01A
0 years, female, white, stage:Stage IB, alive, 95 days
227.4
TCGA-F2-7276-01A
0 years, male, white, stage:Stage IIB, dead, 216 days
216.7
TCGA-FB-AAPZ-01A
0 years, male, white, stage:Stage IIB, alive, 716 days
210.7
TCGA-IB-7649-01A
0 years, female, stage:Stage IIB, dead, 467 days
205.9
TCGA-HZ-A77O-01A
0 years, female, white, stage:Stage IIB, dead, 160 days
205.1
TCGA-IB-A6UG-01A
0 years, male, white, stage:Stage IIB, dead, 41 days
202.1
TCGA-HZ-A9TJ-01A
0 years, male, white, stage:Stage IV, alive, 603 days
199.7
TCGA-2L-AAQI-01A
0 years, male, white, stage:Stage IIB, dead, 103 days
198.8
TCGA-3A-A9IV-01A
0 years, female, white, stage:Stage IB, alive, 1103 days
197.5
TCGA-US-A776-01A
0 years, male, white, stage:Stage IIA, alive, 1216 days
196.1
TCGA-IB-AAUW-01A
0 years, female, white, stage:Stage IIB, dead, 230 days
195.3
TCGA-2J-AAB9-01A
0 years, female, white, stage:Stage IIB, dead, 627 days
194.5
TCGA-IB-7651-01A
0 years, female, white, stage:Stage IIB, dead, 603 days
191.8
TCGA-HZ-7926-01A
0 years, male, black or african american, stage:Stage IIB, dead, 518 days
189.6
TCGA-XD-AAUH-01A
0 years, female, white, stage:Stage IIB, alive, 395 days
187.0
TCGA-HZ-7923-01A
0 years, male, white, stage:Stage IIA, alive, 314 days
176.5
TCGA-IB-7652-01A
0 years, female, asian, stage:Stage IIB, alive, 1116 days
175.2
TCGA-FB-A4P6-01A
0 years, male, white, stage:Stage IIB, alive, 767 days
174.3
TCGA-2J-AABU-01A
0 years, male, white, stage:Stage IIB, dead, 277 days
172.4
TCGA-HZ-A49H-01A
0 years, female, white, stage:Stage IIB, alive, 491 days
171.7
TCGA-3A-A9IL-01A
0 years, female, white, stage:Stage I, alive, 2741 days
170.2
TCGA-HZ-7918-01A
0 years, male, white, stage:Stage IIB, alive, 969 days
169.4
TCGA-3A-A9IO-01A
0 years, male, white, stage:'--, alive, 1942 days
167.1
TCGA-IB-7893-01A
0 years, male, white, stage:Stage IIA, dead, 117 days
163.0
TCGA-LB-A9Q5-01A
0 years, female, white, stage:Stage IIB, dead, 313 days
159.9
TCGA-H8-A6C1-01A
0 years, male, white, stage:Stage IIA, alive, 671 days
155.6
TCGA-HZ-8637-01A
0 years, female, white, stage:Stage IIB, dead, 517 days
155.2
TCGA-IB-7891-01A
0 years, female, white, stage:Stage IIB, dead, 913 days
155.1
TCGA-HZ-7924-01A
0 years, female, white, stage:Stage IIA, alive, 840 days
149.3
TCGA-IB-7897-01A
0 years, female, white, stage:Stage IIB, dead, 486 days
147.1
TCGA-HV-A7OP-01A
0 years, male, asian, stage:Stage IIB, alive, 978 days
146.1
TCGA-F2-A44H-01A
0 years, male, white, stage:Stage IIA, alive, 586 days
145.5
TCGA-3A-A9IJ-01A
0 years, male, white, stage:Stage IB, alive, 1854 days
129.8
TCGA-F2-A44G-01A
0 years, female, white, stage:Stage IIB, dead, 233 days
123.1
TCGA-LB-A7SX-01A
0 years, female, black or african american, stage:Stage IIB, dead, 393 days
122.8
TCGA-3A-A9IN-01A
0 years, female, white, stage:Stage IB, alive, 2084 days
118.2
TCGA-3A-A9IR-01A
0 years, female, white, stage:Stage IB, alive, 1542 days
