Single cell type - ELAVL2 - The Human Protein Atlas

ELAVL2

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ELAVL2
Gene descriptionⁱ Full gene name according to HGNC.	ELAV like RNA binding protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Neuronal signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Inhibitory neurons, Spermatogonia, Oocytes, Excitatory neurons, Early spermatids)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.86
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (MGE interneuron, Mammillary body)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Inhibitory neurons, Spermatogonia, Oocytes, Excitatory neurons, Early spermatids)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (MGE interneuron, Mammillary body)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ELAVL2 is part of cluster 8 Neurons - Neuronal signaling with confidenceⁱ 0.99
265 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZMAT4	Zinc finger matrin-type 4	0.8263	8
TRPC4	Transient receptor potential cation channel subfamily C member 4	0.7707	8
GSG1L2	GSG1 like 2	0.7550	8
OVCH1	Ovochymase 1	0.7505	8
HAPLN4	Hyaluronan and proteoglycan link protein 4	0.7480	8
NHS	NHS actin remodeling regulator	0.7414	8
DLGAP1	DLG associated protein 1	0.7409	8
DEFB131B	Defensin beta 131B	0.7394	8
SETBP1	SET binding protein 1	0.7353	8
BIVM-ERCC5	BIVM-ERCC5 readthrough	0.7295	8
CNTN5	Contactin 5	0.7293	65
CNTNAP2	Contactin associated protein 2	0.7242	69
ABTB3	Ankyrin repeat and BTB domain containing 3	0.7208	8
KCNC2	Potassium voltage-gated channel subfamily C member 2	0.7161	65
SYT3	Synaptotagmin 3	0.7148	69

IMMUNE CELLS

ELAVL2 is part of cluster 20 Non-specific - DNA binding with confidenceⁱ 1
266 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FANCD2OS	FANCD2 opposite strand	1.0000	20
RPS4Y2	Ribosomal protein S4 Y-linked 2	1.0000	20
NSUN7	NOP2/Sun RNA methyltransferase family member 7	1.0000	20
MAB21L3	Mab-21 like 3	1.0000	20
FADS6	Fatty acid desaturase 6	1.0000	20
OR7G2	Olfactory receptor family 7 subfamily G member 2	1.0000	20
HECW1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	1.0000	20
CYP1A2	Cytochrome P450 family 1 subfamily A member 2	1.0000	20
SPACA7	Sperm acrosome associated 7	0.9762	20
FBLIM1	Filamin binding LIM protein 1	0.9762	20
MIPOL1	Mirror-image polydactyly 1	0.9762	20
ATP23	ATP23 metallopeptidase and ATP synthase assembly factor homolog	0.9762	20
HTR3B	5-hydroxytryptamine receptor 3B	0.9762	20
KIF13A	Kinesin family member 13A	0.9762	20
SLC35E3	Solute carrier family 35 member E3	0.9762	20

Adipocytes	1.0 nTPM
Adipose tissue	1.2 nTPM
Breast	0.9 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	0.0 nTPM
Lung	0.0 nTPM

Astrocytes	7.4 nTPM
Brain	7.4 nTPM

B-cells	0.0 nTPM
Thymus	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Salivary gland	0.0 nTPM

Ciliated cells	0.2 nTPM
Endometrium	0.3 nTPM
Fallopian tube	0.3 nTPM
Bronchus	0.2 nTPM
Lung	0.0 nTPM

Club cells	0.1 nTPM
Bronchus	0.1 nTPM
Lung	0.1 nTPM
Prostate	0.1 nTPM

Endothelial cells	1.0 nTPM
Skin	7.3 nTPM
Pancreas	2.6 nTPM
Esophagus	1.8 nTPM
Testis	1.5 nTPM
Ovary	1.0 nTPM
Salivary gland	0.8 nTPM
Prostate	0.7 nTPM
Vascular	0.7 nTPM
Placenta	0.6 nTPM
Tongue	0.5 nTPM
Fallopian tube	0.5 nTPM
Endometrium	0.4 nTPM
Skeletal muscle	0.4 nTPM
Thymus	0.2 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Lung	0.0 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	1.8 nTPM
Rectum	3.4 nTPM
Colon	2.0 nTPM
Small intestine	0.0 nTPM

Fibroblasts	0.2 nTPM
Placenta	1.2 nTPM
Prostate	0.7 nTPM
Skin	0.6 nTPM
Breast	0.3 nTPM
Skeletal muscle	0.2 nTPM
Adipose tissue	0.2 nTPM
Fallopian tube	0.2 nTPM
Salivary gland	0.1 nTPM
Thymus	0.1 nTPM
Vascular	0.1 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM

Granulocytes	0.0 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM
Fallopian tube	0.0 nTPM

Intestinal goblet cells	1.3 nTPM
Colon	2.5 nTPM
Rectum	1.4 nTPM
Small intestine	0.0 nTPM

Lymphatic endothelial cells	0.3 nTPM
Fallopian tube	0.5 nTPM
Ovary	0.0 nTPM

Macrophages	0.0 nTPM
Testis	0.6 nTPM
Adipose tissue	0.2 nTPM
Salivary gland	0.1 nTPM
Kidney	0.0 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

Paneth cells	0.2 nTPM
Rectum	0.7 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Bipolar cells	6.5 nTPM
Eye	6.5 nTPM

Distal tubular cells	3.1 nTPM
Kidney	3.1 nTPM

Plasma cells	0.0 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Fallopian tube	0.0 nTPM

