Single cell type - USP27X - The Human Protein Atlas

USP27X

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	USP27X
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquitin specific peptidase 27 X-linked
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Cytotrophoblasts - Mitochondria (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Cytotrophoblasts, Syncytiotrophoblasts)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.70
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Cytotrophoblasts, Syncytiotrophoblasts)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

USP27X is part of cluster 24 Cytotrophoblasts - Mitochondria with confidenceⁱ 1
235 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PEG10	Paternally expressed 10	0.8016	24
MLLT1	MLLT1 super elongation complex subunit	0.7710	24
PAGE4	PAGE family member 4	0.7600	24
FOXO4	Forkhead box O4	0.7531	24
MORC4	MORC family CW-type zinc finger 4	0.7526	24
GRAMD2A	GRAM domain containing 2A	0.7503	24
SOX14	SRY-box transcription factor 14	0.7486	24
NRK	Nik related kinase	0.7411	24
ADRB1	Adrenoceptor beta 1	0.7368	24
VGLL1	Vestigial like family member 1	0.7335	24
IFI6	Interferon alpha inducible protein 6	0.7317	24
TRBV20OR9-2	T cell receptor beta variable 20/OR9-2 (non-functional)	0.7316	24
MAGEA8	MAGE family member A8	0.7315	24
MBNL3	Muscleblind like splicing regulator 3	0.7248	24
SMAGP	Small cell adhesion glycoprotein	0.7235	24

Adipocytes	3.7 nTPM
Adipose tissue	4.2 nTPM
Breast	3.3 nTPM

Alveolar cells type 1	14.0 nTPM
Lung	14.0 nTPM

Alveolar cells type 2	14.0 nTPM
Lung	14.0 nTPM

Astrocytes	0.6 nTPM
Brain	0.6 nTPM

B-cells	3.4 nTPM
Kidney	15.6 nTPM
Esophagus	5.9 nTPM
Adipose tissue	4.1 nTPM
Thymus	4.0 nTPM
Salivary gland	3.9 nTPM
PBMC	3.1 nTPM
Lymph node	2.2 nTPM
Skin	1.7 nTPM
Stomach	1.3 nTPM
Lung	1.3 nTPM
Bone marrow	1.0 nTPM
Spleen	0.7 nTPM
Liver	0.0 nTPM

Ciliated cells	3.0 nTPM
Lung	6.0 nTPM
Fallopian tube	3.6 nTPM
Endometrium	2.3 nTPM
Bronchus	0.1 nTPM

Club cells	2.7 nTPM
Prostate	4.1 nTPM
Lung	3.7 nTPM
Bronchus	0.2 nTPM

Endothelial cells	5.1 nTPM
Fallopian tube	17.8 nTPM
Heart muscle	14.1 nTPM
Thymus	5.8 nTPM
Salivary gland	5.5 nTPM
Breast	5.3 nTPM
Lung	5.2 nTPM
Skeletal muscle	5.1 nTPM
Tongue	5.1 nTPM
Vascular	4.0 nTPM
Prostate	3.8 nTPM
Endometrium	3.4 nTPM
Esophagus	3.4 nTPM
Ovary	2.9 nTPM
Testis	2.7 nTPM
Pancreas	2.6 nTPM
Skin	2.6 nTPM
Liver	1.3 nTPM
Placenta	1.1 nTPM

Enteroendocrine cells	7.1 nTPM
Small intestine	13.7 nTPM
Rectum	6.7 nTPM
Colon	0.8 nTPM

Fibroblasts	2.4 nTPM
Prostate	5.9 nTPM
Salivary gland	3.9 nTPM
Placenta	3.6 nTPM
Vascular	3.6 nTPM
Fallopian tube	3.0 nTPM
Lung	2.6 nTPM
Breast	2.6 nTPM
Liver	2.4 nTPM
Skeletal muscle	2.0 nTPM
Thymus	1.9 nTPM
Adipose tissue	1.7 nTPM
Skin	1.4 nTPM
Stomach	1.4 nTPM
Esophagus	1.3 nTPM
Pancreas	1.0 nTPM
Heart muscle	0.5 nTPM

