Single cell type - XIAP - The Human Protein Atlas

XIAP

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	XIAP
Gene descriptionⁱ Full gene name according to HGNC.	X-linked inhibitor of apoptosis
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - DNA binding (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.24
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

XIAP is part of cluster 33 Non-specific - DNA binding with confidenceⁱ 0.89
138 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MON1B	MON1 homolog B, secretory trafficking associated	0.5475	55
GNB1	G protein subunit beta 1	0.5128	66
TMED7	Transmembrane p24 trafficking protein 7	0.4998	16
PARP4	Poly(ADP-ribose) polymerase family member 4	0.4877	30
EFCAB14	EF-hand calcium binding domain 14	0.4856	55
ZSWIM1	Zinc finger SWIM-type containing 1	0.4818	68
TADA2B	Transcriptional adaptor 2B	0.4805	33
KLHL9	Kelch like family member 9	0.4636	55
UHMK1	U2AF homology motif kinase 1	0.4551	3
LIN7C	Lin-7 homolog C, crumbs cell polarity complex component	0.4537	33
TMEM127	Transmembrane protein 127	0.4514	58
ZNF562	Zinc finger protein 562	0.4487	35
SEC22B	SEC22 homolog B, vesicle trafficking protein	0.4461	77
STX3	Syntaxin 3	0.4425	25
SLC24A1	Solute carrier family 24 member 1	0.4424	66

IMMUNE CELLS

XIAP is part of cluster 30 Non-specific - DNA binding with confidenceⁱ 1
263 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SLC11A2	Solute carrier family 11 member 2	0.9524	33
CCNJ	Cyclin J	0.9524	14
SRCAP	Snf2 related CREBBP activator protein	0.9286	2
TAF1	TATA-box binding protein associated factor 1	0.9286	30
GPATCH8	G-patch domain containing 8	0.9048	30
UBE2E1	Ubiquitin conjugating enzyme E2 E1	0.9048	7
TMSB4Y	Thymosin beta 4 Y-linked	0.9048	2
RBM28	RNA binding motif protein 28	0.8810	14
RPAP1	RNA polymerase II associated protein 1	0.8810	30
DVL3	Dishevelled segment polarity protein 3	0.8810	7
ZKSCAN1	Zinc finger with KRAB and SCAN domains 1	0.8571	30
KAT2B	Lysine acetyltransferase 2B	0.8571	33
NR2C1	Nuclear receptor subfamily 2 group C member 1	0.8571	30
MICALL1	MICAL like 1	0.8571	30
CPNE3	Copine 3	0.8571	2

Adipocytes	47.3 nTPM
Adipose tissue	58.1 nTPM
Breast	36.6 nTPM

Alveolar cells type 1	65.3 nTPM
Lung	65.3 nTPM

Alveolar cells type 2	76.9 nTPM
Lung	76.9 nTPM

Astrocytes	25.1 nTPM
Brain	25.1 nTPM

B-cells	44.5 nTPM
Esophagus	64.9 nTPM
Salivary gland	59.5 nTPM
Adipose tissue	57.2 nTPM
PBMC	52.3 nTPM
Bone marrow	51.6 nTPM
Liver	48.3 nTPM
Spleen	40.3 nTPM
Lymph node	40.2 nTPM
Lung	38.9 nTPM
Thymus	35.6 nTPM
Stomach	32.9 nTPM
Kidney	31.2 nTPM
Skin	25.4 nTPM

Ciliated cells	37.3 nTPM
Bronchus	46.9 nTPM
Lung	37.2 nTPM
Endometrium	36.9 nTPM
Fallopian tube	28.0 nTPM

Club cells	48.7 nTPM
Prostate	57.0 nTPM
Lung	50.5 nTPM
Bronchus	38.5 nTPM

Dendritic cells	53.6 nTPM
Adipose tissue	56.8 nTPM
PBMC	50.4 nTPM

Endothelial cells	49.0 nTPM
Lung	73.2 nTPM
Liver	66.8 nTPM
Prostate	61.7 nTPM
Salivary gland	60.0 nTPM
Vascular	59.8 nTPM
Heart muscle	58.0 nTPM
Endometrium	49.3 nTPM
Skeletal muscle	48.9 nTPM
Testis	47.3 nTPM
Tongue	46.5 nTPM
Fallopian tube	45.8 nTPM
Ovary	44.1 nTPM
Breast	43.9 nTPM
Esophagus	38.3 nTPM
Thymus	36.9 nTPM
Skin	35.2 nTPM
Pancreas	33.6 nTPM
Placenta	32.9 nTPM

