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The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
S100A6 is not prognostic in Pancreatic Adenocarcinoma (TCGA)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
9925.5
Number of samples
176
Samples
Sample
Description
TPM
TCGA-HZ-A49I-01A
0 years, male, white, stage:Stage IIB, dead, 308 days
30380.8
TCGA-YH-A8SY-01A
0 years, female, white, stage:'--, alive, 388 days
27690.8
TCGA-2J-AABH-01A
0 years, male, white, stage:Stage IIA, alive, 1287 days
24463.5
TCGA-HV-A7OL-01A
0 years, male, asian, stage:Stage IIA, alive, 252 days
23949.8
TCGA-LB-A8F3-01A
0 years, female, black or african american, stage:Stage IIA, alive, 379 days
23234.9
TCGA-FB-AAQ3-01A
0 years, female, white, stage:Stage IIB, dead, 31 days
22635.3
TCGA-S4-A8RO-01A
0 years, female, white, stage:Stage IIB, alive, 525 days
22517.7
TCGA-OE-A75W-01A
0 years, male, white, stage:Stage IIA, dead, 267 days
22153.7
TCGA-XD-AAUL-01A
0 years, male, white, stage:Stage IIA, alive, 498 days
21902.5
TCGA-IB-AAUU-01A
0 years, male, white, stage:Stage IIB, alive, 245 days
21473.3
TCGA-2L-AAQJ-01A
0 years, female, white, stage:Stage III, dead, 394 days
21472.1
TCGA-2J-AAB1-01A
0 years, male, white, stage:Stage IIB, dead, 66 days
20924.7
TCGA-HV-AA8X-01A
0 years, female, asian, stage:Stage IIB, dead, 532 days
20483.9
TCGA-3E-AAAZ-01A
0 years, male, white, stage:Stage IIA, dead, 2182 days
20420.5
TCGA-IB-A5SQ-01A
0 years, female, white, stage:Stage IB, dead, 219 days
20378.6
TCGA-PZ-A5RE-01A
0 years, female, white, stage:Stage IIB, dead, 470 days
20232.4
TCGA-3A-A9IH-01A
0 years, female, white, stage:Stage IA, alive, 1021 days
19428.2
TCGA-RB-A7B8-01A
0 years, female, white, stage:Stage IIB, dead, 466 days
19192.3
TCGA-3A-A9IC-01A
0 years, female, white, stage:Stage IIB, dead, 738 days
19116.8
TCGA-2J-AAB6-01A
0 years, male, white, stage:Stage IIA, dead, 293 days
18498.1
TCGA-2L-AAQA-01A
0 years, male, white, stage:Stage IIB, dead, 143 days
18063.1
TCGA-HV-A7OP-01A
0 years, male, asian, stage:Stage IIB, alive, 978 days
17500.0
TCGA-M8-A5N4-01A
0 years, female, stage:Stage IIA, alive, 584 days
17264.3
TCGA-2J-AABU-01A
0 years, male, white, stage:Stage IIB, dead, 277 days
17104.9
TCGA-3A-A9IU-01A
0 years, male, white, stage:Stage IIB, dead, 458 days
16932.1
TCGA-FB-AAPU-01A
0 years, female, asian, stage:Stage IIA, dead, 381 days
16916.0
TCGA-HZ-A9TJ-01A
0 years, male, white, stage:Stage IV, alive, 603 days
16782.4
TCGA-YY-A8LH-01A
0 years, female, white, stage:Stage IIB, alive, 2016 days
16134.1
TCGA-H6-8124-01A
0 years, female, white, stage:Stage IIB, alive, 392 days
16069.3
TCGA-FB-A78T-01A
0 years, female, white, stage:Stage IIB, dead, 375 days
16034.0
TCGA-2L-AAQL-01A
0 years, male, white, stage:Stage IIB, dead, 292 days
15913.7
TCGA-FB-AAQ0-01A
0 years, male, white, stage:Stage IIA, dead, 473 days
15599.6
TCGA-IB-AAUN-01A
0 years, female, white, stage:Stage IB, dead, 144 days
15473.4
TCGA-US-A779-01A
0 years, female, white, stage:Stage IIB, dead, 511 days
15394.1
TCGA-HV-A5A4-01A
0 years, female, asian, stage:Stage IIA, alive, 232 days
15252.0
TCGA-HZ-A8P1-01A
0 years, male, white, stage:Stage IB, alive, 7 days
15032.1
