Single cell type - ANKFY1 - The Human Protein Atlas

ANKFY1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ANKFY1
Gene descriptionⁱ Full gene name according to HGNC.	Ankyrin repeat and FYVE domain containing 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Macrophages - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.33
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ANKFY1 is part of cluster 58 Macrophages - Innate immune response with confidenceⁱ 1
420 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
COLGALT1	Collagen beta(1-O)galactosyltransferase 1	0.5097	58
KCNAB2	Potassium voltage-gated channel subfamily A regulatory beta subunit 2	0.4886	19
MAN2C1	Mannosidase alpha class 2C member 1	0.4791	55
FMN1	Formin 1	0.4609	8
CLCN7	Chloride voltage-gated channel 7	0.4531	58
GAPVD1	GTPase activating protein and VPS9 domains 1	0.4512	55
PI4K2A	Phosphatidylinositol 4-kinase type 2 alpha	0.4491	58
FKBP15	FKBP prolyl isomerase family member 15	0.4439	58
SLC27A1	Solute carrier family 27 member 1	0.4391	47
MROH1	Maestro heat like repeat family member 1	0.4384	72
NCOR2	Nuclear receptor corepressor 2	0.4379	33
HTT	Huntingtin	0.4364	66
PLD3	Phospholipase D family member 3	0.4362	58
SLC38A6	Solute carrier family 38 member 6	0.4352	34
ADAM17	ADAM metallopeptidase domain 17	0.4348	58

IMMUNE CELLS

ANKFY1 is part of cluster 33 Non-specific - ATP binding with confidenceⁱ 0.81
757 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RAPH1	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	1.0000	33
CDYL2	Chromodomain Y like 2	1.0000	33
WASHC5	WASH complex subunit 5	1.0000	33
ATP1B3	ATPase Na+/K+ transporting subunit beta 3	0.9762	33
PUF60	Poly(U) binding splicing factor 60	0.9762	33
PCCA	Propionyl-CoA carboxylase subunit alpha	0.9762	33
MYO1G	Myosin IG	0.9762	33
RFK	Riboflavin kinase	0.9762	33
PHF19	PHD finger protein 19	0.9762	33
PTGES3	Prostaglandin E synthase 3	0.9762	33
AAMP	Angio associated migratory cell protein	0.9524	33
RIPK3	Receptor interacting serine/threonine kinase 3	0.9524	33
SLC12A7	Solute carrier family 12 member 7	0.9524	33
OGDH	Oxoglutarate dehydrogenase	0.9524	33
ATP8B3	ATPase phospholipid transporting 8B3	0.9286	33

Adipocytes	14.9 nTPM
Adipose tissue	15.2 nTPM
Breast	14.6 nTPM

Alveolar cells type 1	29.1 nTPM
Lung	29.1 nTPM

Alveolar cells type 2	26.6 nTPM
Lung	26.6 nTPM

Astrocytes	40.9 nTPM
Brain	40.9 nTPM

B-cells	11.9 nTPM
Esophagus	17.7 nTPM
Salivary gland	16.6 nTPM
Thymus	16.3 nTPM
Bone marrow	16.0 nTPM
Liver	14.5 nTPM
PBMC	13.9 nTPM
Adipose tissue	12.8 nTPM
Lymph node	11.3 nTPM
Stomach	10.1 nTPM
Spleen	9.1 nTPM
Skin	8.5 nTPM
Lung	8.0 nTPM
Kidney	0.0 nTPM

Ciliated cells	19.9 nTPM
Bronchus	28.1 nTPM
Lung	22.7 nTPM
Fallopian tube	14.9 nTPM
Endometrium	13.8 nTPM

Club cells	16.4 nTPM
Prostate	16.9 nTPM
Lung	16.7 nTPM
Bronchus	15.5 nTPM

Endothelial cells	15.3 nTPM
Heart muscle	24.5 nTPM
Ovary	21.8 nTPM
Lung	19.9 nTPM
Salivary gland	19.8 nTPM
Skeletal muscle	19.3 nTPM
Vascular	18.2 nTPM
Prostate	17.4 nTPM
Testis	15.6 nTPM
Endometrium	14.1 nTPM
Liver	13.9 nTPM
Thymus	13.6 nTPM
Pancreas	12.9 nTPM
Esophagus	12.1 nTPM
Placenta	11.4 nTPM
Fallopian tube	11.2 nTPM
Tongue	11.1 nTPM
Skin	9.9 nTPM
Breast	9.7 nTPM

