Single cell type - FAR1 - The Human Protein Atlas

FAR1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FAR1
Gene descriptionⁱ Full gene name according to HGNC.	Fatty acyl-CoA reductase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Oligodendrocytes - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oligodendrocytes, Late spermatids)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.43
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Late spermatids)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

FAR1 is part of cluster 51 Oligodendrocytes - Unknown function with confidenceⁱ 1
302 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DPYSL5	Dihydropyrimidinase like 5	0.6439	51
SH3GL3	SH3 domain containing GRB2 like 3, endophilin A3	0.6320	51
ZDHHC20	Zinc finger DHHC-type palmitoyltransferase 20	0.6248	51
AGTPBP1	ATP/GTP binding carboxypeptidase 1	0.5961	51
C3orf20	Chromosome 3 open reading frame 20	0.5729	36
PSEN1	Presenilin 1	0.5412	51
CCDC7	Coiled-coil domain containing 7	0.5340	36
PDE1A	Phosphodiesterase 1A	0.5334	51
TTC7A	Tetratricopeptide repeat domain 7A	0.5278	36
LRTOMT	Leucine rich transmembrane and O-methyltransferase domain containing	0.5273	36
SRPK2	SRSF protein kinase 2	0.5183	36
SLC25A46	Solute carrier family 25 member 46	0.5128	36
ITCH	Itchy E3 ubiquitin protein ligase	0.5026	51
DPYD	Dihydropyrimidine dehydrogenase	0.4952	51
CCNY	Cyclin Y	0.4896	36

IMMUNE CELLS

FAR1 is part of cluster 38 Monocytes & Neutrophils - Degranulation with confidenceⁱ 1
501 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SIGLEC9	Sialic acid binding Ig like lectin 9	1.0000	38
SULT1A1	Sulfotransferase family 1A member 1	1.0000	38
PLSCR1	Phospholipid scramblase 1	1.0000	38
KCNE3	Potassium voltage-gated channel subfamily E regulatory subunit 3	1.0000	38
GLB1L	Galactosidase beta 1 like	1.0000	38
SLC12A9	Solute carrier family 12 member 9	1.0000	38
DYNC1LI1	Dynein cytoplasmic 1 light intermediate chain 1	1.0000	38
TMBIM6	Transmembrane BAX inhibitor motif containing 6	1.0000	38
TLR2	Toll like receptor 2	1.0000	38
LCP1	Lymphocyte cytosolic protein 1	1.0000	38
TM9SF2	Transmembrane 9 superfamily member 2	1.0000	38
TLR8	Toll like receptor 8	1.0000	38
MVP	Major vault protein	0.9762	38
PSEN1	Presenilin 1	0.9762	38
PVR	PVR cell adhesion molecule	0.9762	38

Adipocytes	35.4 nTPM
Adipose tissue	39.9 nTPM
Breast	30.8 nTPM

Alveolar cells type 1	42.8 nTPM
Lung	42.8 nTPM

Alveolar cells type 2	31.4 nTPM
Lung	31.4 nTPM

Astrocytes	75.9 nTPM
Brain	75.9 nTPM

B-cells	22.7 nTPM
Skin	45.7 nTPM
Bone marrow	34.2 nTPM
Lymph node	30.1 nTPM
Esophagus	29.5 nTPM
Adipose tissue	28.8 nTPM
Spleen	28.0 nTPM
Stomach	27.8 nTPM
Thymus	21.8 nTPM
Salivary gland	17.6 nTPM
PBMC	12.3 nTPM
Lung	9.4 nTPM
Kidney	5.2 nTPM
Liver	4.8 nTPM

Ciliated cells	20.7 nTPM
Bronchus	26.6 nTPM
Lung	21.8 nTPM
Endometrium	20.8 nTPM
Fallopian tube	13.6 nTPM

Club cells	26.1 nTPM
Bronchus	30.5 nTPM
Prostate	28.9 nTPM
Lung	18.7 nTPM

Dendritic cells	34.7 nTPM
Adipose tissue	47.9 nTPM
PBMC	21.6 nTPM

Endothelial cells	33.9 nTPM
Heart muscle	49.8 nTPM
Tongue	49.1 nTPM
Vascular	44.4 nTPM
Skin	37.7 nTPM
Thymus	36.7 nTPM
Endometrium	36.2 nTPM
Salivary gland	34.9 nTPM
Testis	34.2 nTPM
Skeletal muscle	33.4 nTPM
Liver	32.8 nTPM
Breast	32.5 nTPM
Prostate	31.4 nTPM
Fallopian tube	29.6 nTPM
Esophagus	29.4 nTPM
Pancreas	28.4 nTPM
Lung	27.8 nTPM
Ovary	22.0 nTPM
Placenta	19.3 nTPM