Enteroendocrine cells	43.8 nTPM
Rectum	48.6 nTPM
Small intestine	48.1 nTPM
Colon	34.8 nTPM

Fibroblasts	41.5 nTPM
Liver	87.8 nTPM
Heart muscle	56.5 nTPM
Salivary gland	55.7 nTPM
Skeletal muscle	52.3 nTPM
Adipose tissue	50.5 nTPM
Vascular	48.0 nTPM
Fallopian tube	45.9 nTPM
Prostate	43.6 nTPM
Lung	38.8 nTPM
Esophagus	31.2 nTPM
Skin	30.9 nTPM
Breast	28.9 nTPM
Thymus	28.8 nTPM
Pancreas	26.2 nTPM
Placenta	20.1 nTPM
Stomach	18.7 nTPM

Granulocytes	56.6 nTPM
Fallopian tube	61.9 nTPM
Lung	54.5 nTPM
Tongue	53.4 nTPM

Intestinal goblet cells	61.0 nTPM
Small intestine	75.3 nTPM
Rectum	67.1 nTPM
Colon	40.6 nTPM

Lymphatic endothelial cells	79.7 nTPM
Ovary	81.8 nTPM
Fallopian tube	77.6 nTPM

Macrophages	47.8 nTPM
Lung	83.1 nTPM
Fallopian tube	77.6 nTPM
Adipose tissue	65.9 nTPM
Vascular	62.6 nTPM
Spleen	61.2 nTPM
Salivary gland	57.9 nTPM
Thymus	47.4 nTPM
Prostate	47.3 nTPM
Pancreas	43.2 nTPM
Tongue	42.8 nTPM
Kidney	42.5 nTPM
Skeletal muscle	42.5 nTPM
Skin	40.1 nTPM
Testis	39.1 nTPM
Stomach	38.6 nTPM
Bone marrow	37.5 nTPM
Endometrium	30.7 nTPM
Esophagus	25.7 nTPM
Breast	23.7 nTPM

Basal keratinocytes	32.7 nTPM
Tongue	37.6 nTPM
Skin	27.9 nTPM

Basal prostatic cells	86.0 nTPM
Prostate	86.0 nTPM

Basal respiratory cells	34.1 nTPM
Bronchus	34.1 nTPM

Basal squamous epithelial cells	28.1 nTPM
Esophagus	28.1 nTPM

Paneth cells	51.3 nTPM
Rectum	61.7 nTPM
Colon	50.7 nTPM
Small intestine	41.4 nTPM

Plasma cells	40.7 nTPM
Fallopian tube	56.3 nTPM
Salivary gland	51.0 nTPM
Stomach	47.3 nTPM
Bone marrow	37.8 nTPM
Esophagus	36.4 nTPM
Thymus	35.7 nTPM
Spleen	32.5 nTPM
Liver	28.5 nTPM

Schwann cells	40.4 nTPM
Vascular	45.4 nTPM
Adipose tissue	39.8 nTPM
Esophagus	35.9 nTPM

Serous glandular cells	34.0 nTPM
Salivary gland	54.8 nTPM
Tongue	13.3 nTPM

Smooth muscle cells	37.6 nTPM
Liver	61.1 nTPM
Tongue	49.7 nTPM
Vascular	47.8 nTPM
Salivary gland	46.8 nTPM
Adipose tissue	46.3 nTPM
Lung	45.8 nTPM
Prostate	43.8 nTPM
Skeletal muscle	36.6 nTPM
Fallopian tube	34.3 nTPM
Endometrium	33.4 nTPM
Esophagus	28.8 nTPM
Ovary	26.8 nTPM
Thymus	25.9 nTPM
Skin	25.4 nTPM
Placenta	25.1 nTPM
Breast	24.4 nTPM

Suprabasal keratinocytes	41.9 nTPM
Tongue	49.9 nTPM
Skin	33.9 nTPM

T-cells	40.2 nTPM
Vascular	61.9 nTPM
Prostate	59.8 nTPM
Salivary gland	58.8 nTPM
Tongue	54.3 nTPM
PBMC	54.1 nTPM
Adipose tissue	43.0 nTPM
Thymus	42.2 nTPM
Bone marrow	41.8 nTPM
Lung	41.2 nTPM
Liver	38.1 nTPM
Kidney	36.4 nTPM
Lymph node	35.6 nTPM
Spleen	35.3 nTPM
Fallopian tube	35.0 nTPM
Skeletal muscle	34.4 nTPM
Endometrium	34.2 nTPM
Breast	28.9 nTPM
Stomach	28.6 nTPM
Colon	27.3 nTPM
Skin	27.3 nTPM
Esophagus	26.8 nTPM