Enteroendocrine cells	16.0 nTPM
Rectum	20.1 nTPM
Small intestine	17.2 nTPM
Colon	10.6 nTPM

Fibroblasts	17.5 nTPM
Liver	28.5 nTPM
Vascular	23.9 nTPM
Skeletal muscle	23.8 nTPM
Salivary gland	23.6 nTPM
Adipose tissue	20.4 nTPM
Thymus	19.8 nTPM
Esophagus	19.0 nTPM
Breast	18.3 nTPM
Fallopian tube	15.7 nTPM
Heart muscle	15.5 nTPM
Prostate	13.2 nTPM
Skin	13.1 nTPM
Stomach	13.0 nTPM
Lung	12.8 nTPM
Pancreas	11.7 nTPM
Placenta	8.4 nTPM

Granulocytes	8.8 nTPM
Tongue	9.7 nTPM
Lung	9.1 nTPM
Fallopian tube	7.7 nTPM

Intestinal goblet cells	12.9 nTPM
Rectum	21.4 nTPM
Small intestine	11.3 nTPM
Colon	5.9 nTPM

Lymphatic endothelial cells	13.7 nTPM
Ovary	16.4 nTPM
Fallopian tube	11.1 nTPM

Macrophages	21.1 nTPM
Thymus	38.5 nTPM
Vascular	33.7 nTPM
Lung	33.1 nTPM
Bone marrow	32.4 nTPM
Salivary gland	25.9 nTPM
Pancreas	22.6 nTPM
Prostate	22.0 nTPM
Skeletal muscle	21.9 nTPM
Fallopian tube	21.8 nTPM
Testis	19.8 nTPM
Spleen	18.0 nTPM
Esophagus	16.7 nTPM
Tongue	16.6 nTPM
Skin	15.6 nTPM
Stomach	15.4 nTPM
Adipose tissue	14.5 nTPM
Breast	12.4 nTPM
Kidney	11.5 nTPM
Endometrium	8.6 nTPM

Paneth cells	12.6 nTPM
Colon	14.5 nTPM
Rectum	12.9 nTPM
Small intestine	10.4 nTPM

Basal prostatic cells	19.7 nTPM
Prostate	19.7 nTPM

Basal squamous epithelial cells	14.2 nTPM
Esophagus	14.2 nTPM

Bipolar cells	29.4 nTPM
Eye	29.4 nTPM

Cholangiocytes	7.6 nTPM
Liver	7.6 nTPM

Plasma cells	8.5 nTPM
Thymus	13.0 nTPM
Salivary gland	12.5 nTPM
Bone marrow	12.1 nTPM
Spleen	9.9 nTPM
Fallopian tube	8.4 nTPM
Liver	7.5 nTPM
Stomach	4.6 nTPM
Esophagus	0.0 nTPM

Schwann cells	17.4 nTPM
Vascular	32.9 nTPM
Esophagus	12.0 nTPM
Adipose tissue	7.4 nTPM

Serous glandular cells	12.7 nTPM
Salivary gland	16.6 nTPM
Tongue	8.8 nTPM

Smooth muscle cells	13.4 nTPM
Tongue	19.8 nTPM
Liver	17.8 nTPM
Endometrium	17.8 nTPM
Skin	16.6 nTPM
Vascular	16.0 nTPM
Salivary gland	14.1 nTPM
Breast	13.6 nTPM
Prostate	13.4 nTPM
Placenta	12.7 nTPM
Ovary	11.4 nTPM
Skeletal muscle	11.2 nTPM
Lung	10.6 nTPM
Adipose tissue	10.5 nTPM
Thymus	10.5 nTPM
Fallopian tube	9.8 nTPM
Esophagus	9.6 nTPM

Suprabasal keratinocytes	16.0 nTPM
Tongue	18.0 nTPM
Skin	14.0 nTPM

T-cells	15.9 nTPM
PBMC	21.3 nTPM
Lung	21.0 nTPM
Esophagus	19.5 nTPM
Bone marrow	19.2 nTPM
Salivary gland	18.7 nTPM
Thymus	18.5 nTPM
Tongue	18.5 nTPM
Prostate	16.8 nTPM
Liver	16.5 nTPM
Skeletal muscle	16.3 nTPM
Stomach	16.3 nTPM
Vascular	16.1 nTPM
Spleen	15.2 nTPM
Skin	14.7 nTPM
Lymph node	14.3 nTPM
Fallopian tube	14.1 nTPM
Adipose tissue	14.0 nTPM
Breast	13.6 nTPM
Endometrium	12.9 nTPM
Colon	9.7 nTPM
Kidney	6.2 nTPM

