Single cell type - GFUS - The Human Protein Atlas

GFUS

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GFUS
Gene descriptionⁱ Full gene name according to HGNC.	GDP-L-fucose synthase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Intestinal goblet cells - Mucin production (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Late spermatids)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.34
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Late spermatids)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

GFUS is part of cluster 16 Intestinal goblet cells - Mucin production with confidenceⁱ 1
268 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ARL4A	ADP ribosylation factor like GTPase 4A	0.5900	36
MAPK13	Mitogen-activated protein kinase 13	0.5414	17
SLC50A1	Solute carrier family 50 member 1	0.5068	17
FER1L6	Fer-1 like family member 6	0.5052	46
PYCR1	Pyrroline-5-carboxylate reductase 1	0.5052	77
THEM6	Thioesterase superfamily member 6	0.5032	17
SLC25A39	Solute carrier family 25 member 39	0.5013	1
NARF	Nuclear prelamin A recognition factor	0.4922	1
STARD10	StAR related lipid transfer domain containing 10	0.4880	36
CANT1	Calcium activated nucleotidase 1	0.4872	16
JMJD4	Jumonji domain containing 4	0.4737	36
ESRP2	Epithelial splicing regulatory protein 2	0.4679	36
TMEM222	Transmembrane protein 222	0.4678	36
NEURL1	Neuralized E3 ubiquitin protein ligase 1	0.4659	36
LRRC26	Leucine rich repeat containing 26	0.4539	16

IMMUNE CELLS

GFUS is part of cluster 12 Non-specific - Mitochondrial translation with confidenceⁱ 0.52
566 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PFDN1	Prefoldin subunit 1	1.0000	12
EXOSC10	Exosome component 10	0.9762	12
URM1	Ubiquitin related modifier 1	0.9762	12
SEPHS1	Selenophosphate synthetase 1	0.9524	12
VPS11	VPS11 core subunit of CORVET and HOPS complexes	0.9524	12
PMVK	Phosphomevalonate kinase	0.9524	12
CHCHD4	Coiled-coil-helix-coiled-coil-helix domain containing 4	0.9524	12
PSMC3	Proteasome 26S subunit, ATPase 3	0.9524	12
PSMD11	Proteasome 26S subunit, non-ATPase 11	0.9286	12
KATNA1	Katanin catalytic subunit A1	0.9286	12
MRPL13	Mitochondrial ribosomal protein L13	0.9286	12
GPS1	G protein pathway suppressor 1	0.9286	12
TIMM17A	Translocase of inner mitochondrial membrane 17A	0.9286	12
PDCL3	Phosducin like 3	0.9286	12
NECAP2	NECAP endocytosis associated 2	0.9048	12

Adipocytes	60.0 nTPM
Adipose tissue	70.2 nTPM
Breast	49.9 nTPM

Alveolar cells type 1	56.8 nTPM
Lung	56.8 nTPM

Alveolar cells type 2	97.0 nTPM
Lung	97.0 nTPM

Astrocytes	3.7 nTPM
Brain	3.7 nTPM

B-cells	25.0 nTPM
PBMC	38.5 nTPM
Skin	35.6 nTPM
Bone marrow	27.4 nTPM
Salivary gland	26.6 nTPM
Kidney	26.0 nTPM
Liver	24.2 nTPM
Spleen	23.8 nTPM
Adipose tissue	23.5 nTPM
Lung	22.8 nTPM
Thymus	20.8 nTPM
Stomach	20.2 nTPM
Lymph node	18.1 nTPM
Esophagus	17.7 nTPM

Ciliated cells	38.4 nTPM
Bronchus	54.3 nTPM
Lung	37.2 nTPM
Fallopian tube	31.2 nTPM
Endometrium	30.8 nTPM

Club cells	70.4 nTPM
Bronchus	86.1 nTPM
Lung	67.1 nTPM
Prostate	58.1 nTPM

Dendritic cells	32.2 nTPM
PBMC	36.0 nTPM
Adipose tissue	28.4 nTPM

Endothelial cells	49.1 nTPM
Breast	213.5 nTPM
Tongue	70.9 nTPM
Lung	62.5 nTPM
Placenta	56.2 nTPM
Ovary	55.4 nTPM
Pancreas	54.3 nTPM
Skeletal muscle	46.2 nTPM
Salivary gland	42.6 nTPM
Thymus	38.3 nTPM
Vascular	36.9 nTPM
Fallopian tube	36.6 nTPM
Testis	31.4 nTPM
Esophagus	29.3 nTPM
Skin	27.6 nTPM
Endometrium	25.5 nTPM
Heart muscle	20.5 nTPM
Liver	18.9 nTPM
Prostate	16.2 nTPM

