Single cell type - TRRAP - The Human Protein Atlas

TRRAP

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TRRAP
Gene descriptionⁱ Full gene name according to HGNC.	Transformation/transcription domain associated protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.30
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TRRAP is part of cluster 55 Non-specific - Transcription with confidenceⁱ 1
709 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF740	Zinc finger protein 740	0.5889	55
YLPM1	YLP motif containing 1	0.5696	55
KMT2A	Lysine methyltransferase 2A	0.5109	55
ZBTB40	Zinc finger and BTB domain containing 40	0.5094	55
CTCF	CCCTC-binding factor	0.4982	52
NOL9	Nucleolar protein 9	0.4888	39
DIDO1	Death inducer-obliterator 1	0.4881	55
EP400	E1A binding protein p400	0.4709	79
NUP210	Nucleoporin 210	0.4681	61
HCFC1	Host cell factor C1	0.4675	61
POLR3A	RNA polymerase III subunit A	0.4615	55
MCM3AP	Minichromosome maintenance complex component 3 associated protein	0.4579	49
ASH1L	ASH1 like histone lysine methyltransferase	0.4554	55
RBM12B	RNA binding motif protein 12B	0.4509	55
USP48	Ubiquitin specific peptidase 48	0.4509	77

IMMUNE CELLS

TRRAP is part of cluster 5 Non-specific - Cell proliferation with confidenceⁱ 0.99
689 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SCMH1	Scm polycomb group protein homolog 1	0.9524	5
ACSF3	Acyl-CoA synthetase family member 3	0.9524	5
SDR39U1	Short chain dehydrogenase/reductase family 39U member 1	0.9524	5
NUDCD2	NudC domain containing 2	0.9524	5
ELP6	Elongator acetyltransferase complex subunit 6	0.9524	5
ERCC3	ERCC excision repair 3, TFIIH core complex helicase subunit	0.9524	5
VMAC	Vimentin type intermediate filament associated coiled-coil protein	0.9286	5
ST7	Suppression of tumorigenicity 7	0.9286	5
HNRNPH1	Heterogeneous nuclear ribonucleoprotein H1	0.9286	5
EDEM1	ER degradation enhancing alpha-mannosidase like protein 1	0.9286	5
EIPR1	EARP complex and GARP complex interacting protein 1	0.9286	5
TBC1D4	TBC1 domain family member 4	0.9048	5
UNC45A	Unc-45 myosin chaperone A	0.9048	5
WRAP53	WD repeat containing antisense to TP53	0.9048	5
MAGOH	Mago homolog, exon junction complex subunit	0.9048	5

Adipocytes	11.7 nTPM
Adipose tissue	12.7 nTPM
Breast	10.8 nTPM

Alveolar cells type 1	14.0 nTPM
Lung	14.0 nTPM

Alveolar cells type 2	14.5 nTPM
Lung	14.5 nTPM

Astrocytes	28.8 nTPM
Brain	28.8 nTPM

B-cells	20.5 nTPM
Lymph node	30.9 nTPM
Salivary gland	30.1 nTPM
Bone marrow	29.4 nTPM
Thymus	27.3 nTPM
Adipose tissue	25.1 nTPM
Spleen	24.3 nTPM
Esophagus	23.6 nTPM
PBMC	20.0 nTPM
Stomach	18.6 nTPM
Lung	17.4 nTPM
Skin	10.2 nTPM
Kidney	5.2 nTPM
Liver	4.8 nTPM

Ciliated cells	15.7 nTPM
Fallopian tube	19.2 nTPM
Lung	15.9 nTPM
Endometrium	14.2 nTPM
Bronchus	13.6 nTPM

Club cells	13.0 nTPM
Lung	14.9 nTPM
Prostate	14.7 nTPM
Bronchus	9.4 nTPM

Dendritic cells	25.4 nTPM
Adipose tissue	29.2 nTPM
PBMC	21.6 nTPM

Endothelial cells	16.1 nTPM
Heart muscle	34.6 nTPM
Salivary gland	21.0 nTPM
Endometrium	19.8 nTPM
Vascular	18.9 nTPM
Ovary	17.4 nTPM
Thymus	16.7 nTPM
Prostate	16.4 nTPM
Lung	16.1 nTPM
Skeletal muscle	15.8 nTPM
Testis	15.0 nTPM
Esophagus	14.2 nTPM
Tongue	14.0 nTPM
Liver	13.9 nTPM
Fallopian tube	13.2 nTPM
Skin	11.6 nTPM
Breast	11.4 nTPM
Pancreas	10.3 nTPM
Placenta	10.2 nTPM