Granulocytes	4.3 nTPM
Fallopian tube	6.7 nTPM
Tongue	4.9 nTPM
Lung	1.5 nTPM

Intestinal goblet cells	1.6 nTPM
Rectum	2.1 nTPM
Small intestine	1.4 nTPM
Colon	1.2 nTPM

Lymphatic endothelial cells	4.9 nTPM
Ovary	5.5 nTPM
Fallopian tube	4.3 nTPM

Macrophages	1.8 nTPM
Prostate	3.8 nTPM
Salivary gland	3.0 nTPM
Stomach	2.6 nTPM
Endometrium	2.5 nTPM
Skin	2.2 nTPM
Fallopian tube	2.2 nTPM
Lung	2.1 nTPM
Vascular	2.1 nTPM
Breast	2.1 nTPM
Skeletal muscle	1.9 nTPM
Kidney	1.8 nTPM
Thymus	1.6 nTPM
Adipose tissue	1.5 nTPM
Tongue	1.4 nTPM
Esophagus	1.3 nTPM
Bone marrow	1.0 nTPM
Spleen	1.0 nTPM
Testis	0.6 nTPM
Pancreas	0.0 nTPM

Paneth cells	0.5 nTPM
Rectum	1.5 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Basal prostatic cells	4.8 nTPM
Prostate	4.8 nTPM

Basal respiratory cells	0.3 nTPM
Bronchus	0.3 nTPM

Bipolar cells	12.4 nTPM
Eye	12.4 nTPM

Excitatory neurons	2.8 nTPM
Brain	2.8 nTPM

Plasma cells	0.9 nTPM
Fallopian tube	4.2 nTPM
Salivary gland	2.2 nTPM
Liver	0.5 nTPM
Thymus	0.4 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Schwann cells	1.7 nTPM
Vascular	4.7 nTPM
Adipose tissue	0.4 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	1.1 nTPM
Salivary gland	2.2 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	4.0 nTPM
Lung	9.4 nTPM
Vascular	5.9 nTPM
Prostate	5.5 nTPM
Fallopian tube	4.9 nTPM
Salivary gland	4.0 nTPM
Ovary	3.9 nTPM
Skeletal muscle	3.6 nTPM
Esophagus	3.6 nTPM
Thymus	3.5 nTPM
Breast	3.4 nTPM
Liver	3.0 nTPM
Placenta	2.9 nTPM
Adipose tissue	2.9 nTPM
Endometrium	2.7 nTPM
Tongue	2.4 nTPM
Skin	2.3 nTPM

T-cells	2.5 nTPM
Esophagus	7.3 nTPM
Salivary gland	5.3 nTPM
Thymus	4.8 nTPM
Prostate	4.5 nTPM
Fallopian tube	4.2 nTPM
Tongue	4.1 nTPM
Adipose tissue	3.5 nTPM
Liver	2.7 nTPM
Lung	2.1 nTPM
Breast	2.1 nTPM
Endometrium	2.0 nTPM
Lymph node	1.9 nTPM
PBMC	1.6 nTPM
Skeletal muscle	1.5 nTPM
Skin	1.4 nTPM
Spleen	0.8 nTPM
Stomach	0.8 nTPM
Bone marrow	0.5 nTPM
Vascular	0.4 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM

Undifferentiated cells	1.7 nTPM
Rectum	2.3 nTPM
Small intestine	1.6 nTPM
Colon	1.3 nTPM

Amygdala excitatory	3.7 nTPM
Thalamus	5.0 nTPM
Hippocampus	4.4 nTPM
Hypothalamus	3.6 nTPM
Cerebral cortex	3.3 nTPM
Basal ganglia	3.0 nTPM
Amygdala	2.7 nTPM

Astrocyte	2.1 nTPM
Amygdala	3.1 nTPM
Cerebral cortex	3.0 nTPM
Hippocampus	2.4 nTPM
Hypothalamus	2.4 nTPM
Basal ganglia	2.1 nTPM
Cerebellum	2.1 nTPM
Midbrain	2.1 nTPM
Thalamus	1.9 nTPM
Pons	1.5 nTPM
Medulla oblongata	1.4 nTPM
Spinal cord	1.0 nTPM