Enteroendocrine cells	55.1 nTPM
Colon	80.2 nTPM
Small intestine	54.9 nTPM
Rectum	30.2 nTPM

Fibroblasts	26.9 nTPM
Pancreas	78.2 nTPM
Lung	55.5 nTPM
Placenta	40.3 nTPM
Thymus	29.0 nTPM
Breast	26.5 nTPM
Salivary gland	25.6 nTPM
Vascular	25.5 nTPM
Skin	23.8 nTPM
Fallopian tube	22.2 nTPM
Liver	20.2 nTPM
Adipose tissue	18.7 nTPM
Esophagus	18.4 nTPM
Skeletal muscle	17.2 nTPM
Stomach	13.0 nTPM
Prostate	9.9 nTPM
Heart muscle	6.8 nTPM

Granulocytes	23.6 nTPM
Tongue	29.1 nTPM
Lung	24.7 nTPM
Fallopian tube	17.1 nTPM

Intestinal goblet cells	223.4 nTPM
Colon	293.5 nTPM
Small intestine	223.1 nTPM
Rectum	153.5 nTPM

Lymphatic endothelial cells	132.1 nTPM
Fallopian tube	171.3 nTPM
Ovary	92.7 nTPM

Macrophages	28.4 nTPM
Pancreas	69.9 nTPM
Lung	47.3 nTPM
Breast	37.5 nTPM
Tongue	34.6 nTPM
Kidney	31.9 nTPM
Bone marrow	31.4 nTPM
Endometrium	26.4 nTPM
Fallopian tube	26.4 nTPM
Salivary gland	25.7 nTPM
Testis	24.8 nTPM
Skeletal muscle	24.5 nTPM
Prostate	22.7 nTPM
Adipose tissue	22.5 nTPM
Thymus	21.8 nTPM
Spleen	21.1 nTPM
Skin	20.1 nTPM
Vascular	19.5 nTPM
Esophagus	18.0 nTPM
Stomach	12.9 nTPM

Basal keratinocytes	89.8 nTPM
Tongue	100.1 nTPM
Skin	79.5 nTPM

Basal prostatic cells	22.6 nTPM
Prostate	22.6 nTPM

Basal respiratory cells	65.4 nTPM
Bronchus	65.4 nTPM

Basal squamous epithelial cells	59.8 nTPM
Esophagus	59.8 nTPM

Paneth cells	88.6 nTPM
Small intestine	103.6 nTPM
Colon	101.3 nTPM
Rectum	61.0 nTPM

Plasma cells	45.6 nTPM
Liver	66.1 nTPM
Stomach	55.7 nTPM
Thymus	51.5 nTPM
Salivary gland	47.5 nTPM
Fallopian tube	47.3 nTPM
Spleen	43.5 nTPM
Bone marrow	37.8 nTPM
Esophagus	15.6 nTPM

Schwann cells	21.1 nTPM
Adipose tissue	41.4 nTPM
Vascular	21.9 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	125.5 nTPM
Tongue	132.6 nTPM
Salivary gland	118.3 nTPM

Smooth muscle cells	28.5 nTPM
Placenta	53.1 nTPM
Salivary gland	45.3 nTPM
Lung	36.4 nTPM
Breast	36.2 nTPM
Liver	31.4 nTPM
Vascular	28.4 nTPM
Thymus	27.0 nTPM
Ovary	25.5 nTPM
Tongue	24.5 nTPM
Esophagus	24.0 nTPM
Fallopian tube	23.9 nTPM
Endometrium	23.7 nTPM
Skeletal muscle	23.6 nTPM
Skin	21.5 nTPM
Adipose tissue	15.4 nTPM
Prostate	15.2 nTPM

Suprabasal keratinocytes	120.1 nTPM
Tongue	124.5 nTPM
Skin	115.7 nTPM

T-cells	37.5 nTPM
Breast	60.4 nTPM
Kidney	57.6 nTPM
Lung	51.8 nTPM
Colon	51.7 nTPM
Stomach	47.6 nTPM
Liver	46.6 nTPM
Skin	46.3 nTPM
PBMC	41.7 nTPM
Tongue	41.2 nTPM
Fallopian tube	39.2 nTPM
Endometrium	38.9 nTPM
Bone marrow	36.6 nTPM
Skeletal muscle	33.6 nTPM
Spleen	30.2 nTPM
Adipose tissue	29.2 nTPM
Thymus	28.6 nTPM
Salivary gland	28.0 nTPM
Esophagus	21.9 nTPM
Prostate	20.7 nTPM
Vascular	18.9 nTPM
Lymph node	16.0 nTPM