Undifferentiated cells	13.1 nTPM
Rectum	16.9 nTPM
Small intestine	12.6 nTPM
Colon	9.6 nTPM

Amygdala excitatory	91.8 nTPM
Hypothalamus	100.5 nTPM
Cerebral cortex	94.6 nTPM
Hippocampus	92.9 nTPM
Amygdala	92.4 nTPM
Basal ganglia	86.7 nTPM
Thalamus	83.9 nTPM

Astrocyte	116.0 nTPM
Spinal cord	174.7 nTPM
Hypothalamus	130.7 nTPM
Pons	126.4 nTPM
Medulla oblongata	125.4 nTPM
Cerebellum	124.9 nTPM
Midbrain	113.0 nTPM
Amygdala	103.7 nTPM
Thalamus	103.1 nTPM
Basal ganglia	95.6 nTPM
Hippocampus	93.7 nTPM
Cerebral cortex	84.8 nTPM

Bergmann glia	64.6 nTPM
Medulla oblongata	83.1 nTPM
Cerebellum	74.6 nTPM
Pons	36.0 nTPM

Central nervous system macrophage	133.8 nTPM
Amygdala	171.7 nTPM
Cerebral cortex	143.0 nTPM
Hippocampus	142.7 nTPM
Midbrain	139.2 nTPM
Thalamus	134.0 nTPM
Basal ganglia	131.8 nTPM
Cerebellum	131.5 nTPM
Hypothalamus	128.1 nTPM
Pons	124.7 nTPM
Spinal cord	116.6 nTPM
Medulla oblongata	109.0 nTPM

Cerebellar inhibitory	94.6 nTPM
Spinal cord	121.0 nTPM
Cerebellum	94.6 nTPM
Medulla oblongata	93.5 nTPM
Pons	84.3 nTPM
Midbrain	79.6 nTPM

Cge interneuron	74.8 nTPM
Hypothalamus	97.0 nTPM
Amygdala	77.0 nTPM
Cerebral cortex	73.5 nTPM
Thalamus	72.2 nTPM
Hippocampus	69.0 nTPM
Midbrain	68.0 nTPM
Basal ganglia	66.9 nTPM

Choroid plexus epithelial cell	77.6 nTPM
Basal ganglia	132.6 nTPM
Medulla oblongata	81.6 nTPM
Thalamus	63.0 nTPM
Hippocampus	33.3 nTPM

Committed oligodendrocyte precursor	76.5 nTPM
Hypothalamus	107.2 nTPM
Spinal cord	99.3 nTPM
Thalamus	91.9 nTPM
Hippocampus	81.7 nTPM
Amygdala	79.5 nTPM
Pons	68.2 nTPM
Medulla oblongata	65.8 nTPM
Cerebral cortex	64.0 nTPM
Midbrain	63.8 nTPM
Cerebellum	63.4 nTPM
Basal ganglia	56.9 nTPM

Deep-layer corticothalamic and 6b	82.9 nTPM
Hypothalamus	97.0 nTPM
Amygdala	84.4 nTPM
Hippocampus	84.2 nTPM
Cerebral cortex	84.0 nTPM
Basal ganglia	77.9 nTPM
Midbrain	69.9 nTPM

Deep-layer intratelencephalic	90.1 nTPM
Hypothalamus	111.9 nTPM
Amygdala	90.9 nTPM
Cerebral cortex	86.7 nTPM
Hippocampus	81.7 nTPM
Basal ganglia	79.3 nTPM

Deep-layer near-projecting	81.8 nTPM
Hypothalamus	94.4 nTPM
Amygdala	88.3 nTPM
Cerebral cortex	86.7 nTPM
Basal ganglia	73.3 nTPM
Hippocampus	66.3 nTPM

Eccentric medium spiny neuron	92.4 nTPM
Hypothalamus	105.0 nTPM
Thalamus	94.3 nTPM
Basal ganglia	94.2 nTPM
Cerebral cortex	89.4 nTPM
Amygdala	88.1 nTPM
Hippocampus	83.7 nTPM

Endothelial cell	74.7 nTPM
Basal ganglia	99.7 nTPM
Midbrain	84.1 nTPM
Medulla oblongata	75.9 nTPM
Hippocampus	75.3 nTPM
Amygdala	73.8 nTPM
Cerebellum	73.6 nTPM
Cerebral cortex	72.2 nTPM
Pons	71.2 nTPM
Thalamus	71.2 nTPM
Hypothalamus	65.8 nTPM
Spinal cord	58.7 nTPM