TCGA-2L-AAQI-01A
0 years, male, white, stage:Stage IIB, dead, 103 days
14988.5
TCGA-FB-AAPY-01A
0 years, male, white, stage:Stage IIB, dead, 1059 days
14398.3
TCGA-2L-AAQE-01A
0 years, male, white, stage:Stage IIB, dead, 684 days
14243.0
TCGA-FB-AAQ6-01A
0 years, male, white, stage:Stage IA, dead, 244 days
14242.0
TCGA-Q3-AA2A-01A
0 years, female, white, stage:Stage IB, alive, 95 days
14167.8
TCGA-3A-A9IZ-01A
0 years, male, white, stage:Stage IIB, dead, 308 days
14075.6
TCGA-HZ-8636-01A
0 years, female, white, stage:Stage IV, dead, 545 days
13991.4
TCGA-2J-AAB4-01A
0 years, male, white, stage:Stage IIB, alive, 729 days
13847.6
TCGA-IB-A5SP-01A
0 years, male, white, stage:Stage IIA, alive, 482 days
13698.1
TCGA-IB-7889-01A
0 years, female, white, stage:Stage IIB, dead, 481 days
13646.3
TCGA-2J-AAB8-01A
0 years, male, white, stage:Stage IIB, alive, 80 days
13629.8
TCGA-2J-AABK-01A
0 years, male, white, stage:Stage IIB, alive, 484 days
13526.6
TCGA-US-A776-01A
0 years, male, white, stage:Stage IIA, alive, 1216 days
13507.0
TCGA-F2-6879-01A
0 years, male, white, stage:Stage IIB, dead, 334 days
13318.3
TCGA-FB-AAQ2-01A
0 years, female, white, stage:Stage IIB, dead, 153 days
13206.4
TCGA-HV-A5A6-01A
0 years, female, asian, stage:Stage IIB, dead, 2036 days
13176.2
TCGA-IB-A5SO-01A
0 years, male, white, stage:Stage IIB, dead, 365 days
13025.5
TCGA-HV-AA8V-01A
0 years, male, asian, stage:Stage IIB, alive, 920 days
13004.5
TCGA-US-A77G-01A
0 years, male, white, stage:Stage IIB, dead, 12 days
12984.0
TCGA-IB-7885-01A
0 years, female, white, stage:Stage IIB, alive, 1257 days
12979.3
TCGA-HZ-A4BK-01A
0 years, male, white, stage:Stage IIB, alive, 657 days
12929.5
TCGA-2J-AABE-01A
0 years, male, white, stage:Stage IIA, alive, 676 days
12914.6
TCGA-IB-A7LX-01A
0 years, male, white, stage:Stage IIB, dead, 250 days
12694.2
TCGA-3E-AAAY-01A
0 years, male, white, stage:Stage IIB, alive, 2285 days
12680.9
TCGA-S4-A8RM-01A
0 years, male, white, stage:Stage IIB, alive, 737 days
12519.8
TCGA-YB-A89D-01A
0 years, male, white, stage:Stage IIB, alive, 350 days
12289.5
TCGA-FB-A7DR-01A
0 years, male, asian, stage:Stage IIA, dead, 353 days
12069.9
TCGA-HZ-7289-01A
0 years, male, white, stage:Stage IIB, dead, 661 days
12021.8
TCGA-HV-A5A3-01A
0 years, male, asian, stage:Stage IIA, dead, 128 days
11949.8
TCGA-HZ-7919-01A
0 years, female, white, stage:Stage IIB, dead, 593 days
11753.1
TCGA-FB-A545-01A
0 years, female, white, stage:Stage IIB, dead, 732 days
11751.2
TCGA-FB-AAPQ-01A
0 years, male, white, stage:Stage IIB, dead, 1130 days
11639.5
TCGA-IB-7893-01A
0 years, male, white, stage:Stage IIA, dead, 117 days
11129.0
TCGA-S4-A8RP-01A
0 years, female, white, stage:Stage IIB, dead, 702 days
11006.5
TCGA-HZ-A77O-01A
0 years, female, white, stage:Stage IIB, dead, 160 days
10949.7
TCGA-FB-AAPZ-01A
0 years, male, white, stage:Stage IIB, alive, 716 days
10794.0
TCGA-IB-7646-01A
0 years, male, white, stage:Stage IIB, dead, 145 days
10722.6
TCGA-IB-A6UF-01A
0 years, male, white, stage:Stage IIB, alive, 666 days
10615.0
TCGA-2J-AABO-01A
0 years, male, white, stage:Stage IIB, alive, 440 days
10528.2
TCGA-IB-AAUQ-01A
0 years, male, white, stage:Stage IIB, dead, 183 days