116.9
TCGA-HZ-8638-01A
0 years, female, white, stage:Stage IA, dead, 151 days
111.8
TCGA-Z5-AAPL-01A
0 years, female, white, stage:Stage IIA, alive, 467 days
109.3
TCGA-HZ-8317-01A
0 years, female, white, stage:Stage IIB, dead, 378 days
93.2
TCGA-IB-AAUM-01A
0 years, male, white, stage:Stage IIB, alive, 8 days
74.5
TCGA-FB-AAQ2-01A
0 years, female, white, stage:Stage IIB, dead, 153 days
74.3
TCGA-HZ-8003-01A
0 years, female, white, stage:Stage IIB, dead, 596 days
70.1
TCGA-IB-8126-01A
0 years, female, white, stage:Stage III, alive, 462 days
46.0
TCGA-2J-AABV-01A
0 years, male, white, stage:Stage IIB, dead, 652 days
45.3
TCGA-F2-6880-01A
0 years, male, white, stage:Stage IIB, alive, 295 days
The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
MDK is not prognostic in Pancreatic Adenocarcinoma (validation)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
94.7
Number of samples
80
Samples
Sample
Description
TPM
DO34608
0 years, female, NA, stage:, dead, 709 days
342.1
DO33344
0 years, male, NA, stage:, dead, 361 days
294.9
DO49113
0 years, female, NA, stage:, alive, 413 days
265.6
DO49135
0 years, male, NA, stage:, alive, 270 days
259.0
DO49138
0 years, male, NA, stage:, dead, 230 days
222.7
DO33472
0 years, female, NA, stage:, dead, 388 days
215.2
DO34680
0 years, male, NA, stage:, dead, 99 days
207.0
DO34720
0 years, male, NA, stage:, alive, 555 days
197.4
DO34696
0 years, male, NA, stage:, alive, 689 days
193.8
DO49164
0 years, male, NA, stage:, alive, 272 days
191.1
DO34448
0 years, female, NA, stage:, dead, 719 days
184.3
DO49172
0 years, female, NA, stage:, dead, 1021 days
145.7
DO49168
0 years, male, NA, stage:, alive, 149 days
145.4
DO34640
0 years, female, NA, stage:, dead, 287 days
135.2
DO33408
0 years, female, NA, stage:, alive, 909 days
135.1
DO33128
0 years, male, NA, stage:, dead, 423 days
135.1
DO34656
0 years, female, NA, stage:, alive, 834 days
132.7
DO34432
0 years, female, NA, stage:, dead, 400 days
132.0
DO32860
0 years, male, NA, stage:, dead, 1259 days
131.0
DO34785
0 years, female, NA, stage:, alive, 721 days
126.7
DO34368
0 years, female, NA, stage:, dead, 537 days
120.0
DO34736
0 years, female, NA, stage:, dead, 203 days
113.3
DO32900
0 years, male, NA, stage:, dead, 768 days
110.7
DO49193
0 years, male, NA, stage:, dead, 1 days
110.2
DO34849
0 years, female, NA, stage:, dead, 272 days
106.6
DO34600
0 years, male, NA, stage:, dead, 537 days
105.4
DO49090
0 years, female, NA, stage:, dead, 152 days
104.0
DO33480
0 years, male, NA, stage:, alive, 1054 days
100.3
DO49127
0 years, female, NA, stage:, alive, 392 days
97.3
DO32878
0 years, female, NA, stage:, dead, 260 days
94.5
DO34793
0 years, male, NA, stage:, dead, 427 days
94.5
DO49204
0 years, male, NA, stage:, dead, 156 days
92.7
DO49133
0 years, female, NA, stage:, alive, 188 days
91.4
DO49129
0 years, male, NA, stage:, alive, 337 days
83.9
DO49183
0 years, female, NA, stage:, dead, 429 days