Schwann cells	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Vascular	0.0 nTPM

Serous glandular cells	0.1 nTPM
Salivary gland	0.3 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	0.2 nTPM
Skin	1.1 nTPM
Ovary	0.8 nTPM
Tongue	0.6 nTPM
Breast	0.5 nTPM
Skeletal muscle	0.2 nTPM
Adipose tissue	0.2 nTPM
Placenta	0.1 nTPM
Liver	0.0 nTPM
Endometrium	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Vascular	0.0 nTPM
Fallopian tube	0.0 nTPM

T-cells	0.1 nTPM
Skin	0.7 nTPM
Prostate	0.2 nTPM
Endometrium	0.1 nTPM
Tongue	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

Undifferentiated cells	3.9 nTPM
Colon	5.9 nTPM
Rectum	5.3 nTPM
Small intestine	0.5 nTPM

Amygdala excitatory	155.7 nTPM
Hypothalamus	199.5 nTPM
Cerebral cortex	172.4 nTPM
Thalamus	171.5 nTPM
Basal ganglia	148.5 nTPM
Hippocampus	139.3 nTPM
Amygdala	103.1 nTPM

Astrocyte	5.7 nTPM
Hypothalamus	13.1 nTPM
Thalamus	11.4 nTPM
Medulla oblongata	7.1 nTPM
Cerebral cortex	5.9 nTPM
Amygdala	5.1 nTPM
Pons	4.7 nTPM
Basal ganglia	3.6 nTPM
Midbrain	3.5 nTPM
Spinal cord	3.4 nTPM
Cerebellum	2.5 nTPM
Hippocampus	2.4 nTPM

Bergmann glia	7.9 nTPM
Medulla oblongata	10.7 nTPM
Pons	10.1 nTPM
Cerebellum	3.1 nTPM

Central nervous system macrophage	5.4 nTPM
Hypothalamus	14.1 nTPM
Thalamus	13.7 nTPM
Cerebral cortex	10.4 nTPM
Pons	5.7 nTPM
Amygdala	3.4 nTPM
Medulla oblongata	3.4 nTPM
Basal ganglia	2.7 nTPM
Midbrain	2.4 nTPM
Hippocampus	2.1 nTPM
Cerebellum	1.5 nTPM
Spinal cord	0.6 nTPM

Cerebellar inhibitory	48.7 nTPM
Pons	102.2 nTPM
Medulla oblongata	73.3 nTPM
Midbrain	46.3 nTPM
Cerebellum	21.9 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	227.1 nTPM
Hypothalamus	258.8 nTPM
Amygdala	248.8 nTPM
Thalamus	232.5 nTPM
Hippocampus	231.1 nTPM
Cerebral cortex	226.6 nTPM
Midbrain	204.3 nTPM
Basal ganglia	187.6 nTPM

Choroid plexus epithelial cell	2.4 nTPM
Hippocampus	8.3 nTPM
Medulla oblongata	1.0 nTPM
Basal ganglia	0.3 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	19.2 nTPM
Thalamus	78.6 nTPM
Hypothalamus	32.1 nTPM
Medulla oblongata	19.4 nTPM
Pons	17.7 nTPM
Basal ganglia	13.7 nTPM
Amygdala	13.5 nTPM
Cerebral cortex	12.0 nTPM
Midbrain	10.1 nTPM
Hippocampus	9.8 nTPM
Cerebellum	4.8 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	213.0 nTPM
Hypothalamus	322.4 nTPM
Amygdala	285.6 nTPM
Basal ganglia	245.9 nTPM
Cerebral cortex	153.1 nTPM
Midbrain	147.6 nTPM
Hippocampus	123.3 nTPM

Deep-layer intratelencephalic	231.1 nTPM
Hypothalamus	297.5 nTPM
Amygdala	222.9 nTPM
Hippocampus	222.2 nTPM
Cerebral cortex	215.4 nTPM
Basal ganglia	197.3 nTPM

Deep-layer near-projecting	119.9 nTPM
Hypothalamus	176.2 nTPM
Basal ganglia	162.8 nTPM
Amygdala	103.5 nTPM
Cerebral cortex	89.4 nTPM
Hippocampus	67.6 nTPM

Eccentric medium spiny neuron	41.2 nTPM
Cerebral cortex	80.3 nTPM
Amygdala	59.3 nTPM
Hypothalamus	43.2 nTPM
Basal ganglia	23.7 nTPM
Thalamus	21.3 nTPM
Hippocampus	19.1 nTPM

Endothelial cell	4.3 nTPM
Thalamus	8.5 nTPM
Amygdala	6.7 nTPM
Cerebellum	6.2 nTPM
Midbrain	5.7 nTPM
Pons	5.6 nTPM
Cerebral cortex	4.5 nTPM
Medulla oblongata	4.1 nTPM
Hypothalamus	3.7 nTPM
Hippocampus	1.9 nTPM
Basal ganglia	0.9 nTPM
Spinal cord	0.0 nTPM

Ependymal cell	6.4 nTPM
Hypothalamus	15.2 nTPM
Thalamus	10.5 nTPM
Medulla oblongata	6.6 nTPM
Amygdala	6.3 nTPM
Pons	5.9 nTPM
Midbrain	5.1 nTPM
Basal ganglia	3.9 nTPM
Hippocampus	2.6 nTPM
Spinal cord	1.9 nTPM