10438.7
TCGA-HZ-7926-01A
0 years, male, black or african american, stage:Stage IIB, dead, 518 days
10290.0
TCGA-3A-A9IB-01A
0 years, female, white, stage:Stage IIB, dead, 224 days
10283.5
TCGA-F2-A8YN-01A
0 years, male, white, stage:Stage IIA, alive, 517 days
10211.0
TCGA-FB-AAPP-01A
0 years, male, white, stage:Stage IIB, dead, 485 days
9705.8
TCGA-XD-AAUI-01A
0 years, female, white, stage:Stage IIB, dead, 366 days
9678.0
TCGA-H6-A45N-01A
0 years, female, white, stage:Stage IIB, dead, 397 days
9514.6
TCGA-IB-AAUO-01A
0 years, female, white, stage:Stage IIB, dead, 239 days
9444.6
TCGA-H8-A6C1-01A
0 years, male, white, stage:Stage IIA, alive, 671 days
9427.4
TCGA-IB-8127-01A
0 years, male, white, stage:Stage IIB, alive, 522 days
9332.7
TCGA-3A-A9I7-01A
0 years, male, black or african american, stage:Stage IIB, alive, 1323 days
9269.7
TCGA-FB-AAQ1-01A
0 years, male, white, stage:Stage IIB, dead, 123 days
9190.8
TCGA-F2-A44G-01A
0 years, female, white, stage:Stage IIB, dead, 233 days
9106.9
TCGA-IB-7886-01A
0 years, male, white, stage:Stage IIB, dead, 123 days
9091.4
TCGA-HZ-8638-01A
0 years, female, white, stage:Stage IA, dead, 151 days
9087.7
TCGA-3A-A9J0-01A
0 years, male, white, stage:Stage IIB, alive, 743 days
9054.8
TCGA-HZ-7922-01A
0 years, female, white, stage:Stage IIB, alive, 4 days
9025.0
TCGA-L1-A7W4-01A
0 years, female, white, stage:Stage IIB, dead, 278 days
8708.2
TCGA-IB-A7M4-01A
0 years, male, white, stage:Stage IIB, alive, 483 days
8496.7
TCGA-2J-AABF-01A
0 years, male, white, stage:Stage IIB, dead, 691 days
8250.8
TCGA-IB-7890-01A
0 years, male, stage:Stage IB, dead, 598 days
8227.7
TCGA-2J-AABA-01A
0 years, male, white, stage:Stage IIB, dead, 607 days
8055.4
TCGA-IB-A5SS-01A
0 years, female, white, stage:Stage IIB, dead, 460 days
7751.4
TCGA-IB-AAUR-01A
0 years, male, white, stage:Stage IIB, alive, 338 days
7279.0
TCGA-IB-7652-01A
0 years, female, asian, stage:Stage IIB, alive, 1116 days
7240.8
TCGA-RB-AA9M-01A
0 years, male, white, stage:Stage IIB, alive, 286 days
7196.2
TCGA-3A-A9I9-01A
0 years, male, white, stage:Stage IIA, dead, 634 days
7122.9
TCGA-XN-A8T3-01A
0 years, male, white, stage:Stage IB, alive, 951 days
7091.2
TCGA-RL-AAAS-01A
0 years, female, white, stage:Stage IB, alive, 9 days
7087.9
TCGA-IB-7644-01A
0 years, female, white, stage:Stage IV, dead, 394 days
7032.8
TCGA-HZ-8001-01A
0 years, male, white, stage:Stage III, alive, 706 days
7007.9
TCGA-US-A77E-01A
0 years, male, white, stage:Stage IIB, dead, 430 days
6876.5
TCGA-HZ-A49G-01A
0 years, female, white, stage:Stage IIB, alive, 660 days
6630.7
TCGA-HZ-7925-01A
0 years, male, white, stage:Stage IIB, dead, 614 days
6605.6
TCGA-FB-AAPS-01A
0 years, female, white, stage:Stage IIB, alive, 228 days
6516.7
TCGA-HZ-A77Q-01A
0 years, female, white, stage:Stage IIB, alive, 33 days
6428.8
TCGA-HZ-8315-01A
0 years, female, white, stage:Stage IIA, dead, 299 days
6417.6
TCGA-FB-A5VM-01A
0 years, male, white, stage:Stage IB, dead, 498 days
6381.0
TCGA-FB-A4P5-01A
0 years, female, white, stage:Stage IIB, dead, 179 days
6365.5
TCGA-IB-7887-01A
0 years, female, white, stage:Stage IIB, dead, 110 days
6358.6
TCGA-IB-7888-01A