83.1
DO49074
0 years, male, NA, stage:, dead, 168 days
79.6
DO34616
0 years, female, NA, stage:, alive, 666 days
79.0
DO33600
0 years, female, NA, stage:, alive, 854 days
77.9
DO34809
0 years, female, NA, stage:, dead, 297 days
76.6
DO49199
0 years, male, NA, stage:, dead, 1095 days
76.6
DO49181
0 years, male, NA, stage:, dead, 1534 days
75.7
DO34905
0 years, male, NA, stage:, alive, 1142 days
73.9
DO49170
0 years, male, NA, stage:, alive, 197 days
72.5
DO33392
0 years, male, NA, stage:, alive, 1014 days
72.1
DO33544
0 years, female, NA, stage:, dead, 412 days
71.8
DO49184
0 years, male, NA, stage:, dead, 455 days
71.0
DO49166
0 years, female, NA, stage:, alive, 222 days
68.4
DO34801
0 years, male, NA, stage:, alive, 626 days
66.6
DO33984
0 years, male, NA, stage:, alive, 847 days
64.9
DO34312
0 years, female, NA, stage:, dead, 226 days
63.4
DO33168
0 years, female, NA, stage:, dead, 8 days
60.8
DO49078
0 years, male, NA, stage:, dead, 465 days
60.3
DO33488
0 years, male, NA, stage:, alive, 844 days
56.8
DO49130
0 years, female, NA, stage:, alive, 351 days
56.6
DO32829
0 years, female, NA, stage:T2N0MX, dead, 1874 days
55.4
DO33376
0 years, female, NA, stage:, alive, 909 days
54.0
DO34504
0 years, male, NA, stage:, dead, 257 days
53.6
DO49080
0 years, male, NA, stage:, alive, 83 days
52.1
DO33336
0 years, female, NA, stage:, dead, 451 days
51.0
DO32863
0 years, male, NA, stage:, dead, 715 days
50.1
DO34728
0 years, female, NA, stage:, alive, 508 days
49.6
DO49185
0 years, male, NA, stage:, alive, 179 days
49.4
DO49087
0 years, female, NA, stage:, dead, 260 days
48.6
DO49178
0 years, male, NA, stage:, dead, 27 days
47.8
DO32875
0 years, male, NA, stage:, dead, 348 days
46.8
DO49137
0 years, female, NA, stage:, alive, 232 days
40.2
DO49198
0 years, female, NA, stage:, dead, 251 days
38.3
DO33512
female, NA, stage:, dead, 499 days
37.0
DO34288
0 years, female, NA, stage:, dead, 220 days
35.8
DO33552
0 years, female, NA, stage:, alive, 873 days
33.2
DO34240
0 years, male, NA, stage:, dead, 236 days
33.1
DO33400
0 years, female, NA, stage:, alive, 1043 days
33.1
DO49079
0 years, male, NA, stage:, dead, 332 days
29.9
DO49175
0 years, male, NA, stage:, dead, 414 days
27.3
DO34961
0 years, male, NA, stage:, dead, 632 days
25.1
DO49076
0 years, male, NA, stage:, dead, 480 days
24.6
DO34817
0 years, female, NA, stage:, alive, 540 days
15.9
DO34264
0 years, female, NA, stage:, dead, 1144 days
11.7
DO33368
0 years, male, NA, stage:, dead, 98 days
10.3
DO34336
0 years, female, NA, stage:, alive, 743 days
0.0
Show allShow less
PANCREATIC DUCTAL ADENOCARCINOMA - Protein relative expression (CPTAC)
Number of samples
235
Samples
Sample ID
Sample type
nRPX
KoreanReference2
Tumor
2.8
WU-PDA1
Tumor
1.9
CPT0087890004
Tumor
1.9
KoreanReference3
Tumor
1.8
CPT0094940004
Tumor
1.7
CPT0264150003
Tumor
1.6
CPT0246720003
Tumor
1.6
CPT0238530005
Tumor
1.6
CPT0109010004