Undifferentiated cells	94.5 nTPM
Small intestine	111.9 nTPM
Colon	103.2 nTPM
Rectum	68.5 nTPM

Amygdala excitatory	8.8 nTPM
Basal ganglia	12.8 nTPM
Hippocampus	10.0 nTPM
Cerebral cortex	9.3 nTPM
Amygdala	7.9 nTPM
Hypothalamus	7.4 nTPM
Thalamus	5.4 nTPM

Astrocyte	6.9 nTPM
Cerebral cortex	9.7 nTPM
Cerebellum	8.6 nTPM
Pons	8.4 nTPM
Hippocampus	7.6 nTPM
Thalamus	7.6 nTPM
Midbrain	6.7 nTPM
Basal ganglia	6.5 nTPM
Spinal cord	6.1 nTPM
Medulla oblongata	5.9 nTPM
Amygdala	4.9 nTPM
Hypothalamus	3.8 nTPM

Bergmann glia	3.4 nTPM
Cerebellum	5.9 nTPM
Pons	4.3 nTPM
Medulla oblongata	0.0 nTPM

Central nervous system macrophage	4.4 nTPM
Cerebral cortex	6.6 nTPM
Spinal cord	5.6 nTPM
Hippocampus	5.5 nTPM
Cerebellum	5.4 nTPM
Pons	4.5 nTPM
Midbrain	4.3 nTPM
Thalamus	4.3 nTPM
Amygdala	3.3 nTPM
Basal ganglia	3.3 nTPM
Medulla oblongata	3.3 nTPM
Hypothalamus	2.8 nTPM

Cerebellar inhibitory	7.9 nTPM
Midbrain	9.6 nTPM
Pons	9.0 nTPM
Cerebellum	8.5 nTPM
Medulla oblongata	7.0 nTPM
Spinal cord	5.5 nTPM

Cge interneuron	8.1 nTPM
Basal ganglia	9.5 nTPM
Cerebral cortex	9.3 nTPM
Midbrain	9.0 nTPM
Hippocampus	7.9 nTPM
Thalamus	7.5 nTPM
Amygdala	6.9 nTPM
Hypothalamus	6.5 nTPM

Choroid plexus epithelial cell	9.2 nTPM
Hippocampus	13.9 nTPM
Thalamus	11.0 nTPM
Medulla oblongata	6.4 nTPM
Basal ganglia	5.4 nTPM

Committed oligodendrocyte precursor	6.7 nTPM
Medulla oblongata	9.0 nTPM
Pons	8.9 nTPM
Hippocampus	7.8 nTPM
Basal ganglia	7.7 nTPM
Midbrain	7.6 nTPM
Spinal cord	7.4 nTPM
Cerebral cortex	7.0 nTPM
Amygdala	6.2 nTPM
Thalamus	5.6 nTPM
Hypothalamus	4.8 nTPM
Cerebellum	1.6 nTPM

Deep-layer corticothalamic and 6b	8.7 nTPM
Midbrain	12.2 nTPM
Basal ganglia	9.3 nTPM
Cerebral cortex	8.6 nTPM
Hippocampus	8.4 nTPM
Amygdala	7.6 nTPM
Hypothalamus	6.1 nTPM

Deep-layer intratelencephalic	9.1 nTPM
Basal ganglia	12.0 nTPM
Cerebral cortex	9.5 nTPM
Amygdala	8.9 nTPM
Hippocampus	8.3 nTPM
Hypothalamus	6.5 nTPM

Deep-layer near-projecting	8.2 nTPM
Basal ganglia	12.7 nTPM
Cerebral cortex	10.0 nTPM
Amygdala	6.6 nTPM
Hypothalamus	6.4 nTPM
Hippocampus	5.2 nTPM

Eccentric medium spiny neuron	6.2 nTPM
Hippocampus	7.0 nTPM
Basal ganglia	6.5 nTPM
Amygdala	6.3 nTPM
Hypothalamus	6.3 nTPM
Cerebral cortex	6.0 nTPM
Thalamus	5.3 nTPM