Single cell type - OGDH - The Human Protein Atlas

OGDH

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	OGDH
Gene descriptionⁱ Full gene name according to HGNC.	Oxoglutarate dehydrogenase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Citric acid cycle related proteins Enzymes FDA approved drug targets Human disease related genes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Monocytes - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.31
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

OGDH is part of cluster 29 Monocytes - Innate immune response with confidenceⁱ 0.95
447 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZZEF1	Zinc finger ZZ-type and EF-hand domain containing 1	0.4726	22
KIF16B	Kinesin family member 16B	0.4653	28
SHLD2	Shieldin complex subunit 2	0.4565	39
LARP4B	La ribonucleoprotein 4B	0.4463	55
TENT4B	Terminal nucleotidyltransferase 4B	0.4410	78
GPR132	G protein-coupled receptor 132	0.4401	29
MAPK9	Mitogen-activated protein kinase 9	0.4391	28
KCNAB2	Potassium voltage-gated channel subfamily A regulatory beta subunit 2	0.4309	19
UBR4	Ubiquitin protein ligase E3 component n-recognin 4	0.4228	49
DNAJC11	DnaJ heat shock protein family (Hsp40) member C11	0.4226	39
ACO2	Aconitase 2	0.4196	22
TNFRSF1B	TNF receptor superfamily member 1B	0.4188	29
MBNL1	Muscleblind like splicing regulator 1	0.4183	55
SMG5	SMG5 nonsense mediated mRNA decay factor	0.4180	49
PER1	Period circadian regulator 1	0.4177	78

IMMUNE CELLS

OGDH is part of cluster 33 Non-specific - ATP binding with confidenceⁱ 0.81
757 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GSDMD	Gasdermin D	0.9762	33
PTGES3	Prostaglandin E synthase 3	0.9762	33
ATP8B3	ATPase phospholipid transporting 8B3	0.9762	33
POC1A	POC1 centriolar protein A	0.9762	33
SLC9A9	Solute carrier family 9 member A9	0.9762	33
PUF60	Poly(U) binding splicing factor 60	0.9762	33
PCCA	Propionyl-CoA carboxylase subunit alpha	0.9762	33
WASHC5	WASH complex subunit 5	0.9524	33
VDAC1	Voltage dependent anion channel 1	0.9524	33
SEPTIN10	Septin 10	0.9524	33
ANKFY1	Ankyrin repeat and FYVE domain containing 1	0.9524	33
DIABLO	Diablo IAP-binding mitochondrial protein	0.9524	33
RAPH1	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	0.9524	33
CDYL2	Chromodomain Y like 2	0.9524	33
CHST7	Carbohydrate sulfotransferase 7	0.9524	33

Adipocytes	18.6 nTPM
Adipose tissue	20.4 nTPM
Breast	16.8 nTPM

Alveolar cells type 1	57.3 nTPM
Lung	57.3 nTPM

Alveolar cells type 2	52.3 nTPM
Lung	52.3 nTPM

Astrocytes	46.8 nTPM
Brain	46.8 nTPM

B-cells	22.4 nTPM
Skin	39.0 nTPM
Thymus	30.4 nTPM
Stomach	29.1 nTPM
Adipose tissue	27.2 nTPM
Salivary gland	22.8 nTPM
Bone marrow	22.0 nTPM
Spleen	20.9 nTPM
PBMC	20.0 nTPM
Lymph node	19.7 nTPM
Esophagus	17.7 nTPM
Lung	17.4 nTPM
Kidney	15.6 nTPM
Liver	9.7 nTPM

Ciliated cells	22.4 nTPM
Endometrium	25.6 nTPM
Lung	24.9 nTPM
Bronchus	21.5 nTPM
Fallopian tube	17.5 nTPM

Club cells	20.9 nTPM
Prostate	22.9 nTPM
Lung	22.0 nTPM
Bronchus	17.7 nTPM

Dendritic cells	36.8 nTPM
Adipose tissue	59.2 nTPM
PBMC	14.4 nTPM

Endothelial cells	18.9 nTPM
Lung	37.7 nTPM
Liver	26.5 nTPM
Tongue	24.4 nTPM
Vascular	23.7 nTPM
Salivary gland	22.6 nTPM
Thymus	22.4 nTPM
Placenta	21.0 nTPM
Prostate	20.8 nTPM
Endometrium	20.5 nTPM
Breast	20.2 nTPM
Fallopian tube	16.5 nTPM
Ovary	16.0 nTPM
Esophagus	15.1 nTPM
Testis	14.0 nTPM
Skeletal muscle	13.7 nTPM
Skin	12.2 nTPM
Pancreas	7.8 nTPM
Heart muscle	4.3 nTPM