0 years, female, black or african american, stage:Stage IIA, dead, 1332 days
6324.0
TCGA-2J-AABR-01A
0 years, female, white, stage:Stage IIA, alive, 438 days
6181.3
TCGA-IB-7649-01A
0 years, female, stage:Stage IIB, dead, 467 days
6104.1
TCGA-3A-A9I5-01A
0 years, male, white, stage:'--, alive, 1794 days
6005.1
TCGA-US-A774-01A
0 years, female, white, stage:Stage IIB, dead, 695 days
5982.3
TCGA-IB-7645-01A
0 years, female, stage:Stage IIB, dead, 1502 days
5957.1
TCGA-2J-AAB9-01A
0 years, female, white, stage:Stage IIB, dead, 627 days
5957.0
TCGA-HZ-7918-01A
0 years, male, white, stage:Stage IIB, alive, 969 days
5879.7
TCGA-HV-A5A5-01A
0 years, female, asian, stage:Stage IIB, alive, 289 days
5776.7
TCGA-XN-A8T5-01A
0 years, female, white, stage:Stage IB, alive, 720 days
5697.3
TCGA-HZ-A4BH-01A
0 years, male, white, stage:Stage IIB, alive, 194 days
5677.9
TCGA-LB-A7SX-01A
0 years, female, black or african american, stage:Stage IIB, dead, 393 days
5583.4
TCGA-HZ-A77P-01A
0 years, male, white, stage:Stage IIB, alive, 330 days
5488.6
TCGA-HZ-7924-01A
0 years, female, white, stage:Stage IIA, alive, 840 days
5404.7
TCGA-HZ-8005-01A
0 years, male, white, stage:Stage IIB, dead, 120 days
5373.9
TCGA-IB-AAUS-01A
0 years, female, white, stage:Stage IIB, alive, 225 days
4794.4
TCGA-Z5-AAPL-01A
0 years, female, white, stage:Stage IIA, alive, 467 days
4718.5
TCGA-IB-7651-01A
0 years, female, white, stage:Stage IIB, dead, 603 days
4585.0
TCGA-US-A77J-01A
0 years, female, white, stage:Stage IIB, dead, 568 days
4560.3
TCGA-IB-AAUW-01A
0 years, female, white, stage:Stage IIB, dead, 230 days
4546.0
TCGA-IB-A5ST-01A
0 years, female, white, stage:Stage IIB, alive, 635 days
4425.5
TCGA-2J-AABI-01A
0 years, female, white, stage:Stage IIA, alive, 969 days
4409.3
TCGA-XD-AAUG-01A
0 years, female, white, stage:Stage IV, alive, 420 days
4197.3
TCGA-XD-AAUH-01A
0 years, female, white, stage:Stage IIB, alive, 395 days
4162.2
TCGA-HZ-8317-01A
0 years, female, white, stage:Stage IIB, dead, 378 days
4119.1
TCGA-FB-A4P6-01A
0 years, male, white, stage:Stage IIB, alive, 767 days
3955.9
TCGA-IB-7891-01A
0 years, female, white, stage:Stage IIB, dead, 913 days
3954.4
TCGA-IB-A6UG-01A
0 years, male, white, stage:Stage IIB, dead, 41 days
3931.3
TCGA-3A-A9IX-01A
0 years, male, white, stage:Stage IA, alive, 1037 days
3770.7
TCGA-HZ-A49H-01A
0 years, female, white, stage:Stage IIB, alive, 491 days
3735.6
TCGA-IB-7654-01A
0 years, male, white, stage:Stage IIB, dead, 476 days
3729.3
TCGA-F2-A44H-01A
0 years, male, white, stage:Stage IIA, alive, 586 days
3642.3
TCGA-2J-AABT-01A
0 years, female, white, stage:Stage IIB, alive, 319 days
3626.6
TCGA-F2-A7TX-01A
0 years, male, white, stage:Stage IIB, dead, 95 days
3625.1
TCGA-LB-A9Q5-01A
0 years, female, white, stage:Stage IIB, dead, 313 days
3614.8
TCGA-HZ-7920-01A
0 years, male, white, stage:Stage IB, dead, 236 days
3423.3
TCGA-2J-AABP-01A
0 years, female, white, stage:Stage IIB, alive, 463 days
3394.2
TCGA-IB-AAUP-01A
0 years, male, white, stage:Stage IIB, alive, 431 days
3392.4
TCGA-IB-AAUT-01A
0 years, male, white, stage:Stage IIB, alive, 287 days
3152.3
TCGA-F2-7276-01A
0 years, male, white, stage:Stage IIB, dead, 216 days
3055.6
TCGA-Q3-A5QY-01A
