Single cell type - SLC35B4 - The Human Protein Atlas

SLC35B4

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC35B4
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 35 member B4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Metabolic proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Cytotrophoblasts - Mitochondria (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Cytotrophoblasts, Syncytiotrophoblasts)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.50
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Cytotrophoblasts, Syncytiotrophoblasts)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

SLC35B4 is part of cluster 24 Cytotrophoblasts - Mitochondria with confidenceⁱ 1
235 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MANSC4	MANSC domain containing 4	0.8122	24
VSTM5	V-set and transmembrane domain containing 5	0.7842	24
PAGE4	PAGE family member 4	0.7804	24
AMELY	Amelogenin Y-linked	0.7797	24
SOX14	SRY-box transcription factor 14	0.7726	24
TRBV20OR9-2	T cell receptor beta variable 20/OR9-2 (non-functional)	0.7687	24
FBN2	Fibrillin 2	0.7637	24
SMAGP	Small cell adhesion glycoprotein	0.7592	24
IFI6	Interferon alpha inducible protein 6	0.7544	24
FOXO4	Forkhead box O4	0.7493	24
MAGEA8	MAGE family member A8	0.7474	24
GSDME	Gasdermin E	0.7443	24
MBNL3	Muscleblind like splicing regulator 3	0.7392	24
VGLL1	Vestigial like family member 1	0.7356	24
GRAMD2A	GRAM domain containing 2A	0.7252	24

IMMUNE CELLS

SLC35B4 is part of cluster 33 Non-specific - ATP binding with confidenceⁱ 0.84
757 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TUBB	Tubulin beta class I	0.9762	33
FPGS	Folylpolyglutamate synthase	0.9762	8
TRMT6	TRNA methyltransferase 6 non-catalytic subunit	0.9524	33
ICMT	Isoprenylcysteine carboxyl methyltransferase	0.9524	33
RIPK1	Receptor interacting serine/threonine kinase 1	0.9524	33
PTRH1	Peptidyl-tRNA hydrolase 1 homolog	0.9286	33
COMTD1	Catechol-O-methyltransferase domain containing 1	0.9286	12
LTBP4	Latent transforming growth factor beta binding protein 4	0.9286	8
NPRL3	NPR3 like, GATOR1 complex subunit	0.9286	8
GPD1L	Glycerol-3-phosphate dehydrogenase 1 like	0.9286	33
PDK2	Pyruvate dehydrogenase kinase 2	0.9286	8
UHMK1	U2AF homology motif kinase 1	0.9286	33
PRMT7	Protein arginine methyltransferase 7	0.9286	12
SLC16A7	Solute carrier family 16 member 7	0.9048	33
DSTN	Destrin, actin depolymerizing factor	0.9048	3

Adipocytes	7.4 nTPM
Breast	8.0 nTPM
Adipose tissue	6.7 nTPM

Alveolar cells type 1	11.9 nTPM
Lung	11.9 nTPM

Alveolar cells type 2	7.3 nTPM
Lung	7.3 nTPM

Astrocytes	21.7 nTPM
Brain	21.7 nTPM

B-cells	11.2 nTPM
Liver	24.2 nTPM
Salivary gland	15.7 nTPM
PBMC	15.4 nTPM
Bone marrow	14.4 nTPM
Lymph node	12.4 nTPM
Spleen	12.2 nTPM
Stomach	11.0 nTPM
Thymus	10.7 nTPM
Kidney	10.4 nTPM
Lung	8.0 nTPM
Esophagus	5.9 nTPM
Adipose tissue	5.3 nTPM
Skin	0.0 nTPM

Ciliated cells	4.5 nTPM
Endometrium	5.5 nTPM
Lung	4.8 nTPM
Fallopian tube	4.0 nTPM
Bronchus	3.9 nTPM

Club cells	5.1 nTPM
Bronchus	6.3 nTPM
Lung	5.8 nTPM
Prostate	3.2 nTPM

Endothelial cells	10.0 nTPM
Placenta	15.9 nTPM
Endometrium	15.2 nTPM
Prostate	13.2 nTPM
Liver	12.6 nTPM
Breast	12.3 nTPM
Testis	12.2 nTPM
Vascular	12.1 nTPM
Lung	10.5 nTPM
Thymus	10.2 nTPM
Salivary gland	9.9 nTPM
Esophagus	9.1 nTPM
Fallopian tube	8.4 nTPM
Ovary	8.1 nTPM
Tongue	7.7 nTPM
Heart muscle	6.8 nTPM
Skeletal muscle	6.4 nTPM
Pancreas	5.2 nTPM
Skin	4.0 nTPM