Tumor
1.5
CPT0226570004
Tumor
1.5
KoreanReference1
Tumor
1.4
CPT0011520003
Tumor
1.4
CPT0081470004
Tumor
1.3
CPT0065640003
Tumor
1.2
CPT0174700004
Tumor
1.2
CPT0008750003
Tumor
1.2
CPT0203850004
Tumor
1.2
CPT0081060004
Tumor
1.2
CPT0078000003
Tumor
1.1
CPT0014040003
Tumor
1.1
CPT0246840003
Tumor
1.1
CPT0065570003
Tumor
1.0
CPT0209310004
Tumor
1.0
CPT0089720003
Tumor
0.9
CPT0207780004
Tumor
0.9
CPT0127270003
Tumor
0.9
CPT0237840004
Tumor
0.9
CPT0063970004
Tumor
0.8
CPT0276010003
Tumor
0.8
CPT0183450005
Tumor
0.8
CPT0238820005
Tumor
0.7
CPT0246940003
Tumor
0.7
CPT0174800003
Normal
0.7
CPT0197420004
Tumor
0.7
CPT0078030003
Normal
0.7
CPT0124360003
Tumor
0.7
CPT0248410004
Tumor
0.7
CPT0124500004
Tumor
0.7
CPT0088260004
Tumor
0.6
CPT0226650004
Tumor
0.6
CPT0081360004
Tumor
0.6
CPT0108400003
Tumor
0.6
CPT0186040004
Tumor
0.6
CPT0161770004
Tumor
0.6
CPT0094740004
Tumor
0.6
CPT0094030003
Tumor
0.6
CPT0185920004
Tumor
0.6
CPT0088180004
Tumor
0.6
CPT0000250017
Tumor
0.5
CPT0091660003
Tumor
0.5
CPT0162760003
Tumor
0.5
CPT0226600004
Tumor
0.5
CPT0094130004
Tumor
0.5
CPT0108930003
Tumor
0.5
CPT0093930004
Tumor
0.5
CPT0246990003
Tumor
0.4
CPT0139000004
Tumor
0.4
CPT0109200004
Tumor
0.4
CPT0019410004
Tumor
0.4
CPT0226490004
Tumor
0.4
CPT0078090004
Tumor
0.4
CPT0001730017
Tumor
0.4
CPT0221240004
Tumor
0.4
CPT0237910004
Tumor
0.4
CPT0208840004
Tumor
0.4
CPT0123440003
Tumor
0.4
CPT0183750005
Tumor
0.4
CPT0247040003
Tumor
0.3
CPT0063570003
Tumor
0.3
CPT0161990005
Tumor
0.3
CPT0170240004
Tumor
0.3
CPT0239910004
Tumor
0.3
CPT0138990003
Normal
0.3
CPT0094630004
Tumor
0.3
CPT0078250003
Tumor
0.3
CPT0236340004
Tumor
0.2
CPT0198420004
Tumor
0.2
CPT0208690004
Tumor
0.2
CPT0238040005
Tumor
0.2
CPT0125130003
Tumor
0.2
CPT0109300004
Tumor
0.2
CPT0187550004
Tumor
0.2
CPT0248590004
Tumor
0.2
CPT0197440004
Normal
0.2
CPT0235230004
Tumor
0.2
CPT0093980004
Tumor
0.2
CPT0238920004
Tumor
0.2
CPT0237270005
Tumor
0.2
CPT0025750003
Tumor
0.1
CPT0019300004
Tumor
0.1
CPT0077860003
Tumor
0.1
C3L-00401-04
Normal
0.1
CPT0008800003
Tumor
0.1
CPT0064110003
Normal
0.1
CPT0246950003
Normal
0.0
CPT0236560004
Tumor
0.0
CPT0094230004
Tumor
0.0
CPT0209640005
Tumor
0.0
CPT0088320003
Tumor
0.0
CPT0123750003
Tumor
-0.1
CPT0078160004
Tumor
-0.1
CPT0226530004
Tumor
-0.1
CPT0064520004
Tumor
-0.1
CPT0246810003
Tumor
-0.1
CPT0123990003
Tumor
-0.1
CPT0239100009
Tumor
-0.1
CPT0238440005
Tumor
-0.1
CPT0224460004
Tumor
-0.1
CPT0125090003
Tumor
-0.2
CPT0236780005
Tumor
-0.2
CPT0198700005
Tumor
-0.2
CPT0083270003
Tumor
-0.2
CPT0227930004
Tumor
-0.2
CPT0162660004
Tumor
-0.2
CPT0077930004
Tumor
-0.2
CPT0226760004
Tumor
-0.3
CPT0126160004
Tumor
-0.3
CPT0124980004
Tumor
-0.3
CPT0081260004
Tumor
-0.3
CPT0218200004
Tumor
-0.4
CPT0198910005
Tumor
-0.4
CPT0221470005
Tumor
-0.4
CPT0123860003
Tumor
-0.4
CPT0017040004
Tumor
-0.5
CPT0207980005
Tumor
-0.5
CPT0355180003
Normal
-0.5
CPT0124410004
Tumor
-0.5
CPT0092630003
Tumor
-0.5
CPT0064090003