0 years, male, white, stage:Stage IIB, alive, 416 days
3027.2
TCGA-HZ-7923-01A
0 years, male, white, stage:Stage IIA, alive, 314 days
2867.7
TCGA-HZ-8002-01A
0 years, male, white, stage:Stage IIB, dead, 366 days
2817.9
TCGA-IB-7897-01A
0 years, female, white, stage:Stage IIB, dead, 486 days
2788.3
TCGA-3A-A9IJ-01A
0 years, male, white, stage:Stage IB, alive, 1854 days
2603.5
TCGA-F2-7273-01A
0 years, male, black or african american, stage:Stage IIB, dead, 592 days
2452.6
TCGA-2L-AAQM-01A
0 years, male, white, stage:Stage IIB, alive, 1383 days
2344.0
TCGA-HZ-8637-01A
0 years, female, white, stage:Stage IIB, dead, 517 days
2300.8
TCGA-HZ-8519-01A
0 years, male, white, stage:Stage IA, alive, 454 days
2270.4
TCGA-IB-AAUV-01A
0 years, male, white, stage:Stage IIB, alive, 404 days
2075.6
TCGA-IB-AAUM-01A
0 years, male, white, stage:Stage IIB, alive, 8 days
1906.6
TCGA-2J-AABV-01A
0 years, male, white, stage:Stage IIB, dead, 652 days
1717.5
TCGA-3A-A9IR-01A
0 years, female, white, stage:Stage IB, alive, 1542 days
1231.1
TCGA-3A-A9IN-01A
0 years, female, white, stage:Stage IB, alive, 2084 days
889.2
TCGA-IB-8126-01A
0 years, female, white, stage:Stage III, alive, 462 days
878.7
TCGA-HZ-8003-01A
0 years, female, white, stage:Stage IIB, dead, 596 days
824.2
TCGA-3A-A9IV-01A
0 years, female, white, stage:Stage IB, alive, 1103 days
777.6
TCGA-3A-A9IL-01A
0 years, female, white, stage:Stage I, alive, 2741 days
706.7
TCGA-3A-A9IS-01A
0 years, male, white, stage:Stage IB, alive, 998 days
255.9
TCGA-3A-A9IO-01A
0 years, male, white, stage:'--, alive, 1942 days
216.9
TCGA-F2-6880-01A
0 years, male, white, stage:Stage IIB, alive, 295 days
The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
S100A6 is not prognostic in Pancreatic Adenocarcinoma (validation)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
1118.2
Number of samples
80
Samples
Sample
Description
TPM
DO34817
0 years, female, NA, stage:, alive, 540 days
3118.9
DO34905
0 years, male, NA, stage:, alive, 1142 days
2514.7
DO49193
0 years, male, NA, stage:, dead, 1 days
2248.9
DO34736
0 years, female, NA, stage:, dead, 203 days
2242.0
DO34680
0 years, male, NA, stage:, dead, 99 days
2099.6
DO34616
0 years, female, NA, stage:, alive, 666 days
2054.1
DO33400
0 years, female, NA, stage:, alive, 1043 days
2035.6
DO49129
0 years, male, NA, stage:, alive, 337 days
1835.5
DO49135
0 years, male, NA, stage:, alive, 270 days
1717.8
DO33408
0 years, female, NA, stage:, alive, 909 days
1662.7
DO33128
0 years, male, NA, stage:, dead, 423 days
1642.9
DO34368
0 years, female, NA, stage:, dead, 537 days
1636.7
DO34608
0 years, female, NA, stage:, dead, 709 days
1536.4
DO34785
0 years, female, NA, stage:, alive, 721 days
1508.3
DO34288
0 years, female, NA, stage:, dead, 220 days
1458.4
DO49185
0 years, male, NA, stage:, alive, 179 days
1457.3
DO49178
0 years, male, NA, stage:, dead, 27 days
1456.0
DO49166
0 years, female, NA, stage:, alive, 222 days
1427.9
DO34720
0 years, male, NA, stage:, alive, 555 days
1423.6
DO34264
0 years, female, NA, stage:, dead, 1144 days
1419.9
DO34696
0 years, male, NA, stage:, alive, 689 days
1366.6
DO32860
0 years, male, NA, stage:, dead, 1259 days
1348.8
DO34809