Enteroendocrine cells	4.7 nTPM
Rectum	10.1 nTPM
Colon	4.2 nTPM
Small intestine	0.0 nTPM

Fibroblasts	13.5 nTPM
Thymus	18.4 nTPM
Salivary gland	17.5 nTPM
Stomach	17.3 nTPM
Pancreas	16.9 nTPM
Vascular	16.8 nTPM
Lung	16.6 nTPM
Skeletal muscle	16.4 nTPM
Adipose tissue	15.0 nTPM
Esophagus	14.2 nTPM
Breast	13.8 nTPM
Fallopian tube	11.8 nTPM
Prostate	11.2 nTPM
Placenta	9.6 nTPM
Skin	8.7 nTPM
Liver	7.1 nTPM
Heart muscle	4.3 nTPM

Granulocytes	9.0 nTPM
Tongue	14.6 nTPM
Lung	8.6 nTPM
Fallopian tube	3.8 nTPM

Intestinal goblet cells	5.2 nTPM
Small intestine	7.8 nTPM
Colon	4.7 nTPM
Rectum	3.2 nTPM

Lymphatic endothelial cells	12.7 nTPM
Fallopian tube	14.5 nTPM
Ovary	10.9 nTPM

Macrophages	13.3 nTPM
Pancreas	26.7 nTPM
Thymus	24.5 nTPM
Salivary gland	22.1 nTPM
Prostate	21.0 nTPM
Lung	20.0 nTPM
Testis	16.7 nTPM
Vascular	16.3 nTPM
Bone marrow	12.2 nTPM
Fallopian tube	11.7 nTPM
Breast	10.7 nTPM
Stomach	10.3 nTPM
Tongue	10.0 nTPM
Endometrium	9.8 nTPM
Skeletal muscle	9.6 nTPM
Esophagus	7.7 nTPM
Adipose tissue	6.9 nTPM
Skin	6.7 nTPM
Spleen	6.0 nTPM
Kidney	4.4 nTPM

Paneth cells	4.7 nTPM
Small intestine	6.9 nTPM
Colon	3.6 nTPM
Rectum	3.6 nTPM

Basal respiratory cells	10.6 nTPM
Bronchus	10.6 nTPM

Bipolar cells	41.7 nTPM
Eye	41.7 nTPM

Cholangiocytes	15.3 nTPM
Liver	15.3 nTPM

Collecting duct cells	1.9 nTPM
Kidney	1.9 nTPM

Plasma cells	8.5 nTPM
Bone marrow	18.1 nTPM
Spleen	11.8 nTPM
Thymus	10.4 nTPM
Salivary gland	8.5 nTPM
Liver	8.0 nTPM
Stomach	7.5 nTPM
Fallopian tube	3.5 nTPM
Esophagus	0.0 nTPM

Schwann cells	11.0 nTPM
Vascular	14.6 nTPM
Esophagus	12.0 nTPM
Adipose tissue	6.2 nTPM

Serous glandular cells	3.1 nTPM
Salivary gland	6.1 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	9.6 nTPM
Endometrium	13.6 nTPM
Thymus	13.1 nTPM
Placenta	12.5 nTPM
Vascular	12.2 nTPM
Esophagus	12.0 nTPM
Salivary gland	11.1 nTPM
Prostate	10.3 nTPM
Liver	9.8 nTPM
Tongue	9.6 nTPM
Fallopian tube	9.5 nTPM
Skeletal muscle	8.4 nTPM
Adipose tissue	8.2 nTPM
Breast	7.2 nTPM
Ovary	6.2 nTPM
Skin	4.8 nTPM
Lung	4.7 nTPM

T-cells	8.8 nTPM
Esophagus	17.0 nTPM
Bone marrow	14.0 nTPM
Stomach	12.0 nTPM
Kidney	11.5 nTPM
Skeletal muscle	10.2 nTPM
Lymph node	9.8 nTPM
Skin	9.5 nTPM
Salivary gland	9.2 nTPM
Liver	8.9 nTPM
PBMC	8.7 nTPM
Thymus	8.5 nTPM
Spleen	8.2 nTPM
Prostate	8.1 nTPM
Tongue	7.6 nTPM
Vascular	7.2 nTPM
Endometrium	6.3 nTPM
Fallopian tube	6.2 nTPM
Adipose tissue	6.0 nTPM
Breast	5.9 nTPM
Lung	5.2 nTPM
Colon	3.9 nTPM

Undifferentiated cells	5.5 nTPM
Small intestine	7.3 nTPM
Colon	5.6 nTPM
Rectum	3.7 nTPM