Enteroendocrine cells	11.0 nTPM
Rectum	18.4 nTPM
Colon	11.2 nTPM
Small intestine	3.4 nTPM

Fibroblasts	13.8 nTPM
Salivary gland	19.3 nTPM
Liver	19.0 nTPM
Skeletal muscle	17.6 nTPM
Esophagus	16.5 nTPM
Vascular	16.0 nTPM
Thymus	15.8 nTPM
Heart muscle	15.5 nTPM
Prostate	15.2 nTPM
Fallopian tube	14.8 nTPM
Adipose tissue	12.4 nTPM
Skin	12.3 nTPM
Stomach	11.5 nTPM
Breast	10.5 nTPM
Placenta	9.0 nTPM
Lung	8.5 nTPM
Pancreas	6.5 nTPM

Granulocytes	15.5 nTPM
Tongue	24.3 nTPM
Fallopian tube	13.1 nTPM
Lung	9.1 nTPM

Intestinal goblet cells	14.6 nTPM
Small intestine	20.7 nTPM
Rectum	13.5 nTPM
Colon	9.6 nTPM

Lymphatic endothelial cells	12.2 nTPM
Fallopian tube	13.5 nTPM
Ovary	10.9 nTPM

Macrophages	14.6 nTPM
Salivary gland	24.5 nTPM
Esophagus	20.6 nTPM
Spleen	20.1 nTPM
Thymus	19.4 nTPM
Stomach	18.0 nTPM
Skeletal muscle	17.6 nTPM
Tongue	17.1 nTPM
Fallopian tube	16.5 nTPM
Vascular	16.4 nTPM
Bone marrow	15.2 nTPM
Adipose tissue	13.7 nTPM
Skin	13.4 nTPM
Lung	12.1 nTPM
Prostate	12.1 nTPM
Breast	10.7 nTPM
Kidney	10.6 nTPM
Pancreas	8.2 nTPM
Testis	5.6 nTPM
Endometrium	5.5 nTPM

Basal prostatic cells	12.0 nTPM
Prostate	12.0 nTPM

Basal respiratory cells	8.6 nTPM
Bronchus	8.6 nTPM

Basal squamous epithelial cells	20.2 nTPM
Esophagus	20.2 nTPM

Bipolar cells	37.0 nTPM
Eye	37.0 nTPM

Paneth cells	5.9 nTPM
Rectum	10.9 nTPM
Small intestine	6.9 nTPM
Colon	0.0 nTPM

Plasma cells	22.2 nTPM
Esophagus	41.6 nTPM
Bone marrow	27.2 nTPM
Thymus	25.8 nTPM
Spleen	21.2 nTPM
Stomach	17.6 nTPM
Salivary gland	17.5 nTPM
Fallopian tube	17.4 nTPM
Liver	9.0 nTPM

Schwann cells	10.4 nTPM
Adipose tissue	16.0 nTPM
Vascular	15.1 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	16.8 nTPM
Tongue	17.7 nTPM
Salivary gland	16.0 nTPM

Smooth muscle cells	14.0 nTPM
Salivary gland	20.5 nTPM
Endometrium	18.7 nTPM
Ovary	17.3 nTPM
Skeletal muscle	17.2 nTPM
Adipose tissue	17.1 nTPM
Thymus	16.9 nTPM
Esophagus	16.8 nTPM
Vascular	16.7 nTPM
Tongue	11.7 nTPM
Prostate	11.6 nTPM
Skin	11.3 nTPM
Lung	10.6 nTPM
Placenta	9.9 nTPM
Breast	9.9 nTPM
Liver	9.8 nTPM
Fallopian tube	8.5 nTPM

Suprabasal keratinocytes	15.4 nTPM
Skin	23.1 nTPM
Tongue	7.7 nTPM

T-cells	21.4 nTPM
Salivary gland	37.7 nTPM
Thymus	33.1 nTPM
Lymph node	31.7 nTPM
Tongue	30.0 nTPM
Bone marrow	27.7 nTPM
Esophagus	26.8 nTPM
Vascular	24.1 nTPM
Spleen	21.8 nTPM
PBMC	21.0 nTPM
Adipose tissue	20.7 nTPM
Stomach	20.3 nTPM
Endometrium	20.1 nTPM
Skeletal muscle	19.3 nTPM
Fallopian tube	18.6 nTPM
Breast	17.8 nTPM
Lung	17.4 nTPM
Prostate	14.2 nTPM
Colon	13.6 nTPM
Liver	13.3 nTPM
Skin	11.9 nTPM
Kidney	8.0 nTPM