0 years, female, NA, stage:, dead, 297 days
1336.4
DO32863
0 years, male, NA, stage:, dead, 715 days
1314.4
DO33488
0 years, male, NA, stage:, alive, 844 days
1300.9
DO49113
0 years, female, NA, stage:, alive, 413 days
1294.0
DO49130
0 years, female, NA, stage:, alive, 351 days
1280.2
DO34801
0 years, male, NA, stage:, alive, 626 days
1237.3
DO34448
0 years, female, NA, stage:, dead, 719 days
1223.2
DO49164
0 years, male, NA, stage:, alive, 272 days
1210.7
DO33512
female, NA, stage:, dead, 499 days
1210.7
DO49127
0 years, female, NA, stage:, alive, 392 days
1203.0
DO34793
0 years, male, NA, stage:, dead, 427 days
1197.6
DO33480
0 years, male, NA, stage:, alive, 1054 days
1195.5
DO49090
0 years, female, NA, stage:, dead, 152 days
1183.5
DO49183
0 years, female, NA, stage:, dead, 429 days
1169.8
DO34656
0 years, female, NA, stage:, alive, 834 days
1167.2
DO33344
0 years, male, NA, stage:, dead, 361 days
1136.1
DO49172
0 years, female, NA, stage:, dead, 1021 days
1123.8
DO34432
0 years, female, NA, stage:, dead, 400 days
1108.2
DO49137
0 years, female, NA, stage:, alive, 232 days
1092.3
DO49138
0 years, male, NA, stage:, dead, 230 days
1069.5
DO34849
0 years, female, NA, stage:, dead, 272 days
1053.1
DO34504
0 years, male, NA, stage:, dead, 257 days
1021.1
DO49133
0 years, female, NA, stage:, alive, 188 days
1015.9
DO34961
0 years, male, NA, stage:, dead, 632 days
991.6
DO32875
0 years, male, NA, stage:, dead, 348 days
986.4
DO34312
0 years, female, NA, stage:, dead, 226 days
962.4
DO34600
0 years, male, NA, stage:, dead, 537 days
941.4
DO33368
0 years, male, NA, stage:, dead, 98 days
906.7
DO33376
0 years, female, NA, stage:, alive, 909 days
905.7
DO33600
0 years, female, NA, stage:, alive, 854 days
875.3
DO49078
0 years, male, NA, stage:, dead, 465 days
872.9
DO32829
0 years, female, NA, stage:T2N0MX, dead, 1874 days
869.2
DO33544
0 years, female, NA, stage:, dead, 412 days
862.1
DO49080
0 years, male, NA, stage:, alive, 83 days
833.1
DO49079
0 years, male, NA, stage:, dead, 332 days
807.8
DO34728
0 years, female, NA, stage:, alive, 508 days
796.5
DO33392
0 years, male, NA, stage:, alive, 1014 days
796.2
DO34640
0 years, female, NA, stage:, dead, 287 days
770.8
DO33336
0 years, female, NA, stage:, dead, 451 days
764.0
DO32878
0 years, female, NA, stage:, dead, 260 days
755.4
DO34240
0 years, male, NA, stage:, dead, 236 days
687.0
DO49076
0 years, male, NA, stage:, dead, 480 days
686.1
DO49168
0 years, male, NA, stage:, alive, 149 days
666.7
DO49170
0 years, male, NA, stage:, alive, 197 days
624.1
DO33984
0 years, male, NA, stage:, alive, 847 days
616.9
DO49181
0 years, male, NA, stage:, dead, 1534 days
592.6
DO32900
0 years, male, NA, stage:, dead, 768 days
582.6
DO49087
0 years, female, NA, stage:, dead, 260 days
540.2
DO33472
0 years, female, NA, stage:, dead, 388 days
465.2
DO49184
0 years, male, NA, stage:, dead, 455 days
456.2
DO49204
0 years, male, NA, stage:, dead, 156 days
452.8
DO33552
0 years, female, NA, stage:, alive, 873 days
426.0
DO49074
0 years, male, NA, stage:, dead, 168 days
392.5
DO49198
0 years, female, NA, stage:, dead, 251 days
385.7
DO49199
0 years, male, NA, stage:, dead, 1095 days
354.5
DO33168