Amygdala excitatory	39.4 nTPM
Hypothalamus	45.0 nTPM
Thalamus	41.3 nTPM
Hippocampus	39.8 nTPM
Cerebral cortex	38.0 nTPM
Basal ganglia	36.9 nTPM
Amygdala	35.4 nTPM

Astrocyte	50.6 nTPM
Thalamus	55.0 nTPM
Medulla oblongata	53.7 nTPM
Amygdala	52.7 nTPM
Spinal cord	52.1 nTPM
Pons	52.0 nTPM
Midbrain	51.9 nTPM
Hippocampus	50.9 nTPM
Hypothalamus	49.8 nTPM
Cerebellum	46.7 nTPM
Basal ganglia	46.2 nTPM
Cerebral cortex	45.2 nTPM

Bergmann glia	40.5 nTPM
Cerebellum	48.4 nTPM
Pons	43.2 nTPM
Medulla oblongata	29.8 nTPM

Central nervous system macrophage	37.3 nTPM
Amygdala	43.0 nTPM
Hippocampus	40.0 nTPM
Pons	39.7 nTPM
Cerebellum	39.1 nTPM
Thalamus	38.5 nTPM
Hypothalamus	38.1 nTPM
Basal ganglia	37.8 nTPM
Cerebral cortex	37.8 nTPM
Midbrain	37.8 nTPM
Medulla oblongata	31.3 nTPM
Spinal cord	27.1 nTPM

Cerebellar inhibitory	58.1 nTPM
Spinal cord	68.7 nTPM
Pons	56.8 nTPM
Midbrain	56.0 nTPM
Cerebellum	55.9 nTPM
Medulla oblongata	52.8 nTPM

Cge interneuron	49.7 nTPM
Cerebral cortex	60.1 nTPM
Basal ganglia	52.6 nTPM
Hippocampus	50.2 nTPM
Amygdala	49.1 nTPM
Midbrain	47.7 nTPM
Hypothalamus	47.5 nTPM
Thalamus	40.5 nTPM

Choroid plexus epithelial cell	30.8 nTPM
Basal ganglia	37.0 nTPM
Medulla oblongata	31.0 nTPM
Thalamus	30.1 nTPM
Hippocampus	25.0 nTPM

Committed oligodendrocyte precursor	34.2 nTPM
Cerebral cortex	45.0 nTPM
Thalamus	41.9 nTPM
Pons	37.2 nTPM
Spinal cord	36.8 nTPM
Basal ganglia	36.1 nTPM
Cerebellum	34.9 nTPM
Medulla oblongata	32.3 nTPM
Amygdala	31.0 nTPM
Midbrain	28.6 nTPM
Hippocampus	27.7 nTPM
Hypothalamus	25.3 nTPM

Deep-layer corticothalamic and 6b	40.0 nTPM
Hippocampus	59.1 nTPM
Cerebral cortex	41.6 nTPM
Midbrain	37.7 nTPM
Basal ganglia	36.2 nTPM
Amygdala	35.4 nTPM
Hypothalamus	30.1 nTPM

Deep-layer intratelencephalic	35.1 nTPM
Hippocampus	39.1 nTPM
Cerebral cortex	38.0 nTPM
Amygdala	34.2 nTPM
Hypothalamus	32.2 nTPM
Basal ganglia	31.9 nTPM

Deep-layer near-projecting	66.9 nTPM
Hippocampus	84.9 nTPM
Cerebral cortex	74.0 nTPM
Basal ganglia	63.8 nTPM
Amygdala	57.5 nTPM
Hypothalamus	54.2 nTPM

Eccentric medium spiny neuron	48.3 nTPM
Hypothalamus	55.8 nTPM
Cerebral cortex	50.5 nTPM
Amygdala	47.5 nTPM
Thalamus	46.0 nTPM
Basal ganglia	45.4 nTPM
Hippocampus	44.4 nTPM

Endothelial cell	27.2 nTPM
Hippocampus	35.3 nTPM
Spinal cord	34.5 nTPM
Thalamus	34.5 nTPM
Hypothalamus	31.0 nTPM
Midbrain	30.2 nTPM
Cerebellum	28.7 nTPM
Cerebral cortex	26.2 nTPM
Pons	23.1 nTPM
Amygdala	21.2 nTPM
Basal ganglia	17.7 nTPM
Medulla oblongata	16.4 nTPM

Ependymal cell	62.5 nTPM
Amygdala	73.4 nTPM
Thalamus	70.9 nTPM
Pons	68.7 nTPM
Hippocampus	66.9 nTPM
Midbrain	62.9 nTPM
Hypothalamus	62.5 nTPM
Basal ganglia	58.5 nTPM
Medulla oblongata	56.4 nTPM
Spinal cord	42.2 nTPM