Undifferentiated cells	33.0 nTPM
Rectum	39.3 nTPM
Small intestine	34.4 nTPM
Colon	25.3 nTPM

Amygdala excitatory	57.2 nTPM
Hypothalamus	68.2 nTPM
Thalamus	63.1 nTPM
Amygdala	57.9 nTPM
Hippocampus	54.1 nTPM
Basal ganglia	53.3 nTPM
Cerebral cortex	46.7 nTPM

Astrocyte	60.6 nTPM
Amygdala	70.4 nTPM
Hippocampus	64.3 nTPM
Hypothalamus	63.6 nTPM
Thalamus	62.4 nTPM
Basal ganglia	60.6 nTPM
Cerebral cortex	59.7 nTPM
Midbrain	59.5 nTPM
Cerebellum	59.4 nTPM
Spinal cord	58.6 nTPM
Pons	55.4 nTPM
Medulla oblongata	52.4 nTPM

Bergmann glia	59.2 nTPM
Medulla oblongata	66.1 nTPM
Cerebellum	61.3 nTPM
Pons	50.3 nTPM

Central nervous system macrophage	85.4 nTPM
Amygdala	107.0 nTPM
Hippocampus	96.1 nTPM
Hypothalamus	91.1 nTPM
Midbrain	90.7 nTPM
Thalamus	90.5 nTPM
Pons	85.6 nTPM
Cerebellum	84.5 nTPM
Basal ganglia	84.3 nTPM
Cerebral cortex	76.2 nTPM
Medulla oblongata	66.9 nTPM
Spinal cord	66.5 nTPM

Cerebellar inhibitory	61.3 nTPM
Spinal cord	90.7 nTPM
Midbrain	62.2 nTPM
Cerebellum	55.1 nTPM
Pons	52.2 nTPM
Medulla oblongata	46.4 nTPM

Cge interneuron	72.1 nTPM
Hypothalamus	95.7 nTPM
Thalamus	80.5 nTPM
Amygdala	73.9 nTPM
Hippocampus	67.9 nTPM
Midbrain	64.9 nTPM
Basal ganglia	63.2 nTPM
Cerebral cortex	58.7 nTPM

Choroid plexus epithelial cell	134.6 nTPM
Basal ganglia	188.2 nTPM
Medulla oblongata	140.7 nTPM
Hippocampus	105.4 nTPM
Thalamus	104.1 nTPM

Committed oligodendrocyte precursor	55.8 nTPM
Basal ganglia	70.6 nTPM
Amygdala	66.0 nTPM
Thalamus	64.8 nTPM
Cerebral cortex	64.6 nTPM
Hippocampus	62.1 nTPM
Hypothalamus	58.0 nTPM
Medulla oblongata	52.9 nTPM
Midbrain	48.7 nTPM
Pons	48.7 nTPM
Cerebellum	44.4 nTPM
Spinal cord	33.1 nTPM

Deep-layer corticothalamic and 6b	49.9 nTPM
Hypothalamus	72.8 nTPM
Hippocampus	49.9 nTPM
Amygdala	49.2 nTPM
Cerebral cortex	44.1 nTPM
Midbrain	43.3 nTPM
Basal ganglia	40.1 nTPM

Deep-layer intratelencephalic	51.5 nTPM
Hypothalamus	69.1 nTPM
Amygdala	50.8 nTPM
Hippocampus	47.8 nTPM
Cerebral cortex	46.3 nTPM
Basal ganglia	43.7 nTPM

Deep-layer near-projecting	57.2 nTPM
Hypothalamus	89.3 nTPM
Amygdala	64.4 nTPM
Cerebral cortex	51.8 nTPM
Basal ganglia	45.9 nTPM
Hippocampus	34.5 nTPM

Eccentric medium spiny neuron	79.1 nTPM
Hypothalamus	88.3 nTPM
Hippocampus	87.0 nTPM
Thalamus	79.8 nTPM
Amygdala	75.9 nTPM
Cerebral cortex	73.1 nTPM
Basal ganglia	70.6 nTPM