Enteroendocrine cells	41.9 nTPM
Colon	61.1 nTPM
Small intestine	34.3 nTPM
Rectum	30.2 nTPM

Fibroblasts	24.5 nTPM
Heart muscle	38.6 nTPM
Fallopian tube	34.7 nTPM
Skin	34.5 nTPM
Skeletal muscle	29.8 nTPM
Liver	27.3 nTPM
Adipose tissue	25.4 nTPM
Breast	24.6 nTPM
Vascular	24.2 nTPM
Pancreas	24.1 nTPM
Stomach	21.6 nTPM
Prostate	19.8 nTPM
Thymus	19.6 nTPM
Salivary gland	17.9 nTPM
Lung	17.8 nTPM
Esophagus	17.5 nTPM
Placenta	14.6 nTPM

Granulocytes	30.7 nTPM
Tongue	38.8 nTPM
Lung	26.7 nTPM
Fallopian tube	26.7 nTPM

Intestinal goblet cells	31.1 nTPM
Rectum	40.6 nTPM
Colon	31.5 nTPM
Small intestine	21.2 nTPM

Lymphatic endothelial cells	36.8 nTPM
Ovary	38.2 nTPM
Fallopian tube	35.5 nTPM

Macrophages	51.2 nTPM
Stomach	90.0 nTPM
Spleen	76.2 nTPM
Fallopian tube	68.7 nTPM
Skeletal muscle	64.7 nTPM
Bone marrow	61.8 nTPM
Adipose tissue	57.1 nTPM
Vascular	56.9 nTPM
Tongue	55.2 nTPM
Esophagus	53.9 nTPM
Prostate	44.3 nTPM
Salivary gland	44.0 nTPM
Endometrium	43.7 nTPM
Thymus	42.4 nTPM
Skin	41.2 nTPM
Lung	40.9 nTPM
Kidney	38.1 nTPM
Breast	36.3 nTPM
Testis	35.3 nTPM
Pancreas	22.6 nTPM

Basal keratinocytes	59.5 nTPM
Tongue	82.0 nTPM
Skin	37.0 nTPM

Basal prostatic cells	15.4 nTPM
Prostate	15.4 nTPM

Basal squamous epithelial cells	66.3 nTPM
Esophagus	66.3 nTPM

Bipolar cells	37.1 nTPM
Eye	37.1 nTPM

Paneth cells	43.2 nTPM
Colon	50.7 nTPM
Rectum	47.8 nTPM
Small intestine	31.1 nTPM

Plasma cells	27.8 nTPM
Stomach	37.3 nTPM
Thymus	32.3 nTPM
Fallopian tube	29.9 nTPM
Bone marrow	28.7 nTPM
Spleen	27.2 nTPM
Esophagus	26.0 nTPM
Salivary gland	21.0 nTPM
Liver	20.0 nTPM

Schwann cells	43.2 nTPM
Adipose tissue	50.7 nTPM
Vascular	42.8 nTPM
Esophagus	35.9 nTPM

Serous glandular cells	19.2 nTPM
Salivary gland	20.8 nTPM
Tongue	17.7 nTPM

Smooth muscle cells	23.2 nTPM
Tongue	31.7 nTPM
Adipose tissue	30.5 nTPM
Skin	29.8 nTPM
Esophagus	26.4 nTPM
Endometrium	26.1 nTPM
Skeletal muscle	25.9 nTPM
Vascular	24.8 nTPM
Salivary gland	23.1 nTPM
Fallopian tube	22.0 nTPM
Liver	20.8 nTPM
Prostate	20.7 nTPM
Ovary	20.4 nTPM
Breast	19.6 nTPM
Thymus	19.3 nTPM
Placenta	15.4 nTPM
Lung	14.1 nTPM

Suprabasal keratinocytes	48.6 nTPM
Tongue	78.1 nTPM
Skin	19.2 nTPM

T-cells	25.8 nTPM
Skin	42.8 nTPM
Adipose tissue	40.0 nTPM
Vascular	37.4 nTPM
Tongue	35.7 nTPM
Stomach	34.0 nTPM
Endometrium	31.2 nTPM
Breast	30.6 nTPM
Fallopian tube	29.9 nTPM
Bone marrow	29.5 nTPM
Spleen	29.2 nTPM
Skeletal muscle	28.0 nTPM
Lymph node	26.8 nTPM
Prostate	22.3 nTPM
Esophagus	21.9 nTPM
Thymus	21.3 nTPM
Lung	17.3 nTPM
Salivary gland	17.1 nTPM
Liver	15.6 nTPM
Colon	12.7 nTPM
Kidney	11.5 nTPM
PBMC	8.1 nTPM