0 years, female, NA, stage:, dead, 8 days
235.1
DO49175
0 years, male, NA, stage:, dead, 414 days
233.6
DO34336
0 years, female, NA, stage:, alive, 743 days
4.0
Show allShow less
PANCREATIC DUCTAL ADENOCARCINOMA - Protein relative expression (CPTAC)
Number of samples
235
Samples
Sample ID
Sample type
nRPX
CPT0235230004
Tumor
1.7
CPT0081360004
Tumor
1.2
CPT0238610009
Tumor
1.1
CPT0208550005
Tumor
0.9
CPT0209640005
Tumor
0.9
CPT0078090004
Tumor
0.9
CPT0064090003
Tumor
0.8
CPT0064520004
Tumor
0.8
CPT0081260004
Tumor
0.8
CPT0083270003
Tumor
0.7
CPT0276010003
Tumor
0.7
CPT0019300004
Tumor
0.7
CPT0227930004
Tumor
0.7
CPT0001730017
Tumor
0.7
CPT0019410004
Tumor
0.6
CPT0248590004
Tumor
0.6
CPT0086190004
Tumor
0.6
CPT0125130003
Tumor
0.6
CPT0126160004
Tumor
0.5
CPT0088320003
Tumor
0.5
CPT0237910004
Tumor
0.5
CPT0209310004
Tumor
0.5
CPT0226760004
Tumor
0.5
CPT0081470004
Tumor
0.5
CPT0063970004
Tumor
0.4
CPT0207780004
Tumor
0.4
CPT0011520003
Tumor
0.4
CPT0078250003
Tumor
0.4
CPT0123440003
Tumor
0.4
CPT0088180004
Tumor
0.4
CPT0124980004
Tumor
0.4
CPT0123990003
Tumor
0.4
CPT0124610004
Tumor
0.4
CPT0065570003
Tumor
0.4
CPT0237840004
Tumor
0.3
CPT0248410004
Tumor
0.3
CPT0236780005
Tumor
0.3
CPT0238820005
Tumor
0.3
CPT0236560004
Tumor
0.3
CPT0109010004
Tumor
0.3
CPT0093930004
Tumor
0.3
CPT0236700005
Tumor
0.3
CPT0254680003
Tumor
0.3
CPT0246940003
Tumor
0.3
CPT0198700005
Tumor
0.3
CPT0238710004
Tumor
0.2
CPT0246810003
Tumor
0.2
CPT0246720003
Tumor
0.2
CPT0162660004
Tumor
0.2
CPT0218200004
Tumor
0.2
CPT0077860003
Tumor
0.2
CPT0123860003
Tumor
0.2
CPT0094030003
Tumor
0.2
CPT0093980004
Tumor
0.2
CPT0081060004
Tumor
0.2
CPT0065640003
Tumor
0.2
CPT0109300004
Tumor
0.2
CPT0247040003
Tumor
0.1
CPT0183450005
Tumor
0.1
CPT0241320005
Tumor
0.1
CPT0094230004
Tumor
0.1
CPT0238920004
Tumor
0.1
CPT0078160004
Tumor
0.0
CPT0187550004
Tumor
0.0
CPT0094630004
Tumor
0.0
WU-PDA1
Tumor
0.0
CPT0094180003
Tumor
0.0
CPT0094940004
Tumor
0.0
CPT0014040003
Tumor
0.0
CPT0236340004
Tumor
0.0
CPT0208840004
Tumor
0.0
CPT0238040005
Tumor
0.0
CPT0123750003
Tumor
0.0
CPT0008750003
Tumor
0.0
CPT0000250017
Tumor
0.0
CPT0208690004
Tumor
0.0
CPT0239910004
Tumor
0.0
CPT0092630003
Tumor
-0.1
CPT0087890004
Tumor
-0.1
CPT0246990003
Tumor
-0.1
CPT0226600004
Tumor
-0.1
CPT0127270003
Tumor
-0.1
CPT0170240004
Tumor
-0.1
CPT0078000003
Tumor
-0.1
CPT0094130004
Tumor
-0.1
CPT0185920004
Tumor
-0.1
CPT0186040004
Tumor
-0.1
CPT0355180003
Normal
-0.1
CPT0238530005
Tumor
-0.1
CPT0217700004
Tumor
-0.1
CPT0124500004
Tumor
-0.2
CPT0239100009
Tumor
-0.2
CPT0064110003
Normal
-0.2
CPT0123650003
Tumor
-0.2
CPT0063570003
Tumor
-0.2
CPT0241500004
Tumor
-0.2
CPT0139000004
Tumor
-0.2
CPT0226650004
Tumor
-0.2
CPT0064570003
Normal
-0.3
CPT0161990005
Tumor
-0.3
CPT0091660003
Tumor
-0.3
CPT0246950003
Normal
-0.3
CPT0066020003
Normal
-0.3
CPT0124410004
Tumor
-0.3
CPT0025750003
Tumor
-0.3
CPT0221240004
Tumor
-0.3
CPT0237270005
Tumor
-0.3
CPT0224460004
Tumor
-0.3
CPT0166760004
Tumor
-0.3
CPT0089720003
Tumor
-0.3
CPT0077790004
Tumor
-0.3
CPT0161770004
Tumor
-0.4
CPT0246840003
Tumor
-0.4
CPT0203850004
Tumor
-0.4
CPT0197420004
Tumor
-0.4
CPT0124360003
Tumor
-0.4
CPT0138990003
Normal
-0.4
CPT0207980005
Tumor
-0.4
