Single cell type - MOG - The Human Protein Atlas

MOG

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MOG
Gene descriptionⁱ Full gene name according to HGNC.	Myelin oligodendrocyte glycoprotein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Oligodendrocytes - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enriched (Oligodendrocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.98
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Group enriched (Oligodendrocyte, Committed oligodendrocyte precursor)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enriched (Oligodendrocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Group enriched (Oligodendrocyte, Committed oligodendrocyte precursor)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

MOG is part of cluster 51 Oligodendrocytes - Unknown function with confidenceⁱ 1
302 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OPALIN	Oligodendrocytic myelin paranodal and inner loop protein	0.9979	51
ST18	ST18 C2H2C-type zinc finger transcription factor	0.9951	51
OR9A2	Olfactory receptor family 9 subfamily A member 2	0.9895	51
ERMN	Ermin	0.9830	51
SLCO1A2	Solute carrier organic anion transporter family member 1A2	0.9810	51
TRPV5	Transient receptor potential cation channel subfamily V member 5	0.9804	51
CARNS1	Carnosine synthase 1	0.9786	51
TMEM235	Transmembrane protein 235	0.9754	51
RNF220	Ring finger protein 220	0.9694	51
SLC5A11	Solute carrier family 5 member 11	0.9619	51
MOBP	Myelin associated oligodendrocyte basic protein	0.9318	51
HSD17B3	Hydroxysteroid 17-beta dehydrogenase 3	0.9298	51
MAP6D1	MAP6 domain containing 1	0.9190	51
PLEKHH1	Pleckstrin homology, MyTH4 and FERM domain containing H1	0.9141	51
CTNNA3	Catenin alpha 3	0.9109	51

Adipocytes	0.0 nTPM
Adipose tissue	0.0 nTPM
Breast	0.0 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	0.0 nTPM
Lung	0.0 nTPM

Astrocytes	0.6 nTPM
Brain	0.6 nTPM

B-cells	0.3 nTPM
Skin	3.4 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM

Ciliated cells	0.0 nTPM
Endometrium	0.0 nTPM
Bronchus	0.0 nTPM
Lung	0.0 nTPM
Fallopian tube	0.0 nTPM

Club cells	0.0 nTPM
Bronchus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM

Endothelial cells	0.1 nTPM
Heart muscle	1.7 nTPM
Skin	0.6 nTPM
Skeletal muscle	0.1 nTPM
Ovary	0.1 nTPM
Testis	0.0 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	0.1 nTPM
Skin	0.9 nTPM
Skeletal muscle	0.5 nTPM
Heart muscle	0.2 nTPM
Placenta	0.2 nTPM
Pancreas	0.1 nTPM
Thymus	0.1 nTPM
Liver	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

Granulocytes	0.0 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM
Fallopian tube	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	0.0 nTPM
Fallopian tube	0.0 nTPM
Ovary	0.0 nTPM

Macrophages	0.1 nTPM
Skin	1.1 nTPM
Skeletal muscle	0.7 nTPM
Breast	0.2 nTPM
Vascular	0.1 nTPM
Testis	0.0 nTPM
Kidney	0.0 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Fallopian tube	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Plasma cells	0.0 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Fallopian tube	0.0 nTPM

Schwann cells	0.1 nTPM
Adipose tissue	0.4 nTPM
Esophagus	0.0 nTPM
Vascular	0.0 nTPM

Serous glandular cells	0.0 nTPM
Salivary gland	0.0 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	0.1 nTPM
Prostate	0.6 nTPM
Skeletal muscle	0.2 nTPM
Vascular	0.1 nTPM
Fallopian tube	0.1 nTPM
Ovary	0.1 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Endometrium	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Breast	0.0 nTPM

T-cells	0.0 nTPM
Skin	0.4 nTPM
PBMC	0.2 nTPM
Salivary gland	0.2 nTPM
Adipose tissue	0.1 nTPM
Thymus	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Endometrium	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Amygdala excitatory	1.0 nTPM
Thalamus	1.8 nTPM
Basal ganglia	1.3 nTPM
Amygdala	0.9 nTPM
Hippocampus	0.8 nTPM
Cerebral cortex	0.7 nTPM
Hypothalamus	0.6 nTPM