Undifferentiated cells	32.5 nTPM
Colon	41.7 nTPM
Rectum	37.5 nTPM
Small intestine	18.4 nTPM

Amygdala excitatory	193.5 nTPM
Amygdala	205.0 nTPM
Hippocampus	198.1 nTPM
Thalamus	195.6 nTPM
Hypothalamus	192.6 nTPM
Basal ganglia	186.7 nTPM
Cerebral cortex	183.4 nTPM

Astrocyte	132.2 nTPM
Amygdala	175.4 nTPM
Spinal cord	147.4 nTPM
Hypothalamus	145.2 nTPM
Basal ganglia	144.9 nTPM
Hippocampus	135.0 nTPM
Cerebral cortex	133.0 nTPM
Thalamus	126.6 nTPM
Midbrain	126.5 nTPM
Pons	116.5 nTPM
Cerebellum	103.9 nTPM
Medulla oblongata	100.1 nTPM

Bergmann glia	125.7 nTPM
Cerebellum	131.3 nTPM
Medulla oblongata	127.9 nTPM
Pons	118.0 nTPM

Central nervous system macrophage	187.1 nTPM
Amygdala	236.2 nTPM
Hypothalamus	222.4 nTPM
Spinal cord	221.1 nTPM
Cerebellum	190.6 nTPM
Midbrain	190.2 nTPM
Basal ganglia	182.3 nTPM
Pons	181.6 nTPM
Hippocampus	175.3 nTPM
Thalamus	170.3 nTPM
Medulla oblongata	149.2 nTPM
Cerebral cortex	139.3 nTPM

Cerebellar inhibitory	153.1 nTPM
Midbrain	174.2 nTPM
Pons	161.4 nTPM
Medulla oblongata	150.8 nTPM
Cerebellum	150.0 nTPM
Spinal cord	129.2 nTPM

Cge interneuron	135.9 nTPM
Amygdala	148.9 nTPM
Thalamus	148.2 nTPM
Hippocampus	134.2 nTPM
Midbrain	132.5 nTPM
Basal ganglia	130.8 nTPM
Hypothalamus	130.5 nTPM
Cerebral cortex	126.5 nTPM

Choroid plexus epithelial cell	234.2 nTPM
Basal ganglia	264.2 nTPM
Thalamus	246.6 nTPM
Hippocampus	221.9 nTPM
Medulla oblongata	204.2 nTPM

Committed oligodendrocyte precursor	217.1 nTPM
Hypothalamus	305.9 nTPM
Amygdala	298.3 nTPM
Thalamus	274.9 nTPM
Hippocampus	224.0 nTPM
Cerebral cortex	211.5 nTPM
Basal ganglia	207.0 nTPM
Cerebellum	193.4 nTPM
Pons	186.8 nTPM
Midbrain	184.8 nTPM
Medulla oblongata	157.5 nTPM
Spinal cord	143.5 nTPM

Deep-layer corticothalamic and 6b	180.0 nTPM
Amygdala	189.8 nTPM
Cerebral cortex	186.3 nTPM
Hippocampus	180.0 nTPM
Midbrain	178.6 nTPM
Basal ganglia	178.5 nTPM
Hypothalamus	167.0 nTPM

Deep-layer intratelencephalic	194.0 nTPM
Amygdala	241.8 nTPM
Basal ganglia	200.6 nTPM
Hippocampus	180.2 nTPM
Cerebral cortex	178.5 nTPM
Hypothalamus	169.0 nTPM

Deep-layer near-projecting	159.8 nTPM
Amygdala	179.5 nTPM
Cerebral cortex	169.0 nTPM
Basal ganglia	166.6 nTPM
Hypothalamus	164.6 nTPM
Hippocampus	119.4 nTPM

Eccentric medium spiny neuron	203.9 nTPM
Amygdala	224.3 nTPM
Hippocampus	214.3 nTPM
Thalamus	212.6 nTPM
Hypothalamus	193.7 nTPM
Basal ganglia	192.4 nTPM
Cerebral cortex	186.3 nTPM