Bergmann glia	3.8 nTPM
Cerebellum	5.0 nTPM
Pons	4.3 nTPM
Medulla oblongata	2.1 nTPM

Central nervous system macrophage	2.4 nTPM
Thalamus	3.8 nTPM
Cerebral cortex	3.4 nTPM
Cerebellum	2.6 nTPM
Hypothalamus	2.6 nTPM
Amygdala	2.4 nTPM
Midbrain	2.4 nTPM
Medulla oblongata	2.2 nTPM
Pons	2.0 nTPM
Hippocampus	1.8 nTPM
Basal ganglia	1.7 nTPM
Spinal cord	1.5 nTPM

Cerebellar inhibitory	3.4 nTPM
Cerebellum	5.1 nTPM
Midbrain	4.4 nTPM
Medulla oblongata	4.1 nTPM
Pons	3.4 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	6.0 nTPM
Cerebral cortex	7.1 nTPM
Hippocampus	6.9 nTPM
Hypothalamus	6.6 nTPM
Basal ganglia	5.9 nTPM
Thalamus	5.8 nTPM
Amygdala	5.4 nTPM
Midbrain	4.2 nTPM

Choroid plexus epithelial cell	2.0 nTPM
Hippocampus	5.5 nTPM
Basal ganglia	1.5 nTPM
Medulla oblongata	1.0 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	3.1 nTPM
Spinal cord	7.4 nTPM
Medulla oblongata	5.2 nTPM
Midbrain	4.2 nTPM
Cerebral cortex	3.8 nTPM
Basal ganglia	3.3 nTPM
Cerebellum	3.2 nTPM
Hypothalamus	2.0 nTPM
Pons	1.8 nTPM
Thalamus	1.6 nTPM
Hippocampus	1.3 nTPM
Amygdala	0.0 nTPM

Deep-layer corticothalamic and 6b	4.9 nTPM
Hypothalamus	6.1 nTPM
Basal ganglia	5.5 nTPM
Hippocampus	5.0 nTPM
Amygdala	4.7 nTPM
Cerebral cortex	4.7 nTPM
Midbrain	3.3 nTPM

Deep-layer intratelencephalic	4.1 nTPM
Hippocampus	4.9 nTPM
Cerebral cortex	4.7 nTPM
Hypothalamus	4.3 nTPM
Basal ganglia	3.8 nTPM
Amygdala	2.9 nTPM

Deep-layer near-projecting	8.3 nTPM
Cerebral cortex	9.7 nTPM
Hypothalamus	9.0 nTPM
Amygdala	7.9 nTPM
Basal ganglia	7.9 nTPM
Hippocampus	6.8 nTPM

Eccentric medium spiny neuron	6.2 nTPM
Hypothalamus	9.8 nTPM
Hippocampus	6.2 nTPM
Thalamus	6.1 nTPM
Basal ganglia	5.3 nTPM
Amygdala	5.0 nTPM
Cerebral cortex	5.0 nTPM

Endothelial cell	2.0 nTPM
Midbrain	4.7 nTPM
Spinal cord	3.5 nTPM
Pons	3.1 nTPM
Thalamus	2.8 nTPM
Medulla oblongata	2.1 nTPM
Cerebral cortex	1.9 nTPM
Cerebellum	1.5 nTPM
Hippocampus	1.3 nTPM
Hypothalamus	1.2 nTPM
Amygdala	0.0 nTPM
Basal ganglia	0.0 nTPM

Ependymal cell	5.1 nTPM
Thalamus	7.3 nTPM
Amygdala	6.3 nTPM
Midbrain	5.7 nTPM
Pons	5.5 nTPM
Hippocampus	4.9 nTPM
Hypothalamus	4.5 nTPM
Medulla oblongata	4.4 nTPM
Spinal cord	3.8 nTPM
Basal ganglia	3.2 nTPM