CPT0094740004
Tumor
-0.5
CPT0109200004
Tumor
-0.5
CPT0108400003
Tumor
-0.5
CPT0088260004
Tumor
-0.5
CPT0174700004
Tumor
-0.5
CPT0198420004
Tumor
-0.5
CPT0347850002
Normal
-0.5
CPT0246260004
Tumor
-0.5
CPT0226530004
Tumor
-0.5
CPT0226490004
Tumor
-0.5
CPT0108930003
Tumor
-0.5
CPT0226570004
Tumor
-0.5
CPT0077930004
Tumor
-0.5
CPT0183750005
Tumor
-0.5
CPT0123460003
Normal
-0.6
CPT0017040004
Tumor
-0.6
CPT0238440005
Tumor
-0.6
CPT0276030003
Normal
-0.6
CPT0247090003
Tumor
-0.6
CPT0162760003
Tumor
-0.6
CPT0174800003
Normal
-0.6
CPT0248620003
Normal
-0.7
C3L-00401-04
Normal
-0.7
CPT0162670004
Normal
-0.7
CPT0123670003
Normal
-0.7
CPT0347820002
Normal
-0.8
CPT0077950003
Normal
-0.8
CPT0125010003
Normal
-0.8
CPT0236710004
Normal
-0.8
CPT0187930005
Tumor
-0.8
CPT0226610004
Normal
-0.8
CPT0264150003
Tumor
-0.8
CPT0093860003
Tumor
-0.8
CPT0077880003
Normal
-0.8
CPT0226680005
Tumor
-0.9
CPT0078030003
Normal
-0.9
CPT0162780004
Normal
-0.9
KoreanReference3
Tumor
-0.9
CPT0091680003
Normal
-0.9
CPT0170260004
Normal
-0.9
CPT0246220004
Normal
-0.9
CPT0008800003
Tumor
-0.9
CPT0125090003
Tumor
-0.9
CPT0093880003
Normal
-0.9
CPT0236360004
Normal
-1.0
CPT0166780004
Normal
-1.0
CPT0209650004
Normal
-1.0
CPT0124530003
Normal
-1.0
CPT0247000003
Normal
-1.0
CPT0198910005
Tumor
-1.0
CPT0347790002
Normal
-1.0
CPT0001750003
Normal
-1.0
KoreanReference2
Tumor
-1.1
CPT0221470005
Tumor
-1.1
CPT0246210004
Tumor
-1.1
CPT0207990004
Normal
-1.1
CPT0221250004
Normal
-1.1
CPT0197440004
Normal
-1.2
CPT0123890003
Normal
-1.2
CPT0127290003
Normal
-1.2
CPT0086210003
Normal
-1.2
CPT0238640004
Normal
-1.2
CPT0238940004
Normal
-1.2
CPT0239140004
Normal
-1.2
CPT0077810003
Normal
-1.3
CPT0237850004
Normal
-1.3
KoreanReference1
Tumor
-1.3
CPT0239920004
Normal
-1.3
CPT0347760002
Normal
-1.3
CPT0123770003
Normal
-1.3
CPT0218220004
Normal
-1.3
CPT0241510004
Normal
-1.3
CPT0078180003
Normal
-1.3
CPT0198930003
Normal
-1.3
CPT0011540003
Normal
-1.3
CPT0089750004
Normal
-1.4
CPT0355200003
Normal
-1.4
CPT0063580003
Normal
-1.4
CPT0108960003
Normal
-1.4
CPT0183770004
Normal
-1.4
CPT0198440004
Normal
-1.5
CPT0238740004
Normal
-1.5
CPT0017130003
Normal
-1.5
CPT0208710004
Normal
-1.5
CPT0187540004
Normal
-1.5
CPT0347880002
Normal
-1.5
CPT0025760003
Normal
-1.6
CPT0237920004
Normal
-1.7
CPT0248440003
Normal
-1.7
C3L-03632-04
Normal
-1.7
C3L-00189-04
Normal
-1.7
CPT0355190003
Normal
-1.8
CPT0124000003
Normal
-1.8
CPT0236800004
Normal
-1.8
C3N-02573-03
Normal
-1.8
CPT0208850004
Normal
-1.9
C3N-00709-06
Normal
-1.9
CPT0247050003
Normal
N/A
CPT0108410003
Normal
N/A
CPT0248320003
Normal
N/A
CPT0166650006
Tumor
N/A
CPT0224470004
Normal
N/A
C3L-01687-04
Normal
N/A
CPT0138890003
Normal
N/A
CPT0109110004
Tumor
N/A
WU-pooled sample
Tumor
N/A
CPT0014060003
Normal
N/A
CPT0109130003
Normal
N/A
CPT0138900004
Tumor
N/A
CPT0166680004
Normal
N/A
CPT0094760003
Normal
N/A
CPT0186050004
Normal
N/A
CPT0237290004
Normal
N/A
CPT0264180003
Normal
N/A
CPT0063990003
Normal
N/A
CPT0126200003
Normal
N/A
CPT0198730004
Normal
N/A
Show allShow less
PANCREATIC CANCER - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.
Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
The Human Protein Atlas project is funded