Astrocyte	9.2 nTPM
Spinal cord	25.7 nTPM
Cerebellum	22.2 nTPM
Midbrain	14.8 nTPM
Hippocampus	8.6 nTPM
Pons	6.9 nTPM
Thalamus	6.3 nTPM
Basal ganglia	4.0 nTPM
Cerebral cortex	4.0 nTPM
Medulla oblongata	3.6 nTPM
Amygdala	3.3 nTPM
Hypothalamus	1.4 nTPM

Bergmann glia	3.2 nTPM
Medulla oblongata	6.4 nTPM
Cerebellum	1.7 nTPM
Pons	1.4 nTPM

Central nervous system macrophage	11.7 nTPM
Spinal cord	30.3 nTPM
Midbrain	21.1 nTPM
Cerebellum	16.8 nTPM
Pons	14.9 nTPM
Hippocampus	11.4 nTPM
Thalamus	9.1 nTPM
Medulla oblongata	6.5 nTPM
Basal ganglia	5.9 nTPM
Cerebral cortex	5.7 nTPM
Amygdala	5.2 nTPM
Hypothalamus	1.8 nTPM

Cerebellar inhibitory	1.8 nTPM
Pons	4.0 nTPM
Midbrain	2.2 nTPM
Medulla oblongata	1.7 nTPM
Cerebellum	1.4 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	1.1 nTPM
Hippocampus	1.6 nTPM
Basal ganglia	1.4 nTPM
Thalamus	1.4 nTPM
Amygdala	1.2 nTPM
Cerebral cortex	0.8 nTPM
Midbrain	0.7 nTPM
Hypothalamus	0.5 nTPM

Choroid plexus epithelial cell	12.5 nTPM
Thalamus	41.1 nTPM
Medulla oblongata	6.7 nTPM
Basal ganglia	2.4 nTPM
Hippocampus	0.0 nTPM

Committed oligodendrocyte precursor	307.3 nTPM
Amygdala	412.7 nTPM
Hypothalamus	401.5 nTPM
Thalamus	392.0 nTPM
Hippocampus	343.0 nTPM
Midbrain	321.7 nTPM
Cerebral cortex	307.8 nTPM
Pons	285.1 nTPM
Cerebellum	277.5 nTPM
Basal ganglia	268.3 nTPM
Spinal cord	224.4 nTPM
Medulla oblongata	145.9 nTPM

Deep-layer corticothalamic and 6b	0.9 nTPM
Basal ganglia	1.6 nTPM
Amygdala	1.4 nTPM
Hippocampus	1.0 nTPM
Cerebral cortex	0.8 nTPM
Hypothalamus	0.7 nTPM
Midbrain	0.0 nTPM

Deep-layer intratelencephalic	1.0 nTPM
Basal ganglia	1.6 nTPM
Hippocampus	1.2 nTPM
Amygdala	1.0 nTPM
Cerebral cortex	0.7 nTPM
Hypothalamus	0.5 nTPM

Deep-layer near-projecting	0.8 nTPM
Hippocampus	1.0 nTPM
Amygdala	0.9 nTPM
Hypothalamus	0.9 nTPM
Cerebral cortex	0.7 nTPM
Basal ganglia	0.6 nTPM

Eccentric medium spiny neuron	1.0 nTPM
Thalamus	1.7 nTPM
Hippocampus	1.2 nTPM
Amygdala	0.9 nTPM
Cerebral cortex	0.9 nTPM
Basal ganglia	0.7 nTPM
Hypothalamus	0.5 nTPM

Endothelial cell	8.3 nTPM
Spinal cord	25.9 nTPM
Midbrain	17.0 nTPM
Hippocampus	10.6 nTPM
Cerebral cortex	8.3 nTPM
Pons	6.9 nTPM
Cerebellum	6.2 nTPM
Basal ganglia	4.7 nTPM
Amygdala	4.5 nTPM
Medulla oblongata	4.1 nTPM
Thalamus	2.8 nTPM
Hypothalamus	0.0 nTPM

Ependymal cell	5.1 nTPM
Hippocampus	10.6 nTPM
Spinal cord	9.6 nTPM
Midbrain	7.6 nTPM
Amygdala	6.3 nTPM
Medulla oblongata	3.1 nTPM
Thalamus	2.8 nTPM
Basal ganglia	2.4 nTPM
Pons	2.4 nTPM
Hypothalamus	0.9 nTPM