Undifferentiated cells	10.4 nTPM
Rectum	11.9 nTPM
Small intestine	11.0 nTPM
Colon	8.2 nTPM

Amygdala excitatory	95.9 nTPM
Hypothalamus	110.6 nTPM
Amygdala	101.5 nTPM
Thalamus	94.4 nTPM
Cerebral cortex	93.3 nTPM
Hippocampus	88.8 nTPM
Basal ganglia	87.0 nTPM

Astrocyte	116.2 nTPM
Amygdala	145.9 nTPM
Thalamus	122.5 nTPM
Cerebellum	121.6 nTPM
Hypothalamus	119.9 nTPM
Midbrain	118.4 nTPM
Hippocampus	117.0 nTPM
Cerebral cortex	113.7 nTPM
Basal ganglia	111.1 nTPM
Pons	106.8 nTPM
Medulla oblongata	100.8 nTPM
Spinal cord	100.7 nTPM

Bergmann glia	90.8 nTPM
Cerebellum	120.9 nTPM
Medulla oblongata	81.0 nTPM
Pons	70.5 nTPM

Central nervous system macrophage	125.4 nTPM
Amygdala	170.5 nTPM
Hypothalamus	151.9 nTPM
Thalamus	129.7 nTPM
Midbrain	127.3 nTPM
Hippocampus	122.5 nTPM
Basal ganglia	120.3 nTPM
Cerebral cortex	119.7 nTPM
Cerebellum	117.3 nTPM
Pons	117.1 nTPM
Medulla oblongata	109.3 nTPM
Spinal cord	94.2 nTPM

Cerebellar inhibitory	91.4 nTPM
Spinal cord	107.2 nTPM
Cerebellum	94.4 nTPM
Medulla oblongata	89.3 nTPM
Midbrain	88.0 nTPM
Pons	78.0 nTPM

Cge interneuron	94.6 nTPM
Hypothalamus	121.5 nTPM
Amygdala	99.0 nTPM
Basal ganglia	92.0 nTPM
Cerebral cortex	90.8 nTPM
Midbrain	89.2 nTPM
Hippocampus	85.8 nTPM
Thalamus	83.9 nTPM

Choroid plexus epithelial cell	111.7 nTPM
Basal ganglia	159.4 nTPM
Medulla oblongata	105.6 nTPM
Thalamus	104.1 nTPM
Hippocampus	77.7 nTPM

Committed oligodendrocyte precursor	99.4 nTPM
Hypothalamus	125.6 nTPM
Thalamus	125.2 nTPM
Amygdala	113.3 nTPM
Spinal cord	110.4 nTPM
Hippocampus	101.4 nTPM
Cerebral cortex	100.1 nTPM
Basal ganglia	89.2 nTPM
Cerebellum	88.8 nTPM
Midbrain	86.5 nTPM
Pons	85.9 nTPM
Medulla oblongata	67.1 nTPM

Deep-layer corticothalamic and 6b	89.5 nTPM
Hypothalamus	103.1 nTPM
Cerebral cortex	92.2 nTPM
Basal ganglia	92.1 nTPM
Amygdala	91.9 nTPM
Hippocampus	88.1 nTPM
Midbrain	69.9 nTPM

Deep-layer intratelencephalic	88.4 nTPM
Hypothalamus	103.1 nTPM
Amygdala	92.0 nTPM
Cerebral cortex	84.1 nTPM
Basal ganglia	81.8 nTPM
Hippocampus	80.8 nTPM

Deep-layer near-projecting	101.0 nTPM
Amygdala	120.6 nTPM
Hypothalamus	104.0 nTPM
Basal ganglia	98.9 nTPM
Cerebral cortex	95.4 nTPM
Hippocampus	85.9 nTPM

Eccentric medium spiny neuron	114.7 nTPM
Hypothalamus	119.8 nTPM
Thalamus	116.9 nTPM
Basal ganglia	116.7 nTPM
Cerebral cortex	116.6 nTPM
Amygdala	113.8 nTPM
Hippocampus	104.5 nTPM