Enteroendocrine cells	30.2 nTPM
Small intestine	34.3 nTPM
Colon	31.2 nTPM
Rectum	25.2 nTPM

Fibroblasts	19.4 nTPM
Adipose tissue	33.8 nTPM
Vascular	26.4 nTPM
Skeletal muscle	24.3 nTPM
Thymus	24.0 nTPM
Heart muscle	22.5 nTPM
Salivary gland	22.3 nTPM
Lung	21.9 nTPM
Fallopian tube	20.5 nTPM
Esophagus	17.8 nTPM
Pancreas	15.9 nTPM
Skin	15.5 nTPM
Prostate	15.2 nTPM
Breast	14.9 nTPM
Placenta	14.8 nTPM
Stomach	11.5 nTPM
Liver	9.5 nTPM

Granulocytes	18.2 nTPM
Lung	24.7 nTPM
Fallopian tube	15.4 nTPM
Tongue	14.6 nTPM

Intestinal goblet cells	38.8 nTPM
Small intestine	49.3 nTPM
Rectum	34.6 nTPM
Colon	32.7 nTPM

Lymphatic endothelial cells	26.2 nTPM
Ovary	27.3 nTPM
Fallopian tube	25.0 nTPM

Macrophages	40.0 nTPM
Adipose tissue	75.0 nTPM
Stomach	69.4 nTPM
Skin	69.1 nTPM
Skeletal muscle	62.0 nTPM
Thymus	57.7 nTPM
Vascular	53.4 nTPM
Fallopian tube	46.6 nTPM
Tongue	40.3 nTPM
Spleen	33.1 nTPM
Salivary gland	32.1 nTPM
Lung	31.7 nTPM
Bone marrow	29.4 nTPM
Kidney	28.3 nTPM
Testis	27.3 nTPM
Esophagus	24.4 nTPM
Endometrium	24.0 nTPM
Prostate	22.9 nTPM
Breast	20.4 nTPM
Pancreas	12.3 nTPM

Basal respiratory cells	15.7 nTPM
Bronchus	15.7 nTPM

Basal squamous epithelial cells	22.2 nTPM
Esophagus	22.2 nTPM

Bipolar cells	18.1 nTPM
Eye	18.1 nTPM

Cholangiocytes	13.4 nTPM
Liver	13.4 nTPM

Paneth cells	22.2 nTPM
Colon	25.3 nTPM
Small intestine	20.7 nTPM
Rectum	20.4 nTPM

Plasma cells	29.3 nTPM
Thymus	45.5 nTPM
Fallopian tube	35.1 nTPM
Liver	34.0 nTPM
Bone marrow	33.2 nTPM
Stomach	28.9 nTPM
Spleen	22.1 nTPM
Salivary gland	20.1 nTPM
Esophagus	15.6 nTPM

Schwann cells	35.4 nTPM
Adipose tissue	64.8 nTPM
Vascular	41.3 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	19.9 nTPM
Salivary gland	22.1 nTPM
Tongue	17.7 nTPM

Smooth muscle cells	24.8 nTPM
Thymus	44.5 nTPM
Vascular	39.7 nTPM
Fallopian tube	30.4 nTPM
Esophagus	30.0 nTPM
Salivary gland	29.7 nTPM
Prostate	29.2 nTPM
Adipose tissue	25.4 nTPM
Tongue	21.3 nTPM
Endometrium	20.9 nTPM
Skeletal muscle	20.7 nTPM
Breast	20.7 nTPM
Lung	18.8 nTPM
Placenta	16.7 nTPM
Liver	16.6 nTPM
Skin	16.1 nTPM
Ovary	15.5 nTPM

Suprabasal keratinocytes	33.1 nTPM
Tongue	36.3 nTPM
Skin	29.9 nTPM

T-cells	29.3 nTPM
Adipose tissue	49.1 nTPM
Tongue	45.9 nTPM
Skin	44.2 nTPM
Esophagus	43.8 nTPM
Stomach	40.8 nTPM
Thymus	35.0 nTPM
Spleen	33.1 nTPM
Bone marrow	30.5 nTPM
Lung	29.7 nTPM
Skeletal muscle	29.1 nTPM
Breast	29.1 nTPM
Lymph node	26.9 nTPM
Salivary gland	24.9 nTPM
PBMC	23.3 nTPM
Kidney	21.3 nTPM
Vascular	20.9 nTPM
Fallopian tube	19.5 nTPM
Colon	17.5 nTPM
Prostate	17.4 nTPM
Endometrium	17.2 nTPM
Liver	16.7 nTPM