Tumor
-0.6
CPT0064570003
Normal
-0.6
CPT0236700005
Tumor
-0.7
CPT0254680003
Tumor
-0.7
CPT0246260004
Tumor
-0.7
CPT0248620003
Normal
-0.7
CPT0123770003
Normal
-0.8
CPT0226680005
Tumor
-0.8
CPT0217700004
Tumor
-0.8
CPT0241320005
Tumor
-0.8
CPT0238710004
Tumor
-0.8
CPT0226610004
Normal
-0.9
CPT0208550005
Tumor
-0.9
CPT0123650003
Tumor
-0.9
CPT0094180003
Tumor
-0.9
CPT0124610004
Tumor
-0.9
CPT0246210004
Tumor
-0.9
CPT0241500004
Tumor
-1.0
CPT0248440003
Normal
-1.0
CPT0086190004
Tumor
-1.0
C3N-00709-06
Normal
-1.0
CPT0123670003
Normal
-1.1
CPT0123890003
Normal
-1.1
CPT0066020003
Normal
-1.1
CPT0166760004
Tumor
-1.1
CPT0238610009
Tumor
-1.1
CPT0077950003
Normal
-1.2
CPT0125010003
Normal
-1.2
CPT0089750004
Normal
-1.2
C3N-02573-03
Normal
-1.2
CPT0209650004
Normal
-1.2
CPT0238640004
Normal
-1.2
CPT0347850002
Normal
-1.2
CPT0247000003
Normal
-1.2
CPT0108960003
Normal
-1.2
CPT0077790004
Tumor
-1.3
CPT0207990004
Normal
-1.3
CPT0187930005
Tumor
-1.3
CPT0123460003
Normal
-1.3
CPT0187540004
Normal
-1.4
CPT0086210003
Normal
-1.4
CPT0183770004
Normal
-1.4
CPT0347790002
Normal
-1.5
CPT0276030003
Normal
-1.5
CPT0236710004
Normal
-1.5
CPT0237850004
Normal
-1.6
CPT0166780004
Normal
-1.6
CPT0221250004
Normal
-1.6
CPT0025760003
Normal
-1.7
CPT0124530003
Normal
-1.7
CPT0237920004
Normal
-1.7
CPT0347880002
Normal
-1.8
CPT0247090003
Tumor
-1.8
CPT0347820002
Normal
-1.8
CPT0347760002
Normal
-1.9
CPT0355200003
Normal
-1.9
CPT0208710004
Normal
-1.9
CPT0091680003
Normal
-1.9
CPT0017130003
Normal
-2.0
CPT0239920004
Normal
-2.0
CPT0241510004
Normal
-2.0
CPT0093880003
Normal
-2.0
CPT0246220004
Normal
-2.0
CPT0208850004
Normal
-2.0
CPT0127290003
Normal
-2.0
CPT0236800004
Normal
-2.1
CPT0162780004
Normal
-2.1
CPT0238940004
Normal
-2.1
C3L-00189-04
Normal
-2.2
CPT0355190003
Normal
-2.3
CPT0077810003
Normal
-2.3
CPT0011540003
Normal
-2.4
CPT0001750003
Normal
-2.4
CPT0162670004
Normal
-2.4
CPT0078180003
Normal
-2.5
CPT0198930003
Normal
-2.6
CPT0239140004
Normal
-2.6
C3L-03632-04
Normal
-2.7
CPT0170260004
Normal
-2.7
CPT0198440004
Normal
-2.9
CPT0063580003
Normal
-3.0
CPT0236360004
Normal
-3.0
CPT0218220004
Normal
-3.2
CPT0077880003
Normal
-3.3
CPT0093860003
Tumor
-3.6
CPT0238740004
Normal
-4.0
CPT0124000003
Normal
-4.2
CPT0247050003
Normal
N/A
CPT0108410003
Normal
N/A
CPT0248320003
Normal
N/A
CPT0166650006
Tumor
N/A
CPT0224470004
Normal
N/A
C3L-01687-04
Normal
N/A
CPT0138890003
Normal
N/A
CPT0109110004
Tumor
N/A
WU-pooled sample
Tumor
N/A
CPT0014060003
Normal
N/A
CPT0109130003
Normal
N/A
CPT0138900004
Tumor
N/A
CPT0166680004
Normal
N/A
CPT0094760003
Normal
N/A
CPT0186050004
Normal
N/A
CPT0237290004
Normal
N/A
CPT0264180003
Normal
N/A
CPT0063990003
Normal
N/A
CPT0126200003
Normal
N/A
CPT0198730004
Normal
N/A
Show allShow less
PANCREATIC CANCER - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.
Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
The Human Protein Atlas project is funded