Undifferentiated cells	24.9 nTPM
Rectum	26.7 nTPM
Small intestine	26.1 nTPM
Colon	22.0 nTPM

Amygdala excitatory	73.9 nTPM
Hypothalamus	98.1 nTPM
Amygdala	75.2 nTPM
Hippocampus	70.7 nTPM
Basal ganglia	68.6 nTPM
Cerebral cortex	67.4 nTPM
Thalamus	63.5 nTPM

Astrocyte	100.2 nTPM
Thalamus	118.6 nTPM
Cerebellum	108.7 nTPM
Midbrain	106.9 nTPM
Pons	104.6 nTPM
Amygdala	101.8 nTPM
Cerebral cortex	99.8 nTPM
Hippocampus	98.1 nTPM
Spinal cord	94.1 nTPM
Basal ganglia	91.4 nTPM
Hypothalamus	89.7 nTPM
Medulla oblongata	89.0 nTPM

Bergmann glia	91.5 nTPM
Medulla oblongata	110.8 nTPM
Cerebellum	100.2 nTPM
Pons	63.3 nTPM

Central nervous system macrophage	90.5 nTPM
Amygdala	104.2 nTPM
Cerebellum	104.1 nTPM
Midbrain	96.5 nTPM
Hippocampus	94.1 nTPM
Basal ganglia	93.9 nTPM
Hypothalamus	90.7 nTPM
Pons	87.9 nTPM
Cerebral cortex	87.5 nTPM
Thalamus	85.1 nTPM
Medulla oblongata	82.3 nTPM
Spinal cord	68.9 nTPM

Cerebellar inhibitory	99.1 nTPM
Cerebellum	107.0 nTPM
Pons	104.8 nTPM
Spinal cord	96.2 nTPM
Midbrain	95.2 nTPM
Medulla oblongata	92.4 nTPM

Cge interneuron	61.8 nTPM
Hypothalamus	77.4 nTPM
Thalamus	67.1 nTPM
Amygdala	62.1 nTPM
Hippocampus	60.7 nTPM
Cerebral cortex	55.7 nTPM
Midbrain	55.7 nTPM
Basal ganglia	54.2 nTPM

Choroid plexus epithelial cell	312.4 nTPM
Basal ganglia	507.8 nTPM
Thalamus	298.7 nTPM
Medulla oblongata	279.6 nTPM
Hippocampus	163.6 nTPM

Committed oligodendrocyte precursor	63.1 nTPM
Medulla oblongata	89.1 nTPM
Hippocampus	72.7 nTPM
Thalamus	72.0 nTPM
Basal ganglia	68.4 nTPM
Amygdala	68.2 nTPM
Hypothalamus	67.6 nTPM
Cerebellum	58.7 nTPM
Cerebral cortex	55.1 nTPM
Midbrain	54.6 nTPM
Pons	46.9 nTPM
Spinal cord	40.5 nTPM

Deep-layer corticothalamic and 6b	77.1 nTPM
Hypothalamus	108.5 nTPM
Amygdala	77.7 nTPM
Hippocampus	76.2 nTPM
Cerebral cortex	70.6 nTPM
Basal ganglia	69.8 nTPM
Midbrain	59.9 nTPM

Deep-layer intratelencephalic	74.8 nTPM
Hypothalamus	99.8 nTPM
Amygdala	75.7 nTPM
Hippocampus	67.5 nTPM
Cerebral cortex	67.4 nTPM
Basal ganglia	63.6 nTPM

Deep-layer near-projecting	66.1 nTPM
Hypothalamus	91.8 nTPM
Amygdala	66.2 nTPM
Cerebral cortex	62.0 nTPM
Basal ganglia	57.7 nTPM
Hippocampus	52.7 nTPM

Eccentric medium spiny neuron	57.9 nTPM
Hypothalamus	61.6 nTPM
Cerebral cortex	59.3 nTPM
Thalamus	58.7 nTPM
Basal ganglia	57.8 nTPM
Amygdala	56.5 nTPM
Hippocampus	53.5 nTPM